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CLINICAL REPORT
Alteration in the Skin Microbiome in Cutaneous Graft Versus Host Disease
Ying Gu, Jing Sun, Kun Li, Xia Wu, Jianzhong Zhang
Graft versus host disease (GVHD) is a common complication of haematopoietic stem cell transplantation. This study examined the cutaneous microbiome in relation to the pathogenesis of cutaneous GVHD. Bacterial swabs were taken from several sites on 12 patients with cutaneous GVHD. Microbiotas were characterized by sequencing 16S rRNA bacterial genes on the MiSeq platform. Microbiome diversity in pa ...
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CLINICAL REPORT
Towards More Shared Decision Making in Dermatology: Develop­ment of Evidence-based Decision Cards for Psoriasis and Atopic Eczema Treatments
Francisca M. Vermeulen, Gayle E. van der Kraaij, Ronald A. Tupker, Anne Bijlsma, Hans Blaauwbroek, Francine Das, Tessa Geltink, Josine S. van der Kraan, Renske Kranenburg, Dirk J. van der Veen, Kristie Venhorst, Phyllis I. Spuls
In shared decision making (SDM) patients and physi­cians make treatment decisions together based on the best available evidence and the values and preferences of patients. SDM is very suitable for use in dermatological practice, but is infrequently applied by dermatologists. To support the application of SDM in dermatology we developed Decision Cards: 1-page overviews of possible treatment option ...
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SHORT COMMUNICATION
Unusual Skin Involvement in Statin-induced Anti-HMGCR Immune-mediated Necrotizing Myopathy
Camille Scard, Corina Bara-Passot, Kévin Chassain, Hervé Maillard
Abstract is missing (Short communication)
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SHORT COMMUNICATION
Bullous Pemphigoid-like Eruption Triggered by Targeted Therapy for Metastatic Melanoma
Hanna Eriksson, Johan Hansson, Britta Krynitz, Giuseppe Masucci, Ada Girnita, Jan Lapins, Auris O. Huen, Hussein A. Tawbi, Michael A. Davies, Michael T. Tetzlaff, Jonathan L. Curry
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SHORT COMMUNICATION
Pyoderma Gangrenosum Revealing Myeloid Activation of Fanconi Anaemia: Two Case Reports
Alexandra Mokrzycki, Coralie Lheure, Nathalie Franck, Gérard Socié, Clémence Mauppin, Flore Sicre de Fontbrune, Régis Peffault De Latour, Clémence Lepelletier, Adèle de Masson, Maxime Battistella, Guy Leverger, Pierre Sohier, Jean-David Bouaziz, Nicolas Dupin
Abstract is missing (Short Communication)
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SHORT COMMUNICATION
Photosensitive Dermatitis Induced by Nivolumab/Ipilimumab Combination Therapy in a Patient with Malignant Melanoma
Yuri Sakaguchi, Takaya Komori, Megumi Aoki, Atsushi Otsuka, Kenji Kabashima, Shigeto Matsushita
Abstract is missing (Short communication)
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SHORT COMMUNICATION
Vaccination Granuloma Itch Treated with Capsaicin 8% Patches
Stine Hoffmann, Jesper Elberling
Abstract is misisng (Short communication)
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SHORT COMMUNICATION
Hypohidrotic Ectodermal Dysplasia with c.28delG Mutation in Ectodysplasin A Gene and Severe Atopic Dermatitis Treated Successfully with Tofacitinib
Xiangqian Li, Xia Wu, Dirk M. Elston, Jianzhong Zhang, Cheng Zhou
Abstract is missing (Short communication)
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SHORT COMMUNICATION
Dermal Periostin: A New Player in Itch of Prurigo Nodularis
Takashi Hashimoto, Leigh A. Nattkemper, Hei Sung Kim, Christina D. Kursewicz, Emilie Fowler, Serena M. Shah, Sonali Nanda, Rachel A. Fayne, Paolo Romanelli, Gil Yosipovitch
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SHORT COMMUNICATION
Are the Recommended Excision Margins for Basal Cell Carcinoma Too Defensive? A Retrospective Chart Study and Evaluation of the Dutch Guideline
Eva van Loo, Patty J. Nelemans, Corine Peters, Myrurgia Abdul-Hamid, Nicole W.J. Kelleners-Smeets
Abstract is missing (Short communication)
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QUIZ
Enlarging Alopecic Plaque on the Scalp: A Quiz
Yujie Wen, Shuxia Yang, Yang Wang
Abstract is missing (Quiz)
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INVESTIGATIVE REPORT
Histamine 2 Receptor Agonism and Histamine 4 Receptor Antagonism Ameliorate Inflammation in a Model of Psoriasis
Kristine Rossbach, Katharina Wahle, Gustav Bruer, Ralph Brehm, Marion Langeheine, Kristina Rode, Katrin Schaper-Gerhardt, Ralf Gutzmer, Thomas Werfel, Manfred Kietzmann, Wolfgang Bäumer
Psoriasis is a chronic inflammatory skin disorder characterized by hyperproliferative keratinocytes and immune cell infiltration into the skin, often accompanied by itch. Histamine, acting via histamine 1–4 receptors, is known to modulate immune responses in the skin and to induce itch. The aim of this study was to test the role of histamine 2 receptors and histamine 4 receptors in the imiquimod ...
