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Content - Volume 78, Issue 2

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Hepatic cytochrome P450 CYP2C activity in psoriasis: studies using proguanil as a probe compound: Investigative reports
Nuala A. Helsby, Stephen A. Ward, Richard A. Parslew, Peter S. Friedmann, Lesley E. Rhodes
Retinol and proguanil are metabolised by the same family of hepatic cytochrome P450, i.e. CYP2C. We used proguanil as a probe to study CYP2C activity, and by implication retinol metabolism, in psoriasis. In vitro studies showed that retinol competitively inhibited the hepatic metabolism of proguanil to cycloguanil. Proguanil metabolism was assessed in 82 patients with chronic plaque psoriasis. Fo ...
Pages: 81-83
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Psoriatic Keratinocytes Express High Levels of Nerve Growth Factor
Siba P. Raychaudhuri, Wen-Yue Jiang, Eugene M. Farber
Many investigators have reported proliferation of terminal cutaneous nerves and upregulation of various neuropeptides (substance P, vasoactive intestinal polypeptide, calcitonin gene-related peptide) in psoriatic lesions. Nerve growth factor promotes growth of nerves and causes upregulation of neuropeptides like substance P and calcitonin gene-related peptide.
In this study we investigated th ...
Pages: 84-86
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Differential expression of nerve growth factor in Leishmania major murine cutaneous Leishmaniasis
Ahmed Abdelaziz Ahmed, Klas Nordlind, Stine Söderström, Sture Lidén
The cross-talk between the immune and nervous systems is becoming an interesting field of research and there is accumulating evidence supporting this notion. In the present study we investigated the levels of nerve growth factor in a murine model of cutaneous leishmaniasis, using a two-site ELISA. Two strains of inbred mice were used for this purpose, namely BALB/c and C57BL/6, genetically suscep ...
Pages: 87-91
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Modulation of cutaneous SP receptors in atopic dermatitis after UVA irradiation
V. Staniek, C. Liebich, E. Vocks, S. G. Odia, J. D. Doutremepuich, J. Ring, A. Claudy, D. Schmitt, L. Misery
Atopic dermatitis is a pruritic inflammatory skin disorder, involving immunological and non-immunological factors. Substance P seems to be involved in the pathogenesis of atopic dermatitis. Substance P-containing nerve fibers are increased in the lesional skin of patients with atopic dermatitis and a reduced weal and flare reaction to intradermal injection of substance P has been observed. We inv ...
Pages: 92-94
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Free radicals as potential mediators of metal allergy: effect of ascorbic acid on lymphocyte proliferation and IFN-? production in contact allergy to Ni2+ and Co2+
Leon T. Van Den Broeke, Astrid Gräslund, Per H. Larsson, J. Lars G. Nilsson, Jan E. Wahlberg, Annika Scheynius, Ann-Therese Karlberg
A possible free radical mechanism in metal allergy was investigated in peripheral blood mononuclear cell (PBMC) cultures from 6 subjects, contact allergic to Ni2+ and Co2+ and 6 control individuals. Ni2+ and Co2+-mediated free radical generation was studied with electron spin resonance spectroscopy. The immune response was characterized by cellular [met ...
Pages: 95-98
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Possible involvement of interleukin-1 in the pathogenesis of dermatofibroma
Toshiyuki Yamamoto, Ichiro Katayama, Kiyoshi Nishioka
Dermatofibroma (DF) is histologically characterized by proliferation of fibroblasts in the dermis. Multiple DFs occasionally develop in patients with autoimmune disorders under immunosuppressive therapy; however, the pathogenesis of DF is still unclear. To elucidate immunological involvement in the mechanism of the fibrosis in DF, we studied the role of interleukin-1 (IL-1), which has a number of ...
Pages: 99-102
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In vivo study of skin mechanical properties in scleredema of Buschke
H. Dobrev
A non-invasive, in vivo suction device was used to investigate the mechanical properties of the skin in a patient with scleredema of Buschke. Clinical scoring of skin induration and measurements of skin elasticity were performed over 9 anatomic regions on admission and after 3 (on discharge), 17 and 28 months. Immediate distension, final distension and immediate retraction were significantly decr ...
Pages: 103-106
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Expression of skin-derived antileukoproteinase (SKALP) in reconstructed human epidermis and its value as a marker for skin irritation
Esther Boelsma, Susan Gibbs, Maria Ponec
For the investigation of the skin irritancy potential of chemicals in an in vitro model, it is necessary to have sensitive end-points that predict the effects on native human skin. Our aim was to investigate whether the induction of the proteinase inhibitor SKALP in reconstructed epidermis can be used as a marker.
The influence of culture conditions and the effect of topical application of so ...
