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Content - Volume 88, Issue 5

Editors choice in this issue

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Obituary: Nils Thyresson
Anders Vahlquist
The previous Editor-in-Chief of this journal, Professor Emeritus Nils Thyresson, sadly died on the 21st of June 2008, only a few weeks before his 93rd birthday. Nils Thyresson received his medical training at Uppsala University and later in Stockholm at the Karolinska Institute, where he was appointed specialist in Dermatology and Venereology in 1952. He completed his PhD degree at the Karolinska ...
Pages: 433-433
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IN THIS ISSUE
In this Issue: Secondary Modifiers and the Phenotypic Variability of Junctional Epidermolysis Bullosa
Leena Bruckner-Tuderman
In this issue Professor Dédée Murrell, Sydney, Australia, and collaborators (Dang et al. p. 438–448) report on phenotypic variability in junctional epidermolysis bullosa with pyloric atresia (JEB-PA). They conclude that environmental factors and genetic modifiers must contribute to the clinical manifestations of this disease, which is caused by mutations in the ITGB4 gene. JEB-PA is an au ...
Pages: 436-436
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IN THIS ISSUE
In this Issue: Penetration Pushes Pigmentation in Vitiligo: Calcineurin Inhibitors Under Occlusion
Tilo Biedermann
Therapeutic options in vitiligo include photochemo­therapy, ultraviolet B (UVB) therapy, systemic steroids, or, as more recent studies have proposed, vitamin D3-analogs, excimer laser or topical calcineurin inhibitors (1). Meta-analysis of controlled studies has revealed that there is no one therapeutic option that could be considered the gold standard in vitiligo. Therapeutic efficacy depends ...
Pages: 436-437
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Differential Expression of Pyloric Atresia in Junctional Epidermolysis Bullosa with ITGB4 Mutations Suggests that Pyloric Atresia is due to Factors Other than the Mutations and Not Predictive of a Poor Outcome: Three Novel Mutations and a Review of the Li
Ningning Dang, Sandra Klingberg, Adam I. Rubin, Matthew Edwards, Siegfried Borelli, John Relic, Penelope Marr, Kim Tran, Anne Turner, Nicholas Smith, Dédée F. Murrell
Junctional epidermolysis bullosa with pyloric atresia (JEB-PA) is an autosomal recessive blistering disease including lethal and non-lethal variants due to mutations in ITGB4 and ITGA6. It is unclear whether PA is caused directly by the mutations in these genes or by other factors. Skin biopsies from patients with JEB were processed for immunofluorescence mapping. When staining for integrin β4 or ...
Pages: 438-448
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Different Roles of Capsaicin-sensitive and H1 Histamine Receptor-expressing Sensory Neurones in Itch of Mosquito Allergy in Mice
Tasuku Nakano, Tsugunobu Andoh, Atsushi Sasaki, Hiroshi Nojima, Yasushi Kuraishi
Although mosquito allergy induces the release of histamine, the itch-related response, scratching, is not effectively suppressed by blockade of H1 histamine receptors. To address this question, we examined the effects of neonatal capsaicin treatment on allergic reactions and H1 histamine receptor-expressing sensory neurones in mice. Neonatal capsaicin treatment almost completely abolished allergy- ...
Pages: 449-454
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Comparison of Perceived Itch Induced by Skin Prick-tests with Histamine and Codeine
Jennifer Theunis, David Black, Arnaud Degouy, Anne-Marie Schmitt, Laurent Misery
The role of personal factors makes it difficult to correlate subjective data, such as those obtained with the use of a visual analogue scale, and objective data, such as a quantity of injected histamine. In this study, prick tests with histamine and codeine on the forearms allowed a coherent variation in itch scores to be obtained over time, with highly significant differences from controls and wi ...
