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Content - Volume 65, Issue 114

All articles

Altered Releasability of Vasoactive Mediator Secreting Cells in Atopic Eczema
Johannes Ring and Walter Dorsch
A summarizing survey of different studies in atopic eczema involving three types of cells (platelets, neutrophils, basophils) and their mediators is given. Platelets were found to release normal amounts of serotonin upon stimulation with epinephrine, thrombin and slightly reduced amounts after aggregated IgG stimulation. Serotonin uptake by washed platelets was found to be slower in atopics than i ...
Pages: 9-23
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Cyclic AMP-Phosphodiesterase Activity and Histamine Release in Cord Blood Leukocyte Preparations
J. C. McMILLAN, N. S. HESKEL and J. M. HANIFIN
Atopic dermatitis, allergic rhinitis and asthma are a common group of diseases with a familial predisposition. At present there is no suitable predictive or diagnostic marker. Adults with atopic dermatitis or allergic respiratory disease have elevated mononuclear leukocyte cAMP-phosphodiesterase activity. This activity correlates closely with histamine release from basophils. We investigated newbo ...
Pages: 24-32
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A Diagnostic Tool for Atopic Dermatitis based on Clinical Criteria
Åke Svensson, Björn Edman and Halvor Möller
Forty-seven patients with atopic dermatitis was compared to non-eczematous controls with regard to the occurrence of different symptoms and signs. This comparison made it possible to analyze statistically atopic symptoms and signs with regard to their diagnostic importance. Hereby, a diagnostic point system was constructed which in 96% of probands gave the correct diagnosis. This diagnostic tool m ...
Pages: 33-40
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Non-specific lmmunotherapy and Specific Hyposensitization in Severe Atopic Dermatitis
HUGH ZACHARIAE, MARIE CRAMERS, TROELS HERLIN, J0RGEN JENSEN, KNUO KRAGBALLE, THOMAS TERNOWITZ and KRISTIAN THESTRUP-PEDERSEN
No abstract available
Pages: 48-54
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Basophil Histamine release in Atopic Dermatitis and lts Relationship to Disordered Cyclic Nucleotide Metabolism
J. M. BUTLER. M. EBERTZ, S. C. CHAN, S. R. STEVENS, D. SOBIESZCZUK and J. M. HANIFIN
Maximal histamine release (HR) from leucocytes, in response to Concanavalin A (Con A) was significantly higher in a group of 16 adults with moderate to severe atopic dermatitis (AD) when compared to 13 non-atopic adults. In a further 4 adults with AD, HR was similar to that in the normals, suggesting the existence of 'high releaser' and 'low releaser' subsets within the AD group. Leucocyte cyclic ...
Pages: 55-60
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Enzyme-linked lmmunosorbent Assay (ELISA) for lsotypespecific Ouantitation of Antibodies to Staphylococcus aureus in Patients with Atopic Dermatitis
Tor-Oivind Gabrielsen and Per Brandtzaeg
An enzyme-linked immunosorbent assay (ELISA) was developed to study the serum antibody response against Staphylococcus aureus within four immunoglobulin classes (IgG, IgA, IgM and IgE) in patients with atopic dermatitis (AD) and in normal controls. Soluble antigens released from S. aureus Wood 46 (protein A deficient) were partially purified by gel filtration of supernatant culture fluid. Median E ...
Pages: 61-66
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Epidermal Changes in Atopic Dermatitis
D. VAN NESTE, M. DOUKA, J. R AHIER2 and M. J. STAQUET
The epidermal changes occurring in various lesions of atopic dermatitis are reported. Quantitative evaluation or epidermal thickening suggests that both differentiated and undifferentiated compartments are increased in lichenified lesions. In dry skin (xerosis) of atopic dermatitis moderate but obvious inflammatory changes are observed. There is a mild increase of the epidermal volume without fold ...
Pages: 67-71
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Studies of HLA-ABC and DR Antigens in Pure Atopic Dermatitis and Atopic Dermatitis Combined with Allergic Respiratory Disease
Else Svejgaard, Bodil Jakobsen and Arne Svejgaard
The HLA-ABC antigens were investigated in 29 patients with pure atopic dermatitis and 43 patients with atopic dermatitis combined with atopic respiratory disease (ARD). Furthermore, the DR antigens were studied in 10 patients with dermatitis alone and in 24 patients with combined atopic disease. The frequencies of antigens and the HLA phenotypes A1, B8 and A3, B7 in the entire group of patients an ...
Pages: 72-76
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Delayed type hypersensitivity in atopic dermatitis.
Young E, Bruijnzeel-Koomen C, Berrens L.
Three different aspects of delayed type hypersensitivity in atopic dermatitis (A.D.) were studied. (a) Intradermal testing demonstrated that positive reactions to bacterial vaccines were distinctly lower in patients with A.D. (b) Patch testing in patients with A.D. compared to tests in patients with anal eczema showed a striking difference in results concerning the substances to which positive rea ...
