Content

Content - Volume 84, Issue 5

Editor's choice in this issue

All articles

In this issue…
This article does not have an abstract.
Pages: 337-338
Abstract  PDF
LETTER TO THE EDITOR
Malassezia sympodialis Stimulation Differently Affects Gene Expression in Dendritic Cells from Atopic Dermatitis Patients and Healthy Individuals
Jerome Bickenbach, Alan Tennant, Gerold Stucki
It is known that 28-84% of patients with atopic dermatitis exhibit IgE and/or T-cell reactivity to the opportunistic yeast Malassezia sympodialis,which can be taken up by immature monocyte-derived dendritic cells(MDDCs), resulting in MDDC maturation. The aim of this study was toinvestigate whether MDDCs from patients with atopic dermatitis responddifferently to M. sympodialis compare ...
Pages: 339-345
Abstract  PDF
LETTER TO THE EDITOR
Atopic Dermatitis - a Total Genome-scan for Susceptibility Genes
Atopicdermatitis is one of the most common chronic diseases of childhood andclosely related to other clinical manifestations of allergy. Theincidence is high and still increasing. The genetic contribution todisease development is substantial and complex. Only recently geneticresearch has begun to focus on this phenotype, and specificsusceptibility genes remain to be found. To identify candidate re ...
Pages: 346-352
Abstract  PDF
LETTER TO THE EDITOR
Expression of CCR2 on Monocytes and Macrophages in Chronically Inflamed Skin in Atopic Dermatitis and Psoriasis
Monocytes form a significant component of the inflammatory reaction taking place in the skin of atopic dermatitis and psoriasis. Chemokines are pivotalin mediating the attraction of leucocytes to sites of inflammation. The CC-chemokine, monocyte chemotactic protein 1 (MCP-1/CCL2), is expressed by keratinocytes in both atopic dermatitis and psoriasis. MCP-1 binds to the chemokine receptor CCR2 whic ...
Pages: 353-358
Abstract  PDF
LETTER TO THE EDITOR
Urinary 9a,11β-Prostaglandin F2 in Children with Atopic Eczema/Dermatitis Syndrome: An Indicator of Mast Cell Activation?
Tostudy the role of mast cell activation in children with atopiceczema/dermatitis syndrome (AEDS), we measured levels of urinary9α,11β-prostaglandin F2 (U-9α,11β-PGF2) by enzyme-linked immunoassay in 88 children (mean age 44 months, range 3-135) with mild (n=32), moderate (n=34) or severe (n=22)A ...
Pages: 359-362
Abstract  PDF
LETTER TO THE EDITOR
Immunofluorescence Localization of Nuclear Retinoid Receptors in Psoriasis Versus Normal Human Skin
Psoriasisresponds favourably to treatment with retinoids but the cellularpathways mediating these effects are poorly understood. Retinoidsregulate keratinocyte proliferation and maturation via binding tonuclear retinoic acid receptors (mainly RARα and RARγ) which formheterodimers with the 9-cis-RA receptor, RXRα. We have previously shownthat mRNA expression of RARα and RXR& ...
Pages: 363-369
Abstract  PDF
LETTER TO THE EDITOR
NoEvidence for Increased Skin Cancer Risk in Psoriasis Patients Treatedwith Broadband or Narrowband UVB Phototherapy: A First RetrospectiveStudy
Phototherapyof skin diseases such as psoriasis is an effective and safe treatmentmodality. However, increasing the risk of skin cancer by phototherapyis a serious concern. An increased skin cancer risk occurs afterprolonged photochemotherapy (PUVA). In contrast, the role of broadbandUVB or narrowband UVB therapy in skin carcinogenesis of humans withpsoriasis is less clear. Therefore, we investigat ...
Pages: 370-374
Abstract  PDF
LETTER TO THE EDITOR
Pruritus, Personality Traits and Coping in Long-term Follow-up of Burn-injured Patients
Pruritusis a major problem after burn injury; however, prevalence andpredictors of prolonged pruritus are not known. The aims were to assessfrequency of pruritus and the role of personality traits and coping inprolonged pruritus. The participants were burn patients injured 1-18years earlier (n=248). Pruritus was assessed with an item fromthe Abbreviated Burn Specific Health Scale, personali ...
Pages: 375-380
Abstract  PDF
LETTER TO THE EDITOR
Frequency of IgA Antibodies in Pemphigus, Bullous Pemphigoid and Mucous Membrane Pemphigoid
Alexander Zink, Anna Gensbaur, Michael Zirbs, Florian Seifert, Isabel Leon Suarez, Vagkan Mourantchanian, Stephan Weidinger, Martin Mempel, Johannes Ring, Markus Ollert
Circulatingand bound IgA antibodies can be found in the autoimmune blisteringdiseases, but their prevalence, clinical relevance and target antigensremain unknown. Thirty-two patients with pemphigus, 73 with bullouspemphigoid and 28 with mucous membrane pemphigoid were studiedretrospectively. Direct immunofluorescence (DIF) analysis of IgG, IgA,IgM and C3 was carried out for all cases. Sera were st ...
Pages: 381-384
Abstract  PDF
LETTER TO THE EDITOR
Anetodermic Lupus Panniculitis and Antiphospholipid Antibodies: Report of Three Cases
Anetodermais a rare cutaneous disease characterized by a loss of normal elastictissue that is presented clinically as localized areas of wrinkled orflaccid skin. This form may be associated with several immunologicalabnormalities, most notably lupus erythematosus and antiphospholipidantibodies with or without clinical manifestations of theantiphospholipid syndrome. A retrospective study was conduc ...
Pages: 385-388
Abstract  HTML  PDF
LETTER TO THE EDITOR
Enzyme Replacement Therapy in Severe Fabry Disease with Renal Failure: A 1-year Follow-up
Wepresent here the course of clinical response of a 53-year-oldhaemodialysed Fabry patient who received recombinant human α-galactosidase A at a dose of 1 mg/kg every other week over a period of 1 year. The therapy was well tolerated by the patient, who revealedan impressive favourable cutaneous, gastrointestinal, neurological andpsychiatric response and a dramatic improvement in his quality ...
Pages: 389-392
Abstract  PDF
1,2-Ethanedithiol-induced Erythema Multiforme-like Contact Dermatitis
Contactdermatitis simulating erythema multiforme can be caused by manyallergens. The chemical agent 1,2-ethanedithiol, which serves as aprotective group in chemical synthesis, has hitherto only beenimplicated as an irritant. We report on a 22-year-old female chemistrystudent who developed widespread erythema multiforme-like lesions afterlocal contact with 1,2-ethanedithiol. Many target lesions wer ...
Pages: 393-396
Abstract  PDF
LETTERS TO THE EDITOR
This article does not have an abstract.
Pages: 397-416
Abstract  PDF