Pages: 455-457
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INVESTIGATIVE REPORT
Equipotent Concentrations of Botox® and Dysport® in the Treatment of Palmar Hyperhidrosis
Alma Rystedt, Carl Swartling, Catarina Färnstrand, Hans Naver
There are indications that the dilution of botulinum toxin affects dose-response. This must be considered when comparing different products. The aim of this study was to estimate a concentration of Dysport® in physiological saline that is approximately equivalent to Botox® 100 U/ml with respect to anhidrotic and muscular effect. Thirty-six patients with primary palmar hyperhidrosis were treated ...
Pages: 458-461
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Efficacy of a Single Oral Dose of 200 mg Pramiconazole in Vulvovaginal Yeast Infections: An Exploratory Phase IIa Trial
Gilbert Donders, Jannie Ausma, Luc Wouters, Geert Cauwenbergh, Marcel Borgers, Dirk Janssens
Pramiconazole (R126638) is a novel azole with potent antifungal activity against yeasts, dermatophytes and many other fungal species. The aim of this study was to evaluate the efficacy and tolerance of a single oral dose of 200 mg pramiconazole in acute and recurrent vulvovaginal yeast infections. Thirty-two patients (15 acute and 17 recurrent cases) were KOH microscopy- and culture-positive at in ...
Pages: 462-466
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Societal Cost of Skin Cancer in Sweden in 2005
Gustav Tinghög, Per Carlsson, Ingrid Synnerstad, Inger Rosdahl
Skin cancer is one of the most rapidly increasing cancers among the Swedish population and a significant cause of illness and death. This study aims to estimate the total societal cost of skin cancer in Sweden for 2005, using a prevalence-based cost-of-illness approach. The total cost of skin cancer was estimated at €142.4 million (€15/inhabitant), of which €79.6 million (€8/inhabitant) wa ...
Pages: 467-473
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CLINICAL REPORT
Occlusive Treatment Enhances Efficacy of Tacrolimus 0.1% Ointment in Adult Patients with Vitiligo: Results of a Placebo-controlled 12-month Prospective Study
Anke Hartmann, Eva-Bettina Bröcker, Henning Hamm
Topical tacrolimus was recently introduced as a novel therapeutic option in vitiligo. Excellent results were seen mainly on the face and neck areas. We treated 30 adult vitiligo patients with tacrolimus 0.1% ointment twice daily, and compared the results with those of placebo ointment. In 20 patients, defined areas on the right arm or leg were occluded overnight with 3 different dressings. Repigme ...
Pages: 474-479
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CLINICAL REPORT
Immediate Whealing Urticaria in Red Light Exposed Areas During Photodynamic Therapy
Jeanette Kaae, Peter A. Philipsen, Merete Hædersdal, Hans Christian Wulf
One of the recommended first-line treatments for basal cell carcinomas, actinic keratoses and Bowen's disease is photodynamic therapy. Commonly associated side-¬effects include pain and phototoxicity. Histamine release is a part of this reaction, but whealing urticaria follow¬ing photodynamic therapy has only been reported by the manufacturer. The aim of this study was to investigate the prevale ...
Pages: 480-483
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CLINICAL REPORT
Two Cases of Anti-Epiligrin Cicatricial Pemphigoid With and Without Associated Malignancy
Satoshi Fukushima, Kiyofumi Egawa, Hazuki Nishi, Shoji Wakasugi, Norito Ishii, Takashi Hashimoto, Kim B. Yancey, Hironobu Ihn
Anti-epiligrin cicatricial pemphigoid (AECP) is a chronic, mucous membrane-dominated, subepithelial blistering disease characterized by circulating anti-basement membrane zone auto-antibodies to laminin 5. Recent studies have shown that people with AECP have an increased relative risk for malignant tumours. In this report we describe two patients with AECP. In both cases, in¬direct immunofluores ...
Pages: 484-487
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CLINICAL REPORT
Intractable Chronic Pruritus in a 67-year-old Man
Elke Weisshaar
Chronic pruritus (> 6 weeks) can be caused by skin diseases and systemic diseases, including malignancies. It is a distressing symptom that requires a precise medical history, thorough physical examination, laboratory and radiological diagnostics. The interpretation of results may sometimes be difficult and may often reveal several patho¬logical findings. This case report demonstrates prosta ...
