Content - Volume 76, Issue 4

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Impaired expression of stem cell factor in dermatofibroma fibroblasts
Yamamoto T, Katayama I, Nishioka K.
The number of mast cells is increased in dermatofibroma lesions and plays a role in the induction of fibrosis or its proliferation. We have investigated stem cell factor expression in solitary and multiple dermatofibromas by immunohistochemical straining. We also analyzed messenger RNA (mRNA) expression of stem cell factor in dermatofibroma tissues and cultured fibroblasts derived from dermatofibr ...
Pages: 257-259
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Ethanol enhances the mitogen-driven lymphocyte proliferation in patients with psoriasis
Schopf RE, Ockenfels HM, Morsches B.
Ethanol has been reported to exacerbate psoriasis. Since immunological mechanisms are considered to be important for the pathogenesis of psoriasis, we compared the effects of ethanol on lymphocyte proliferation in 15 healthy control individuals and 15 patients with psoriasis. We employed the spontaneous and phytohemagglutin in (PHA)-induced uptake of 3H-TdR to measure lymphocyte proliferation. Eth ...
Pages: 260-263
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Effectiveness of antioxidants (vitamin C and E) with and without sunscreens as topical photoprotectants.
Darr D, Dunston S, Faust H, Pinnell S
Considerable interest has been recently generated concerning the use of natural compounds, anti-oxidants in particular, in photoprotection. Two of the best known anti-oxidants are vitamins C and E, both of which have been shown to be somewhat effective in different models of photodamage. Very little has been reported, however, on the effectiveness of a combination of the two (known to be biologica ...
Pages: 264-268
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The vitronectin receptor alpha-V beta-3, contrary to ICAM-1, is not modulated by interferon-gamma and tumour necrosis factor-alpha on melanoma cell lines.
Boccaletti V, Temponi M, Wang Z, Manganoni AM, Marcelli M, Maio M, Ferrone S, De Panfilis G.
A correlation was recently shown between expression of the vitronectin receptor (VnR) and the tumorigenic capacity of cultured human melanoma cell lines. On the other hand, modulation of VnR expression by interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) was observed on different non-melanoma cell lines. We tested IFN-gamma, TNF-alpha and interleukin-2 (IL-2), which are pre ...
Pages: 269-273
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Temperature dependency of skin susceptibility to water and detergents.
Ohlenschlaeger J, Friberg J, Ramsing D, Agner T.
Exposure to water and detergents is an important factor for development of irritant contact dermatitis. The aim of the present study was to investigate the effect of temperature on the damaging effects of water and detergents on the skin. Twenty healthy volunteers participated in the study. Ten participants had right and left forearms immersed into a detergent (soap) solution for 2 days twice dail ...
Pages: 274-276
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Cyclophosphamide and interleukin-12 synergistically upregulate the acquisition of allergic contact dermatitis in the mouse.
Maguire HC Jr.
Cyclophosphamide given before allergen and recombinant interleukin-12 administered at the time of allergic sensitization substantially increase the acquisition of allergic contact dermatitis in the mouse. Since their immunoadjuvant mechanisms appeared different, it seemed probable that combining cyclophosphamide pretreatment with interleukin 12 administration would result in a more intense allergi ...
Pages: 277-279
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Effect of oral terbinafine treatment on cyclosporin pharmacokinetics in organ transplant recipients with dermatophyte nail infection.
Jensen P, Lehne G, Fauchald P, Simonsen S.
Eleven patients with either kidney, heart or lung transplants, immunosuppressed with cyclosporin A, and with culture-proven dermatophyte toe nail infection, were given 250 mg terbinafine orally daily for 12 weeks. No changes in cyclosporin A dosage were made. A statistically significant decrease in mean specific cyclosporin A blood trough levels was found at 4, 8 and 12 weeks. No other statistical ...
Pages: 280-281
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Expression of gastrin-releasing peptide receptor in human skin.
Staniek V, Misery L, Peguet-Navarro J, Sabido O, Cuber JC, Dezutter-Dambuyant C, Claudy A, Schmitt D.
Bombesin-related peptides are expressed in the skin of batrachians and mammals. As gastrin-releasing peptide belongs to this family, we searched for the presence and distribution of gastrin-releasing peptide receptors (GRPr) in the skin of healthy human adults by immunohistochemistry, flow cytometry and electron microscopy. The results indicated that GRPr are expressed on nerves and vessels in the ...
Pages: 282-286
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Regulation of collagen expression by interleukin-1 beta is dependent on donor age.
Jarisch A, Krieg T, Hunzelmann N.
Cultured skin fibroblasts derived from old (> 60 years) donors differ in various morphological and functional aspects from cells obtained from young (< 20 years) donors. We were interested in whether fibroblasts obtained from old and young donors differ in their cellular response to interleukin-1 beta, a cytokine which has been shown to affect the synthesis of extracellular matrix proteins in huma ...
Pages: 287-290
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Evaluation of port wine stains by laser Doppler perfusion imaging and reflectance photometry before and after pulsed dye laser treatment.
Troilius AM, Ljunggren B.
Treatment of choice for congenital capillary malformations of the port wine stain type is presently the pulsed dye laser. Although treatment results have usually been excellent or good, a few patients respond less well. Looking for a tool to predict and monitor the treatment we used laser Doppler perfusion imaging and reflectance photometry. Measurements with laser Doppler perfusion imaging were p ...