Pages: 107-113
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Laser Doppler imaging of skin microcirculation
Cecilia Svedman, George W. Cherry, Elizabeth Strigini, Terence J. Ryan
Laser Doppler imaging (LDI), a new technique which allows measurement of skin blood perfusion at a distance from the skin surface, was assessed methodologically in healthy volunteers.
Each skin LDI value was based on virtually real-time measurements obtained from a number of discrete measuring sites. In scans made along the circumference of the lower arm, valid figures for LDI (as distinct fr ...
Pages: 114-118
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An amorphous hydrogel enhances epithelialisation of wounds
M. S. Ågren
Hydrogel dressings are gaining increased clinical acceptance as a wound management modality. The purpose of this study was to compare the effect of three amorphous hydrogels with occlusive, control treatment (Tegaderm®) on healing of experimental wounds.
Eight partial-thickness cutaneous wounds (2.5 cm × 2.5 cm × 0.04 cm) were made, using an electrokeratome, and the four treatme ...
Pages: 119-122
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Histamine and cutaneous nociception: histamine-induced responses in patients with atopic eczema, psoriasis and urticaria
Gisela Heyer, Wolfgang Koppert, Peter Martus, Hermann O. Handwerker
Having observed altered itch and flare reactions after histamine application in patients with atopic eczema, we tried to determine these reactions in patients with urticaria and psoriasis. We investigated 16 healthy non-atopic subjects, 16 atopics in an eczema-free interval, 16 with acute atopic eczema, 16 with urticaria and 16 with psoriasis. Histamine was iontophoretically applied. The resultin ...
Pages: 123-126
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Multiple basal cell carcinoma: a clinical evaluation of risk factors: Clinical reports
Peter Wallberg, Taavi Kaaman, Magnus Lindberg
Basal cell carcinoma (BCC) is the most common malignant skin tumour. There is evidence that the number of patients who develop more than one basal cell carcinoma (mBCC) is increasing. The aim of this study was to elucidate possible risk factors for developing mBCC. Among twelve risk factors considered, skin tumour among relatives was the strongest, with an odds ratio of 10.9 (p<0.001). ...
Pages: 127-129
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Repeated open application tests (ROAT) in patients allergic to colophony - evaluated visually and with bioengineering techniques
Gunilla Färm
It is desirable to further evaluate the clinical relevance of a positive patch test. The repeated open application test (ROAT) has been suggested as such a supplementary method. To compare the results of patch testing with the outcome of ROATs, 13 colophony-sensitive subjects and 9 controls were patch-tested with colophony in a serial dilution test. Five microlitres, of three concentrations of a ...
Pages: 130-135
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Grafting of in vitro cultured melanocytes onto laser-ablated lesions in vitiligo
R. Kaufmann, D. Greiner, S. Kippenberger, A. Bernd
A variety of grafting procedures using autologous melanocytes have achieved promising results in the treatment of vitiligo. We here report on the preparation of an adequate graft recipient bed by pulsed Erbium-YAG laser skin ablation. In particular, for irregular lesions on delicate sites, which cannot be approached by utilization of suction blisters or dermabrasion, this technique may offer a di ...
Pages: 136-138
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House dust mite antigen exposure of patients
Sanne Krogsbøll Hansen, Mette Deleuran, Hanne Jøhnke, Kristian Thestrup-Pedersen
We studied the amount of house dust antigen in the beds of 55 patients with atopic dermatitis, eleven patients with psoriasis and ten healthy volunteers using a commercial ELISA which can determine the amount of antigen from Dermatophagoides pteronyssinus, D. farinae and D. microseras expressed as nanogram (ng) antigen per gram of house dust. The World Health Organization has indica ...
Pages: 139-141
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Changes in sexual behaviour focusing on condom use in STD clinic attenders in Göteborg, Sweden, from 1989 to 1994 - a questionnaire survey
G Hallhagen, G. B Löwhagen, B Toshach
During the 4 years from 1989/1990 to 1994 an increase in the use of condoms was registered. A high frequency of condom failures was reported and probably reflects inappropriate use. More efforts should be made to educate people how to use the condom. The impact of alcohol intake as a risk factor for unsafe sex seems to be significant and should also be stressed in educational safer sex programmes ...
Pages: 142-144
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Unusual suction-like contact dermatitis due to ECG electrodes
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Page: 145
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Ectopic cilia in a Caucasian girl with atopic eczema
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Pages: 146-147
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Photoprotection in vitiligo and normal skin
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Pages: 149-150
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Response to the letter by Westerhof & Uscanga
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Page: 150
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Onychomycosis in HIV-infected patients
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Pages: 151-152
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Giant pendulous fibroma arising on the areola
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Page: 152
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Exogenous pseudoxanthoma elasticum: a new case in an old farmer
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Pages: 153-154
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Congenital multiple annular glomus tumors
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Pages: 154-155
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Congenital leukonychia totalis in two brothers
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Pages: 156-157
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Announcements in 78:2
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Page: 160
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Book reviews
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Page: 160
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