Content - Volume 60, Supplement

All articles

Morphology of atopic eczema
Nicholas A. Soter, Martin C. Mihm, Jr
Atopic eczema, an inflammatory skin disorder characterized by acute vesicular lesions or chronic lichenified plaques, both accompanied by pruritus, occurs at any period of life in patients with personal or family histories of atopy. Previous histologic studies of atopic eczema using biopsy specimens stained with hematoxylin and eosin or with toluidinc blue and ultrastructural studies of infantile ...
Pages: 11-15
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Bacteriology of atopic dermatitls
Raza Aly
The aerobic bacterial flora of dermatitic skin. uninvolved skin, and the anterior nares of subjects with atopic eczema was investigated. A general comparison of the bacterial flora of subjects with atopic eczema, psoriasis and from a normal population was made. The incidence of Staphylococcus aureus in atopics was: 93%, 76% and 79% in the lesions, non-involved skin and the anterior nares respectiv ...
Pages: 16-18
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Adrenoceptor binding studies with [3H]dihydroalprenolol and [3H]dihydroergocryptine on membranes of lymphocytes from patients with a topic disease
A. Szentivanyi, O. Heim, P. Schultze, J. Szentivanyi
Using [3H]dihydroalprenolol (DHA) and [3H]dihydroergocryptine (DHE), that is specific radioligands for the measurement of beta- and alpha-adrenoceptors, respectively, binding studies were performed on membranes of lymphocytes from patients with atopic dermatitis, patients with non­atopic skin diseases, and normal individuals. A shift in the numbers of receptors from beta- to alpha was found in th ...
Pages: 19-21
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Use of in vitro epidermal cell cultures to study growth mechanisms in hyperplastic skin disorders
Cynthia L. Marcelo, John J. Voorhees
Both atopic dermatitis and psoriasis are proliferative skin disordcrs that are self-limited, show hereditary tendencies and are postulated to result from changes in the cyclic AMP-beta adrenergic system of the epidermis. Cyclic nucleotides, polyamines, arachidonic acid and its metabolites, and several drugs are associated with changes in the hyperproliferative epidermis. These biologically active ...
Pages: 22-24
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Characterlzation of P-adrenoreceptors on intact circulating lymphocytes from patients with atopic dermatitis
R. Pochet, G. Delespesse, J. De Maubeuge
[125l)hydroxy benzyl pindolol (HYP) was used in a binding assay to compare the number and affinity of beta-adrenergic receptors on circulating lymphocytes from 8 patients with severe atopic dermatitis (AD) and 8 age-matched controls. The number of receptors per lymphocyte (RT) found in the atopic group (856± 132) was not statistically different from that of the controls (702±107). By contrast, t ...
Pages: 26-29
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Small vessel reactivity in atopic dermatitis
P. Thune, G. Rajka
The vascular reaction following local applicacion of thurfyl nicotinate and i.d. injection or 10–2 mg metacholine were studied. Temporal variations in response and multiple patterns were found. Erythematous skin (increased amount of blood in the subpapillary venous plexus) always corresponded to arteriolar dilation, but in blanched skin an aneriolar fluctuation between dilatation and constrictio ...
Pages: 30-32
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Computer analysis of nocturnal scratch in atopic dermatitis
Toshiyuki Aoki, Higashi Kushimoto, Eijiro Kobayashi, Yoichi Ogushi
Scratch behavior was monitored with a paper strain gauge attached to the dorsum of the hand and an amplifier. The all-night recording was subsequently analysed every 60 sec with a specially devised computer system and the duration of scratching and the time(s) of its occurrence were printed out. This technique was applied in 10 patients with moderate or severe atopic dermatitis, 5 with generalized ...
Pages: 33-37
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Itch and IgE in atopic dermatitis
Georg Rajka
It was found that a correlation exists between the values of IgE in the serum and the duration of experimental itch elicited by trypsin in 20 patients with atopic dermatitis.