Pages: 291-294
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Acute urticaria: clinical aspects and therapeutic responsiveness
Zuberbier T, Iffländer J, Semmler C, Henz BM
Although acute urticaria is common, its eliciting factors, clinical course and therapeutic responsiveness have not been intensively investigated. We have therefore prospectively studied all patients with acute urticaria attending the department of dermatology (n = 72) and a rural dermatology office (n = 37) during the course of 1 year. After a standardized history and physical examination, patient ...
Pages: 295-297
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Autosomal recessive cutis laxa syndrome. A case report.
Jung K, Ueberham U, Hausser I, Bosler K, John B, Linse R.
Congenital cutis laxa (CCL) is a rare, genetically heterogeneous connective tissue disorder, manifested by loose, hanging skin, giving the appearance of premature aging. We report a 6-year-old female child with autosomal recessive CCL type III, to assess possible correlations between clinical, ultrastructural, cellular and biochemical features. Morphological aberrations of the elastic and collagen ...
Pages: 298-301
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Macular posterior pigmentary incontinence: its relation to macular amyloidosis and notalgia paresthetica.
Westermark P, Ridderström E, Vahlquist A.
Patients with clinical features of dorsal macular amyloidosis but without subepidermal amyloid deposits were followed for 2-11 years. The clinical appearance was fairly stable during this period of time, with little tendency of healing. Only 2 of the patients developed typical macular amyloidosis during the follow-up. It is concluded that a condition strongly resembling macular amyloidosis but wit ...
Pages: 302-304
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Increased collagen propeptides in the skin of a scleredema patient but no change in re-epithelialisation rate.
Haapasaari KM, Kallioinen M, Tasanen K, Risteli J, Palatsi R, Oikarinen A.
Scleredema is a rare disease, affecting the skin connective tissue with increased amounts of collagen and glycosaminoglycans. In the present study, the collagen synthesis and re-epithelialisation rate were measured from a 64-year-old male patient, who rapidly developed extensive tightening of the skin, without any underlying disease. The skin was thickened at several sites when measured with ultra ...
Pages: 305-309
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Delayed-type hypersensitivity in palmoplantar pustulosis: effect of cyclosporin A treatment on skin testing with recall antigens.
Remitz A, Lauerma AI, Erkko P, Reitamo S.
Delayed-type hypersensitivity reactions to skin antigens are an indirect measure of cellular immune response. We studied in a double-blind manner whether clinically effective doses of cyclosporin A in palmoplantar pustulosis would diminish delayed-type hypersensitivity reactions in vivo. For testing delayed-type hypersensitivity, we applied intradermally a standardized panel of seven recall antige ...
Pages: 310-313
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Skin disease and age-related cataract.
Phillips CI, Donnelly CA, Clayton RM, Cuthbert J.
Dermatological conditions and treatments were analysed in a study comparing cataract patients and stringently matched controls. One thousand patients were taken from the cataract waiting list of a specialist eye hospital. For each patient a matched control of the same gender, half-decade of age, and family doctor but without cataract was selected. Venepunctures and eye examinations were performed ...
Pages: 314-318
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Foil bath PUVA in the treatment of prurigo simplex subacuta.
Streit V, Thiede R, Wiedow O, Christophers E.
Prurigo simplex subacuta is a chronic pruritic condition of unknown aetiology. The skin lesions respond to topical corticosteroids, UV-A and UV-B therapy only to a limited degree. Ten patients suffering from prurigo simplex subacuta were treated with foil bath PUVA at a concentration of 0.5 mg 8-methoxypsoralen/l. Using the foil bath method the volume of the psoralen/bath-water solution is restric ...
Pages: 319-320
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Local expression of migration inhibitory factor and Th1 type cytokine mRNA in sporotrichosis lesions
Fujimura T, Asai T, Miyata T, Muguruma K, Masuzawa M, Katsuoka K.
No Abstract available
Pages: 321-322
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Climatotherapy at the Dead Sea stimulates vitamin D3 metabolism
Kragballe K, Avrach WW, Politi Y, Landau M, Brenner S.
No Abstract available.
Pages: 324-325
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Granuloma annulare: clinical and laboratory findings in a pediatric group of patients
Patrizi A, Neri I, Guerrini V, Marini R, Fiorillo L.
No Abstract available.
Pages: 326-328
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Allopurinol therapy in post-kala-azar dermal leishmaniasis
Ramesh V.
No Abstract available.
Pages: 328-329
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Localised bullous pemphigoid following radiotherapy.
Cliff S, Harland CC, Fallowfield ME, Mortimer PS.
No Abstract available.
Pages: 330-331
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Multiple facial cylindromas in twins.
Cucurell M, Diaz C, Barranco C, Giménez-Arnau A, Camarasa JG.
No Abstract available.
Pages: 333-334
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Tri-chloroacetic acid: a cause of vulvar vestibulitis.
Nunns D, Mandal D.
No Abstract available.
Pages: 334-334
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Conjugal chondrodermatitis nodularis helicis.
Camacho F, Ramos ML, Muñoz MA, Moreno JC, Mazuecos J.
No Abstract available.
Pages: 335-335
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