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Content - Volume 80, Issue 1

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Variation in Epidermal Housekeeping Gene Expression in Different Pathological States
Yih-Yiing Wu, Jonathan L. Rees
Using non-radioactive in situ hybridization we studied the expression of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and PolyA+ RNA in psoriasis and normal skin, and GAPDH in epidermis following application of a range of noxious stimuli, including ultraviolet radiation, Sellotape stripping and various irritants. In keeping with what might have been expected from previous re ...
Pages: 2-3
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Decreased mRNA Levels of Retinoic Acid Receptor a, Retinoid X Receptor a and Thyroid Hormone Receptor a in Lesional Psoriatic Skin
Hans Törmä, Teresa Karlsson, Gerd Michaëlsson, Ola Rollman, Anders Vahlquist
Retinoic acid, vitamin D3 and triiodothyronine regulate keratinocyte proliferation and differentiation - processes that are disturbed in psoriatic skin - via binding to nuclear receptors for retinoic acid (RAR-α,-γ), vitamin D3 (VDR), thyroid hormone (TR-α,-β) plus the common heterodimer partners, the 9-cis-retinoic acid receptors (RXR-α,-β). By using a new quantitative real-time ...
Pages: 4-9
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In Vivo Gene Transfer Method in Keratinocyte Gene Therapy: Intradermal Injection of DNA Complexed with High Mobility Group-1 Protein in Rats
Shinsuke Ina, Daisuke Sawamura, Xianmin Meng, Katsuto Tamai, Katsumi Hanada, Isao Hashimoto
In order to develop a more efficient method of introducing genes into keratinocytes in vivo, we intradermally injected DNA bound to high mobility group 1 protein, thereby taking advantages of the naked DNA and hemagglutinating virus of the Japan-liposome method reported previously. First we performed a gel mobility shift assay, which confirmed DNA binding to high mobility group 1. Then we ...
Pages: 10-13
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Expression of PGP9.5 on Langerhans' Cells and Their Precursors
Hind Hamzeh, Alain Gaudillère, Odile Sabido, Isabelle Tchou, Claude Lambert, Daniel Schmitt, Christian Genin, Laurent Misery
Langerhans' cells are epidermal dendritic cells, derived from blood precursors. Their main function is antigen presentation to T-cells. They are able to express neuronal proteins, such as neuron­specific enolase or substance P-receptor. They are closely associated with nerve fibres. PGP9.5 is the most specific neuronal protein in the epidermis. Epidermal Langerhans' cells can express PGP9.5 if d ...
Pages: 14-16
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Superantigen Staphylococcal Enterotoxin B Induces Release of IL-1ß in Human Epidermis
L. Skov, J. V. Olsen, M. Ramm, O. Baadsgaard
Lesional skin in patients with inflammatory skin diseases is often colonized with Staphylococcus aureus, which is capable of releasing superantigens. We therefore studied whether application of superantigen on the skin led to release of cytokines, especially IL-1β. Suction blisters were raised on vehicle- and superantigen-treated skin and IL-1β protein levels measured in suction blister ...
Pages: 17-18
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Blood Perfusion Studies on Basal Cell Carcinomas in Conjunction with Photodynamic Therapy and Cryotherapy Employing Laser-Doppler Perfusion Imaging
Annika M. K. Enejder, Claes af Klinteberg, Ingrid Wang, Stefan Andersson-Engels, Niels Bendsoe, Sune Svanberg, Katarina Svanberg
Superficial blood perfusion was monitored using laser-Doppler perfusion imaging in connection with a phase III clinical trial comparing photodynamic therapy, utilizing topically applied δ-aminolevulinic acid, with cryotherapy of basal cell carcinomas. A total of 526 images were recorded before and immediately after the treatment and during the follow-up period. Before treatment, the lesions exhi ...
Pages: 19-23
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Antipruritic Action of Thalidomide
B. Martina Daly
The effect of thalidomide on itch was studied in 11 patients with chronic pruritus from psoriasis, eczema, nodular prurigo, senile pruritus and primary biliary cirrhosis. Itch, assessed subjectively by the patients on a 10 cm line and measured objectively as nocturnal scratch movement, was decreased by thalidomide 200 mg on the 2 nights it was given. There was no improvement in the underlying dis ...
