Content

Content - Volume 91, Issue 3

Editor's choice in this issue

INVESTIGATIVE REPORT
Identical Glycine Substitution Mutations in Type VII Collagen May Underlie Both Dominant and Recessive Forms of Dystrophic Epidermolysis Bullosa
Noor Almaani, Lu Liu, Patricia J. C. Dopping-Hepenstal, Joey E. Lai-Cheong, Alvin Wong, Arti Nanda , Celia Moss, Anna E. Martinez, Jemima E. Mellerio, John A. McGrath
Autosomal dominant and recessive forms of dystrophic epidermolysis bullosa (DEB) result from mutations in the type VII collagen gene (COL7A1). Although paradigms have emerged for genotype/phenotype correlation in DEB, some pathogenic mutations in COL7A1, notably glycine substitutions within the type VII collagen triple helix, may lead to diagnostic difficulties, since certain glycine substitutions ...
Pages: 262-266
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INVESTIGATIVE REPORT
Polymorphisms of GSTM1 and GSTT1, Sun Exposure and the Risk of Melanoma: A Case-control Study
Cristina Fortes, Simona Mastroeni, Paolo Boffetta, Luciano Innocenzi, Gianluca Antonelli, Raffaella Giovinazzo, Patrizia Anzidei, Franco Melchi, Stefania D’Atri, Paolo Pasquini1, Frederica Venanzetti
Glutathione S-transferases (GSTs) are a family of enzymes that are known to play an important role in cellular protection against oxidative stress, including the oxidative stress caused by ultraviolet radiation. This study focused on the possible involvement of GSTM1 and GSTT1 polymorphisms in risk modulation of cutaneous melanoma. Within a case-control study, the presence of the null polymorphism ...
Pages: 284-289
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INVESTIGATIVE REPORT
Utility of Non-rule-based Visual Matching as a Strategy to Allow Novices to Achieve Skin Lesion Diagnosis
R. Benjamin Aldridge, Dominik Glodzik, Lucia Ballerini, Robert B. Fisher, Jonathan L. Rees
Non-analytical reasoning is thought to play a key role in dermatology diagnosis. Considering its potential importance, surprisingly little work has been done to research whether similar identification processes can be supported in non-experts. We describe here a prototype diagnostic support software, which we have used to examine the ability of medical students (at the beginning and end of a derma ...
Pages: 279-283
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CLINICAL REPORT
Epidermolysis Bullosa Acquisita: A Retrospective Clinical Analysis of 30 Cases
Jong Hoon Kim, Yeon Hee Kim, Soo-Chan Kim
Epidermolysis bullosa acquisita (EBA) is an acquired, autoimmune blistering disorder caused by autoantibody production against type VII collagen. The aim of this study was to examine the clinical types, treatments, and outcomes of 30 patients with EBA. In our cohort, the median age of onset was 44.0 years, with a similar incidence for both genders (46.7% male, 53.3% female). The majority of patien ...
Pages: 307-312
Abstract  HTML  PDF

All articles

INVESTIGATIVE REPORT
Identical Glycine Substitution Mutations in Type VII Collagen May Underlie Both Dominant and Recessive Forms of Dystrophic Epidermolysis Bullosa
Noor Almaani, Lu Liu, Patricia J. C. Dopping-Hepenstal, Joey E. Lai-Cheong, Alvin Wong, Arti Nanda , Celia Moss, Anna E. Martinez, Jemima E. Mellerio, John A. McGrath
Autosomal dominant and recessive forms of dystrophic epidermolysis bullosa (DEB) result from mutations in the type VII collagen gene (COL7A1). Although paradigms have emerged for genotype/phenotype correlation in DEB, some pathogenic mutations in COL7A1, notably glycine substitutions within the type VII collagen triple helix, may lead to diagnostic difficulties, since certain glycine substitutions ...