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CLINICAL REPORT
Systematic Literature Review and Network Meta-analysis of the Efficacy and Acceptability of Interventions in Actinic Keratoses
Khaled Ezzedine, Caroline Painchault, Melanie Brignone
A systematic literature review was conducted to identify and qualitatively assess randomized controlled trials in immunocompetent patients ≥ 18 years with head- region lesions of actinic keratoses who were treated with field-directed, lesion-directed and other therapies. Network meta-analysis was used to quantitatively evaluate field-directed therapies (5-fluorouracil formulations, diclofenac ...
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CLINICAL REPORT
Cryosurgery of Periocular Moderately Aggressive Basal Cell Carcinoma
Oscar Finskas, Oscar Zaar, Karin Svedberg
Uncertainty exists regarding the results of treating basal cell carcinomas with a more aggressive growth pattern than nodular growth with cryosurgery. Over the years, some medium aggressive, well-defined basal cell carcinomas have been treated with cryosurgery at the combined ophthalmology-dermatology recipiency at Sahlgrenska University Hospital, Gothenburg in Sweden. The medical records of these ...
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SHORT COMMUNICATION
Prevalence of Atrophic and Hypertrophic Skin Ageing Phenotypes: A UK-based Observational Study
Abigail K. Langton, Zara Ali, Mark Hann, Jean Ayer, Rachel E.B. Watson, Christopher E.M. Griffiths
Abstract is missing (Short communication)
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SHORT COMMUNICATION
Avapritinib for Cutaneous Mastocytosis
Hannah Lee, Tian Li, Joshua Wisell, Jeffrey Schowinsky, William A. Robinson
Abstract is missing (Short communication)
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INVESTIGATIVE REPORT
Health Economic Consequences of a Tightly Controlled Dose Reduction Strategy for Adalimumab, Etanercept and Ustekinumab Compared with Standard Psoriasis Care: A Cost-utility Analysis of the CONDOR Study
Selma Atalay, Juul M.P.A. van den Reek, Marisol E. Otero, Marcellus D. Njoo, Johannes M. Mommers, Paul M. Ossenkoppele , Marjolein I. Koetsier, Maartje M. Berends, Peter C.M. van de Kerkhof, Hans M.M. Groenewoud, Alfons A. den Broeder, Elke M.G.J. de Jong, Wietske Kievit
A dose reduction strategy for adalimumab, etanercept and ustekinumab in patients with psoriasis who have stable and low disease activity has recently been compared with usual care in the CONDOR study (CONtrolled DOse Reduction) of biologics in patients with psoriasis with low disease activity. The aim of the current study was to perform a cost-utility analysis with a 12-month time horizon alongsid ...
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CLINICAL REPORT
Management of Congenital Melanocytic Naevi in Children: A French National Survey Using Clinical Vignettes
Hélène Aubert, Morgane Pere, Frédérique Bellier Waast, Pierre Perrot, Sébastien Barbarot, on behalf of the Groupe de Recherche en Dermatologie Pédiatrique
Management of congenital melanocytic naevi in childhood may vary depending on the habits and experience of the treating clinician. The aim of this study was to assess current practice and determinants of surgical excision decision-making among French physicians. A national survey was conducted among dermatologists, paediatricians and surgeons, using clinical vignettes illustrating 29 scenarios. Th ...
