Content - Volume 77, Issue 5

Editor's choice in this issue

All articles

Preventive and therapeutic effects of a moisturizer. An experimental study of human skin
Ramsing DW, Agner T.
The effect of a moisturizer was tested on experimentally irritated human skin in two studies. In a prevention study, 12 volunteers had both hands immersed into a 0.375% sodium lauryl sulphate solution, 10 min twice daily for 2 days. Before each immersion one hand was treated with the moisturizer; the other hand served as control. In a therapeutic study, 12 volunteers had both hands immersed in the ...
Pages: 335-337
Abstract  PDF
Colocalization of somatostatin- and HLA-DR-like immunoreactivity in dendritic cells of psoriatic skin
Talme T, Schultzberg M, Sundqvist KG, Marcusson JA.
This study presents an immunohistochemical characterization of somatostatin-positive dendritic cells in psoriatic lesions. Somatostatin is a neuropeptide with inhibitory action on several neuropeptides and hormones, but also with immunomodulating properties, and has been used in several studies as treatment for psoriasis. The number of somatostatin-positive dendritic cells was found to be larger i ...
Pages: 338-342
Abstract  PDF
The skin and the gut in psoriasis: the number of mast cells and CD3+ lymphocytes is increased in non-involved skin and correlated to the number of intraepithelial lymphocytes and mast cells in the duodenum
Michaëlsson G, Kraaz W, Hagforsen E, Pihl-Lundin I, Lööf L, Scheynius A
The aim of this work was to study tryptase+ mast cells and CD3+ T lymphocytes in non-involved skin in psoriasis and their possible relation to mast cells and lymphocytes in the duodenal mucosa. Skin biopsy specimens were obtained from 43 patients with psoriasis of variable severity and from 10 healthy subjects. Compared with the reference subjects, the number of mast cells in non-involved skin was ...
Pages: 343-346
Abstract  PDF
Desmoplastic trichilemmoma: a case report with immunohistochemical characterization of the extracellular matrix components
The case of unusual desmoplastic variant of trichilemmoma arising in the neck of a 56-year-old man is reported. The tumour was characterized by the presence of a densely sclerotic stroma, surrounded by lobules of epithelial cells with features of outer root sheath differentiation, including glycogen-rich, clear cytoplasm and peripheral palisading. In the central part of the tumour, irregular cords ...
Pages: 347-349
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Expression of retinoid nuclear receptor superfamily members in human hair follicles and its implication in hair growth
Billoni N, Gautier B, Mahé YF, Bernard BA
Since clinical evidence of hair loss and hair depigmentation following etretinate therapy has been reported, we decided to study the expression levels of several members of the retinoid nuclear receptor superfamily in dermal and epithelial compartments of the human hair follicle. Additionally, we evaluated the effects of several ligands for these receptors on human hair growth in culture in vitro. ...
Pages: 350-355
Abstract  PDF
Differences in extracellular matrix proteins, epidermal growth and differentiation in discoid lupus erythematosus, lichen planus and the overlap syndrome
de Jong EM, van der Vleuten CJ, van Vlijmen-Willems IM
Lichen planus (LP) and discoid lupus erythematosus (DLE) are separate disease entities. Nevertheless, patients with a so-called "overlap syndrome" have been described occasionally. The aim of the present study was to establish whether the LE/LP overlap syndrome, based on clinical and routine histological features, could be delineated from DLE or LP using immunohistochemical techniques. Formalin-fi ...
Pages: 356-360
Abstract  PDF
Phorbol-myristate-acetate, but not interleukin-1 beta or insulin-like growth factor-I, regulates protein kinase C isoenzymes in human dermal papilla cells
Eicheler W, Huth A, Happle R, Hoffmann R
The in vitro growth of human hair follicles is inhibited by interleukin (IL)-1 beta and phorbol esters, such as phorbol-myristate-acetate (PMA), but enhanced by insulin-like growth factor (IGF)-I. Although this process is only incompletely understood, the dermal papilla as a pivotal part of the hair follicle is almost certainly involved. Since protein kinase C (PKC) isoenzymes are activated by pho ...