Pages: 262-266
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Novel and Recurrent FERMT1 Gene Mutations in Kindler Syndrome
Tanasit Techanukul, Gomathy Sethuraman, Abraham Zlotogorski, Liran Horev, Michal Macarov , Alison Trainer, Kenneth Fong, Marko Lens , Ljiljana Medenica, Venkatesh Ramesh , John A. McGrath, Joey E. Lai-Cheong
Kindler syndrome (OMIM 173650) is an autosomal recessive condition characterized by skin blistering, skin atrophy, photosensitivity, colonic inflammation and mucosal stenosis. Fewer than 100 cases have been described in the literature. First reported in 1954, the molecular basis of Kindler syndrome was elucidated in 2003 with the discovery of FERMT1 (KIND1) loss-of-function mutations in affected i ...
Pages: 267-270
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INVESTIGATIVE REPORT
Role of p38 Mitogen-activated Protein Kinase Isoforms in Murine Skin Inflammation Induced by 12-O-tetradecanoylphorbol 13-acetate
Louise L. Lilleholt, Claus Johansen, J. Simon Arthur, Anne Funding, Bo M Bibby, Knud Kragballe, Lars Iversen
p38 mitogen-activated protein kinase plays a pivotal role in skin inflammation. The purpose of this study was to investigate the role of the various p38 isoforms. p38β/δ-knockout-C57BL/6 mice were generated, studied in a 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced skin inflammation model and compared with wild-type mice. The inflammatory response was determined by ear thickness, myelopero ...
Pages: 271-278
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Utility of Non-rule-based Visual Matching as a Strategy to Allow Novices to Achieve Skin Lesion Diagnosis
R. Benjamin Aldridge, Dominik Glodzik, Lucia Ballerini, Robert B. Fisher, Jonathan L. Rees
Non-analytical reasoning is thought to play a key role in dermatology diagnosis. Considering its potential importance, surprisingly little work has been done to research whether similar identification processes can be supported in non-experts. We describe here a prototype diagnostic support software, which we have used to examine the ability of medical students (at the beginning and end of a derma ...
Pages: 279-283
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Polymorphisms of GSTM1 and GSTT1, Sun Exposure and the Risk of Melanoma: A Case-control Study
Cristina Fortes, Simona Mastroeni, Paolo Boffetta, Luciano Innocenzi, Gianluca Antonelli, Raffaella Giovinazzo, Patrizia Anzidei, Franco Melchi, Stefania D’Atri, Paolo Pasquini1, Frederica Venanzetti
Glutathione S-transferases (GSTs) are a family of enzymes that are known to play an important role in cellular protection against oxidative stress, including the oxidative stress caused by ultraviolet radiation. This study focused on the possible involvement of GSTM1 and GSTT1 polymorphisms in risk modulation of cutaneous melanoma. Within a case-control study, the presence of the null polymorphism ...
Pages: 284-289
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Effects of Topical Corticosteroid and Tacrolimus on Ceramides and Irritancy to Sodium Lauryl Sulphate in Healthy Skin
Jakob Mutanu Jungersted, Julie K. Høgh, Lars I. Hellgren, Gregor B.E. Jemec, Tove Agner
The skin barrier, located in the stratum corneum, is influenced mainly by the lipid and protein composition of this layer. In eczematous diseases impairment of the skin barrier is thought to be of prime importance. Topical anti-inflammatory drugs and emollients are the most widely used eczema treatments. The aim of this study was to examine the effects of topically applied corticosteroid, tacrolim ...
Pages: 290-294
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INVESTIGATIVE REPORT
Multicentre Patch Testing with Compositae Mix by the Swedish Contact Dermatitis Research Group
Marléne Isaksson, Christer Hansson, Annica Inerot, Carola Lidén, Mihaly Matura, Berndt Stenberg, Halvor Möller, Magnus Bruze
Sesquiterpene lactone mix detects contact allergy to these compounds present in the plant family Asteraceae. This marker is present in many baseline series. An additional marker is Compositae mix, which is not present in many baseline series. To investigate whether this allergen should be inserted into the Swedish baseline series, sex dermatology centres representing the Swedish Contact Dermatitis ...