Pages: 24-25
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Topical Photodynamic Therapy for Localized Scleroderma
Sigrid Karrer, Christoph Abels, Michael Landthaler, Rolf-Markus Szeimies
Therapy of localized scleroderma is unsatisfactory, with numerous treatments being used that have only limited success or considerable side-effects. The aim of this trial was to determine whether topical photodynamic therapy would be effective in patients with localized scleroderma. Five patients with progressive disease, in whom conventional therapies had failed, were treated by application of a ...
Pages: 26-27
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Excision of Lipodermatosclerotic Tissue: An Effective Treatment for Non-healing Venous Ulcers
Ingela Ahnlide, Mats Bjellerup, Henrik Åkesson
In longstanding venous ulcers, the development of lipodermatosclerosis of the skin surrounding the ulcer is common. According to our clinical experience lipodermatosclerosis impairs the opportunities for the ulcer to heal. In this combined retrospective and prospective study the lipodermatosclerotic skin area was excised in 7 non-healing venous ulcers and then covered with split skin graft. All 7 ...
Pages: 28-30
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Azathioprine as a Corticosteroid Sparing Agent for the Treatment of Dermatitis Caused by the Weed Parthenium
Kaushal K. Verma
Air-borne contact dermatitis caused by Parthenium hysterophorus is a serious problem in India. Patients with this condition have to use corticosteroids regularly in order to maintain clinical remissions, but prolonged usage causes serious side-effects. The weed cannot be eradicated. We have used 3 therapeutic regimens with azathioprine, which led to an effective control with minimal side-e ...
Pages: 31-32
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Patch-testing with Serial Dilutions of Tixocortol Pivalate and Potential Cross-reactive Substances
Marléne Isaksson, Magnus Bruze, An Goossens, Jean-Pierre Lepoittevin
Of patch-tested patients with dermatitis, 4-5% are allergic to corticosteroids. Four groups of corticosteroids are recognized (A-D), where substances from the same group may cross-react. We investigated the potential cross-reactivity pattern and dose-response relationship for several corticosteroids from group A. We also included the corresponding aldehyde to hydrocortisone, as this degradation p ...
Pages: 33-38
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Dorfman-Chanarin Syndrome in a Turkish Kindred: Conductor Diagnosis Requires Analysis of Multiple Eosinophils
A. Wollenberg, E. Geiger, M. Schaller, H. Wolff
Dorfman-Chanarin syndrome is a rare, autosomal recessive inherited lipid storage disease with congenital ichthyotic erythroderma due to an acylglycerol recycling defect. Demonstration of lipid vacuoles in neutrophils from peripheral blood smears (Jordans' anomaly) in patients with ichthyotic erythroderma leads to the diagnosis. In spite of frequent liver, muscle, ear, eye and central nervous syst ...
Pages: 39-43
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Behavioural and Social Characteristics of Subjects with Repeated Sexually Transmitted Diseases
Milan Bjeki', Hristina Vlajinac, Jelena Marinkovi'
A case-control study was performed in order to assess risk factors for repeated sexually transmitted diseases. The study comprised 101 patients who had had sexually transmitted diseases 3 or more times during their lives and 182 controls who had no history of sexually transmitted disease. The subjects all attended the City Department for Skin and Venereal Diseases in Belgrade, Yugoslavia, from Ju ...
Pages: 44-47
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Frequent Presence of Helicobacter pylori Infection in Chronic Urticaria
Michael Radenhausen, Jörg-Dieter Schulzke, Christoph C. Geilen, Ulrich Mansmann, Regina Treudler, Christian Bojarski, Constantin E. Orfanos, Beate Tebbe
This article does not have an abstract.
Pages: 48-49
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Perianal Ulcer as a Leading Symptom of Paediatric Langerhans' Cell Histiocytosis
László Török, László Tiszlavicz, Tihamér Somogyi, György Tóth, Mária Tápai
This article does not have an abstract.
Pages: 49-50
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Cross-allergy to Latex and Spinach
H. Maillard, L. Machet, Y. Meurisse, D. Garot, C. Toledano, V. Jan, L. Vaillant
This article does not have an abstract.