Pages: 361-364
Abstract  PDF
Acute cutaneous barrier perturbation induces maturation of Langerhans' cells in hairless mice
Katoh N, Hirano S, Kishimoto S, Yasuno H.
Perturbation of the cutaneous water permeability barrier has been shown to result in many physiological events in keratinocytes, including upregulation of proinflammatory cytokine production. However, little is known about the effect of barrier disruption on Langerhans' cells (LC). In the present study, we examined whether acute barrier perturbation by acetone treatment or tape stripping affects t ...
Pages: 365-369
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Contact allergy to gold and gold therapy in patients with rheumatoid arthritis
Möller H, Svensson A, Björkner B, Bruze M, Lindroth Y, Manthorpe R, Theander J
Patients with rheumatoid arthritis were investigated for contact allergy to gold in connection with treatment with gold preparations. There were 57 patients with rheumatoid arthritis previously treated with gold, with or without cutaneous side-effects, as well as 20 patients intended for such treatment; all were exposed to patch and intradermal tests with gold sodium thiosulfate, gold sodium thiom ...
Pages: 370-373
Abstract  PDF
Ultraviolet light exposure, pigmentary traits and the development of melanocytic naevi and cutaneous melanoma. A case-control study of the German Central Malignant Melanoma Registry
Breitbart M, Garbe C, Büttner P, Weiss J, Soyer HP, Stocker U, Krüger S, Breitbart EW, Weckbecker J, Panizzon R, Bahmer F, Tilgen W, Guggenmoos-Holzmann I, Orfanos CE
The present study firstly aimed at understanding the relationship between sun exposure, pigmentary traits and the history of sunburns. Secondly, the significance of UV-exposure for cutaneous melanoma and for melanocytic naevi was investigated. The case-controlled study comprised 513 patients with primary cutaneous melanoma and 498 controls matched by age and gender. Multivariate logistic regressio ...
Pages: 374-378
Abstract  PDF
Evaluation of the clinical usefulness of measuring urinary excretion of 5-S-cysteinyldopa in melanoma: ten years' experience of 50 patients
The urinary excretion of 5-S-cysteinyldopa (5-S-CD) is known to be increased in certain patients with melanoma. To evaluate its diagnostic and prognostic utility, we measured the urinary excretion of 5-S-CD on at least three different occasions in 50 patients with melanoma. No significant increase was found in 26 patients without metastases, in 10 patients with regional lymph node metastasis and 2 ...
Pages: 379-381
Abstract  PDF
Venous hemangioma. An immunohistochemical and ultrastructural study
Ichikawa MM, Ishida-Yamamoto A, Hashimoto Y, Matsuo S, Iizuka H
We present a case of (arterio) venous hemangioma of 15 years' duration, which arose in a 43-year-old Japanese man on his right infraorbital area. Elastic stain and electron microscopy did not show any evidence for arterial components. Some thick-walled vessels showed mucin deposition and wide intercellular spaces between smooth muscle cells. Several glomoid cells were encountered among these cells ...
Pages: 382-384
Abstract  PDF
Evaluation of PUVA bath phototoxicity
Neumann NJ, Kerscher M, Ruzicka T, Lehmann P
Administration of 8-methoxypsoralen in a dilute bath water solution is an effective therapeutic alternative to its systemic application, avoiding systemic side effects. Although PUVA bath photochemotherapy is now widely used, standardized guidelines are not yet available. Therefore, the aim of our study was to determine the optimal time interval between 8-methoxypsoralen bath and UVA irradiation a ...
