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Content - Volume 76, Issue 5

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Phototoxicity of non-steroidal anti-inflammatory drugs: in vitro studies with visible light.
Becker L, Eberlein-König B, Przybilla B
Photosensitivity reactions due to non-steroidal anti-inflammatory drugs (NSAID) are well-known side-effects of these agents and are usually attributed to ultraviolet (UV) radiation. Eight NSAID (carprofen, diclofenac, ibuprofen, ketoprofen, naproxen, piroxicam, phenylbutazone, tiaprofenic acid) were assessed in a photohemolysis test for phototoxic effects in the visible light range. For the studie ...
Pages: 337-340
Abstract  PDF
Measurement of sodium lauryl sulfate-induced skin irritation.
Treffel P, Gabard B
Besides visual evaluation, skin irritation induced by sodium lauryl sulfate (SLS) may be characterized by bioengineering measurements, such as skin colour reflectance, transepidermal water loss (TEWL) or hydration. Short application times or low concentrations of the irritant usually do not modify the visual aspect of the skin, and the measurements described above are unchanged or only slightly al ...
Pages: 341-343
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On T-cell recognition of nickel as a hapten.
Emtestam L, Olerup O
T-cells recognize antigens as peptides associated with self-molecules encoded by genes of the HLA region. In patients with contact allergy to nickel, T-cells that are specific for non-peptide haptens have been described. Previously, we have isolated HLA class II-restricted nickel-specific T-cell clones from patients with nickel sensitivity. In this paper, data on the fine specificity of a nickel-s ...
Pages: 344-347
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Immunohistochemical studies of proinflammatory cytokines and their receptors in hair follicles of normal human skin.
Ahmed AA, Nordlind K, Schultzberg M, Brakenhoff J, Bristulf J, Novick D, Svenson SB, Azizi M, Lidén S
Immunoreactivity to interleukin-1 alpha, interleukin-1 beta, interleukin-6 and tumour necrosis factor-alpha and their receptors, as well as the endogenous interleukin-1 receptor antagonist, was investigated in hair follicles in paraffin-embedded normal human skin. Interleukin-1 beta- and tumour necrosis factor-alpha-like immunoreactivities were found in the inner root sheath layer of hair follicle ...
Pages: 348-352
Abstract  PDF
Topical treatment by urea reduces epidermal hyperproliferation and induces differentiation in psoriasis.
Hagemann I, Proksch E.
The mechanisms of action of urea-containing ointments in the treatment of eczema, ichthyosis and psoriasis are only partly known and related to proteolysis and keratinolysis. In this study, we have examined the effects of topical urea on epidermal proliferation and differentiation in 10 patients with psoriasis. Plaque type lesions were treated for 2 weeks with an ointment containing 10% urea, with ...
Pages: 353-356
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Soluble interleukin-2 receptor (sIL-2R) is a marker of disease activity in psoriasis: a comparison of sIL-2R, sCD27, sCD4, sCD8 and sICAM-1.
De Rie MA, Zonneveld IM, Witkamp L, Van Lier RA, Out TA, Bos JD
Psoriasis is a T-cell-mediated inflammatory skin disease which can be treated successfully with immunosuppressive drugs. Our purpose was to evaluate disease activity of psoriasis and the effect of immunosuppressive treatment by monitoring the soluble T-cell products sIL-2R, sCD27, sCD4, sCD8 and sICAM-1. Twenty-two patients were treated orally with escalating dosages of cyclosporin A (n = 17)(3-5 ...
Pages: 357-360
Abstract  PDF
A quantitative description of echographic images of sclerotic skin in patients with systemic sclerosis, as assessed by computerized image analysis on 20 MHz B-scan recordings.
Seidenari S, Belletti B, Conti A
The aim of our study was to find image descriptors enabling the characterization of sclerotic skin and its differentiation from normal skin, in order to find an objective method for the assessment of skin involvement in systemic sclerosis (SSc). Echographic evaluations were carried out using a 20 MHz B-scanner, on 18 female patients with SSc and on 20 healthy women serving as controls, at 3 differ ...
Pages: 361-364
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Focal dermal hypoplasia (Goltz syndrome): a decreased accumulation of hyaluronic acid in three-dimensional culture.
Sato M, Ishikawa O, Yokoyama Y, Kondo A, Miyachi Y
We report a 28-year-old female with focal dermal hypoplasia, (Goltz syndrome). We compared the growth kinetics and the production of type I collagen and glycosaminoglycans by fibroblasts from affected and unaffected skin. Fibroblasts were grown in conventional medium supplemented with ascorbic acid 2-phosphate, which makes fibroblasts from a tissue-like structure in vitro. The population doubling ...
Pages: 365-367
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Urinary glycosaminoglycans excretion in Graves' disease.
Priestley GC, Aldridge RD, Hurel S
Urinary excretion of glycosaminoglycans was measured in 10 patients with pretibial myxoedema, 7 of whom also had thyroid-associated ophthalmopathy, and in 3 additional patients with ophthalmopathy but no skin changes. Total uronic acid excretion was raised above control levels in only 2 patients, who had both eye and skin disease of recent onset. In these patients excretion was initially three tim ...
Pages: 368-370
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Comparison of cyclosporine and topical betamethasone-17,21-dipropionate in the treatment of severe chronic hand eczema.
Granlund H, Erkko P, Eriksson E, Reitamo S
Topical corticosteroids are the standard treatment for hand eczema. However, in chronic forms of the disease they are often ineffective or lose their efficacy due to tachyphylaxis. In a previous open study cyclosporine showed efficacy in chronic hand eczema. The aim of this study was to compare oral cyclosporine at 3 mg/kg/day with topical 0.05% beta-methasone-17,21-dipropionate (BDP) cream in the ...
