Content - Volume 72, Issue 1

All articles

Candida albicans grown in glucose-free media contains serum-independent chemotactic activity.
Brasch J, Schröder JM, Christophers E
Infection of skin with Candida albicans is usually followed by infiltration of neutrophil granulocytes (PMN). So far, chemotaxins for PMN have been isolated from C. albicans cultures grown in the presence of glucose. However, since glucose is not present in skin in vivo, a contribution of such factors to Candida-triggered cutaneous inflammation would appear unlikely. In order to clarify this quest ...
Pages: 1-3
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Transepidermal water loss related to volar forearm sites in humans.
Panisset F, Treffel P, Faivre B, Lecomte PB, Agache P
The aim of this study was to demonstrate differences in human skin transepidermal water loss (TEWL) in vivo related to site on volar forearm. Fourteen healthy volunteers entered the study and seven sites were tested. After randomization of both forearm and measure order, TEWL measurements were performed using the Servo Med Evaporimeter. TEWL values next to the wrist were found statistically greate ...
Pages: 4-5
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Evaluation of port wine stain perfusion by laser Doppler imaging and thermography before and after argon laser treatment.
Troilius A, Wårdell K, Bornmyr S, Nilsson GE, Ljunggren B
Thirteen patients with port wine stains (PWS) were treated with argon laser therapy. Before and at different points in time following treatment, skin blood perfusion and temperature were mapped with laser Doppler imaging and thermography. In nine patients no elevation in blood perfusion was observed in the PWS in comparison with the surrounding normal skin before treatment. In the remaining four p ...
Pages: 6-10
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Werner's syndrome: no difference in in vitro life span of dermal fibroblasts from proximal and distal parts of the body.
Kondo S, Hozumi Y, Aso K
Recently it has been reported that fibroblasts from distal parts of the body of a patient with Werner's syndrome grew poorly in vitro as compared with those from the proximal part of the same patient. To confirm this observation, cultures of fibroblasts from different parts of the body were set up in 2 cases of Werner's syndrome, but no significant difference in life span was observed. Fetal calf ...
Pages: 11-14
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A comparison of morphoea and lichen sclerosus et atrophicus in vitro: the effects of para-aminobenzoate on skin fibroblasts.
Griffiths MR, Priestley GC
To study the effects of para-aminobenzoate on the dermis, fibroblast cell lines derived from lesions of lichen sclerosus et atrophicus, from morphoea and from normal skin were incubated with Potaba in vitro. Monolayer cultures containing Potaba showed a dose-dependent inhibition of proliferation beginning at 1,000 micrograms/ml with total inhibition at 10,000 micrograms/ml. Mean ID50 values for th ...
Pages: 15-18
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Hypertrichosis lanuginosa acquisita.
Bégány A, Nagy-Vezekényi K
Hypertrichosis lanuginosa acquisita was observed in a female patient with stage IV malignant melanoma and also diffuse melanosis of the skin. The patient died within 2 months after the appearance of HL.
Pages: 18-19
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Extraocular sebaceous carcinoma.
AM. Tchornobay, V. Lévigne, J. Favre, AL. Claudy
A 79-year-old man with no history of previous irradiation presented with a large ulcerated tumour of the cheek. The histological features favoured a true sebaceous carcinoma. Neither squamous nor basal differentiation were seen. Sudan stainings were positive. Tumour cells expressed suprabasal keratins and were negative for carcinoembryonic antigen, vimentin and S 100 protein. Extraocular sebaceous ...
Pages: 20-21
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Schnitzler's syndrome (urticaria and macroglobulinemia) associated with pseudoxanthoma elasticum.
Machet L, Vaillant L, Machet MC, Esteve E, De Muret A, Khallouf R, Arbeille B, Muller C, Lorette G
Schnitzler's syndrome, first described in 1974, is defined by chronic non-pruritic urticaria, osteocondentation, and a monoclonal IgM dysproteinemia, but without criteria of lymphoproliferative disease. We report a patient with chronic urticaria and macroglobulinemia. In addition, he had double monoconal dysproteinemia IgM kappa (31.3 g/l) and IgA lambda, osteocondensation, and some cutaneous lesi ...
Pages: 22-24
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Coeliac-type dental enamel defects in patients with dermatitis herpetiformis.
Aine L, Mäki M, Reunala T
The teeth of 30 adult patients with dermatitis herpetiformis and 66 sex- and age-matched healthy controls were examined for dental enamel defects. Sixteen of the patients (53%) with dermatitis herpetiformis, opposed to only one (2%) of the healthy controls (p less than 0.001), were found to have coeliactype permanent-tooth enamel defects. The grades of these defects were milder than those describe ...
