Content - Volume 67, Issue 6

All articles

Glucocorticoid receptors in cultured human skin fibroblasts: evidence for down-regulation of receptor by glucocorticoid hormone
Oikarinen A, Oikarinen H, Meeker CA, Tan EM, Uitto J.
In the present study, we have determined the specific glucocorticoid receptors in cultured human skin fibroblasts with [3H]dexamethasone as the ligand. The whole-cell assay was employed for determination of glucocorticoid receptor densities and binding affinities in fibroblast cultures established either from 16 healthy control subjects, from 4 patients with active progressive systemic sclerosis ( ...
Pages: 461-468
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Enhanced releasability of prostaglandin E2 and leukotrienes B4 and C4 from leukocytes of patients with atopic eczema
Ruzicka T, Ring J.
The releasability of arachidonic acid-derived inflammatory mediators (eicosanoids) from peripheral blood leukocytes has been tested in patients with atopic eczema and healthy, non-atopic controls. Spontaneous and stimulated release of prostaglandin E2 (PGE2), leukotriene B4 (LTB4) and leukotriene C4 (LTC4) has been measured after challenge of cells with various concentrations of anti-IgE, Ca-ionop ...
Pages: 469-475
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IgE in atopic dermatitis: a study of the intercellular fluid
Beck HI, Hagdrup HK, Brandrup F, Bonnevie-Nielsen V.
In 33 adult patients with atopic dermatitis of mild to severe degree the concentration of IgE in serum (S) and intercellular fluid (IF) was studied by suction blister technique. The median value of IF/S-IgE was 0.20 and not different from the ratio 0.21 found in controls. Furthermore, by subdividing the patients into groups with asthma/rhinitis or different severities of eczema no significant diff ...
Pages: 476-480
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Neutrophil function in psoriasis: effects of retinoids
Coble BI, Dahlgren C, Molin L, Stendahl O.
The present investigation focused on the oxidative response of polymorphonuclear neutrophil leukocytes in psoriasis, in particular pustular psoriasis and how this response was affected by different retinoid compounds. In the active phase of pustular psoriasis, the neutrophil chemiluminescence response to the chemotactic peptide f-met-leu-phe and to phorbol myristate acetate was enhanced and correl ...
Pages: 481-490
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Papulo-vesicular count for the rating of allergic patch test reactions. A simple technique based on polysulfide rubber replica
Peters K, Serup J.
Silicone rubber replica of patch test reactions were obtained from 12 patients with allergic contact dermatitis. 85 positive or doubtful reactions to allergens included in a standard battery were studied. The number of papulo-vesicles and sweat pores as seen in the replica were counted under a stereomicroscope. The papulo-vesicular count increased significantly in relation to clinical reading of t ...
Pages: 491-495
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A follow-up study of leg and foot ulcer patients
Hansson C, Andersson E, Swanbeck G.
Three hundred and fifty patients treated in 1980 at the Department of Dermatology for leg and foot ulcers were asked to come for an interview concerning the development of their ulcerations up to the end of 1983. Forty-five of 186 patients were free from ulcers from 1981 to 1983. Thirty patients had leg ulcers continuously throughout the period and their ulcers were not healed at any time. Ninety- ...
Pages: 496-500
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PUVA therapy for photosensitive psoriasis
The purpose of this study was to assess the prophylactic effect of oral photochemotherapy with psoralens and UVA (PUVA) on patients with light-sensitive psoriasis. Of fifteen patients with photosensitive psoriasis, ten with a history of polymorphous light eruption (PMLE) slowly developing into psoriasis were treated with trimethylpsoralen (TMP) and UVA. Five patients with no preceding PMLE reactio ...
Pages: 501-505
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Hendersonula toruloidea infection: successful response of onychomycosis to nail avulsion and topical ciclopiroxolamine
Rollman O, Johansson S.
The exotic mould Hendersonula toruloidea may occasionally produce a ringwormlike, non-inflammatory, therapy-resistant mycosis of the skin and nails simulating chronic dermatophytosis. We report on a 30-year-old Nigerian male who, after two years´ sojourn in Sweden, developed finger-nail dystrophy and mild scaling of the palm and sole skin due to H. toruloidea infection. Nail avulsion followed by ...