Pages: 38-39
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Experimental itch as a diagnostic method
K. Harnack
Experimental trypsin itch was investigated in 100 patients with atopic dermatitis and in 115 controls. The duration or itch exceeded 2 minutes in 62.8% for involved skin and in 37% for uninvolved skin of atopic dermatitis patients, which are significantly higher percentages than in controls. The longer itch duration is not a specific feature of atopic dermatitis, however.
Pages: 40-41
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The significance of Morgan’s fold in children with atopic dermatitis
F.O.C. Meenan
Among 40 children with alopic dermatitis between 1-4 years 5 had Morgan’s fold, whereas none among 40 controls. Among 60 children with atopic dermatitis with an age average of 8 years 4 had this sign and in matched control series 2 children.
Pages: 42-43
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Diagnostic Features of Atopic Dermatitis
Jon M. Hanifin, Georg Rajka
Abstract is missing.
Pages: 44-47
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Natural killer cells and interferon production in atopic dermatitis
Inga-Lisa Strannegård, Örjan Strannegård
Natural killer (NK) cells, cytotoxic for Burkittl lymphoma cells, were found to be more active in atopic than in non-atopic children. Upon stimulation of lymphocyte cultures with Sendai virus, less interferon was produced by cells from atopic than from non-atopic individuals. lncreased NK activity and decreased interferon production may both be consequences of a T lymphocyte deficiency which has b ...
Pages: 48-51
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Chemotaxls inhibition by plasma from patients with atopic dermatitis
Jon M. Hanifin, Janet L. Rogge, Richard H. Bauman
We previously reported depressed polymorphonuclear leukocyte and monocyte chemotaxis in patients with severe atopic dermatitis. The degree of impairment roughly correlated with the disease severity and chemotaxis was noted to improve rapidly with clinical remissions. This rapid improvement suggested the presence of a short-lived plasma inhibitor of leukocyte function. We used a radio­labeled PMN ...
Pages: 52-56
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Anti-IgE induced histamine release from basophils in children with atopic dermatitis
B. Lebel, P. Y. Venencie, J. H. Saurat, C. Soubrane, J. Paup
Histamine release (HR) induced by anti-lgE (1 to 10 000 ng/ml from whole-blood basophils has been evaluated in 29 children with atopic dermatitis (AD). HR was round to be reproducible and did not vary with the clinical improvement or aggravation of AD. Children with AD were found to have a higher HR than controls. Two groups of children with AD could be distinguished on the basis of histamine rele ...
Pages: 57-59
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Histamine receptor-bearing mononuclear cells in atopic dermatitis
C. Ponvert, B. Lebel, P. Y. Venencie, J. H. Saurat, J. Paupe
The number of mononuclear cells bearing membrane receptors for histamine was investigated in peripheral blood from children with atopic dermatitis (AD) by means of the Rosette Histamine Assay, using erythrocytes coated with histamine. Histamine Rosettes (H R) varied from 5.70 to 11.85% in healthy adults; from 3.25 to 7.75% in control children and from 2 to 6.55% in children with AD. Histidine and ...
Pages: 60-62
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Thymosin-inducible ‘null’ cells in atopic children
N. A. Byrom
No abstract available
Page: 63
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Common immunochemistry in atopic dermatitis and bronchial asthma
Kjell Aas
Atopic dermatitis and bronchial asthma are closely associated with respect to hereditary factors, epidemiology and occurrence in the same individuals. Both depend on more or less common genetic and environmental traits. Both are typical multifactorial diseases. They have also much in common as regards the complex immunological and chemical mechanisms involved. This becomes particularly evident whe ...
Pages: 64-66
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Comparative study of the immune response involvement in atopic dermatitis and psoriasis
Jean-facques Guilhou, Jacques Clot, Jean Meynadier
Immunological and pharmacological disturbances in atopic dermatitis and psoriasis are compared. This comparative study revcaled several analogies: T cell deficiency; hyperfunction of B cells leading to antibody production, defect in the beta-adrenergic response. The role of immunological and pharmacological factors in the pathogenesis of the two diseases is discussed.
