Content » Vol 71, Issue 4

Ultrastructural changes of the skin induced by human leukocyte elastase and cathepsin G.

Glinski W, Kuligowski M, Pierozynska-Dubowska M, Glinska-Ferenz M, Jablonska S
DOI: 10.2340/0001555571277282


Human neutrophil elastase and cathepsin G at a concentration of 10(-6) M were found to attack various substrates when normal skin biopsy specimens were incubated at 37 degrees C for 1 h with either of these enzymes. Elastase damaged primarily hemidesmosomes, leading to the epidermal cleavage from the dermis, whereas cathepsin G damaged the membrane structures. Both these neutral proteinases were highly specific to basal lamina of blood vessels. This indicates that neutrophil elastase and neutrophil cathepsin G may play different roles in various skin diseases related to enhanced activity and infiltration of neutrophils.


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