Pages: 295-298
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INVESTIGATIVE REPORT
Evaluation of Three Serological Tests Manufactured in Belarus for the Diagnosis of Syphilis
Iryna Shimanskaya, Larisa Zhurauskaya, Oleg Pankratov, Magnus Unemo, Ronald C. Ballard, Marius Domeika
The performance of three serological tests manufactured in Belarus for the diagnosis of syphilis, i.e. a microprecipitation reaction (MPR) and two enzyme-linked immunosorbent assays (ELISAs) were compared with internationally recognized assays, namely the rapid plasma reagin test and the Treponema pallidum passive particle agglutination assay (TPPA). Sera from 392 consecutive patients attending Br ...
Pages: 299-302
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CLINICAL REPORT
Evidence for Methotrexate as a Useful Treatment for Steroid-dependent Chronic Urticaria
Lior Sagi, Michal Solomon, Sharon Baum, Anna Lyakhovitsky, Henri Trau, Aviv Barzilai
Chronic urticaria is a relatively common disorder that can be severe and may impair quality of life. The management of recalcitrant chronic urticaria that is not responding to histamine antagonists includes short-term systemic corticosteroids, anti-inflammatory drugs (colchicine, dapsone and sulfasalazine) and immunomodulatory agents, such as cyclosporine, methotrexate, plasmapheresis and intraven ...
Pages: 303-306
Abstract  HTML  PDF
CLINICAL REPORT
Epidermolysis Bullosa Acquisita: A Retrospective Clinical Analysis of 30 Cases
Jong Hoon Kim, Yeon Hee Kim, Soo-Chan Kim
Epidermolysis bullosa acquisita (EBA) is an acquired, autoimmune blistering disorder caused by autoantibody production against type VII collagen. The aim of this study was to examine the clinical types, treatments, and outcomes of 30 patients with EBA. In our cohort, the median age of onset was 44.0 years, with a similar incidence for both genders (46.7% male, 53.3% female). The majority of patien ...
Pages: 307-312
Abstract  HTML  PDF
CLINICAL REPORT
Quality of Life in Patients with Uraemic Xerosis and Pruritus
Jacek C. Szepietowski, Elias Balaskas, Klaus-Michael Taube, Alain Taberly, Patrick Dupuy
A total of 334 end-stage renal disease patients with moderate-to-severe uraemic xerosis were surveyed for quality of life assessment, using the generic Short-Form (SF-12) scale and the Dermatology Life Quality Index (DLQI). In parallel, the intensity of xerosis at four sites (the two lower legs, chest, forearm without arterio-venous shunt) was assessed, using a five-point lesional intensity score. ...
Pages: 313-317
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CLINICAL REPORT
Psychosocial Stress and Coping in Alopecia Areata: A Questionnaire Survey and Qualitative Study Among 45 Patients
Franziska Matzer, Josef Wilhelm Egger, Daisy Kopera
The controversial role of psychosocial stress in alopecia areata has been discussed widely, but there has been little research into patients’ subjective stress experiences and coping. The aim of this study was to explore general and specific coping strategies in alopecia areata and to assess the role of psychosocial stress in the onset and course of alopecia areata from the patient’s viewpoint ...
Pages: 318-327
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CLINICAL REPORT
Psychosocial Impact of Hidradenitis Suppurativa: A Qualitative Study
Solveig Esmann, Gregor B.E. Jemec
Hidradenitis suppurativa influences patients' lives in many ways. It is therefore necessary to focus on the effects of the disease on daily life in order better to define patient-related outcomes in hidradenitis suppurativa studies. Interviews were conducted with 12 patients with hidradenitis suppurativa. Initial single interviews were followed by semi-structured and structured qualitative focus g ...
Pages: 328-332
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CLINICAL REPORT
Survey of Diagnostic Services for Genital Herpes in Fourteen Countries in Eastern Europe
Marius Domeika, Karen Babayan, Rashad Ismailov, Iryna Shimanskaya, Krasimira Chudomirova, Tatjana Brilene, Oleg Kvlividze, Judith Deak, Gulsum Askarova, Galina Mamajeva, Vesta Kucinskiene, Natalia Frigo, Alevtina Savicheva, Tatiana Krasnoselskich, Gennadiy Mavrov, Olim Kasymov, Olga Izvekova, Magnus Unemo, Ronald Campbell Ballard
This paper reports survey-based data on the diagnosis and management of genital herpes simplex virus (HSV) infection in 14 countries of the Eastern European Network for Sexual and Reproductive Health (EE SRH). Only 43% of the countries could provide the number of genital HSV cases recorded at national level. Eighty-six percent of countries employed syndromic management in cases of genital ulcer di ...