Pages: 488-490
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CLINICAL REPORT
A Young Woman with Recurrent Vesicles on the Lower Lip: Fixed Drug Eruption Mimicking Herpes Simplex
Frauke Benedix, Melany Schilling, Martin Schaller, Martin Röcken, Tilo Biedermann
A 23-year-old woman presented with recurrent herpetiform vesicles of the lower lip, but all diagnostic measures for herpes virus infection including herpes viridae specific PCR were negative. Medical history revealed that she also had chronic recurrent vulvovaginal candidiasis, which had been treated with various regimes, including repetitive applications of fluconazole. Consequently, fluconazole- ...
Pages: 491-494
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CLINICAL REPORT
The Combination of Etanercept and Methotrexate Increases the Effectiveness of Treatment in Active Psoriasis Despite Inadequate Effect of Methotrexate Therapy
Claus Zachariae, Nils-Jørgen Mørk, Timo Reunala, Henrik Lorentzen, Edvard Falk, Seija-Liisa Karvonen, Anders Johannesson, Birgitta Claréus, Lone Skov, Gro Mørk, Siân Walker and Susanne Qvitzau
Many patients with moderate-to-severe plaque psoriasis do not respond adequately to methotrexate monotherapy. This pilot study, with a small patient population, was performed to evaluate the effectiveness and safety of etanercept and methotrexate combination in patients with plaque psoriasis and inadequate response to methotrexate. Outpatients with plaque psoriasis (Psoriasis Area and Severity Ind ...
Pages: 495-501
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LETTER TO THE EDITOR
Validation of Diagnosis Criteria of Functional Itch Disorder or Psychogenic Pruritus
Laurent Misery, Joanna Wallengren, Elke Weisshaar, Anna Zalewska, French Psychodermatology Group
This article does not have an abstract.
Pages: 503-504
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LETTER TO THE EDITOR
Lupus Miliaris Disseminatus Faciei Without Facial Involvement
Dae Suk Kim, Kyu Yeop Lee, Jung U. Shin, Mi Ryung Roh, Min Geol Lee
This article does not have an abstract.
Pages: 504-505
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LETTER TO THE EDITOR
Increased Expression of Hematopoietic Prostaglandin D Synthase in CCR4-positive T Cells From Patients with Atopic Dermatitis
Chieko Shimura, Takahiro Satoh, Hiroo Yokozeki
This article does not have an abstract.
Pages: 506-508
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LETTER TO THE EDITOR
Mycetoma of the Chest Wall due to Nocardia brasiliensis
Carolina Gouveia, Ana Fraga, Paulo Filipe, Horténsia Sequeira, Patrick Boiron, Andrée Couble, Verónica Rodriguez-Nava, Manuel Marques Gomes
This article does not have an abstract.
Pages: 508-510
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LETTER TO THE EDITOR
Congenital Hyponychia without RSPO4 Mutation
Motonobu Nakamura, Yoshiki Miyachi
This article does not have an abstract.
Pages: 511-512
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LETTER TO THE EDITOR
Angiosarcoma of the Scalp with Metastasis to the Gingiva
Kenichi Tanabe, Mikio Masuzawa, Ryouichi Aki, Mamiko Masuzawa, Satoru Arai, Kazushige Hayakawa, Kensei Katsuoka, Takashi Kobayashi
This article does not have an abstract.
Pages: 512-513
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LETTER TO THE EDITOR
Ciliated Cyst of the Vulva: Oestrogen and Progesterone Receptors
Shuichi Kuniyuki, Yuko Fukushima, Yuki Yoshida, Kazuhoshi Yamanaka, Naoki Maekawa, Takeshi Inoue
This article does not have an abstract.