Pages: 67-69
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Tuberculin reaction in atopic dermatitis
Masami Uehara
Serial examinations of tuberculin reactivity were performed in 16 patients with atopic dcrmatitis (AD) and in 14 patients with allergic contact dermatitis. Transient suppression of already established tuberculin reactivity was seen in the contact dermatitis patients. Tuberculin reactivity in the AD patients also fluctuated with the condition of the dermatitis. When the dermatitis was active, there ...
Pages: 70-71
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Class and subclass distribution of specific antibodies to codfish allergen in a patient with atopic allergy
T. Lea, L. R. Braathen, T. Moen
Using an indirect ELlSA technique together wilh rabbit antisera specific for human immunoglobulin classes and lgG subclasses, an estimate was made of the contribution of immunoglobulin classes and subclasses to the overall antibody response against codfish allergen in serum from a patient allergic to codfish. Allergen-specific antibodies were found to be of immunoglobulin classes lgM, lgD and lgE ...
Pages: 73-76
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Immunological, histological and electron-microscopical lnvestigations of the gut in atopic dermatitis
Lasse R. Braathen, Kåre Baklien, Torstein Hovig, Olav Fausa, Per Brandtzaeg
Jejunal biopsy specimcns were obtained from ten patients with severe atopic dermatitis and 15 controls. Light microscopical examination of hematoxylin-eosin stained sections showed normal condition in all atopic patients and intra-epithelial lymphocyte counts did not differ significantly from counts in controls. Scanning electron-microscopical examination demonstrated minor mucosal changes in five ...
Pages: 78-80
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The atopic-chronic-dermatophytosis syndrome
Henry E. Jones
This articlc reviews the clinical and laboratory aspects of the relationship between atopy and dermatophytosis. This newly appreciated relationship; chronic, stabilized dermatophytosis and bronchial asthma and/or allergic rhinitis, constitutes a clinical syndrome of importance and interest. The relevant host defense; correlate, cell mediated immunity, is subject to the modulating effects of the me ...
Pages: 81-85
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Results of food testing in atopic dermatitis
Matti Hannuksela
Skin testing to find food allergy in atopic dermatitis is recommcnded from the age of 4 months up the early adulthood. Scratch, scratch-chamber, prick and intra­cutancous tests may be used. In order to obtain optimal benefit from skin testing, both commercial extracts and fresh foodstuffs must be used. Extracts of protein-rich foods. such as fish, egg and nuts, work very well in skin tests, but f ...
Pages: 87-90
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History of food allergy, RAST and challenge test in atopic dermatitis
E. Bonifazi, L. Garofalo, A. Monterisi,C. L. Meneghini
In 541 patients with atopic dermatitis (AD), a history with special reference to food allergy, RAST and challenge tests were performed. In 84 patients cutaneous symptoms (exacerbation of the dermatitis or acute urticaria) were attributed to ingestion of various foods, especially eggs, milk, fish and peaches. While in cases of acute urticaria the history agreed largely with the results of the RAST ...
Pages: 91-93
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Hyperimmunoglobulinaemia E in atopic eczema (atopic dermatitis) is associated with "food allergy"
R. St C. Barnetson
Thirty-two adult patients with atopic eczema were compared with a similar group of atopics with asthma and/or rhinitis. Twelve patients with eczema had a history of food allergy, either to fish or eggs: only one of the asthma/rhinitis group gave such a history. When "prick'' testing to foods was performed, all but one of these patients with a history of food allergy had a positive skin test to foo ...
Pages: 94-96
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Treatment of atopic dermatitis with tolerogenic doses of antigen
David L. Morris
The principles of allergic management of atopic dermatitis, with special reference to sublingual hyposensitization, are briefly elucidated.
Pages: 97-98
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Dietary antigen avoidance in the treatment of atopic dermatitis
D.J. Atherton
There is now good evidence that food allergy is an important aetiological factor in atopic dermatitis and that dietary antigen avoidance is a helpful form or therapy, particularly in younger children. Allergy history, prick tests and the RAST are of limited value in identifying the allergies present in individual children. A systematic practical approach to allergy diagnosis is currently under eva ...
