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Content - Volume 75, Issue 5

Editor's choice in this issue

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Multinucleate cell angiohistiocytoma. A review and report of four cases
Multinucleate cell angiohistiocytoma (MCA) was first characterized by Smith & Wilson-Jones. Although only a few cases have been published, this very characteristic benign tumor is probably not rare. The clinical pictures are firm circumscribed papules, mainly of the hands, which progress slowly over the years. The histologic features show an increase of capillaries and venules in the reticular der ...
Pages: 337-339
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A study of the steroid sulfatase gene in families with X-linked ichthyosis using polymerase chain reaction
We have studied the steroid sulfatase (STS) gene in three Japanese families with X-linked ichthyosis (XLI), using polymerase chain reaction (PCR). PCR was performed using three sets of intraexonic primers covering exons 1, 5 and 10. In affected individuals from two of the families, DNA was not amplified in any of the three exons, suggesting that XLI in these families was due to the complete deleti ...
Pages: 340-342
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Human in vivo cutaneous microdialysis: estimation of histamine release in cold urticaria
A novel bioanalytical in vivo sampling technique, cutaneous microdialysis, was used to follow the chronology of skin histamine release in 3 patients with cold urticaria and in 2 healthy volunteers. Laser Doppler perfusion imaging was used simultaneously to monitor the skin circulatory response. Microdialysis samples were collected at 10-min intervals and analysed by radioimmunoassay technique. Fif ...
Pages: 343-347
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Histamine-induced itch and alloknesis (itchy skin) in atopic eczema patients and controls
Alloknesis ("itchy skin") after histamine iontophoresis was studied together with itch sensations and skin reactions in 19 atopic eczema patients and 20 controls at the forearm and at the scapular area. Compared to controls, atopic eczema patients showed significantly reduced alloknesis or total lack of it in the area around a skin site to which histamine had been iontophoretically applied, althou ...
Pages: 348-352
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Modulation of CD3-dependent lymphocyte proliferation by extracellular matrix proteins in atopic dermatitis
Patients with atopic dermatitis were found to have an about 7-fold increased spontaneous proliferative response of peripheral blood lymphocytes and an about 4-fold elevation of CD3-dependent lymphocyte transformation as compared to normal controls. The CD3-dependent lymphocyte response in patients with severe atopic dermatitis lesions was increased to a lower degree than in those with mild skin le ...
Pages: 353-356
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Pityrosporum ovale extracts increase interleukin-4, interleukin-10 and IgE synthesis in patients with atopic eczema
Evidence for a possible role of the lipophilic yeast Pityrosporum ovale in the pathophysiology of atopic eczema has been found both in laboratory and therapeutical studies. Positive type I prick test reactions to P. ovale correlate with the intensity of eczematous skin lesions in the head and neck regions of patients with atopic eczema. Furthermore, antifungal treatment has been shown to be helpfu ...
Pages: 357-360
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Intracutaneous transport of orally administered fluconazole to the stratum corneum
Fluconazole administered at 150 mg/week for 1-5 weeks is effective orally against dermatophytes and yeast in stratum corneum. Clinical and mycological cure rates approach 90%, but the precise distribution of the drug within various layers of skin is uncertain. We administered fluconazole at 150 mg/week for 2 weeks to 5 volunteers. Distribution of fluconazole in biopsies of skin was imaged by energ ...
Pages: 361-363
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The effect of calcipotriol on lesional fibroblasts from patients with active morphoea
We examined the responsiveness of cultured dermal fibroblasts from biopsies of 6 patients with active morphoea and a similar number of matched controls to the cell proliferation inhibition activity of calcipotriol. Cultured fibroblasts from controls showed no significant response to calcipotriol (at concentrations of 1 x 10(-8) to 1 x 10(-4) M). However, calcipotriol did inhibit the proliferation ...
Pages: 364-366
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The stimulatory effects of PDGF and TGF-beta 1 on dermal fibroblast attachment
We investigated the effects of various growth factors (platelet-derived growth factor (PDGF), epidermal growth factor (EGF), basic fibroblast growth factor (bFGF), transforming growth factor-alpha (TGF-alpha), transforming growth factor-beta 1 (TGF-beta 1), tumor necrosis factor-alpha (TNF-alpha), keratinocyte growth factor (KGF)) on fibroblast attachment to plastic plates. It is thought that cell ...
Pages: 367-371
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Raimer's bands: case report with a review of solar elastosis
Raimer's solar elastotic bands of the forearm are a rarely described clinical variant of severe solar elastosis. We report a case of Raimer's bands on the forearm of a 43-year-old woman. Light microscopy demonstrated solar elastosis and electron microscopy revealed activated fibroblasts appearing to secrete the elastotic material. The clinical variants of solar elastosis are outlined and the possi ...
Pages: 372-374
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High-frequency ultrasound for torture-inflicted skin lesions
Objectivity, reproducibility and non-invasiveness are required for a medico-legal evaluation of skin lesions in torture victims. In this report we describe the use of the high-frequency method for imaging of scars presumed to be inflicted by torturing. The extent of scarring and the size of the lesions could be determined precisely and objectively. We suggest that skin ultrasonography may be a use ...
