Content

Content - Volume , Issue

All articles

CLINICAL REPORT
Secukinumab Exhibits Sustained and Stable Response in Patients with Moderate-to-Severe Psoriasis: Results from the SUPREME Study
Antonio Costanzo, Filomena Russo, Marco Galluzzo, Luca Stingeni, Roberta Scuderi, Leonardo Zichichi, Manuela Papini, Luisa Di Costanzo, Andrea Conti, Martina Burlando, Andrea Chiricozzi, Francesca Maria Gaiani, Cristina Mugheddu, Maria Letizia Musumeci, Paolo Gisondi, Stefano Piaserico, Paolo Dapavo, Marina Venturini, Gianluca Pagnanelli, Paolo Amerio, Concetta Potenza, Ketty Peris, Franca Cantoresi, Sara Trevisini, Francesco Loconsole, Annamaria Offidani, Santo Raffaele Mercuri, Viviana Lora, Francesca Prignano, Marta Bartezaghi, Giovanni Oliva, Elisabetta Aloisi, Roberto Orsenigo for the SUPREME study group
Secukinumab, a fully human monoclonal antibody, neutralizes interleukin-17A, a cornerstone cytokine driving the multiple manifestations of psoriasis. This post-hoc analysis of the SUPREME study was performed to determine the sustainability of response to secukinumab in terms of Psoriasis Area and Severity Index (PASI) 90 in patients with moderate-to-severe plaque psoriasis. Based on PASI 90 respon ...
Page: 0
Abstract  PDF
REVIEW
Diagnostic Accuracy of Trichoscopy in Trichotillomania: A Systematic Review
Agnieszka Kaczorowska, Lidia Rudnicka, Catherine M. Stefanato, Anna Waskiel-Burnat, Olga Warszawik-Hendzel, Malgorzata Olszewska, Adriana Rakowska
Trichotillomania is formally classified as a mental health disorder, but it is commonly diagnosed by dermatologists. The aim of this systematic review is to assess the diagnostic value of trichoscopy in diagnosing trichotillomania. The analysis identified the 7 most specific trichoscopic features in trichotillomania. These features had the following prevalence and specificity: trichoptilosis (57.5 ...
Page: 0
Abstract  PDF
SHORT COMMUNICATION
Syringotropic Mycosis Fungoides with Vasculopathic Ulcers and Expression of T-follicular-helper Cell Markers
Emmanuel Ribereau-Gayon, Joann Le Borgne De Lavillandre, Thibaut Deschamps, Brigitte Balme, Olivier Harou, Florent Grange
Abstract is missing (Short Communication)
Page: 0
Abstract  PDF
SHORT COMMUNICATION
Type I Interferon Signature in Chilblains Following SARS-CoV-2 mRNA Vaccine: A Case Report
Karim Souaid, Bénédicte Oulès, Pierre Sohier, Lydia Deschamps, Sélim Aractingi, Nicolas Dupin
Abstract is missing (Short communication)
Page: 0
Abstract  PDF
QUIZ
Cutaneous Horn on Four-year-old Child’s Arm: A Quiz
Cassandre Pottier, Annabel Maruani, Fanny Dujardin, Juliette Robert
Abstract is missing (Quiz)
Page: 0
Abstract  PDF
SHORT COMMUNICATION
Generalized Reticulated Scars and Milia in a Neonate: A Quiz
Jin-Yuan Ma, Tian Chen, Dong-Lai Ma
Abstract is missing (Quiz)
Page: 0
Abstract  PDF
SHORT COMMUNICATION
Xerosis in Patients with Type 2 Diabetes: An Italian Multicentre Study
Luca Stingeni, Marta Tramontana, Lorenzo Cordera, Michela Castello, Aurora Parodi
Abstract is missing (Short communication)
Page: 0
Abstract  PDF
SHORT COMMUNICATION
A Rare, Recurrent Spindle Cell Lipoma of the Nose
Minna E. Kubin, Ulla Lantto, Outi Lindgren, Kaisa Tasanen
Abstract is missing (Short communication)
Page: 0
Abstract  PDF
SHORT COMMUNICATION
Screening for Body Dysmorphic Disorder among Patients Seeking Dermatological and Cosmetic Care: A Cross-sectional Study
Valérie Peeters, Sherief R. Janmohamed, Samira Baharlou, Jan Gutermuth, Ria Willemsen
Abstract is missing (Short communication)
Page: 0
Abstract  PDF
SHORT COMMUNICATION
Multiple Keratoacanthoma Centrifugum Marginatum in a Patient with Primary Myelofibrosis: A Case Report with Dermoscopic Findings
Magdalena Żychowska, Joanna Muda-Urban, Kamila Jaworecka, Ewa Kaznowska, Adam Reich
Abstract is missing (Short communication)
Page: 0
Abstract  PDF
INVESTIGATIVE REPORT
Epidemiology, Comorbidity and Risk Factors for Psoriatic Arthritis: a Health Insurance Claims Database Analysis
Maximilian Reinhardt, Claudia Garbe, Jana Petersen, Matthias Augustin, Natalia Kirsten, Mona H.C. Biermann, Benjamin Häberle, Kristina Hagenström
Psoriatic arthritis is a frequent manifestation of psoriasis, and has a high level of impact on physical functioning, work ability and quality of life. However, there have been few studies of the epidemiology, development of and risk factors for concomitant psoriatic arthritis in patients with psoriasis. This study analysed data from a German public health insurance database of > 2 million indiv ...