Pages: 99-102
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Monocyte cytotoxicity in clinical exacerbation and remission of atopic dermatitis
Knud Kragballe, Troels Herlin
Six adult patients with severe atopic dermatitis were followed up for an average time of 9 months, through periods of clinical exacerbation and remission. Sequential studies of monocyte function measured as antibody-dependent cell-mediated cytotoxicity showed depressed function which did not normalize during clinical remission.
Pages: 103-105
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RAST with human dander allergen in atopic dermatitis
L. Berrens, C. L. H. Guikers
Using highly purified allergens from skin flakes of the human scalp and from house dust, it was demonstrated that lgE antibodies against the former can be detected only in cases of severe atopic dermatitis (AD), but not in asthma (without eczema) and not in hay fever or rhinitis patients. The RAST scores for human dander correlated well with total lgE levels. Also, RAST scores for human dander all ...
Pages: 106-108
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Prurigo reaction in atopic dermatitis
Masami Uehara
A total of 41 biopsy specimens of the first visible prurigo papule were obtained from 32 adult patients with atopic dermatitis. In 38 of the 41 biopsy specimens, histological changes were seen in connection with hair follicle. The follicular wall showed spongiosis and vesicle formation with mononuclear cell migration. The remaining 3 biopsy specimens revealed an eczematous change which involved th ...
Pages: 109-110
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Seasonal factors in atopic dermatitis and their relationship to allergy
E. Young
The number of first visits to an out-patient department by patients with atopic dermatitis, as well as anamnesticat data from such patients, clearly shows seasonal changes in the course of this disease. An obvious relation is demonstrable between seasonal exacerbations and allergy to seasonal allergens.
Pages: 111-112
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The natural history of atopic eczema
C. F. H. Vickers
A long-term follow-up study of 2 000 children with atopic ecxema for from two to twenty-one years: clearance rates, pubertal recurrence rates and factors with or without prognostic significance are reported. Late onset "reversed pattern" and possibly social factors are adverse features, whilst early onset, seborrhoeic pattern and male sex are favourable prognostic signs. These results are based on ...
Pages: 113-115
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Effects of histamine receptor antagonists on histamine-induced responses in human skin
Östen Hägermark, Kjell Strandberg, Reidar Grönneberg
Abstract is not available
Page: 116
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Recent therapeutic events: cimetidine® and PUVA
Georg Rajka
Abstract is not available
Pages: 117-118
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The uses of PUVA in atopic dermatitis
Harry C. Goldberg
PUVA is an acronym which stands for the use or Psoralen as a photo-sensitizer for patients exposed to ultra­violet light type A (320-400 nm). Such use was brought to worldwide attention by Parrish et al. in 1974. Its deserved popularity is warranted by a remarkable improvement in over 85% of psoriatic patients. It was expected that PUVA would be tried for many skin conditions. Good results have a ...
Pages: 119-120
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Experimental treatment in atopic dermatitis: lmmunological background and preliminary results
H. Zachariae, K. Thestrup-Pedersen, H. Thulin, J. Thormann, T. Herlin, M. Cramers, J. Jensen, K. Kragballe, H. Afzelius, Overgaard Petersen
Experimental treatment in atopic dermatitis was undertaken with transfer factor, hyposensitization, or topical sodium chromoglycate. Both transfer factor and hyposensitization in open trials produced some clinical benefit. In both cases all patients could be controlled with medium strength topical steroids during therapy. In the latter case consumption of topical steroid was measured and found to ...
Pages: 121-127
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Atopic dermatitis and systemic treatment with a new chromone compound (FPL 57787) A double blind clinical trial
Finn Schultz Larsen, Keld Urup Jacobsen
In a double-blind cross-over trial, 23 adults with atopic dermatitis were treatrd systemically during two 6-week periods wilh a new anti-allergic chromone compound (FPL 57787) 18 mg four times a day or matched placebo in randomized order. Twenty patients completed the study: 11 preferred the active period, 9 prefcrred the placebo period. There were no statistically significant differences for any ...
Pages: 128-129
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