Content

Content - Volume 72, Issue 3

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Abnormal expression of Ki-67 antigen in hair follicle of alopecia areata
van Baar HM, Perret CM, van Vlijmen IM, van de Kerkhof PC, Happle R, Schalkwijk J.
The monoclonal antibody Ki-67 was used to determine the numbers of cycling cells in hair follicles both in alopecia areata and in normal scalp skin. Pronounced nuclear staining was limited to the area below the critical line of Auber and the exterior part of the outer root sheath. In alopecia areata there is reduced nuclear Ki-67 binding in the bulb of anagen hair follicles. These findings indicat ...
Pages: 161-164
Abstract  PDF
Interleukin-6 in normal skin and psoriasis.
Castells-Rodellas A1, Castell JV, Ramirez-Bosca A, Nicolas JF, Valcuende-Cavero F, Thivolet J.
Interleukin-6 (IL-6 or BSF-2/IFN beta 2) is a component of normal human skin. IL-6 was immunologically detected in basal keratinocytes, endothelial cells and in a number of mononucleated cells and fibroblasts in normal skin and sudoriparous ducts. In psoriasis, intense labelling of the cytoplasm in the vicinity of keratinocyte membranes was detected in all epidermal layers and other skin appendage ...
Pages: 165-168
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Serum levels of vitamin D metabolites in isotretinoin-treated acne patients
Rødland O, Aksnes L, Nilsen A, Morken T
Serum levels of vitamin D metabolites were determined in 11 patients treated for cystic acne with a four-month course of isotretinoin (Roaccutane). The levels were measured before treatment and after two months of medication. We found a significant fall in the level of 1,25-dihydroxyvitamin D (p less than 0.01) and a significant increase in the molar ratio of 24, 25-dihydroxyvitamin D to 25-hydrox ...
Pages: 217-219
Abstract  PDF
Effect of psoriasis heliotherapy on epidermal urocanic acid isomer concentrations
Snellman E, Koulu L, Pasanen P, Lammintausta K, Neuvonen K, Ayräs P, Jansén CT
A noninvasive Finn Chamber sampling method and HPLC analysis were used to determine epidermal urocanic acid (UCA) concentrations of psoriasis patients during 4 weeks of heliotherapy on the Spanish Canary Islands and a follow-up period of 8 weeks. During heliotherapy the epidermal cis-UCA concentration increased from a mean initial value of 0.2 nmol/cm2 to a mean final value of 2.9 nmol/cm2. The to ...
Pages: 231-233
Abstract  PDF