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Content - Volume 76, Issue 2

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Flow-cytometric investigation of epidermal cell characteristics in monogenic disorders of keratinization and their modulation by topical calcipotriol treatment
Lucker GP, Steijen PM, Suykerbuyk EJ, Kragballe K, Brandrup F, van de Kerkhof PC
A flow-cytometric study was performed in monogenic disorders of keratinization, to assess DNA distribution as well as the expression of keratins and involucrin. In addition, the changes in expression of these markers under influence of calcipotriol treatment were investigated. Proliferation, measured by the percentage of epidermal cells in SG2M-phase of the cell cycle, was increased in Darier's di ...
Pages: 97-101
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Inhibitory effect of vasoactive intestinal polypeptide and ketanserin on established allergic contact dermatitis in man
Bondesson L, Nordlind K, Mutt V, Lidén S
Neuromediators may influence the immune response. To investigate their potential immunomodulating role in established allergic contact dermatitis in man, the following neuromediators were tested: vasoactive intestinal polypeptide (VIP), serotonin, and the serotonin antagonists ketanserin, methiotepine and ICS-205-930. Positive patch test reactions were elicited by application of nickel sulphate fo ...
Pages: 102-106
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Normolipidemic xanthelasma palpebrarum: lipid composition, cholesterol metabolism in monocyte-derived macrophages, and plasma lipid peroxidation
Bergman R, Kasif Y, Aviram M, Maor I, Ullman Y, Gdal-On M, Friedman-Birnbaum R
The lipid compositions of 8 normolipidemic xanthelasma palpebrarum (XP) lesions were analyzed using thin-layer chromatography, with the adjacent uninvolved skin used as control. The lesions were found to be composed predominantly of cholesterol, mostly cholesteryl ester, whereas in the control specimens phospholipids predominated. The degradation rates of 125I-low-density lipoprotein (LDL), oxidiz ...
Pages: 107-110
Abstract  PDF
A novel endogenous mediator of cutaneous inflammation: leukemia inhibitory factor
McKenzie RC, Paglia D, Kondo S, Sauder DN
Keratinocytes produce a variety of cytokines, including leukemia inhibitory factor. We hypothesised that this cytokine may play a pro-inflammatory role in the skin and tested this hypothesis by injecting recombinant leukemia inhibitory factor (1-100 ng) into the ear pinnae of C3H/HeJ mice. To other groups of animals, we injected boiled leukemia inhibitory factor or phosphate-buffered saline (negat ...
Pages: 111-114
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Expression of heat shock protein 72 on peripheral blood mononuclear cells from patients with pustulosis palmaris et plantaris
Tamada Y, Takama H, Yokochi K, Ikeya T, Yokochi T, Matsumoto T
The expression of heat shock protein (HSP) 72 on peripheral blood mononuclear cells (PBMC) from patients with pustulosis palmaris et plantaris (PPP) was studied. PBMC isolated freshly from patients with PPP expressed HSP72, while those from psoriasis patients did not. PBMC from patients with PPP continued to express it in in vitro cultures at 37 degrees C. This expression was further augmented by ...
Pages: 115-117
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Role of adhesion molecules in the development of pustular lesions in patients with pustulosis palmaris et plantaris
Yokochi K, Tamada Y, Takama H, Ikeya T, Ohashi M
The expression of adhesion molecules and the ligands on endothelial cells and infiltrating inflammatory cells in lesional skin specimens from patients with pustulosis palmaris et plantaris was studied. Intercellular adhesion molecule-1 and E-selectin were expressed on endothelial cells of microvessels in the papillary dermis. Intercellular adhesion molecule-1 was also expressed focally on keratino ...
Pages: 118-122
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Increased degradation of type I collagen in acne fulminans
Oikarinen A, Autio P, Karvonen SL, Risteli J, Reunala T
Acne fulminans is a rare, severe type of acne with unknown etiology. Ulcerative acne lesions, fever and musculoskeletal pain are typical symptoms. In addition, osteolytic or even destructive osteomyelitis-like bone lesions occur in many patients with acne fulminans. In the present study the degradation product (ICTP) of type I collagen, the most abundant collagen of the skeleton, was measured from ...
Pages: 123-125
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Occurrence and distribution of peptidergic nerve fibers in skin biopsies from patients with systemic sclerosis.
Wallengren J, Akesson A, Scheja A, Sundler F
Systemic sclerosis is characterized by vascular dysfunction. Itch is sometimes present in early stages of the disease. This prompted us to study the innervation of the skin by immunocytochemistry. Antibodies to neuropeptide Y and vasoactive intestinal peptide were used for autonomic nerves. Sensory innervation was studied using antibodies to substance P and calcitonin gene-related peptide. Protein ...
Pages: 126-128
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Effects of topical application of capsaicin to human skin: a comparison of effects evaluated by visual assessment, sensation registration, skin blood flow and cutaneous impedance measurements.
Magnusson BM, Koskinen LO
A new non-invasive device, which enables local measurements of electrical impedance, has been used to evaluate the degree of irritation in human skin. The results have been compared with visual scoring, sensations and laser Doppler flowmetry. Capsaicin (50 microliters 1% solution) and control solutions (50 microliters 50% ethanol) were applied in a chamber for 30 min on the volar forearm of 7 volu ...
