Content - Volume 76, Issue 1

All articles

Lennart Juhlin
Abstract is missing (Editorial)
Pages: 1-1
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Elevated levels of circulating intercellular adhesion molecule-3 (cICAM-3) in Psoriasis
Griffiths CE, Boffa MJ, Gallatin WM, Martin S.
Intercellular adhesion molecule (ICAM)-3 is important in regulating leukocyte function and T-lymphocyte-antigen presenting cell interactions. Soluble, circulating forms of ICAM-3 and ICAM-1 (cICAM-3, cICAM-1) exist in serum, and levels are elevated in a variety of autoimmune diseases. Two types of soluble circulating tumour necrosis factor receptor (cTNF-R1, cTNF-R2) are found in the sera of healt ...
Pages: 2-5
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Response of the clinically uninvolved skin of psoriatic patients to tape stripping during acitretin treatment
Gerritsen MJ, van Pelt JP, van de Kerkhof PC.
The aromatic retinoids etretinate and acitretin are widely used in the systemic treatment of severe psoriasis. The purpose of the present investigation was to further elucidate the mode of action of acitretin on abnormal keratinization and epidermal hyperproliferation in an in vivo model. Studies on the interference of acitretin with epidermal hyperproliferation and abnormal keratinization in psor ...
Pages: 6-9
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Soluble Pityrosporum-derived chemoattractant for polymorphonuclear leukocytes of psoriatic patients
Bunse T, Mahrle G.
The chemoattraction of polymorphonuclear leukocytes (PMNs) from psoriatic patients, atopic patients and healthy control persons by Pityrosporum orbicularelovale was investigated using the Boyden chamber method. The chemotactical attraction of PMNs from psoriatic patients by Pityrosporum (stimulation index SI = 58 +/- 50) was significantly increased (p < 0.05) compared to PMNs from atopic patients ...
Pages: 10-12
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The membrane attack complex of complement alters the membrane integrity of cultured endothelial cells: a possible pathophysiology for immune complex vasculitis.
Kawana S.
Recently, the possibility of direct involvement of the membrane attack complex of complement in the endothelial damage of immune complex vasculitis has been pointed out. However, no studies have so far elucidated this mechanism. The present study investigated the effects of complement on the membrane integrity of endothelial cells, using the fluorescein diacetate and ethidium bromide staining meth ...
Pages: 13-16
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Growth factor mRNA levels in alopecia areata before and after treatment with the contact allergen diphenylcyclopropenone.
Hoffmann R, Wenzel E, Huth A, van der Steen P, Schäufele M, König A, Happle R.
The early immune response in alopecia areata is characterized by a Th1 T helper cell cytokine pattern and an aberrant expression of ICAM-1 and HLA-DR molecules on lesional hair bulbs. A counteracting cytokine pattern induced by a therapeutic contact dermatitis is supposed to mediate the hair regrowth. In addition to cytokines, growth factors have been shown to influence immune responses, and we th ...
Pages: 17-20
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Serum cytokine and anti-Fc gamma R autoantibody measurements in patients with systemic sclerosis
Szegedi A, Czirják L, Unkeless JC, Boros P.
The serum IL-1 beta, IL-2, IL-4, IL-6, IL-8, TNF-alpha and soluble IL-2 receptor levels were measured, and the presence of anti-Fc gamma receptor (Fc gamma R) antibodies was investigated in the sera of 18 patients with systemic sclerosis (SSc). An increase of TNF-alpha was detected in 8 of the 18 cases. II-1 beta was elevated in all the 18 patients. Both IL-2 and IL-4 were elevated in 7 cases. The ...
Pages: 21-23
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Integrin molecules: a clue to the non-metastasizing behaviour of basal cell carcinomas?
Baum HP, Schmid T, Reichrath J.
Does the integrin profile of basal cell carcinomas explain their non-metastasizing behaviour? Immunohistochemical Investigation of nodular (n = 31) and superficial (n = 17) tumours yielded a strong expression of alpha 2, alpha 3, alpha 6, beta 1, and beta 3 subunits and a weak expression of alpha 4 subunits by the epithelial tumour component. alpha 5 subunits were focally detected in superficial b ...
Pages: 24-27
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Cell-mediated immunity of patients who have had basal cell carcinomas.
Czarnecki D, Mar A, Kulinskaya E.
The cell-mediated immunity of patients who had basal cell carcinomas (BCCs) removed was studied by measuring cuntaneous delayed hypersensitivity reactions to recall antigens (Multitest CMI, Pasteur-Merieux), and by measuring lymphocyte counts and subsets. One group of patients had multiple BCCs (3 or more) removed and were considered to have a high risk of new BCC formation. The other group consis ...
Pages: 28-30
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Sun exposure and sunscreen use among sunbathers in Denmark
Stender IM, Andersen JL, Wulf HC.
Eight hundred and eight sunbathing Danes were interviewed in order to register the duration of sun exposure and sunscreen use. The mean sun exposure time, 203 min, was found to be independent of sex, age and use of sunscreen. Overall, sunscreens were used by 65%, 73% of the females and 52% of the males. The median sun protection factor used by subjects older than 10 years was 5; in the case of chi ...
