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Content - Volume 87, Issue 1

Editor's choice in this issue

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IN THIS ISSUE
In this Issue: Topical Calcineurin Inhibitors: Facts and Fears
Kristian Thestrup-Pedersen
Section Editor
Page: 3
Abstract  PDF
IN THIS ISSUE
In this Issue: Natural course of Lyme borreliosis
Urban Forsum
Professor of Clinical Microbiology
Page: 3
Abstract  PDF
INVESTIGATIVE REPORT
In vivo Estimation of Stratum Corneum Thickness from Water Concentration Profiles Obtained with Raman Spectroscopy
Mariko Egawa, Tetsuji Hirao and Motoji Takahashi
Stratum corneum thickness was estimated from water concentration profiles of the skin measured by a confocal Raman spectrometer. Stratum corneum apparent thickness (SCAT) was defined as the depth where the water content reached an almost constant value. Site variations were determined using 15 healthy Japanese subjects (6 males, 9 females), and age variations at the cheek and forearm were examined ...
Pages: 4-8
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CLINICAL REPORT
Histamine, But Not Leukotriene C4, is an Essential Mediator in Cold Urticaria Wheals
Pauliina Nuutinen, Ilkka T. Harvima and Leena Ackermann
In addition to histamine, leukotriene C4 (LTC4) might also play a role in mediating cold urticaria wheals. To study the significance of LTC4 vs. histamine, 6 patients with cold urticaria were challenged with the ice cube test before and after ingestion of 10 mg cetirizine (antihistamine), 10 mg montelukast (leukotriene antagonist) or a combination of both drugs. Cetirizine diminished the cold-indu ...
Pages: 9-13
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INVESTIGATIVE REPORT
High Prevalence of Torque Teno (TT) Virus in Classical Kaposi's Sarcoma
Céline Girard, Laure Ottomani, Jacques Ducos, Olivier Dereure, Marie J. Carles and Bernard Guillot
Human herpes virus 8 infection is the primary and necessary factor in the development of Kaposi's sarcoma, but is not sufficient per se to trigger the onset of the disease. In order to search for virological cofactors associated with the occurrence of the disease, we investigated the prevalence of active infection by two newly discovered viruses, hepatitis G virus a ...
Pages: 14-17
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INVESTIGATIVE REPORT
Five Novel Mutations of RNA-specific Adenosine Deaminase Gene with Dyschromatosis Symmetrica Hereditaria
Yanxia Hou, Jianjun Chen, Min Gao, Fusheng Zhou, Wenhui Du, Yujun Shen, Sen Yang and Xue-Jun Zhang
Dyschromatosis symmetrica hereditaria (OMIM127400) is a rare autosomal dominant pigmentary genodermatosis caused by mutations in the RNA-specific adenosine deaminase (ADAR) gene. This study investigated 5 families and 3 sporadic patients with dyschromatosis symmetrica hereditaria in the Chinese Han population from Anhui province, China. By direct sequencing, 5 novel ADAR gene mutations (c.982C> ...
Pages: 18-21
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INVESTIGATIVE REPORT
Absence of an Active Metabolite for the Triazole Antifungal Pramiconazole
Jannie Ausma, Gennethel Pennick, Hilde Bohets, Vera van de Velde, Marcel Borgers and Annette Fothergill
Pramiconazole is an antifungal with high potential for the treatment of dermatophyte and yeast infections of the skin. It is currently not known whether pramiconazole is active alone as the parent agent or assisted by active metabo­lites. The in vitro metabolism as well as the metabolic stability of pramiconazole was investigated in subcellular liver fractions and ...
Pages: 22-26
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INVESTIGATIVE REPORT
Effect of UV Irradiation on Cutaneous Cicatrices: A Randomized, Controlled Trial with Clinical, Skin Reflectance, Histological, Immunohistochemical and Biochemical Evaluations
Eva Due, Kristian Rossen, Lars Tue Sorensen, Anette Kliem, Tonny Karlsmark and Merete Haedersdal
The aim of this study was to examine the effect of ultra­violet (UV) irradiation on human cutaneous cicatrices. In this randomized, controlled study, dermal punch biopsy wounds served as a wound healing model. Wounds heal­ed by primary or second intention and were randomized to postoperative solar UV irradiation or to no UV exposure. Evaluations after 5 and 12 weeks included blinded clinical ass ...