Page: 0
Abstract  PDF
CLINICAL REPORT
Rapid and Sustained Effect of Dupilumab on Work Productivity in Patients with Difficult-to-treat Atopic Dermatitis: Results from the Dutch BioDay Registry
Lieneke F.M. Ariëns, Daphne S. Bakker, Lotte S. Spekhorst, Jorien van der Schaft, Judith L. Thijs, Inge Haeck, Annebeth E. Flinterman, Marijke Kamsteeg, Marie L.A. Schuttelaar, Marjolein S. De Bruin-Weller
Dupilumab treatment improves signs, symptoms, and quality of life in patients with moderate-to-severe atopic dermatitis. This study evaluated the impact of dupilumab treatment on absenteeism, presenteeism, and related costs in a large multi-centre cohort of adult patients with difficult-to-treat atopic dermatitis in daily practice. Patients treated with dupilumab participating in the Dutch BioDay ...
Page: 0
Abstract  PDF
INVESTIGATIVE REPORT
Antipruritic Effect of Topical Acetaminophen Gel in Histaminergic and Non-histaminergic Itch Provocation: A Double-blind, Vehicle-controlled Pilot Study
Leigh A. Nattkemper, Kaining Zhi, Kaeli E. Romero, Serena M. Shah, Terresa Ju, Kayla Fourzali, Rachel Shireen Golpanian, Flor MacQuhae, Yiong Huak Chan, David B. Lebo, Gil Yosipovitch
There is a need for new topical antipruritics that are effective on many types of itch. This study examined the antipruritic efficacy of a new formulation of topical acetaminophen. In vitro skin permeability studies showed that 2.5% and 5% formulations are able to rapidly deliver an adequate amount of the drug into the skin. In a double-blind, vehicle-controlled, randomized study in 17 healthy vol ...
Page: 0
Abstract  PDF
CLINICAL REPORT
General Burden of Adult Atopic Dermatitis: An Observational Study of Disease Perceptions among Patients and Dermatologists in France
Angèle Soria, Claire Thénié, Christina Bienenfeld, Delphine Staumont-Sallé
It is important to understand patients’ and dermatologists’ perceptions of various aspects of atopic dermatitis, but there is a lack of studies on quality of life and stakeholder viewpoints in this therapy area. The aim of this study was to compare patients’ and dermatologists’ viewpoints regarding the impact of atopic dermatitis that is uncontrolled by topical corticosteroids. Data were c ...
Page: 0
Abstract  PDF
REVIEW
Pruritus in Keloid Scars: Mechanisms and Treatments
Ahmed A. Hawash, Giuseppe Ingrasci, Keyvan Nouri, Gil Yosipovitch
Keloids are scars that extend beyond the margins of an insulting cutaneous injury. Keloids are often thought to be primarily a cosmetic issue, as they are typically quite raised and pigmented. However, these scars also present with functional symptoms of pruritus and pain that significantly impact quality of life. The symptom of pruritus is frequently overlooked by dermatologists, and treatments a ...