Pages: 51-53
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Successful Treatment of Hailey-Hailey Disease with a Scanned Carbon Dioxide Laser
Andreas Kruppa, Bernhard Korge, Jörg Lasch, Karin Scharffetter-Kochanek, Nicolas Hunzelmann
This article does not have an abstract.
Pages: 53-54
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Bullous Herpes Zoster
S. Veraldi, C. Carrera, R. Gianotti, R. Caputo
This article does not have an abstract.
Page: 55
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Ehlers-Danlos Syndrome Type VIII with Severe Periodontitis and Apical Root Resorption After Orthodontic Treatment
Sigrid Karrer, Michael Landthaler, Gottfried Schmalz
This article does not have an abstract.
Pages: 56-57
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Clinical Features of Ehlers-Danlos Syndrome Type VII in Chromosome 6q Deletion
A. Flórez, P. Gómez Centeno, V. Fernández-Redondo, J. Toribio
This article does not have an abstract.
Pages: 58-59
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Ultrasonic Measurement of Skin Thickness in Patients with Systemic Sclerosis
Kim Brocks, Ida Stender, Tonny Karlsmark, Susanne Ullman, Poul Halberg, Søren Jacobsen
This article does not have an abstract.
Pages: 59-60
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Elevated Serum Xylosyltransferase Activity Correlates with a High Level of Hyaluronate in Patients with Systemic Sclerosis
Christian Götting, Joachim Kuhn, Stephan Sollberg, Christina Huerkamp, Thomas Brinkmann, Thomas Krieg, Knut Kleesiek
This article does not have an abstract.
Pages: 60-61
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Linear Scleroderma Associated with Hypertrichosis in the Absence of Melorheostosis
Bum-Jin Juhn, Yang-Hoon Cho, Mu-Hyoung Lee
This article does not have an abstract.
Pages: 62-63
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Pseudoaneurysm of the Superficial Temporal Artery
Masao Fukuzawa, Toshiaki Saida
This article does not have an abstract.
Pages: 65-66
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Topical All-trans Retinoic Acid Does not Influence Minimal Erythema Doses for UVB Light in Normal Skin
J. V. Smit, E. M. G. J. de Jongh, G. J. de Jongh, P. C. M. van de Kerkhof
This article does not have an abstract.
Pages: 66-67
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Leukocytoclastic Vasculitis in a Patient with HHV-6 Infection
Francesco Drago, Paolo Rampini, Carlo Brusati, Alfredo Rebora
This article does not have an abstract.
Page: 68
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Monoterpenoids and Tetralin as Pediculocides
A. M. R. Downs, K. A. Stafford, G. C. Coles
This article does not have an abstract.
Pages: 69-70
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Treatment of Eosinophilic Annular Erythema with Chloroquine
Peter Kahofer, Eva Grabmaier, Elisabeth Aberer
This article does not have an abstract.
Pages: 70-71
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Itraconazole-induced Drug Eruption Confirmed by Challenge Test
Yasushi Goto, Takeshi Kono, Kayoko Teramae, Masamitsu Ishii
This article does not have an abstract.
Page: 72
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Interferon-? Production in the Peripheral Lymphocytes of a Patient with Carbamazepine Hypersensitivity Syndrome
Tetsuya Koga, Yumiko Kubota, Juichiro Nakayama
This article does not have an abstract.
Page: 73
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Primary Cutaneous Aspergillosis in an Immunocompetent Host
Shruti Lakhanpal, R. K. Pandhi, Binod K. Khaitan, Venkateswaran K. Iyer, Uma Bannerjee
This article does not have an abstract.
Pages: 74-75
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Asymptomatic Bilateral Optic Perineuritis in Secondary Syphilis
S. Gartaganis, S. Georgiou, A. Monastirli, J. Katsimpris, E. Pasmatzi, D. Tsambaos
This article does not have an abstract.
Pages: 75-76
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Multiple Pilomatricomas, Sternal Cleft and Mild Coagulative Defect
R. Strumìa, D. Sansone, A. Voghenzi
This article does not have an abstract.
Page: 77
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Ashy Dermatosis in an HIV Antibody-positive Patient
J. Molinero, J.J. Vilata, E. Nagore, L. Obón, C. Grau, A. Aliaga
This article does not have an abstract.
Pages: 78-79
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BOOK REVIEWS
This article does not have an abstract.
Page: 80
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