Pages: 385-387
Abstract  PDF
Comparison of immune reactivity profiles against various environmental allergens between adult patients with atopic dermatitis and patients with allergic respiratory diseases
Matsumura N, Aiba S, Tanaka M, Aoyama H, Tabata N, Tamura G, Tagami H
To clarify the pathomechanisms underlying the involvement of different organs by atopic dermatitis (AD) and allergic respiratory disease (ARD), we compared the immune reactivities to various environmental allergens between 46 adult patients who suffered only from AD but were without any history of ARD and 41 patients who had only ARD, using a RAST FEIA (radioallergosorbent test/fluoroenzyme immuno ...
Pages: 388-391
Abstract  PDF
The applicability of clinical scoring systems: SCORAD and PASI in psoriasis and atopic dermatitis
Jemec GB, Wulf HC
The lack of standard systems for assessment of disease severity poses a problem for the introduction of rational quality control in dermatology. The scoring systems often involve assessment of the same aspects of disease, and it may therefore be conceivable that one system could potentially be applied to routine clinical work and form the basis of disease quantification in dermatology. This study ...
Pages: 392-393
Abstract  PDF
Isotretinoin, tetracycline and circulating hormones in acne
Palatsi R, Ruokonen A, Oikarinen A
Isotretinoin, used to treat severe acne, has been shown to induce hormonal changes, especially to reduce 5 alpha-reductase in the production of the tissue-derived dihydrotestosterone (DHT) metabolite 3 alpha-Adiol G. However, the effects of isotretinoin on other pituitary, adrenal or gonadal hormones have not been thoroughly elucidated. In the present study, isotretinoin administered at a dose of ...
Pages: 394-396
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A new patient with idiopathic tripe palms
Siragusa M, Batolo D, Schepis C
No Abstract available
Pages: 397-397
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Circulating sICAM-1 during UV therapy of psoriasis
Petersen AA, Bech-Thomsen N, Mainolfi EA, Wulf HC, Vejlsgaard GL
No Abstract available
Pages: 398-399
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Oral psoriasis: report on a case without epidermal involvement
Rozell B, Grevér AC, Marcusson JA
No Abstract available
Pages: 399-400
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Follicular lymphomatoid papulosis and multiple myeloma
Rongioletti F, Basso GI, Sementa A, Gambini C, Rebora A
No Abstract available
Pages: 403-403
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Normal serum adenosine deaminase activity in mycosis fungoides
Yalçin B, Sahin S, Ciliv G
No Abstract available
Pages: 403-404
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Verrucous hemangioma
Kawaguchi H, Kawaguchi T, Ishii N, Nakajima H, Ichiyama S
No Abstract available
Pages: 405-406
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"Clown nose" as a first manifestation of lung carcinoma
De Simoni I, Iacovelli P, Lunghi F, Peris K, Chimenti S
No Abstract available
Pages: 406-407
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Ketoconazole as a therapeutic modality in subcorneal pustular dermatosis
Verma KK, Pasricha JS
No Abstract available
Pages: 407-408
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An uncommon case of the acute disseminated haemorrhagic bullous type of dermatitis ulcerosa
Weisshaar E, Sabel R, Gollnick H
No Abstract available
Pages: 408-409
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"Twisted and rolled body hairs": an ultrastructural study by means of scanning electron microscopy
Barbareschi M, Sibillo E, Greppi F, Bruscagin C, Crosti C
No Abstract available
Pages: 409-410
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Stevens-Johnson syndrome after albendazole
Dewerdt S, Machet L, Jan-Lamy V, Lorette G, Therizol-Ferly M, Vaillant L
No Abstract available
Pages: 411-411
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Scar depigmentation in systemic sclerosis
Ramam M, Dogra D
No Abstract available
Pages: 411-412
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Transient acantholytic dermatosis after treatment with 2-chlorodeoxyadenosine
Cohen PR, Kurzrock R
No Abstract available
Pages: 412-413
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White sponge naevus successfully treated with tetracycline mouth rinse
Becker LR, Lutz C, Erbard H, Bröcker EB, Hamm H
No Abstract available
Pages: 413-413
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