Pages: 77-81
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Clinical and Histological Features of Dry Skin in Atopic Dermatitis
Masami Uehara
Of 200 atopic dermatitis patients observed during cold months, 44 (22%) had ichthyosis vulgaris. Histologically, the dry skin in atopic dermatitis coexistent with ichthyosis demonstrated ichthyotic features which were frequently superimposed with eczematous changes. The dry skin in pure atopic dermatitis demonstrated the histology of mild eczema. Examinations using monoclonal antibodies showed tha ...
Pages: 82-86
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A Prospective Computerized Study of 500 Cases of Atopic Dermatitis in Childhood
C. QUEILLE-ROUSSEL. F. RAYNAUD and J.-H. SAURAT
We report the initial results arising from analysis of a prospective computerized study of infantile atopic dermatitis in which, among other factors, the criteria of severity of the dermatitis was considered for the first time. Besides providing informations on the natural history of childhood AD, this study showed that onset of asthma was significantly earlier in children affected with severe AD.
Pages: 87-92
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Adrenoceptor Function in Atopic Dermatitis: in Vitro and in Vivo Observations
C. B. ARCHER, J. M. HANSON, J. MORLEY and D. M. MACDONALD
Impaired beta-adrenergic and enhanced alpha-adrenergic reactivity have been implicated in the pathogenesis of atopic dermatitis. We have measured the elevation of cyclic AMP in peripheral blood leukocytes in response to isoprenaline, histamine and prostaglandin E2, in the presence and absence of a phosphodiesterase inhibitor. An impaired response to beta-adrenergic stimulation was demonstrated in ...
Pages: 93-97
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Role of Some lnfectious Agents in Atopic Dermatitis
E. BONIFAZI, L. GAROFALO. V. PISANI and C. L. MENEGHINI
Certain infections such as Kaposi's herpetic eruption, impetigo, recurrent cutaneous herpes simplex and warts are more frequent in subjects with atopic dermatitis. It is likely that the continuous alterations of the skin are more important than immunological factors in increasing the frequency of some infections in subjects with atopic dermatitis. Moreover, these infections do not seem to affect s ...
Pages: 98-100
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The lmmune Response to S. aureus in Atopic Dermatitis
C. HAUSER, B. WUETHRICH, 2 L. MATTER. J. A. WILHELM and K. SCHOPFER
The skin of patients with atopic dermatitis is heavily colonized with S. aureus, and their immune response to S. aureus shows some particular features: (1) A selective hyporesponsiveness to purified S. aureus cell walls in delayed type hypersensitivity skin reactions. (2) The presence of IgE to cell walls and soluble antigens of S. aureus in patients with high serum IgE levels. (3) Elevated cell w ...
Pages: 101-104
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Reduction of Active Natural Killer Cells in Patients with Atopic Dermatitis Estimated at the Single Cell Level
J0RGEN R. JENSEN
The natural killer cell cytotoxicity of peripheral blood lymphocytes from twenty-one patients with moderate to severe atopic dermatitis was studied directly by a single cell assay. Suspensions of conjugated effector cells bound to target cells were examined with a light microscope to evaluate the cell lysis using trypan blue exclusion. The binding to the K562 target cells and the kinetics of lysis ...
Pages: 105-108
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Allergy to Hen's Egg White in Atopic Dermatitis
Tor Langeland
Clinical parameters of 84 egg-allergic children were recorded. The individual allergens in hen's egg white were studied by means of crossed radio-immunoelectrophoresis (CRIE). Thirteen of the proteins in the egg white were found to have given rise to IgE-antibody production in the egg-allergic children. The major allergens were identified as ovalbumin, ovomucoid and ovotransferrin. Pruritus and ex ...
Pages: 109-112
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Patch test reactions in atopic patients.
Marghescu S.
No abstract available.
Pages: 113-116
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Long Term Follow-up in Atopic Dermatitis
Ingela Rystedt
A long-term follow-up study (minimum 24 years) has been carried out on 955 individuals with a history of atopic dermatitis (AD), who in childhood had been in- or out-patients at the Department of Dermatology, Karolinska Hospital, Stockholm. 62% of the in-patients and 40% of the out-patients still had dermatitis at investigation. The most common site was the hands. Eczematous hand involvement in ch ...
Pages: 117-120
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Viral lnfections in Atopic Dermatitis
Örjan Strannegård, Inga-Lisa Strannegård and Ingela Rystedt
In a study of almost 1000 patients with past or present atopic dermatitis (AD) it was found that histories of recurrent (greater than 5 episodes/year) cold sores and upper respiratory infections, as well as histories of zoster were significantly more common in AD patients than in non-atopic controls. Serological studies revealed that AD patients have clearly elevated titers of antibodies against E ...