Pages: 333-336
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LETTER TO THE EDITOR
A Case of Acne Fulminans Successfully Treated with Cyclosporin A and Prednisolone
Osamu Tago, Yayoi Nagai, Yoichiro Matsushima, Osamu Ishikawa
Abstract is missing (letter)
Pages: 337-338
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LETTER TO THE EDITOR
Haemophagocytosis-related Intravascular Large B-cell Lymphoma Associated with Skin Eruption
Hideki Maejima, Ryoji Tanei, Takehiko Morioka, Shigeasburo Miyakoshi
Abstract is missing (Letter)
Pages: 339-340
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LETTER TO THE EDITOR
Recurrent Deep Ulcers Resembling Rare Cancers as a Form of Factitious Disorder
Aleksandra Okuniewska, Beata Imko Walczuk, Maria Czubek, Wojciech Biernat
Abstract is missing (letter)
Pages: 341-342
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LETTER TO THE EDITOR
Thermal Angiooedema Induced by Hot Water
Aya Kobayashi, Hisashi Uhara, Atsuko Ashida, Yukiko Kiniwa, Ryuhei Okuyama
Abstract is missing (Letter)
Pages: 343-344
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LETTER TO THE EDITOR
Efficacy of Thalidomide in the Treatment of Prurigo Nodularis
Hamid Taefehnorooz, François Truchetet, Annick Barbaud, Jean-Luc Schmutz, Anne-Claire Bursztejn
Abstract is missing (Letters)
Pages: 344-345
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LETTER TO THE EDITOR
Intra-familial Variability of Ectodermal Defects Associated with WNT10A Mutations
Emma K. Wedgeworth, Nikoletta Nagy, Jonathan M.L. White, Andrew C. Pembroke, John A. McGrath
Abstract is missing
Pages: 346-347
Abstract  HTML  PDF
LETTER TO THE EDITOR
Gastrointestinal Tuberculosis with Anal and Perianal Involvement Misdiagnosed as Crohn’s Disease for 15 Years
Reza Yaghoobi, Ahmad Khazanee, Nooshin Bagherani, Mahru Tajalli
Abstract is missing (Letter)
Pages: 348-349
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LETTER TO THE EDITOR
Febrile Exanthema Revealing Toxocariasis: A Case Report
Celine Bernardeschi , Gentiane Monsel, Camille Frances, François Bricaire, Luc Paris, Eric Caumes
Abstract is missing (Letter)
Pages: 350-351
Abstract  HTML  PDF
LETTER TO THE EDITOR
Meyerson Phenomenon Around Naevi: Resolution After Sun Exposure?
Anna Balato, Serena Lembo, Teresa Cirillo, Matteo Megna, Maddalena Napolitano, Nicola Balato
Abstract is missing (Letter)
Pages: 352-353
Abstract  HTML  PDF
LETTER TO THE EDITOR
Age-specific Incidence Ratios in Malignant Melanoma in Turkey: Melanoma in Older People is Increasing
Faruk Tas
Abstract is missing (letter)
Pages: 353-354
Abstract  HTML  PDF
LETTER TO THE EDITOR
Rapid Growth of Merkel Cell Carcinoma During Etanercept Treatment of Psoriatic Arthritis: Cause or Coincidence?