Pages: 31-33
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Stage-dependent expression of CD7, CD45RO, CD45RA and CD25 on CD4-positive peripheral blood T-lymphocytes in cutaneous T-cell lymphoma.
Jakob T, Neuber K, Altenhoff J, Kowalzick L, Ring J.
Flow cytometric analysis of T-cell surface markers in peripheral blood has revealed abnormal patterns in patients with cutaneous T-cell lymphomas (CTCL). Here we investigated CD7, CD25, CD45RO and CD45RA expression on CD4+ T-lymphocytes in patients with CTCL stage I/II and III/IV and in patients with severe inflammatory skin diseases (ISD), as well as in healthy controls. Only late stage CTCL (III ...
Pages: 34-36
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Appearance of Sézary-like atypical lymphocytes in the regressing lesions of juvenile xanthogranuloma. Its role in the spontaneous regression.
Bang D, Cho NJ, Lee IJ, Ahn SK.
A case of juvenile xanthogranuloma of the skin was sequentially biopsied for 10 months. In the electron microscopic examination of the regressing lesions, we observed that cells with highly indented nuclei, Sézary-like cells, were in close apposition to vacuolated degenerating histiocytes in many foci. In immunohistochemical stain, the number of UCHL-1+ cells were increased in regressing lesions ...
Pages: 37-39
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Multiple keratoacanthomas, giant keratoacanthoma and keratoacanthoma centrifugum marginatum: development in a single patient and treatment with oral isotretinoin.
Schaller M, Korting HC, Wolff H, Schirren CG, Burgdorf W.
A 78-year-old man is described, who over 18 years developed three different types of keratoacanthoma: multiple keratoacanthomas, keratoacanthoma centrifugum marginatum and giant keratoacanthoma. Histological examination of the different neoplasms showed similar changes, all typical of a keratoacanthoma. In situ hybridisation revealed no human papilloma virus in the tumours. Complete examination sh ...
Pages: 40-42
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Treatment of chronic idiopathic urticaria with topical steroids. An open trial.
Ellingsen AR, Thestrup-Pedersen K.
Twenty-three patients with chronic idiopathic urticaria and 3 patients with urticaria pigmentosa received a 2-week treatment with daily application of potent topical steroid using plastic occlusion. Seventy per cent of the chronic urticaria patients had a statistically significant, immediate response, which, however, did not last until the final evaluation after 1.5 years. Relapse occurred after o ...
Pages: 43-44
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Pruritus circumscriptus sine materia: a sequel of postzosteric neuralgia. Evaluation by quantitative psychophysical examination and laser-evoked potentials.
Darsow U, Lorenz J, Bromm B, Ring J.
A case of circumscribed pruritus existing since 1 year on clinically uninvolved skin is reported, in which careful history revealed a 5-year previous episode of herpes zoster in the same dermatome. Impairment of cutaneous sensitivity was evaluated by use of a quantitative psychophysical examination and laser-evoked cortical potentials (LEP).
Pages: 45-47
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Two-point discrimination of itch in patients with atopic dermatitis and healthy subjects.
Wahlgren CF, Ekblom A.
The ability to perceive two pruritic stimuli as separate depending on the distance between them (two-point discrimination of itch) was determined in a single-blind study of 20 patients with atopic dermatitis and 20 healthy subjects. Itch was induced with pairs of histamine injections (0.1 micrograms each) given on the upper arm, either along its axis (longitudinally within a dermatome) or at right ...
Pages: 48-51
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Lack of sympathetic involvement in dermatitis confined to the median nerve territory. A case report.
Casale R, Buonocore M, Teofoli P, Matucci-Cerinic M, Elam M.
Both decreased and increased sympathetic nerve activity has been suggested as a possible underlying mechanism in inflammatory skin lesions. Modulation of sympathetic function has been proposed in the treatment of dermatitis. This case report describes the investigation strategy and normal findings in a case of dermatitis strictly confined to the median nerve territory, illustrating the need for sp ...
Pages: 52-54
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Flare-up at contact allergy sites in a gold-treated rheumatic patient.
Möller H, Larsson A, Björkner B, Bruze M, Hagstam A.
Contact allergy to gold sodium thiosulfate and gold sodium thiomalate was established by skin testing in a rheumatic patient intended for gold therapy. An intramuscular test dose of gold sodium thiomalate (Myocrisin) induced a flare-up of previously positive epicutaneous and intradermal test reactions, with a histological and immunohistochemical picture compatible with an allergic contact dermatit ...
Pages: 55-58
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Familial Kaposi's sarcoma: case reports and review of the literature.
Cottoni E, Masia IM, Masala MV, Mulargia M, Contu L.
We report 4 new families with Kaposi's sarcoma, occurring in 2 members of the same family (2 pairs of brothers, uncle and nephew and father and son) in a series of 160 patients with Kaposi's sarcoma. In addition, HLA typing was also carried out for 6 of the 8 patients. A detailed review of the literature is also presented. The total number of familial cases of Kaposi's sarcoma is low (only 30 case ...
Pages: 59-61
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Brittle and sparse hair with normal cystine content caused by methionine deficiency?