Pages: 121-124
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Eczema in Primary Immune-deficiencies
J.H. Saurat
Eczema is one of the cutaneous manifestations of primary immune deficiencies. It may therefore serve as a model for the understanding of atopic dermatitis (AD) provided the eczema in the immune deficiency under consideration is a constant feature and is similar to AD. In the Wiskott-Aldrich syndrome the eczematous eruption is (i) a constant feature of the syndrome, (ii) indistinguishable from AD w ...
Pages: 125-128
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Skin Reactions to Foods in Patients with Atopic Dermatitis
E. C. BENIDN and R. C. BARNETSON
Thirty-seven patients with moderate or severe persistent atopic dermatitis gave a history of skin reactions following the ingestion of certain foods. These reactions fell into three groups: immediate reactions (within one hour) which included angio-oedema, contact urticaria, generalised itching and erythema, or urticaria; late reactions, where patients experienced late urticaria, late angio-oedema ...
Pages: 129-132
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T-cell Subsets in Patients with Mild and Severe Atopic Dermatitis
Mononuclear cells separated from peripheral blood from 34 patients with mild and 19 patients with severe atopic dermatitis, and 24 controls, were stained with OKT3, OKT4 and OKT8, using immunofluorescence technique and counted. In patients with severe atopic dermatitis a highly significant decrease in OKT3, OKT4- and OKT8-positive lymphocytes was found, as compared with controls, as well as an inc ...
Pages: 133-136
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Ultraviolet Light Therapy in Atopic Dermatitis
MATTI HANNUKSELA, JAAKKO KARVONEN, MERJA HUSA, RITVA JOKELA, LUSA KATAJAMÄKI and MARKKU LEPPISAARI
In 1979-1981, 107 patients with atopic dermatitis were treated with Psorilux 9050 emitting 1.24 mW/cm2 at 280-315 nm and 7.33 mW/cm2 at 315-400 nm. Half of the patients received one treatment course, 20% 2-3 courses, and one third more than 3 treatment courses. A good result was obtained in 93% of the cases but in the other cases the treatment was either ineffective or the patients were too sensit ...
Pages: 137-139
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Correlation between Clinical and lmmunological Findings in Atopic Dermatitis
C. L. MENEGHINJ and E. BONIFAZI
Many immunological alterations have been reported in atopic dermatitis, and it is likely that in some cases they are capable of worsening the clinical course of atopic dermatitis (AD). More frequently these alterations are responsible for conditions associated with AD such as asthma, food allergy and infections. It seems probable that in some cases they are evidence of a preclinical allergic manif ...
Pages: 140-142
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Atopic Dermatitis and Essential Fatty Acids: a Biochemical Basis for Atopy?
Steve Wright
The effects of dietary supplementation with evening primrose oil (Efamol) in 99 patients with atopic dermatitis were investigated in a double blind, controlled crossover study. Simultaneously, plasma phospholipid essential fatty acid status was determined in 50 of these patients before and after treatment. In a separate study, lymphocyte subsets and mitogen responses were investigated in 15 atopic ...
Pages: 143-145
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Pityrosporum Orbiculare-a Pathogenic Factor in Atopic Dermatitis of the Face, Scalp and Neck?
ATLE WfERSTED and NIELS HJORTH
Pityrosporum orbiculare (pit.o.), the yeast form of Malassezia furfur, though usually considered to be a non-pathogenic saprophyte, in some individuals trigger various types of dermatitis. It is earlier shown that it is of importance in atopic dermatitis in the head-neck area in adults, and that elimination of the yeast by help of treatment with ketoconazole improve the dermatitis. In this large r ...
Pages: 146-148
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Adenylate Cyclase Activity in Mononuclear Leucocytes from Patients with Atopic Dermatitis
C. A. HOLDEN, S. C. CHAN, and J. M. HANIFIN
No abstract available.
Pages: 149-151
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lnvolvement of Complement in Atopic Dermatitis
A. KAPP and E. SCHÖPF
There is little information about the role of complement in atopic dermatitis (AD). We studied the levels of both normal complement components and activation products in peripheral blood of patients with mild to intermediate disease. 35 patients had not received systemic or topical steroid therapy 6 weeks prior to blood collection. C3, C4 and C1 INA were determined in serum by radioimmunodiffusion ...
Pages: 152-154
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A Comparison of Antihistaminic and Sedative Effects of Some H 1 -receptor Antagonists*
Östen Hägermark, Sten Levander and Mona Ståhle
No abstract available.
Pages: 155-156
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Treatment of Atopic Dermatitis with Steroids
S. MARGHESCU
No abstract available.
Pages: 157-158
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Atopic Dermatitis in a Population Based Twin Series
F. V. SCHULTZ LARSEN and N. V. HOLM
No abstract available.
Pages: 159-159
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Curriculum Vitm et Scripta
No abstract available.
Pages: 160-164
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