Pages: 371-376
Abstract  PDF
Generalised acanthosis nigricans with vitiligo.
Blume-Peytavi U, Spieker T, Reupke H, Orfanos CE
We report on a 19-year-old woman with generalised acanthosis nigricans of the inherited type and concomitant vitiligo. Cutaneous velvety thickening of the skin with intensification of skin markings and progressive development of hyperpigmented papillomatous, verrucoid lesions in the body folds started to develop in early childhood. These hyperpigmentations were continuously replaced by a progressi ...
Pages: 377-380
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Sun-related behaviour in individuals with dysplastic naevus syndrome.
Brandberg Y, Jonell R, Broberg M, Sjödén PO, Rosdahl I
In Sweden, individuals with dysplastic naevus syndrome are regularly screened and informed about self-examination and sun-protection at special clinics. This study describes sun-related behaviour in this group. A total of 54/65 consecutive patients with dysplastic naevus syndrome (28 women and 26 men) completed diary recordings of sun-related behaviour during 1 month in 1994. A majority (81%) repo ...
Pages: 381-384
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Cutaneous reactions after treatment with 2-chlorodeoxyadenosine.
Meunier P, Castaigne S, Bastie JN, Chosidow O, Aractingi S
2-chlorodeoxyadenosine (2-CdA) is a new purine analogue which has shown great efficacy in the treatment of hairy cell leukemia. Only one case of cutaneous reaction after this treatment has previously been reported. The data from 33 patients treated with 2-CdA were retrospectively reviewed. Seven of these (21%) developed a disseminated eruption during the month following 2-CdA. One had toxic epider ...
Pages: 385-386
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A novel dithranol formulation (Micanol): the effects of monotherapy and UVB combination therapy on epidermal differentiation, proliferation and cutaneous inflammation in psoriasis vulgaris.
Van der Vleuten CJ, Gerritsen MJ, De Jong EM, Elbers M, De Jongh GJ, van de Kerkhof PC
Micanol, in which dithranol is micro-encapsulated in crystalline monoglycerides, is easy to wash off and staining and irritation are inconspicuous. These features make it appropriate to use in an out-patient setting. In this study the immunohistochemical effects of this new dithranol formulation were studied and compared with UVB and the combination of these therapies in skin biopsies of 8 patient ...
Pages: 387-391
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Købner reaction induced by photodynamic therapy using delta-aminolevulinic acid. A case report.
Stender IM, Wulf HC
We report a case of psoriasis reactivation following photodynamic therapy with delta-aminolevulinic acid. An 84-year-old women received several UVB treatment sessions because of severe psoriasis at her crura in the period from 1960 to 1990. Since then her psoriasis had been inactive. In 1994 she was admitted to our out-patient clinic because of multiple dysplastic lesions as well as multiple carci ...
Pages: 392-393
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Differential expression of desmosomal glycoproteins in keratoacanthoma and squamous cell carcinoma of the skin: an immunohistochemical aid to diagnosis.
Krunic AL, Garrod DR, Smith NP, Orchard GS, Cvijetic OB
The distinction between keratoacanthoma and squamous cell carcinoma is a common dermatopathological dilemma. Although the mainstay of the diagnosis is still clinico-pathological correlation, many dermatopathologists now include keratoacanthomas in the spectrum of squamous cell carcinomas. Recent reports, however, have pointed out that keratoacanthoma is "deficient squamous cell carcinoma" since it ...
Pages: 394-398
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Transient hyperpigmentation after calcipotriol ointment and PUVA therapy in psoriatic patients.
Vázqvez-López F, Pérez-Oliva N
No abstract available.
Pages: 400-400
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Keratosis lichenoides chronica with chronic hepatitis: a coincidence?
Marschalkó M, Papp I, Szalay L, Hársing J, Horváth A
No abstract available.
Pages: 401-402
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Lobular panniculitis associated with venous congestion in right-sided heart failure.
Husebye ES, Pontén F, Wibell L
No abstract available.
Pages: 402-403
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Isoprenosine improves symptoms in young females with chronic vulvodynia.
Sand Petersen C, Weismann K
No abstract available.
Pages: 404-404
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Drug photosensitivity in Norway.
Selvaag E, Thune P
No abstract available.
Pages: 405-406
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Dramatic vasculopathy in a patient with antiphospholipid syndrome.
Lalova A, Popov I, Dourmishev A, Baleva M, Nikolov K
No abstract available.
Pages: 406-406
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Negative patch test reactions to sweat in atopic dermatitis.
Adachi J, Endo K, Fukuzumi T, Kojima M, Aoki T
No abstract available.
Pages: 410-411
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Xanthomatous reaction in lupus panniculitis.
Ishikawa O, Akimoto S, Sato M, Okugi Y, Takeuchi Y, Miyachi Y
No abstract available.
Pages: 411-412
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Schnitzler's syndrome (urticaria and macroglobulinemia): evolution to Waldenström's disease is not uncommon.
Machet L, Vaillant L, Machet MC, Reisenleiter M, Goupille P, Lorette G
No abstract available.
Pages: 413-413
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Inguinal mycetoma.
Dogra D, Ramam M, Banerjee U
No abstract available.
Pages: 414-414
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Pruritus ani caused by beta-haemolytic streptococci.
Weismann K, Sand Petersen C, Røder B
No abstract available.
Pages: 415-415
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