Pages: 375-376
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Effects of gemfibrozil (Lopid) on hyperlipidemia in acitretin-treated patients. Results of a double-blind cross-over study
Hyperlipidemia is a common side-effect of oral retinoid treatment, which sometimes interferes with long-term therapy. To evaluate the safety and efficacy of the lipid-lowering drug gemfibrozil on retinoid-associated hyperlipidemia, we studied the clinical response and the plasma lipoprotein levels in 22 acitretin-treated (0.25-0.75 mg/kg) patients mainly suffering from psoriasis. Gemfibrozil or pl ...
Pages: 377-380
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Topical treatment of psoriatic plaques with 1 alpha, 24 dihydroxyvitamin D3: a multiparameter flow cytometrical analysis of epidermal growth, differentiation and inflammation
The clinical efficacy and tolerability of the vitamin D3 analogues calcitriol, calcipotriol and 1 alpha, 24 dihydroxyvitamin D3 in the treatment of psoriasis have been assessed in various clinical studies. In vitro and in vivo investigations have shown interference of these compounds with epidermal growth, keratinisation and inflammation. In this study we quantified the in vivo cell biological eff ...
Pages: 381-385
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UVB versus UVB plus calcipotriol (MC 903) therapy for psoriasis vulgaris
It is well known that UVB therapy of psoriasis vulgaris is potentiated by the association with topical and oral drugs, while till now there have been very few reports on the association between UVB and calcipotriol. In order to evaluate the efficacy and tolerance of this association, we studied 19 patients with psoriasis vulgaris of mild severity (PASI: 5-10). Each patient was treated with UVB and ...
Pages: 386-387
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The hair root pattern after calcipotriol treatment for scalp psoriasis
Scalp psoriasis is associated with hair loss and an increased telogen/anagen ratio. Topical treatment of scalp psoriasis (with corticosteroids, dithranol or tar) results in decreased scaling, induration and erythema of the plaques. Calcipotriol is effective in the treatment of psoriasis vulgaris. However, the potent growth-inhibiting potential of this compound might theoretically induce hair loss. ...
Pages: 388-390
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Methotrexate-linked ventricular arrhythmias
A 36-year-old male, who 1 year previously had survived a large anterior myocardial infarction, followed by cardiac arrest, was treated a few months for psoriasis with oral methotrexate, at single weekly oral doses of up to 10 mg, when he had to be hospitalized due to anginal pain and palpitation. Repeated 24-hour electrocardiogram recordings revealed ventricular ectopy up to 580 premature beats pe ...
Pages: 391-392
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Interruption of long-term methotrexate treatment in psoriasis. Evaluation of clinical course and laboratory parameters after discontinuation and reintroduction of weekly oral methotrexate
The effects of interval treatment were evaluated in 10 psoriatic patients on long-term treatment with low-dose oral methotrexate (MTX). In all patients, the dosage of MTX had already been tapered off as much as possible. After interruption of MTX treatment, the clinical course and changes in laboratory parameters were evaluated. The mean MTX-free period was 17 weeks, and the mean reduction in cumu ...
Pages: 393-396
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ELISA inhibition test using monoclonal antibody specific for Treponema pallidum as the serologic test for syphilis
Monoclonal antibodies (Mabs) specific for Treponema pallidum were produced using hybridoma technology. In this study an ELISA inhibition test based on competitive inhibition by antibodies from human test sera of the binding of the enzyme-labelled Mabs to T. pallidum was performed. Inhibition of the seroreactivity of Mabs was decreased according to the dilution of rabbit antiserum to T. pallidum. S ...
Pages: 397-399
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NCBINCBI Logo Skip to main content Skip to navigation Resources How To About NCBI Accesskeys Sign in to NCBI PubMed US National Library of Medicine National Institutes of Health Search database Search term Clear input Advanced Help Result Filters Format: Abstract Send to Acta Derm Venereol. 1995 Sep;75(5):400-3. Cutaneous complications in heart transplant recipients in Norway 1983-1993
All Norweigian heart transplant recipients with more than one year's survival (n = 140) were investigated for dermatological disorders. Observation time after transplantation was 1-10 years (mean 5.0 years). Patients alive at the end of 1993 (n = 122) were examined clinically, and medical records for all patients were reviewed. The histopathological diagnoses of excised skin specimens were reevalu ...
Pages: 400-403
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LETTER TO THE EDITOR
Cutaneous vasculitis with lesions mimicking degos' disease and revealing Crohn's disease.
Castanet J, Lacour JP, Perrin C, Rodot S, Ortonne JP
Pages: 408-409
Abstract  PDF
LETTER TO THE EDITOR
Transient acantholytic dermatosis associated with superior vena caval syndrome in a patient with carcinoid tumour of the thymus.
Miralles ES, Núñez M, Ledo A.
Transient acantholytic dermatosis (Grover's disease) in a patient with gastric carcinoma
Pages: 410-410
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LETTER TO THE EDITOR
Successful treatment of papillomatosis cutis lymphostatica with acitretin.
Feind-Koopmans A, van de Kerkhof PC.
Pages: 411-411
Abstract  PDF
LETTER TO THE EDITOR
Apoptosis in normal skin.
Hisa T, Taniguchi S, Kobayashi H, Shigenaga Y, Nomura S, Takigawa M.
Pages: 412-413
Abstract  PDF
LETTER TO THE EDITOR
Isotretinoin-induced pemphigus.
Georgala S, Rigopoulos D, Gourgiotou K, Christofidou E.
Pages: 413-413
Abstract  PDF