Content - Volume 69, Issue 1

The contact sensitivity evaluated by the ear swelling test and the dynamic changes of epidermal Ia+ dendritic cells (Ia+DECs) and Thy-1+ dendritic cells (Thy-1+DECs) were studied in trinitrochlorobenzene (TNCB) sensitized different age group C3H/He mice after challenge. A significant increase of ear swelling was observed between 6 h and 10 days of both 8-10 week (wk) and 40-48 wk groups; the ear s ...

The antibody activities and complement fixing ability of the IgG subclass antibodies of herpes gestationis (HG) and bullous pemphigoid (BP) antibodies were investigated. IgG was prepared by DEAE Affi-Gel Blue column. IgG3 and IgG 1.2.4 fractions were isolated through Protein-A Sepharose CL-4B column. In HG, neither IgG nor C3 deposits were detected at the basement membrane zone (BMZ) in the skins ...

The photoprotective and antierythematous effects of topical corticosteroids, acetylsalicylic acid (ASA), indomethacin (IM), butylhydroxytoluene (BHT) and diphenhydramine hydrochloride (DPH) and the influence of the application time on the formation of erythema were studied in healthy volunteers. The test substances, incorporated in o/w creams, were applied to the back in large Finn Chambers 24, 4 ...

A eutectic mixture of 5% lidocaine and prilocaine was applied under occlusion for 1 or 2 hours on 25-100 cm2 areas of normal and diseased skin, and the absorption was followed by measuring the concentrations of the drugs in the draining vein and the general circulation at different time intervals after the application. The analgesic and vascular effects in the skin were also recorded. When the mix ...

Several studies have indicated that certain lipoxygenation products of arachidonic acid, particularly leukotriene B4 (LTB4), may be involved in psoriatic pathophysiology. One way of inhibiting the formation of LTB4 is to replace arachidonic acid in phospholipids with eicosapentaenoic acid. Eicosapentaenoic acid is converted into LTB5, which has a lower biologic activity than LTB4. In the present s ...

Concentrations of selenium in whole blood and plasma in 113 patients with moderate to severe psoriasis were compared with those in 104 healthy reference subjects. Most of the patients (85%) had had their psoriasis for at least 10 years and all had previously been treated with PUVA baths. Selenium concentrations both in whole blood and plasma were decreased both in male and female psoriasis patient ...

Acitretin, the free acid of etretinate, is less lipophilic and has a much shorter terminal half-life than the parent compound. The present double-blind, randomized study compared the therapeutic effectiveness and the tolerability of acitretin (n = 127) and etretinate (n = 41) in psoriasis. Patients were treated with 40 mg daily for the first 4 weeks and with an individually adjusted dose for the s ...

Two scoring methods evaluating the severity of atopic dermatitis have been compared. One was simple, quick and compatible with a busy outpatients clinic. The other was more complicated and time consuming; it took into account most of the evaluable clinical signs of disease activity in each involved site. There was a highly significant correlation between the two methods of scoring, thus validating ...

Thirty patients having skin problems experienced being caused by work with visual display units (VDU) were tested double-blind with two VDUs. One VDU had strong electrostatic and electromagnetic fields and the other VDU had an identical appearance but the electrostatic field and electromagnetic fields were practically eliminated. Approximately 80% of the patients reacted with stinging or itching i ...

A retrospective survey during a 2-year period disclosed 18 patients with acute febrile neutrophilic dermatosis (Sweet´s syndrome). An associated lympho- or myeloproliferative malignancy was found in 6 patients. Attacks of Sweet´s syndrome preceded the diagnosis of neoplasia in 4 patients (3 months to 6 years). Some differences in symptoms and signs were found in the group of patients with associ ...

Basal keratinocytes reportedly comprise two ultrastructurally recognizable populations, usually referred to as serrated basal keratinocytes (SBK) and non-serrated basal keratinocytes (NSBK). The former are responsible for dermal-epidermal anchoring, whereas the latter serve in epidermal turnover (stem cells). The size and shape of these cells were investigated by electron microscopy and computer-a ...

Patients with a contact allergy to chromium, cobalt and/or nickel, patch test verified before implantation of a metallic orthopaedic device, were followed up years later by clinical and radiographic examination as well as with epicutaneous and intracutaneous tests. Eighteen patients had been exposed to an orthopaedic implant for several years (mean 6.3 years) containing a metal to which they were ...

Sera from 31 patients with progressive systemic sclerosis (PSS), 5 patients with widespread localized scleroderma (LS), and 3 patients with lichen sclerosus et atrophicus were analyzed for aminoterminal propeptide of type III procollagen (PIIINP) using a radioimmunoassay based on human propeptide. Thirty-eight per cent of the patients with PSS had levels above normal range, including all of the 3 ...

A 70-year-old white man developed 7 eccrine poromas in an area of chronic radiation dermatitis of his right lower extremity over a period of 37 years. To our knowledge, multiple eccrine poromas unequivocally linked to chronic X-ray damage are hitherto unreported.

Eleven patients with S?©zary syndrome were treated with intermittent leukapheresis in addition to low-dose chlorambucil and prednisone. The results were as good as or better than those with chemotherapy alone. We believe the combined program with continuous leukapheresis to be optimal therapy but note that intermittent treatment offers some benefit for patients.

A case of inflammatory linear verrucous epidermal nevus (ILVEN) is reported. Short contact treatment with dithranol resulted in complete relief from itching and a remarkable clearing of all linear lesions except from a small verrucous band on the shin. In patients with ILVEN it is advisable to try dithranol therapy before carrying out surgical procedures such as excision, cryotherapy, electrocaute ...

The effect of grenz ray therapy in the treatment of psoriatic nails was assessed in 22 patients by randomly allocating active treatment to the psoriatic nails of one hand while the other one, which received simulated therapy, served as a control. Five Gy of grenz rays were applied on 10 occasions at intervals of 1 week. There was a significantly better response to active treatment compared with th ...

A new experimental fluorescent lamp emitting UVB mainly in a narrow peak around 311 nm was compared with a conventional broad band UVB lamp in the treatment of psoriasis with the Ingram regimen. In 20 patients one arm was treated with the new lamps and the other arm with conventional lamps. In 12 patients the results were same, but the new lamp was more effective in 8 patients. In another trial, 5 ...

The following is a description of the improvement of a HIV-negative patient with psoriasis and monoarthritis who received treatment with Peptide-T, a synthetic octapeptide that shares a segment of the envelope glycoprotein (gp 120) of the human immunodeficiency virus.

Two patients with psoriasis and one with pityriasis rubra pilaris developed squamous cell carcinomas in relation to cyclosporin A therapy. Dermatological patients previously treated with ultraviolet radiation and other kinds of immunosuppressive therapy may represent a special risk group with respect to cyclosporin. A related malignancies.

No abstract available.