Content - Volume 89, Issue 4

Itch is the most frequent symptom in dermatology and has been researched more extensively in recent years. Nevertheless, there are few true epidemiological studies on itch. The aim of this paper is to review the current state of research on the epidemiology of chronic itch in Western and non-Western populations. The electronic databases PubMed, Medline and the Cochrane Library were searched. Confe ...

Transforming growth factor beta (TGFβ) has been suggested to be an effective inhibitor of the increased keratinocyte proliferation in psoriasis. Three TGFβ isoforms are described (TGFβ1, 2 and 3), signalling via a heteromeric receptor complex of TGFβRI and TGFβRII. Receptor binding activates SMAD2, 3 and 4, which translocate into the nucleus and regulate TGFβ-responsive genes. SMAD6 and 7 pr ...

Multiple exposures to ultraviolet radiation (UVR) are the norm in nature and phototherapy. However, studies of the kinetics of pigmentation following UVA exposure have includ­ed only fair-skinned persons. The aim of this study was to investigate steady-state pigmentation and fading in 12 Scandinavians and 12 Indians/Pakistanis after 6 and 12 exposures on the back using broadband UVA and UVA1 wi ...

The aim of this study was to assess the role of stressful life events, lack of social support and attachment insecurity in triggering exacerbations of psoriasis. Outpatients experiencing exacerbation of psoriasis in the last 6 months (n = 110) were compared with outpatients affected by skin conditions in which psychosomatic factors are believed to play a minor role (n = 200). Stressful lif ...

Existing scoring systems for facial acne focus on the lesions themselves, but clinical decisions are based on a general assessment of severity, including the time since onset, the site(s) of involvement, the patient’s history, and the response to prior treatments. The aim of this study was to investigate the influence of some of these factors on the global assessment of acne severity. Involvemen ...

This controlled study investigated single low-dose red light photodynamic therapy and methyl-aminolevulinate (MAL) for treatment of moderate to severe facial acne in 19 patients. The right cheek was treated with MAL (160 mg/g) for 3 h prior to illumination. The left cheek received red light only. Both cheeks were illuminated with narrow-band red light (635 nm) at a light dose of 15 J/cm2. The glob ...

Although pruritus is an essential symptom of atopic dermatitis, its complex pathomechanism is not fully understood. The aim of this study was to characterize the clinical pattern of itch in adult subjects with atopic dermatitis. A total of 89 patients (59 females, 30 males) with atopic dermatitis, age range 18–60 years, were included in the study. Each patient completed a questionnaire about cli ...

The use of nickel in certain consumer goods has been regulated in Denmark since 1990. The aim of this study was to reveal the clinical characteristics of nickel-allergic patients seen in seven private dermatology clinics and to identify current sources of nickel that may elicit nickel dermatitis. During 2006 to 2007, 634 patients with dermatitis aged 17–91 years were patch-tested and completed a ...

Although the pathophysiology of chronic urticaria is not fully understood, it is possible that dysfunctioning of peripheral cutaneous nerve fibres may be involved. It has also been suggested that fibromyalgia syndrome, a multi-symptomatic chronic pain condition, may be associated with alterations and dysfunctioning of peripheral cutaneous nerve fibres. The aim of this study was to determine whethe ...

Hydroa vacciniforme is a rare, usually quite severe, photo­dermatosis. Association with Epstein-Barr virus infection and a possibly increased risk of lymphoprolifera­tive malignancy have been demonstrated. We describe here four patients with Epstein-Barr virus-associated hydroa vacciniforme treated with acyclovir/valacyclovir therapy with a good clinical response. The children were reported to ...

Digital ulcers and gangrene are common skin manifestations of connective tissue diseases, especially systemic sclerosis, although they are relatively rare in systemic lupus erythematosus. We describe here three patients with digital gangrene and systemic lupus erythematosus. None of the patients showed high disease activity of systemic lupus erythematosus at the time the digital gangrene developed ...

Unlike in common melanocytic naevi, an acquired leukoderma (halo) surrounding a congenital melanocytic naevus is a rare phenomenon. A 6-year-old boy developed a depigmentation around a congenital melanocytic naevus on the right thigh. Simultaneously, segmental vitiligo appeared on the thigh, lower abdomen and buttock of the same side with sharp midline demarcation. Examination for associated autoi ...

Abstract is missing (Letter)

Abstract is missing (Letter)

Abstract is missing (Letter)

Abstract is missing (Letter)

Abstract is missing (Letter)

Abstract is missing (Letter)

Abstract is missing (Letter)

Abstract is missing (Letter)

Abstract is missing (Letter)

Abstract is missing (Letter)

Abstract is missing (Letter)

Abstract is missing (Letter)

Abstract is missing (Letter)

Abstract is missing (Letter)

Abstract is missing (Letter)

Abstract is missing (Letter)

Abstract is missing (Letter)

This article does not have an abstract.

Abstract is missing (Quiz)

Abstract is missing (Quiz)