Pages: 25-27
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Clinical and non-invasive evaluation of 12% ammonium lactate emulsion for the treatment of dry skin in atopic and non-atopic subjects
Vilaplana J, Coll J, Trullás C, Azón A, Pelejero C
Clinical dryness of the leg skin is a common problem among dermatological patients. The efficacy and safety of 12% ammonium lactate emulsion (Keratisdin) for the treatment of dry skin on the legs of atopic and non-atopic subjects has been assessed by clinical criteria and by five different non-invasive methods. These methods measure biophysical parameters such as electrical capacitance of stratum ...
Pages: 28-33
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The in vivo effect of UVB radiation on skin bacteria in patients with atopic dermatitis.
Jekler J, Bergbrant IM, Faergemann J, Larkö O
Fourteen patients suffering from atopic dermatitis under treatment with UVB radiation were subjected to aerobic bacterial cultures in order to investigate whether this ultraviolet waveband has any in vivo germicidal effects, and, if so, whether there is a correlation with clinical improvement. Treatments were given 3 times a week for 8 weeks. Bacterial samples were collected before, midway and aft ...
Pages: 33-36
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Atypical presentation of co-existent Haemophilus ducreyi and Treponema pallidum infection in an HIV-positive male.
Kumar B, Kaur I, Thami GP
A 25-year-old homosexual black male presented with asymmetrical perianal ulceration of uncertain clinical origin. Indepth microbiological examination revealed the combined presence of Haemophilus ducreyi and Treponema pallidum. The atypical clinical appearance may have been due to the changed immunological status of the host's being infected with Human Immunodeficiency Virus.
Pages: 37-38
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Non-specific immunity in patients with primary anogenital warts treated with interferon alpha plus cryotherapy or cryotherapy alone.
Handley JM, Maw RD, Horner T, Lawther H, McNeill T, Dinsmore WW
Combination treatment of primary anogenital warts with subcutaneous interferon alpha 2a plus cryotherapy was no more efficacious than cryotherapy alone. Patients with primary AG warts showed no in vitro or in vivo suppression of non-specific immunity. In patients treated with interferon plus cryotherapy non-specific cellular immunity was stimulated, both in vitro and in vivo compared with patients ...
Pages: 39-40
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Lichen planus: an unusual cause of phimosis.
Itin PH, Hirsbrunner P, Büchner S
We report on a 47-year-old man with oral and genital lichen planus. After some months of the disease, increasing phimosis developed which had not been present before. Retraction of the foreskin was now impossible and sexual intercourse was painful. Treatment with triamcinoloneacetonide and etretinate ameliorated the phimosis but the patient was still not comfortable and circumcision was performed. ...
Pages: 41-42
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Moisturizers prevent irritant dermatitis.
Hannuksela A, Kinnunen T
The purpose of this study was to investigate the ability of eight different moisturizers to prevent irritant dermatitis. Twelve healthy female students washed the outer aspect of their upper arms with a liquid detergent for one minute twice a day for one week. Seven skin creams and one skin oil were applied to 3 x 7 cm areas of the left upper arm just after each washing, while the right upper arm ...
Pages: 42-44
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Nickel contact sensitivity in the guinea pig. An efficient open application test method.
Nielsen GD, Rohold AE, Andersen KE
Nickel contact sensitivity was successfully induced in guinea pigs using an open epicutaneous application method. Immediately after pretreatment with 1% aqueous sodium lauryl sulfate, upper back skin was treated daily for 4 weeks with 0.3%-3% nickel sulfate in either a 1% lanolin cream (Vaseline, pH 5 SAD crème) or hydroxypropyl cellulose. Weekly intradermal injections with aluminium potassium su ...
Pages: 45-48
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Drug-triggered pemphigus in a predisposed woman.
Ruocco V, Gombos F, Lombardi ML
A 31-year-old woman with three pemphigus-prone antigens in her HLA haplotype (B7, DR4, DQw7) developed the disease soon after taking a pyrazolone derivative, viz. feprazone. The pemphigus lesions persisted despite withdrawal of the drug and worsened appreciably when she used ceftriaxone (a new cephalosporin with three sulphur atoms) for a bout of acute pharyngitis. Thiol groups formed from the met ...
Pages: 48-49
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Bullous impetigo caused by group A streptococci. A case report.
Helsing P, Gaustad P
Bullous impetigo is considered to be a staphylococcal disease. Staphylococcus aureus, phage type 71, produces an epidermolytic toxin, assumed to be the cause of bullous formation in the skin. We present a case of bullous impetigo. Microbiological tests suggested beta-hemolytic streptococci, group A, M-type 3, as the etiological agent. Group A streptococci were isolated from the throat of the patie ...
