Content - Volume 68, Issue 1

All articles

The expression of PNA-lectin binding sites and S-100 protein in histiocytic lesions of the skin. A comparative immunohistochemical study
Kanitakis J, Roche P, Thivolet J.
In this work the potential usefulness of antibodies to S-100 protein and the lectin Peanut Agglutinin (PNA) in the differential diagnosis of histiocytic lesions of the skin was assessed. Out of 54 deparaffinized specimens studied through an avidin-biotin-alkaline phosphatase technique, 35 proved to comprise S-100 (+) and 12 PNA (+) cells. The results show that antibodies to S-100 protein are usefu ...
Pages: 1-7
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Keratin expression in epidermolysis bullosa simplex (Dowling-Meara)
Tidman MJ, Eady RA, Leigh IM, MacDonald DM.
The Dowling-Meara variant of epidermolysis bullosa simplex (EBS) is characterized microscopically by clumping of the keratin tonofilaments within areas of incipient blistering, thereby raising the possibility that an abnormality of the keratin cytoskeleton might underlie blister formation in this condition. In order to investigate keratin expression in Dowling-Meara EBS, the staining profile of a ...
Pages: 15-20
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The effect of testosterone and anabolic steroids on the skin surface lipids and the population of Propionibacteria acnes in young postpubertal men
Király CL, Alén M, Korvola J, Horsmanheimo M.
The effect of testosterone and anabolic steroids on skin surface lipids and the population of Propionibacteria acnes (P. acnes) was studied in power athletes. The subjects used self-administered high doses of testosterone and anabolic steroids during a 12-week strength training period. After 8 weeks´ use of hormones the amount of dissolved skin surface lipids (SSL), and the Colony Forming Units/c ...
Pages: 21-26
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Adenylate and guanylate cyclase activities in isolated guinea pig epidermal cells at various stages of differentiation
Takigawa M, Yamada M, Taniguchi S, Imamura S.
The enzymatic properties of adenylate and guanylate cyclases were examined in sonicates of trypsinized guinea pig epidermal cells as enzyme source. Adenylate cyclase was found to be membrane-bound, while guanylate cyclase activity was detected in both membrane and cytosolic fractions. The maximal activities of the enzymes were obtained in the presence of Mn++ in the pH range 7.8-8.8. The apparent ...
Pages: 27-32
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Ultrastructure of vascular changes in cutaneous manifestations of Behçet´s disease
Bang D, Honma T, Saito T, Nakagawa S, Ueki H, Lee S.
We observed small dermal blood vessels embolized by thrombus at the sites of needle-prick reaction as well as erythema nodosum-like lesions in 4 patients with Beh?ßet´s disease, by means of electron microscopy. The ultrastructural finding associated with overproductive proliferation of the endothelial cells leading to obliteration of the vascular lumen was the sporadical appearance of degenerate ...
Pages: 33-40
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Photoallergy to systemic quinidine in the mouse
Wirestrand LE, Ljunggren B.
Using the mouse, photoallergy to the antiarrhythmic agent quinidine could be induced following systemic administration. After pretreatment with cyclophosphamide 150 mg/kg, groups of 5-10 mice were injected i.p. with quinidine chloride 100 mg/kg on 2 consecutive days, followed by exposure of shaved abdominal skin to UVB 0.1 J/cm2 and UVA 5.0 J/cm2. Five days later challenge was performed on the lef ...
Pages: 41-47
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Seborrheic dermatitis and malignancy. An investigation of the skin flora
Clift DC, Dodd HJ, Kirby JD, Midgley G, Noble WC.
The skin flora of patients with disseminated malignant disease and seborrheic dermatitis has been investigated and compared with controls as well as with otherwise healthy patients suffering from seborrheic dermatitis. Although significant differences were detected in both bacterial and yeast counts between different sites on the body, no significant qualitative or quantitative differences were fo ...
Pages: 48-52
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Dermatophytosis and HIV infection. A study in homosexual men
Torssander J, Karlsson A, Morfeldt-Månson L, Putkonen PO, Wasserman J.
Mycological and clinical investigations were carried out in 193 homosexual men, 83 of whom had HIV antibodies, and 117 heterosexual men. Dermatophytes were recovered from the feet in 37.3% of HIV seropositive homosexual men, 31.8% of seronegative homosexual men and 8.6% of heterosexual men. Tinea pedis in homosexual men was significantly more common with increasing age. There was an increased numb ...
Pages: 53-56
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Topical application of clobetasol-17-propionate inhibits the intra-epidermal accumulation of polymorphonuclear leukocytes
Chang A, van de Kerkhof PC.
