Content » Vol 66, Issue 4

The perivascular cell populations in human skin after topical application of leukotriene B4

Winkelmann RK, Camp R, English JS, Greaves MW.
DOI: 10.2340/0001555566340343


Fifteen timed biopsies of human skin were performed after application of 100 nanograms of leukotriene B4 in a Finnchamber for six hours. The number of inflammatory cells were counted per high power perivascular field and compared to three control biopsies. At 24 hours a peak of neutrophiles was observed and subsequently lymphocytes predominated. Eosinophils were never prominent. This pattern of successive cell populations has been described in inflammatory and whealing skin disease.


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