Goerz G, Behrens W, Megahed M, Kuester W, Fohles J, Tsambaos D, Nikiforidis G, Balas C.
The unusual case of an 8-year-old girl with a hair disorder is presented, characterized by brittle, short and sparse hair. On polarizing microscopy the latter reveals a "tiger tail" pattern, whereas severe cuticular defects are detected on scanning electron microscopy. The patient's hair has a normal cystine content but is completely devoid of methionine and reveals distinct changes of its visoela ...
Pages: 62-64
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A therapeutic approach to erythrodermic psoriasis: report of a case and a discussion of therapeutic options.
van der Vleuten CJ, Gerritsen MJ, Steijlen PM, de Jong EM, van de Kerkhof PC.
In this case report a patient with therapeutically recalcitrant erythrodermic psoriasis is presented. After various attempts with several major therapies in this patient, the first substantial improvement was achieved using the combination of cyclosporine and calcipotriol, followed by the combination of UVB and calcipotriol. The therapeutic options for severe psoriasis are discussed, and since com ...
Pages: 65-67
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Generalized pustular psoriasis in Japan: two distinct groups formed by differences in symptoms and genetic background
Ohkawara A, Yasuda H, Kobayashi H, Inaba Y, Ogawa H, Hashimoto I, Imamura S
A multi-center study for investigating generalized pustular psoriasis was carried out in Japan in order to clarify the prevalence, the etiology, and the standard therapy. Through questionnaires, 541 cases of patients with generalized pustular psoriasis and related disorders were collected, and the history, the precipitating factors, the symptoms and the laboratory findings were analyzed from medic ...
Pages: 68-71
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Morphologic features and clinical significance of skin involvement in patients with AIDS-related cryptococcosis.
Manfredi R, Mazzoni A, Nanetti A, Mastroianni A, Coronado O, Chiodo F.
Eight out of 30 consecutive patients with AIDS and cryptococcal meningoencephalitis (26,7%) presented cutaneous involvement, in the form of papulo-nodular lesions in 3 patients, molluscum contagiosum-like lesions in 3 patients, and pustular-ulcerative lesions in 2 patients. Skin localization represented an untoward prognostic sign, and in 3 out of 8 patients the lesions were diagnosed 2 to 6 weeks ...
Pages: 72-74
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Scrotal angiokeratoma in a young man
Hisa T, Taniguchi S, Goto Y, Teramae H, Osato K, Kakudo K, Takigawa M.
No abstract available.
Pages: 75-75
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A possible role of interleukin-8 in the induction of psoriasis-like lesions in Torre-Muir syndrome.
Yamamoto T, Katayama I, Nishioka K.
No abstract available.
Pages: 75-77
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Clofazimine in inflammatory facial dermatosis--granuloma faciale and lipogranulomatosis subcutanea (Rothmann-Makai)
Wollina U, Karte K, Geyer A, Stuhlert A, Bocker T.
No abstract available.
Pages: 77-79
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Recurrent aphthous stomatitis: treatment with pentoxifylline.
Pizarro A, Herranz P, Navarro A, Casado M.
No abstract available.
Pages: 79-80
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Pretibial epidermolysis bullosa with vulvar involvement.
Petersen CS, Brocks K, Weismann K, Kobayasi T, Thomsen HK.
No abstract available.
Pages: 80-81
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Intralesional bleomycin for the treatment of non-genital warts in HIV-infected patients
Shah M, Murphy M, Price JD, Lacey CJ.
No abstract available.
Pages: 81-82
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Discoloration of the nail plate due to the misuse of amorolfine 5% nail lacquer.
Rigopoulos D, Katsambas A, Antoniou C, Christofidou E, Balaskas E, Stratigos J.
No abstract available.
Pages: 83-84
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Immunological features of chronic adult paracoccidioidomycosis: report of a case treated with fluconazole
Pereiro M Jr, Pereiro M, García García A, Toribio J.
No abstract available.
Pages: 84-85
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Cutaneous Horn in a lesion of prurigo nodularis.
Khaitan BK, Bajaj N, Verma KK.
No abstract available.
Pages: 85-86
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Wound healing with a new growth factor formula.
Veraart JC, Asselman AH, Gronenschild EH, Neumann HA.
No abstract available.
Pages: 86-87
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Discoid lupus erythematosus during treatment with cyclosporine.
Di Lernia V, Bisighini G.
No abstract available.
Pages: 87-88
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Milker's nodule--a report of 15 cases in the county of North Jutland.
Hansen SK, Mertz H, Krogdahl A, Veien NK.
No abstract available.
Pages: 88-88
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Cold urticaria and delayed pressure urticaria in the same patient.
Valsecchi R, Rozzoni M, Sena P, Pansera B.
No abstract available.
Pages: 89-89
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Cytokine profile of bilateral pseudocyst of the auricle.
Yamamoto T, Yokoyama A, Umeda T.
No abstract available.
Pages: 92-93
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Ofuji's papuloerythroderma: report of a new case responding to PUVA.
Depaire F, Dereure O, Guilhou JJ.
No abstract available.
Pages: 93-94
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