The in vivo effect of topical clobetasol-17-propionate (CP) on the leukotriene B4- and trauma-induced intra-epidermal accumulation of polymorphonuclear leukocytes (PMN) was investigated in normal volunteers. PMN accumulation was assessed using elastase, a specific and sensitive marker for these cells. A profound inhibition of PMN accumulation was shown in the first 2 days of treatment with CP, an ...
Pages: 57-60
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Referral pattern and accuracy of clinical diagnosis of cutaneous melanoma
Rampen FH, Rümke P.
Between 1981 and 1983, 329 patients with cutaneous melanoma registered in Amsterdam and Rotterdam, The Netherlands, were analysed with respect to the referral pattern and accuracy of clinical diagnosis. With increasing Breslow thickness, a greater proportion of the patients were referred to the surgeon than to the dermatologist (p less than 0.01). The overall clinical suspicion rate was 61.6%. Sus ...
Pages: 61-64
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Skeletal involvement in pustulosis palmo-plantaris with special reference to the sterno-costo-clavicular joints
Hradil E, Gentz CF, Matilainen T, Möller H, Sanzén L, Udén A.
Skeletal scintigraphy was performed in patients with pustulosis palmo-plantaris. There was an increased isotope uptake in the sterno-costo-clavicular area in 16 of 73 patients (22%). The skeletal involvement was further studied by computer tomography showing seven characteristics (including unilaterality) typical of the disease. Clinically, the arthritis is aseptic and benign, and only 9 of 16 pat ...
Pages: 65-73
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Natural and Chang liver cell cytotoxic studies of methotrexate-treated psoriatic patients with liver cirrhosis
Thestrup-Pedersen K, Laurberg G, Søgaard H, Rønnevig JR.
Forty patients with psoriasis were investigated for unspecific and specific lymphocyte cytotoxicity in order to evaluate the significance for liver cell damage in methotrexate-treated (MTX) patients. We found no difference between psoriasis patients with regard to cytotoxicity. We also observed a normal proliferation of lymphocytes after stimulation with tuberculin and phytohemagglutinin.
Pages: 74-77
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HLA-DR and DQ antigens in lichen planus
Valsecchi R, Bontempelli M, Rossi A, Bellavita P, Barcella A, Di Landro A, Cainelli T.
A study on HLA-DR and DQ typing in 40 patients with lichen planus (26 males and 14 females) and in 92 normal blood donors of both sexes was performed. Twenty-seven patients had cutaneous lesions, 11 cutaneous and mucosal involvement and 2 patients had oral erosive lesions. Serological typing revealed a highly significant increase of HLA-DR 1 antigen in the patient group. No difference has been obs ...
Pages: 77-80
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Ultrastructure of angiokeratoma vulvae
Karlsmark T, Weismann K, Kobayasi T.
A case of vulvar angiokeratoma studied by electron microscopy is described. The patient, a 51-year-old woman, had noticed eruptions for the last 15 years, though without symptoms. Osmiophilic bodies with myelin-like figures were found in the vascular endothelial cells. The findings support previous opinion that vulvar angiokeratoma is a variant of scrotal angiokeratoma.
Pages: 80-82
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Bromocriptine treatment in patients with late onset acne and idiopathic hyperprolactinemia
Okano M, Kitano Y, Yoshikawa K, Ishimura K, Fujita H.
Twenty female patients with late onset acne and idiopathic hyperprolactinemia--but without increased levels of androgens or decreased levels of SHBG--were treated with bromocriptine. All patients had a fall of basal prolactin levels to normal and a great improvement in or even disappearance of their acne.
Pages: 83-84
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Spironolactone and cimetidine in treatment of acne
Hatwal A, Bhatt RP, Agrawal JK, Singh G, Bajpai HS.
In an open therapeutic trial, 50 patients with acne vulgaris were randomly allocated to one of two groups. One group received spironolactone 100 mg daily and the other cimetidine 1.6 g daily for 12 weeks. Clinical severity of acne and sebum excretion decreased significantly at the end of the trial with both drugs, but significantly more with spironolactone. Mean serum levels of testosterone, andro ...
Pages: 84-87
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Axillary hyperhidrosis. Local treatment with aluminium-chloride hexahydrate 25% in absolute ethanol with and without supplementary treatment with triethanolamine
Glent-Madsen L, Dahl JC.
In a randomized, double-blind, half-sided experiment, 30 volunteers were treated in both armpits with aluminium chloride hexahydrate 25% in ethanol. In order to neutralize pH and thus reduce the skin irritation, post-treatment was performed in one armpit with triethanolamine 50% in ethanol. The sweat production was measured after physical labour by means of a combined colorimetric/gravimetric meth ...
Pages: 87-89
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Sexual dysfunction in a patient treated with etretinate
Halkier-Sørensen L.
No Abstract is available
Pages: 90-91
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