Page: 0
Abstract  PDF
INVESTIGATIVE REPORT
Biogeographical Landscape of the Human Face Skin Microbiome Viewed in High Definition
Michael Brandwein, Garold Fuks, Avigail Israel, Emmilia Hodak, Fareed Sabbah, Doron Steinberg, Zvi Bentwich, Noam Shental, Shiri Meshner
The bacterial population that colonizes the human face imparts physiochemical and physiological effects on the facial skin. These skin-microbe interactions impact dermatological, cosmetic and skincare applications due to the centrality of the human face in daily interactions. However, fine-scale characterization of the human face skin microbiome is lacking. Using 16S rRNA sequencing and 3D cartogr ...
Page: 0
Abstract  PDF
CLINICAL REPORT
Long-term Outcome of Chilblains Associated with SARS-CoV-2
Florence Poizeau, Sébastien Barbarot, Yannick Le Corre, Emilie Brenaut, Mahtab Samimi, Hélène Aubert, Alexis Toubel, Alain Dupuy
Numerous cases of chilblains have been observed associated with the COVID-19 pandemic. The aims of this study were to provide comprehensive follow-up data for patients reporting chilblains, and to determine the risk factors for incomplete recovery. Patients referred to 5 hospitals in France between March and May 2020 for chilblains were surveyed on December 2020. A teleconsultation was offered. Am ...
Page: 0
Abstract  PDF
INVESTIGATIVE REPORT
Factors Associated with Affective Symptoms and Quality of Life in Patients with Atopic Dermatitis
Silvia Mariel Ferrucci, Simona Tavecchio, Luisa Angileri, Teresa Surace, Emilio Berti, Massimiliano Buoli
The aim of this study was to detect demographic and clinical factors associated with affective symptoms and quality of life in patients with severe atopic dermatitis. First, one-way analyses of variance and correlations were performed to compare a large set of qualitative and quantitative clinical variables. Three final multivariable regression models were performed, with depression/anxiety subsca ...
Page: 0
Abstract  PDF
INVESTIGATIVE REPORT
Detailed Long-term Dynamics of Neutrophil-to-Lymphocyte Ratio under Biologic Treatment Reveals Differential Effects of Tumour Necrosis Factor-alpha and Interleukin 12/23 Antagonists
Jochen H.O. Hoffmann, Christian Knoop, Alexander Enk, Eva N. Hadaschik
Psoriasis is thought to be associated with a reduced life expectancy through systemic inflammation. A comparative, retrospective analysis of neutrophil-to-lympho-cyte ratio, a biomarker of systemic inflammation and cardiovascular risk, under 196 treatments with tumour necrosis factor-α and interleukin-12/23 antagonists was performed. Neutrophil-to-lympho-cyte ratio decreased significantly within ...
Page: 0
Abstract  PDF
CLINICAL REPORT
Interobserver Agreement on Dermoscopic Features and their Associations with In Situ and Invasive Cutaneous Melanomas
Sam Polesie, Lisa Sundback, Martin Gillstedt, Hannah Ceder, Johan Dahlén Gyllencreutz, Julia Fougelberg, Eva Johansson Backman, Jenna Pakka, Oscar Zaar, John Paoli
Several melanoma-specific dermoscopic features have been described, some of which have been reported as indicative of in situ or invasive melanomas. To assess the usefulness of these features to differentiate between these 2 categories, a retrospective, single-centre investigation was conducted. Dermoscopic images of melanomas were reviewed by 7 independent dermatologists. Fleiss’ kappa (κ) was ...
Page: 0
Abstract  PDF
CLINICAL REPORT
Real-life Effectiveness and Safety of Risankizumab in Moderate-to-severe Plaque Psoriasis: A 40-week Multicentric Retrospective Study
Riccardo G. Borroni, Piergiorgio Malagoli, Luigi Gargiulo, Mario Valenti, Giulia Pavia, Paola Facheris, Emanuela Morenghi, Isotta Giunipero di Corteranzo, Alessandra Narcisi, Michela Ortoncelli, Paolo Dapavo, Antonio Costanzo
Risankizumab is a humanized monoclonal antibody that binds the p19 subunit of interleukin-23. It is approved for treatment of moderate-severe chronic plaque psoriasis. This retrospective study included 66 consecutive adults with moderate-to-severe psoriasis vulgaris treated with risankizumab in monotherapy up to week 40 in a “real-life” setting. At week 40, 98.7%, 85.7% and 62.3% of patients a ...
Page: 0
Abstract  PDF