Content » Vol 66, Issue 5

HLA genotypes in a family with a case of homozygous C2 deficiency and discoid lupus erythematosus

Braathen LR, Bratlie A, Teisberg P.
DOI: 10.2340/0001555566419422


A fifty-year-old man with a history of recurrent bronchial and renal infections, and rheumatoid arthritis was admitted with a sunexposure-induced discoid lupus erythematosus. Complement levels and HLA typing of the patient and his family revealed a homozygous C2 deficiency in the patient and his HLA-identical healthy younger sister. The C2 deficiency gene was associated with HLA-A10, B18, DR2, C4A4B2, BfS on one chromosome and with HLA-A2, B7, DR2, C4A4B2, BfS on the other.


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