Content » Vol 67, Issue 4

Psoriatic hair follicle cells. III. Characterization of aberrant morphology in differentiating cultures

Lenoir MC, Vermeesch-Markslag AM, Goos CM, Shroot B, Vermorken AJ.
DOI: 10.2340/0001555567277283


Psoriatic and control human hair follicle keratinocytes were cultured on bovine eye lens capsules in Epicult dishes for a period of 5-6 weeks and examined using light microscopy. The following morphological differences between cultures were observed: 1. The lower cell layers contained predominantly flattened cells in psoriatic cultures instead of roundish in control cultures. 2. The differentiation pattern was irregular in psoriatic cultures instead of regular in control cultures. 3. The differentiated zone of psoriatic cultures was more compact and thicker in comparison to normal cultures. These differences might allow discrimination between normal and psoriatic cultures.


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