Pages: 27-32
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CLINICAL REPORT
Predicting Factors of Interstitial Lung Disease in Dermatomyositis and Polymyositis
Yi-Ju Chen, Chun-Ying Wu and Jui-Lung Shen
The aim of this study was to define the predicting factors and evaluate the prognosis of interstitial lung disease in dermatomyositis/polymyositis. For the period 1995-2005, we retrospectively reviewed the clinical information and laboratory data of 56 patients who were diagnosed as definite and probable dermatomyositis and polymyositis. Interstitial lung disease is common (41.9%) in these patient ...
Pages: 33-38
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INVESTIGATIVE REPORT
Course of Borrelia burgdorferi DNA Shedding in Urine after Treatment
Elisabeth Aberer, Andreas R. Bergmann, Anna-Maria Derler and Bruno Schmidt
Diagnosis of Lyme borreliosis by urine polymerase chain reaction (PCR) has been recognized as having better diagnostic sensitivity in patients with erythema migrans than serological methods. We made serial tests with 192 urine specimens from 70 patients with erythema migrans and 60 urine specimens from 21 patients with acrodermatitis chronica atrophicans to evaluate the course of positive urine PC ...
Pages: 39-42
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CLINICAL REPORT
Factors Associated with Atypical Moles in New Hampshire, USA
Linda Titus-Ernstoff, Jiao Ding, Ann E. Perry, Steven K. Spencer, Bernard F. Cole and Marc S. Ernstoff
Only a few studies, conducted in Sweden, assessed factors associated with the presence of atypical moles in the general population. We conducted a population-based, case-control study in New Hampshire, USA, to identify factors associated with atypical moles. In our study, atypical moles affected 14% of the study population. The adjusted odds ratio (OR) was 0.34 (95% confidence interval (CI)=0.14-0 ...
Pages: 43-48
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LETTER TO THE EDITOR
Cutaneous Manifestations in Patients Positive for Anti-Hepatitis C Virus Antibodies
Seçil Soylu, Ülker Gül and Arzu Kılıç
Cutaneous diseases can indicate the presence of hepatitis C virus (HCV) infection. The aim of this study was to analyse the frequency of cutaneous findings in HCV infection and HCV RNA positive cases in Turkey. Fifty consecutive patients positive for anti-HCV antibodies, negative controls, and patients positive and negative for HCV RNA were examined for any cutaneous findings that could be associa ...
Pages: 49-53
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INVESTIGATIVE REPORT
Long-term Safety and Efficacy of Tacrolimus Ointment for the Treatment of Atopic Dermatitis in Children
Anita Remitz, John Harper, Malcolm Rustin, Wouter F. M. Goldschmidt, Riitta Palatsi, Pieter G. M. van der Valk, Graham Sharpe, Catherine H. Smith, Attila Dobozy, Kristiina Turjanmaa, on behalf of the European Tacrolimus Ointment Study Group
Tacrolimus ointment is a topical calcineurin inhibitor for the treatment of atopic dermatitis. The primary objective of this open-label study was to assess the long-term safety of tacrolimus ointment. The primary end-point was the incidence of adverse events. Secondary end-points included the Eczema Area and Severity Index and a modified version of this index
Pages: 54-61
INVESTIGATIVE REPORT
An Efficient New Formulation of Fusidic Acid and Betamethasone 17-Valerate (Fucicort® Lipid Cream) for Treatment of Clinically Infected Atopic Dermatitis
Finn Schultz Larsen, Lene Simonsen, Anita Melgaard, Katja Wendicke and Anne S. Henriksen
To relieve the dryness of atopic dermatitis skin, a lipid formulation of fusidic acid and betamethasone 17-valerate (Fucicort® Lipid cream) was developed as an additional treatment option to the established Fucicort® cream. The two formulations were compared in patients with clinically infected atopic dermatitis. A total of 629 patients were randomized to twice daily double ...