Pages: 514-515
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LETTER TO THE EDITOR
Sweet Syndrome Subsequent to Relapsing Polychondritis and Myelodysplastic Syndrome in a Japanese Patient
Tamihiro Kawakami, Ayumi Kawase, Sora Takeuchi, Shinji Yoshioka, Norihiro Fujimoto, Shingo Tajima, Masako Mizoguchi, Yoshinao Soma
This article does not have an abstract.
Pages: 517-519
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LETTER TO THE EDITOR
Papular Granuloma Annulare with Subcutaneous Granulomatous Reaction Induced by a Bee Sting
Kaoru Takayama, Takahiro Satoh, Hiroo Yokozeki
This article does not have an abstract.
Pages: 519-520
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LETTER TO THE EDITOR
Fluconazole-induced Stevens-Johnson Syndrome in a HIV-negative Patient
Alexandra Monastirli, Efi Pasmatzi, Eleftheria Vryzaki, Sophia Georgiou, Dionysios Tsambaos
This article does not have an abstract.
Pages: 521-522
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LETTER TO THE EDITOR
Cytomegalovirus Complicating Biological Immunosuppressive Therapy in Two Patients with Psoriasis Receiving Treatment with Etanercept or Efalizumab
Bibi Petersen, Henrik Lorentzen
This article does not have an abstract.
Pages: 523-524
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LETTER TO THE EDITOR
Labial Melanotic Macule Diagnosed by Dermoscopy
Yuichiro Tsunemi, Hidehisa Saeki, Kunihiko Tamaki
This article does not have an abstract.
Pages: 524-525
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LETTER TO THE EDITOR
Ulcerative Sarcoidosis: Case Report and Review of the Japanese Literature
Yoshiro Ichiki, Yasuo Kitajima
This article does not have an abstract.
Pages: 526-528
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LETTER TO THE EDITOR
Linear Syringocystadenoma Papilliferum of the Arm: A Rare Localization of an Uncommon Tumour
Müzeyyen Gönül, Seçil Soylu, Ülker Gül, İlhan Kaya, Levent Albayrak, Tuba Ünal
This article does not have an abstract.
Pages: 528-529
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LETTER TO THE EDITOR
Bullous Wells' Syndrome Associated with Non-Hodgkin's Lymphocytic Lymphoma
Matteo Spinelli, Elena Frigerio, Alessandra Cozzi, Cecilia Garutti, Matteo Claudio Garavaglia, Gianfranco Altomare
This article does not have an abstract.
Pages: 530-531
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LETTER TO THE EDITOR
Concurrence of Palmoplantar Psoriasiform Eruptions and Hair Loss during Carbamazepine Treatment
Sang Ho Oh, Dae Suk Kim, Yeon Sook Kwon, Ju Hee Lee, Kwang Hoon Lee
This article does not have an abstract.
Pages: 532-533
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LETTER TO THE EDITOR
Successful Isotretinoin Treatment of Acne in a Patient with Apert Syndrome
Mateja Dolenc-Voljč, Meta Finžgar-Perme
This article does not have an abstract.
Pages: 534-535
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LETTER TO THE EDITOR
Anetoderma Associated with Lyme Disease: A Case Report
Giusto Trevisan, Cristina Padovan, Maria Teresa Scaini, Marina Cinco, Romina Floris, Serena Bonin
This article does not have an abstract.
Pages: 536-538
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LETTER TO THE EDITOR
Congenital Dermoid Fistula of the Anterior Chest Region
Toshiaki Numajiri, Kenichi Nishino, Maki Uenaka, Yoshihiro Sowa
This article does not have an abstract.
Pages: 538-540
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LETTER TO THE EDITOR
Full Dapsone Dose Made Possible by Control of Anaemia with Darbepoetin-alpha
Ellen Flosadóttir, Bolli Bjarnason
This article does not have an abstract.
Pages: 540-541
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LETTER TO THE EDITOR
Haemorrhagic Nails in Pemphigus Vulgaris
Adam Reich, Beata Wiśnicka, Jacek C. Szepietowski
This article does not have an abstract.
Page: 542
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