Vincenzo de Giorgi, Silvia Benemei, Marta Grazzini, Torello Lotti, Pierangelo Geppetti
Abstract is missing (letter)
Pages: 354-355
Abstract  PDF
LETTER TO THE EDITOR
Notalgia Paresthetica: Successful Treatment with Exercises
Anne B Fleischer, Tammy J. Meade, Alan B. Fleischer
Abstract is missing (Letter)
Pages: 356-357
Abstract  HTML  PDF
LETTER TO THE EDITOR
Serious Adverse Events Reporting on Systemic Terbinafine: A Danish Register-based Study
Nannie Bangsgaard, Ditte Marie Saunte, Maja Folkenberg, Claus Zachariae
Abstract is missing (Letter)
Pages: 358-359
Abstract  HTML  PDF
LETTER TO THE EDITOR
Lower Limbs Erosions Induced by Sunitinib
Nicolas Kluger, Angélique Chapelle, William Jacot, Bernard Guillot
Abstract is missing (Letter)
Pages: 360-361
Abstract  PDF
LETTER TO THE EDITOR
Psoriasiform Drug Eruption due to Abatacept
Kohei Kato, Takahiro Satoh, Aya Nishizawa, Hiroo Yokozeki
Abstract is missing (letter)
Pages: 362-363
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LETTER TO THE EDITOR
Infantile Acropustulosis Treated Successfully With Topical Maxacalcitol
Masaaki Kimura , Tetsuya Higuchi, Masami Yoshida
Abstract is missing (Letter)
Pages: 363-364
Abstract  HTML  PDF
LETTER TO THE EDITOR
Extensive Digital Gangrene Without Evidence of Large-vessel Occlusion in Hypereosinophilic Syndrome
Taegyun Kim, Mi Ri Kim, Jong Hoon Kim, Hyungjoong Jee , Soo-Chan Kim
Abstract is missing (Letter)
Pages: 365-366
Abstract  HTML  PDF
LETTER TO THE EDITOR
Sebaceous Carcinoma of the Nose with a Regional Metastasis Following False-negative Sentinel Lymph Node Biopsy
Shin-Ichi Osada, Takashi Ueno, Shunta Inai, Yayoi Niimi, Munenaga Nakamizo, Shin-ichi Ansai, Seiji Kawana
Abstract is missing (letter)
Pages: 367-368
Abstract  HTML  PDF
LETTER TO THE EDITOR
Zosteriform Venous Malformations with an Atypical Presentation
Shinji Noda, Yoshihide Asano, Rumi Sugie, Kyoko Mizuno, Makoto Adachi
Abstract is missing (Letter)
Pages: 369-371
Abstract  HTML  PDF
LETTER TO THE EDITOR
Basophils Infiltrate Skin Lesions of Eosinophilic Pustular Folliculitis (Ofuji’s Disease)
Takahiro Satoh, Yuichi Ito, Chiyako Miyagishi, Hiroo Yokozeki
Abstract is missing (Letter)
Pages: 371-372
Abstract  HTML  PDF
LETTER TO THE EDITOR
Recurrence of Hydroxyurea-induced Leg Ulcer After Discontinuation of Treatment
Kazuhiro Kikuchi, Ken Arita, Yasuki Tateishi, Masahiro Onozawa , Masashi Akiyama, Hiroshi Shimizu
Abstract is missing (letter)
Pages: 373-374
Abstract  HTML  PDF
LETTER TO THE EDITOR
Cutaneous Glomangiopericytoma on the Tip of the Nose
Young Bok Lee, Kyung Jin Lee, Hyun Jeong Park, Baik Kee Cho
Abstract is missing (Letter)
Pages: 375-376
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LETTER TO THE EDITOR
Melanotropic Peptides: What Exactly is Meant by ”Melanotan”?
Ewan Langan, Lesley E. Rhodes
Abstract is missing (Letter)
Pages: 377-378
Abstract  HTML  PDF
QUIZ
Tripe Palms, Digital Clubbing and Jaccoud’s-type Arthropathy: A Quiz
Myriam Ben Hmida, Ines Zaraa, Dalia Mrabet, Jouda Cherif, Ines Chelly, Mohamed Zitouna, Majed Beji, Slaheddine Sellami, Mourad Mokni, Amel Ben Osman
Abstract is missing (Quiz)
Pages: 380-383
Abstract  HTML  PDF
QUIZ
Asymmetrically Pigmented Patch on the Vulvo-perineal Area: A Quiz
Maria Lentini, Maria Le Donne
Abstract is missing (Quiz)
Pages: 380-382
Abstract  HTML  PDF
QUIZ
Nodule on the Chest: A Quiz
Namita Talsania, S. Yum Chan, Camilo Diaz
Abstract is missing (Quiz)
Pages: 381-383
Abstract  HTML  PDF