Content - Volume 60, Supplement
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Atopic eczema, an inflammatory skin disorder characterized by acute vesicular lesions or chronic lichenified plaques, both accompanied by pruritus, occurs at any period of life in patients with personal or family histories of atopy. Previous histologic studies of atopic eczema using biopsy specimens stained with hematoxylin and eosin or with toluidinc blue and ultrastructural studies of infantile ...
The aerobic bacterial flora of dermatitic skin. uninvolved skin, and the anterior nares of subjects with atopic eczema was investigated. A general comparison of the bacterial flora of subjects with atopic eczema, psoriasis and from a normal population was made. The incidence of Staphylococcus aureus in atopics was: 93%, 76% and 79% in the lesions, non-involved skin and the anterior nares respectiv ...
Using [3H]dihydroalprenolol (DHA) and [3H]dihydroergocryptine (DHE), that is specific radioligands for the measurement of beta- and alpha-adrenoceptors, respectively, binding studies were performed on membranes of lymphocytes from patients with atopic dermatitis, patients with nonatopic skin diseases, and normal individuals. A shift in the numbers of receptors from beta- to alpha was found in th ...
Both atopic dermatitis and psoriasis are proliferative skin disordcrs that are self-limited, show hereditary tendencies and are postulated to result from changes in the cyclic AMP-beta adrenergic system of the epidermis. Cyclic nucleotides, polyamines, arachidonic acid and its metabolites, and several drugs are associated with changes in the hyperproliferative epidermis. These biologically active ...
No abstract available
[125l)hydroxy benzyl pindolol (HYP) was used in a binding assay to compare the number and affinity of beta-adrenergic receptors on circulating lymphocytes from 8 patients with severe atopic dermatitis (AD) and 8 age-matched controls. The number of receptors per lymphocyte (RT) found in the atopic group (856± 132) was not statistically different from that of the controls (702±107). By contrast, t ...
The vascular reaction following local applicacion of thurfyl nicotinate and i.d. injection or 10–2 mg metacholine were studied. Temporal variations in response and multiple patterns were found. Erythematous skin (increased amount of blood in the subpapillary venous plexus) always corresponded to arteriolar dilation, but in blanched skin an aneriolar fluctuation between dilatation and constrictio ...
Scratch behavior was monitored with a paper strain gauge attached to the dorsum of the hand and an amplifier. The all-night recording was subsequently analysed every 60 sec with a specially devised computer system and the duration of scratching and the time(s) of its occurrence were printed out. This technique was applied in 10 patients with moderate or severe atopic dermatitis, 5 with generalized ...
It was found that a correlation exists between the values of IgE in the serum and the duration of experimental itch elicited by trypsin in 20 patients with atopic dermatitis.
Experimental trypsin itch was investigated in 100 patients with atopic dermatitis and in 115 controls. The duration or itch exceeded 2 minutes in 62.8% for involved skin and in 37% for uninvolved skin of atopic dermatitis patients, which are significantly higher percentages than in controls. The longer itch duration is not a specific feature of atopic dermatitis, however.
Among 40 children with alopic dermatitis between 1-4 years 5 had Morgan’s fold, whereas none among 40 controls. Among 60 children with atopic dermatitis with an age average of 8 years 4 had this sign and in matched control series 2 children.
Abstract is missing.
Natural killer (NK) cells, cytotoxic for Burkittl lymphoma cells, were found to be more active in atopic than in non-atopic children. Upon stimulation of lymphocyte cultures with Sendai virus, less interferon was produced by cells from atopic than from non-atopic individuals. lncreased NK activity and decreased interferon production may both be consequences of a T lymphocyte deficiency which has b ...
We previously reported depressed polymorphonuclear leukocyte and monocyte chemotaxis in patients with severe atopic dermatitis. The degree of impairment roughly correlated with the disease severity and chemotaxis was noted to improve rapidly with clinical remissions. This rapid improvement suggested the presence of a short-lived plasma inhibitor of leukocyte function. We used a radiolabeled PMN ...
Histamine release (HR) induced by anti-lgE (1 to 10 000 ng/ml from whole-blood basophils has been evaluated in 29 children with atopic dermatitis (AD). HR was round to be reproducible and did not vary with the clinical improvement or aggravation of AD. Children with AD were found to have a higher HR than controls. Two groups of children with AD could be distinguished on the basis of histamine rele ...
The number of mononuclear cells bearing membrane receptors for histamine was investigated in peripheral blood from children with atopic dermatitis (AD) by means of the Rosette Histamine Assay, using erythrocytes coated with histamine. Histamine Rosettes (H R) varied from 5.70 to 11.85% in healthy adults; from 3.25 to 7.75% in control children and from 2 to 6.55% in children with AD. Histidine and ...
No abstract available
Atopic dermatitis and bronchial asthma are closely associated with respect to hereditary factors, epidemiology and occurrence in the same individuals. Both depend on more or less common genetic and environmental traits. Both are typical multifactorial diseases. They have also much in common as regards the complex immunological and chemical mechanisms involved. This becomes particularly evident whe ...
Immunological and pharmacological disturbances in atopic dermatitis and psoriasis are compared. This comparative study revcaled several analogies: T cell deficiency; hyperfunction of B cells leading to antibody production, defect in the beta-adrenergic response. The role of immunological and pharmacological factors in the pathogenesis of the two diseases is discussed.