Pages: 129-132
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A case of actinic granuloma associated with periumbilical perforating pseudoxanthoma elasticum.
Lee HW, Park MA, Lee SC, Won YH, Chun IK
We report an unusual case of actinic granuloma of the face and periumbilical perforating pseudoxanthoma elasticum located superior to the umbilicus in a 57-year-old Korean woman. Histopathologically, these two dermatoses have a similar degeneration of elastic fibers, but they show different host reactions to the altered elastic fibers. In the actinic granuloma, actinically damaged elastic fibers w ...
Pages: 133-135
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The Allergen Bank: a source of extra contact allergens for the dermatologist in practice.
Andersen KE, Rastogi SC, Carlsen L
The Allergen Bank was established to give dermatologists easy access to special test materials in order to make early diagnoses of special cases of allergic contact dermatitis. The Allergen Bank comprises a computer system to register several hundred contact allergens in appropriate patch test concentrations available at the allergy laboratory and the patch test results. At the request of dermatol ...
Pages: 136-140
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Generalized morphea with vascular involvement. A case report and disaccharide analysis of the skin glycosaminoglycans.
Akimoto S, Ishikawa O, Yokoyama Y, Amano H, Miyachi Y
We report a 69-year-old man with severe generalized morphea, who showed over 80% of skin involvement, while the internal organs were not affected. We performed histological examinations and analysis of skin disaccharides constituting chondroitinase-digestible glycosaminoglycans in the center and periphery of the sclerotic lesions and the clinically uninvolved skin. In both the central and peripher ...
Pages: 141-143
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Clinical aspects of the use of gamma linolenic acid in systemic sclerosis.
Stainforth JM, Layton AM, Goodfield MJ
Systemic sclerosis is a multi system disorder, for which there is no satisfactory treatment. Theoretically, dietary supplementation with essential fatty acids may lead to an increase in their derivatives, the vasoactive prostaglandins, which benefit the acute and chronic ischaemic lesions of this disease. We assessed the value of concentrated essential fatty acids in patients with systemic scleros ...
Pages: 144-146
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Sexually transmitted diseases and risk of HIV infection.
Parazzini F, D'Oro LC, Naldi L, Bianchi C, Chatenoud L, Ricci E, Cainelli T, Pansera B, Mezzanotte C, Tessari GP, Locatelli A
We have analyzed the association between sexually transmitted diseases (STD) and HIV infection, using data from a cross-sectional survey of subjects attending STD clinics in Northern Italy conducted since 1988. A total of 1,711 subjects (1,259 males, 452 females), who had referred themselves to three STD clinics in Northern Italy for suspected STD or STD treatment, were included for the study. Out ...
Pages: 147-149
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Casual sex, extramarital sex, condom use and alcohol intake among heterosexual patients attending an STD clinic in Norway.
Tveit KS, Nyfors A, Nilsen A
A study excluding homosexuals was performed to study casual sex, extramarital sex, the use of a condom with a casual sexual partner and the combination of alcohol intake and casual sex among patients attending a clinic for sexually transmitted diseases (STDs). Heterosexual patients (467) received a questionnaire, and 458 were included. Men reported more (94%) casual sexual partners than did women ...
Pages: 150-153
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Treatment of lipoid proteinosis with etretinate.
Gruber F, Manestar D, Stasic A, Grgurevic Z
No abstract available
Pages: 154-155
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Hailey-Hailey disease with acrokeratosis verruciformis Hopf.
Yakis G, Csató M, Kemény L, Korom I, Morvay M, Dobozy A
No abstract available
Pages: 157-157
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Burning mouth syndrome: hypersensitivity to sodium metabisulfite.
Levanti C, Ricciardi L, Isola S, Cilia M, Guarneri F, Purello D'Ambrosio F
No abstract available
Pages: 158-159
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Herpes zoster-associated trigeminal neurotrophic ulcer.
Nielsen NH, Petersen CS
No abstract available
Pages: 159-160
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Treatment of lichen simplex chronicus with topical capsaicin cream.
Kantor GR, Resnik KS
No abstract available
Pages: 161-161
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Anaphylactoid symptoms due to oral minocycline.
Okano M, Imai S
No abstract available
Pages: 164-164
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Acquired zosteriform naevus flammeus: a cutaneous marker of central nervous system angiomatosis.
Requena L, Escalonilla P, Sarasa JL, Fariña C, Piqué E, Martín L, Salinas F
No abstract available
Pages: 165-166
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Bullous scabies.
Veraldi S, Scarabelli G, Zerboni R, Pelosi A, Gianotti R
No abstract available
Pages: 167-168
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A case of Neumann type pemphigus vegetans showing reactivity with the 130 kD pemphigus vulgaris antigen.
Ohata Y, Komiya H, Kawahara Y, Watanabe K, Nishikawa T, Hashimoto T
No abstract available
Pages: 169-170
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Is EMLA effective in Dercum's disease?
Reggiani M, Errani A, Staffa M, Schianchi S
No abstract available
Pages: 170-171
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Cutaneous leishmaniasis. an old disease with a new face.
Kibbi AG, Hassouna L, Rubeiz NG
No abstract available
Pages: 171-172
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Extramammary Paget's disease of the axilla with an underlying apocrine carcinoma.
Morgan JM, Carmichael AJ, Ritchie C
No abstract available
Pages: 173-174
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