Content » Vol 68, Issue 6

Lectin-binding sites in squamous cell carcinomas and keratoacanthomas

Ramírez-Bosca A, Reano A, Valcuende-Cavero F, Thivolet J, Castells-Rodellas A.
DOI: 10.2340/0001555568480485


The lectin-binding pattern of malignant and benign human epidermal tumours was studied. Twelve squamous cell carcinomas and ten kerato-acanthomas were investigated, using fluorochrome-conjugated lectins. Lectins used were Canavalia ensiformis agglutinin (Con-A), Helix pomatia agglutinin (HPA), Phaseolus vulgaris agglutinin (PHA-L), and Ricinus communis agglutinin (RCA-120). Two types of fluorescence pattern, Intercellular ´Pemphigus-like´ and Peritumoral, were noted. Both allowed classification of these tumours on the basis of their lectin-binding reactivity. Moreover, the expression of receptors for these lectins made it possible to distinguish between low-grade and well-differentiated squamous cell carcinomas.


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