Serial examinations of tuberculin reactivity were performed in 16 patients with atopic dcrmatitis (AD) and in 14 patients with allergic contact dermatitis. Transient suppression of already established tuberculin reactivity was seen in the contact dermatitis patients. Tuberculin reactivity in the AD patients also fluctuated with the condition of the dermatitis. When the dermatitis was active, there ...
No abstract available
Using an indirect ELlSA technique together wilh rabbit antisera specific for human immunoglobulin classes and lgG subclasses, an estimate was made of the contribution of immunoglobulin classes and subclasses to the overall antibody response against codfish allergen in serum from a patient allergic to codfish. Allergen-specific antibodies were found to be of immunoglobulin classes lgM, lgD and lgE ...
No abstract available
Jejunal biopsy specimcns were obtained from ten patients with severe atopic dermatitis and 15 controls. Light microscopical examination of hematoxylin-eosin stained sections showed normal condition in all atopic patients and intra-epithelial lymphocyte counts did not differ significantly from counts in controls. Scanning electron-microscopical examination demonstrated minor mucosal changes in five ...
This articlc reviews the clinical and laboratory aspects of the relationship between atopy and dermatophytosis. This newly appreciated relationship; chronic, stabilized dermatophytosis and bronchial asthma and/or allergic rhinitis, constitutes a clinical syndrome of importance and interest. The relevant host defense; correlate, cell mediated immunity, is subject to the modulating effects of the me ...
No abstract available
Skin testing to find food allergy in atopic dermatitis is recommcnded from the age of 4 months up the early adulthood. Scratch, scratch-chamber, prick and intracutancous tests may be used. In order to obtain optimal benefit from skin testing, both commercial extracts and fresh foodstuffs must be used. Extracts of protein-rich foods. such as fish, egg and nuts, work very well in skin tests, but f ...
In 541 patients with atopic dermatitis (AD), a history with special reference to food allergy, RAST and challenge tests were performed. In 84 patients cutaneous symptoms (exacerbation of the dermatitis or acute urticaria) were attributed to ingestion of various foods, especially eggs, milk, fish and peaches. While in cases of acute urticaria the history agreed largely with the results of the RAST ...
Thirty-two adult patients with atopic eczema were compared with a similar group of atopics with asthma and/or rhinitis. Twelve patients with eczema had a history of food allergy, either to fish or eggs: only one of the asthma/rhinitis group gave such a history. When "prick'' testing to foods was performed, all but one of these patients with a history of food allergy had a positive skin test to foo ...
The principles of allergic management of atopic dermatitis, with special reference to sublingual hyposensitization, are briefly elucidated.
There is now good evidence that food allergy is an important aetiological factor in atopic dermatitis and that dietary antigen avoidance is a helpful form or therapy, particularly in younger children. Allergy history, prick tests and the RAST are of limited value in identifying the allergies present in individual children. A systematic practical approach to allergy diagnosis is currently under eva ...
Six adult patients with severe atopic dermatitis were followed up for an average time of 9 months, through periods of clinical exacerbation and remission. Sequential studies of monocyte function measured as antibody-dependent cell-mediated cytotoxicity showed depressed function which did not normalize during clinical remission.
Using highly purified allergens from skin flakes of the human scalp and from house dust, it was demonstrated that lgE antibodies against the former can be detected only in cases of severe atopic dermatitis (AD), but not in asthma (without eczema) and not in hay fever or rhinitis patients. The RAST scores for human dander correlated well with total lgE levels. Also, RAST scores for human dander all ...
A total of 41 biopsy specimens of the first visible prurigo papule were obtained from 32 adult patients with atopic dermatitis. In 38 of the 41 biopsy specimens, histological changes were seen in connection with hair follicle. The follicular wall showed spongiosis and vesicle formation with mononuclear cell migration. The remaining 3 biopsy specimens revealed an eczematous change which involved th ...
The number of first visits to an out-patient department by patients with atopic dermatitis, as well as anamnesticat data from such patients, clearly shows seasonal changes in the course of this disease. An obvious relation is demonstrable between seasonal exacerbations and allergy to seasonal allergens.
A long-term follow-up study of 2 000 children with atopic ecxema for from two to twenty-one years: clearance rates, pubertal recurrence rates and factors with or without prognostic significance are reported. Late onset "reversed pattern" and possibly social factors are adverse features, whilst early onset, seborrhoeic pattern and male sex are favourable prognostic signs. These results are based on ...
Abstract is not available
Abstract is not available
PUVA is an acronym which stands for the use or Psoralen as a photo-sensitizer for patients exposed to ultraviolet light type A (320-400 nm). Such use was brought to worldwide attention by Parrish et al. in 1974. Its deserved popularity is warranted by a remarkable improvement in over 85% of psoriatic patients. It was expected that PUVA would be tried for many skin conditions. Good results have a ...
Experimental treatment in atopic dermatitis was undertaken with transfer factor, hyposensitization, or topical sodium chromoglycate. Both transfer factor and hyposensitization in open trials produced some clinical benefit. In both cases all patients could be controlled with medium strength topical steroids during therapy. In the latter case consumption of topical steroid was measured and found to ...
In a double-blind cross-over trial, 23 adults with atopic dermatitis were treatrd systemically during two 6-week periods wilh a new anti-allergic chromone compound (FPL 57787) 18 mg four times a day or matched placebo in randomized order. Twenty patients completed the study: 11 preferred the active period, 9 prefcrred the placebo period. There were no statistically significant differences for any ...