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INVESTIGATIVE REPORT
Cumulative Sum Analysis of the Learning Curve for Optical Coherence Tomography Assisted Diagnosis of Basal Cell Carcinoma
Eva van Loo, Kelly A.E. Sinx, Julia Welzel, Sandra Schuh, Nicole W.J. Kelleners-Smeets, Klara Mosterd, Patty J. Nelemans
The amount of training needed to correctly interpret optical coherence tomography scans of the skin is undefined. The aim of this study was to illustrate how cumulative sum charts can be used to determine how many optical coherence tomography scans novice assessors should evaluate in order to obtain competence in diagnosing basal cell carcinoma. Four hundred lesions suspected for non-melanoma skin ...
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CLINICAL REPORT
Mohs Micrographic Surgery for Primary Versus Recurrent or Incompletely Excised Facial High-risk Basal Cell Carcinomas
Hannah Ceder, Malin Grönberg, John Paoli
Facial high-risk basal cell carcinomas are preferably treated with Mohs micrographic surgery, but only 10% of patients are offered Mohs micrographic surgery in Sweden. The aim of this retrospective study was to examine the differences between primary and recurrent or incompletely excised facial high-risk basal cell carcinomas undergoing Mohs micrographic surgery, with regard to the number of stage ...
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CLINICAL REPORT
An Analysis of Patient-reported Outcomes in IXORA-S: Comparing Ixekizumab and Ustekinumab over 52 Weeks in Moderate-to-severe Psoriasis
Lluís Puig, Mark Lomaga, Kristin Hollister, Yves Dutronc, Lovisa Berggren, Peter C.M. van de Kerkhof
Patient-reported outcomes are valuable for assessing new psoriasis therapies. This study investigated patient-reported outcomes in patients with moderate-to-severe plaque psoriasis treated with ixekizumab or ustekinumab, dosed according to their respective labels, for 52 weeks (IXORA-S-NCT02561806). Patient-reported outcomes investigated included patient global assessment, pruritus, skin pain, hea ...
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INVESTIGATIVE REPORT
Investigator’s Global Assessment of Chronic Prurigo: A New Instrument for Use in Clinical Trials
Claudia Zeidler, Manuel P. Pereira, Matthias Augustin, Mary Spellman, Sonja Ständer
Chronic prurigo is a pruritic disease characterized by the development of pruriginous lesions due to scratching. The number of lesions is representative of the stage of the disease, while the presence of excoriations reflects the scratching activity. Investigator’s Global Assessment scales for stage and activity were completed for 187 patients with chronic prurigo, who also reported patient-repo ...
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INVESTIGATIVE REPORT
The Amygdala Network for Processing Itch in Human Brains
Hideki Mochizuki, Loren Hernandez, Gil Yosipovitch, Norihiro Sadato, Ryusuke Kakigi
Itch is an unpleasant and aversive somatosensory experience. These negative emotions significantly affect mental health in chronic itch patients. Therefore, it is important to understand the brain mechanism of negative emotions due to itch. The amygdala is an important hub of network to regulate negative emotions due to itch. However, the exact network remains unknown. Thus, using functional magne ...
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CLINICAL REPORT
Melanoma Risk is Increased in Patients with Mycosis Fungoides Compared with Patients with Psoriasis and the General Population*
Shany Sherman, Noa Kremer, Adam Dalal, Efrat Solomon-Cohen, Einav Berkovich, Yehonatan Noyman, Maya Ben-Lassan, Assi Levi, Lev Pavlovsky, Hadas Prag Naveh, Emmilia Hodak, Iris Amitay-Laish
Patients with mycosis fungoides (MF) are thought to be at increased risk of melanoma. However, studies addressing surveillance-bias and treatments as a possible confounder are lacking. This retrospective study compared the prevalence and risk of melanoma between 982 patients with MF, and 3,165 patients with psoriasis attending tertiary cutaneous-lymphoma/psoriasis clinics during 2009 to 2018. Mela ...
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INVESTIGATIVE REPORT
Tumour Necrosis Factor Alpha-induced Protein 3 Negatively Regulates Cutibacterium acnes-induced Innate Immune Events in Epidermal Keratinocytes
Lilla Erdei, Beáta Szilvia Bolla, Renáta Bozó, Gábor Tax, Edit Urbán, Katalin Burián, Lajos Kemény, Kornélia Szabó
Human epidermal keratinocytes sense the presence of human skin microbiota through pathogen recognition receptors, such as toll-like receptors, and induce innate immune and inflammatory events. In healthy epidermis there is an absence of inflammation despite the continuous presence of cutaneous microbes, which is evidence of an effective immune regulatory mechanism. The aim of this study was to inv ...
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