Pages: 50-51
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Morphometry in clinical dermatology.
Bahmer FA, Smolle J
Rapid and simple methods are presented which allow the estimation of areas, area fraction and contour lengths in clinical dermatology. They are based on point counting and intercept measurements using simple grids made on transparent film or on overhead foils. Because of their ease of use, these grids allow the determination of the size as well as the irregularity of skin lesions even during daily ...
Pages: 52-55
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Birthmarks in 4346 Finnish newborns.
Karvonen SL, Vaajalahti P, Marenk M, Janas M, Kuokkanen K
We examined all babies born live (4346) at two Finnish hospitals in the course of one year to determine the frequency of birthmarks, specially pigmented lesions, among Finnish newborns. All birthmarks excluding common salmon patches on the forehead and neck were recorded and photographed at birth. The babies were re-examined at the age of three months. Various birthmarks were recorded for 241 of 4 ...
Pages: 55-57
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Relapsing bullous staphyloderma.
Brasch J, Mrowietz U, Schubert C, Christophers E
Relapsing eruptions of bullae rapidly turning into pustules were seen in a 69-year-old woman of good general health. At different times during several months of observation, strains of S. aureus were grown from various lesions, including one (phage group III) producing enterotoxin C. Systemic involvement except for high BSR was absent and repeated blood cultures were negative. Histopathological fi ...
Pages: 58-60
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Allogeneic cultured keratinocytes in the treatment of leg ulcers. A pilot study.
Forty-two patients (10 males and 32 females) with 52 chronic leg ulcers were treated with sheets of cultured allogeneic keratinocytes. Sixty-five % of the ulcers healed completely and the healing rate differed between various diagnostic groups. The best results were obtained in patients with venous ulcers and wounds with mixed etiology, whereas less improvement was observed with ischaemic ulcers. ...
Pages: 61-64
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A new micronized 5-methoxypsoralen preparation. Higher bioavailability and lower UVA dose requirement.
Treffel P, Makki S, Humbert P, Khaldoun H, Agache P
A new tablet of micronized 5-methoxypsoralen (5-MOP) and a commonly used tablet in therapy (Psoraderm 5) were compared in 12 healthy subjects. Each subject ingested 1.2 mg/kg body weight of each formulation on different days. Bioavailability and phototoxicity of 5-MOP were compared. The results showed that serum and suction blister concentrations were significantly higher and occurred earlier afte ...
Pages: 65-67
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Peptide T in the treatment of severe psoriasis.
Delfino M, Fabbrocini G, Brunetti B, Procaccini EM, Santoianni P
We investigated the effect of treatment with peptide T on severe psoriasis in 5 patients. Within 2 months, peptide T led to complete remission of all lesions in 1 patient and to good improvement in 3 others. In 1 patient, no effect was observed.
Pages: 68-69
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Successful treatment of chronic skin diseases with clobetasol propionate and a hydrocolloid occlusive dressing.
Volden G
The lesions of 141 patients with chronic skin diseases unresponsive to therapy were treated once a week with clobetasol propionate lotion left under the completely occlusive patch Duoderm. In 131 patients the lesions resolved completely, while partial remission was observed in the remaining 10. The mean interval to complete remission was: for chronic plaque psoriasis, 12 days; psoriasis on palms a ...
Pages: 69-71
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Anthralin is a potent inhibitor of pityrosporum orbiculare/ovale in vitro.
Bunse T, Mahrle G
Two strains of Pityrosporum orbiculare/ovale were grown in a liquid medium and exposed to different concentrations of the imidazoles ketoconazole and clotrimazole as well as anthralin, liquor carbonis detergens and salicylic acid. With regard to growth inhibition of yeast cells, the efficacies of anthralin and the imidazoles were similar, a half-maximal inhibition being achieved with an anthralin ...
Pages: 72-73
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Treatment of pityriasis versicolor with a single dose of fluconazole.
Faergemann J
Twenty-four patients with extensive or recurrent pityriasis versicolor were treated with a single oral dose of 400 mg of fluconazole. Twenty-three patients returned for follow up. Seventeen or 74%, were free of lesions 3 weeks after treatment and no recurrences were seen 6 weeks after treatment. The majority of the patients found the treatment effective, safe and convenient.
Pages: 74-75
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Eeosinophils in allergic contact dermatitis.
Lundin A, Fredens K, Michaëlsson G, Venge P
Pages: 76-77
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