Pages: 62-68
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INVESTIGATIVE REPORT
Vulvar Lichen Sclerosus: 11 Women Treated with Tacrolimus 0.1% Ointment
Annarosa Virgili, Maria Michela Lauriola, Lucia Mantovani and Monica Corazza
Lichen sclerosus is a chronic relapsing disease, usually treated with ultra-potent corticosteroids. As immuno­lo­gical alterations are considered important aetio­patho­genetic factors in lichen sclerosus, the new immunomodu­lating topical agents, such as tacrolimus and pimecrolimus, have been employed sporadically as alternative therapies. The aim of this study was to evaluate the therapeutic ...
Pages: 69-72
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LETTER TO THE EDITOR
Treatment of Ocular Cicatricial Pemphigoid with the Tumour Necrosis Factor Alpha Antagonist Etanercept
Sorilla Prey, Pierre-Yves Robert, Mireille Drouet, Agnés Sparsa, Cyril Roux, Jean-Marie Bonnetblanc and Christophe Bédane
This article does not have an abstract.
Pages: 74-75
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LETTER TO THE EDITOR
Idiopathic CD4+ T-cell Lymphocytopaenia Associated with Recalcitrant Viral Warts and Squamous Malignancy
Evmorfia Ladoyanni, Jonathan North and Chin Y. Tan
This article does not have an abstract.
Pages: 76-77
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LETTER TO THE EDITOR
Psoriasiform Drug Eruptions Under Anti-TNF Treatment of Arthritis are Not True Psoriasis
Julien Seneschal, Sebastian Lepreux, Marie-Laure Bouyssou-Gauthier, Isabelle Héliot-Hosten, Andra Economu, Joel Dehais, Thierry Schaeverbeke and Alain Taïeb
This article does not have an abstract.
Pages: 77-80
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LETTER TO THE EDITOR
Quadruple Extra-mammary Paget's disease
Shoko Abe, Kenji Kabashima, Daisuke Nishio, Hiroshi Yasuda, and Yoshiki Tokura
This article does not have an abstract.
Pages: 80-81
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LETTER TO THE EDITOR
Ichthyosiform Mycosis Fungoides: A Neoplastic Acquired Ichthyosis
Luca Bianchi, Marina Papoutsaki, Augusto Orlandi, Luigi Citarella and Sergio Chimenti
This article does not have an abstract.
Pages: 82-83
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LETTER TO THE EDITOR
Epidermal Naevus with Eccrine Duct Changes: an Orthokeratotic Variant of Eccrine Ostial and Dermal Duct Naevus?
Elisabet Parera, Fernando Gallardo, Montserrat Gilaberte, Carles Barranco and Ramon M. Pujol
This article does not have an abstract.
Pages: 84-85
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LETTER TO THE EDITOR
Treatment of Scalp Psoriasis with Betamethasone Dipropionate and Calcipotriol Two-compound Product1
Nicoletta Cassano and Gino A. Vena
This article does not have an abstract.
Pages: 85-86
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CLINICAL REPORT
Lichen Aureus Induced By Interferon-Alpha plus Ribavirin
Beatriz González-Sixto, Ignacio Garcia-Doval, Alberto Conde, Eugenia Mayo, Raquel Pardavila, Carlos De La Torre and Manuel Cruces.
This article does not have an abstract.
Pages: 87-88
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LETTER TO THE EDITOR
Papular and Reticular Elastolytic Giant Cell Granuloma: Rapid Spontaneous Regression
Noriyuki Misago, Yasuko Ohtsuka, Kenji Ishii and Yutaka Narisawa
This article does not have an abstract.
Pages: 89-90
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LETTER TO THE EDITOR
Long-lasting Scrofuloderma of Hands and Foot
Özlem Karabudak, Bilal Dogan and Yavuz Harmanyeri
This article does not have an abstract.
Pages: 91-92
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LETTER TO THE EDITOR
Alopecia Neoplastica due to Metastatic Colon Adenocarcinoma
Ülker Gül, Arzu Kılıç1, Ayşe Akbaş, Erkan Aslan and Murat Demiriz
This article does not have an abstract.
Pages: 93-94
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