Pages: 506-510
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High prevalence of cervical dysplasia in female consorts of men with genital warts
Höckenström T, Jonassen F, Knutsson F, Löwhagen GB, Rådberg T.
Altogether 51 regular female consorts of men attending a venereal disease clinic for genital warts were examined using colposcopy, vaginal cytology and--when needed--surgical biopsy. Abnormal cytological smears were found in 18 out of 49 consorts (37%), which should be compared with 8 out of 124 (6%) matched female controls from a family planning clinic (p less than 0.001). Possibly premalignant l ...
Pages: 511-516
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The majority of epidermal Merkel cells are non-proliferative: a quantitative immunofluorescence analysis
Vaigot P, Pisani A, Darmon YM, Ortonne JP.
Although epidermal Merkel cells (MC) are able to form synapses and synthetize neuromediators, they can be considered as being of epithelial nature because of the presence of cytokeratins in their cytoskeleton and desmosomes on their membranes. Since epidermis is an epithelium undergoing permanent renewal, it was important to determine whether MC were able to renew, as neighbouring keratinocytes do ...
Pages: 517-520
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T-helper cell activation in bullous pemphigoid
Schaller J, Haustein UF, Fiebig H.
In 10 untreated patients suffering from acute bullous pemphigoid the number of peripheral blood T cells (CD 3), T suppressor (CD 8) and T helper cells (CD 4) as well as activation antigens (DR and Tac) bearing lymphocytes was evaluated by monoclonal antibodies. While the pan-T cell population (CD 3) and T suppressor subpopulation (CD 8) were normal, the T helper subpopulation (CD 4) and the number ...
Pages: 520-523
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Carcinomas following Grenz ray treatment of benign dermatoses
Mortensen AC, Kjeldsen H.
During the years 1977-1986 five patients were referred to the Department of Plastic Surgery. University Hospital, Arhus, for treatment of carcinomas occurring in the skin on the sites previously treated with Grenz rays for benign dermatoses. Grenz ray treatment had been given for eight to nineteen years. The dose given, in one case, was very extensive. Otherwise a dose between 10,000 rad (100 Gy) ...
Pages: 523-525
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Growth kinetics of fibroblasts derived from normal skin and hypertrophic scar
Oku T, Takigawa M, Fukamizu H, Inoue K, Yamada M.
In vitro growth kinetics of fibroblasts derived from normal skin and hypertrophic scar were performed using continuous 3H-thymidine labeling method. In fibroblasts derived from normal skin, aging of the donor affects cell growth mainly by growth fraction (GF), but not labeling index (LI) and DNA synthetic time (Ts). When hypertrophic scar-derived fibroblasts are compared with normal fibroblasts, t ...
Pages: 526-528
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Human epidermal Langerhans´ cells in bullous pemphigoid
Emtestam L, Hovmark A, Lindberg M, Asbrink E.
Through the epidermal analysis of 13 patients with bullous pemphigoid compared to controls, using OKT6 monoclonal antibodies on the light microscopic level and electron-microscopy, we found a redistribution of the Langerhans´ cells towards the basal membrane in combination with an increased total number of Langerhans´ cells. This redistribution was also noted in clinically normal skin from patie ...
Pages: 529-532
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Effects of PUVA and mechlorethamine treatment of psoriatic patients on epidermal Langerhans´ cells
Torinuki W, Mauduit G, Haftek M, Thivolet J.
Using OKT6 monoclonal antibody, we investigated the number of epidermal Langerhans´ cells (LCs) in involved skin from patients with psoriasis, before and after mechlorethamine (HN2) or PUVA treatment. The number of LCs remained at about pretreatment number during three weeks of HN2 treatment alone, though they were reduced after 10 systemic PUVA treatments. Therefore, in contrast to PUVA which in ...
Pages: 532-535
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Solid facial edema as a complication of acne vulgaris: treatment with isotretinoin and clofazimine
Helander I, Aho HJ.
We present two patients, a 20-year-old female and an 18-year-old male, who suffered from persistent solid facial edema as a complication of acne vulgaris. They were treated with isotretinoin with moderate response and thereafter with lymph massage with further response. The female patient also received clofazimine with good response.
Pages: 535-537
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