Content

Content - Volume 91, Issue 6

Editor's choice in this issue

REVIEW
Mast Cells as Regulators of Skin Inflammation and Immunity
Ilkka T. Harvima, Gunnar Nilsson
Mast cells are known to be the effector cells of immediate-type allergy, but experimental evidence obtained during the last decade has revealed their role in innate and acquired immunity. Upon activation mast cells can undergo an anaphylactic or piecemeal degranulation or degranulation-independent mediator secretion, resulting in rapid or slow release of soluble mediators, such as serine proteinas ...
Pages: 644-650
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CLINICAL REPORT
Teledermatological Monitoring of Psoriasis Patients on Biologic Therapy
Silvia Koller, Rainer Hofmann-Wellenhof, Dieter Hayn, Wolfgang Weger, Peter Kastner, Günter Schreier, Wolfgang Salmhofer
Patients with psoriasis who are being treated with biologics require intensive monitoring. However, the monitoring tool teledermatology is not commonly used. We investigated the applicability of a mobile phone based teledermatological system for monitoring psoriasis patients on biologic therapy. Nineteen patients were given mobile phones with built-in cameras, in order to transmit health status da ...
Pages: 680-685
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LETTER TO THE EDITOR
A Fatal Case of Hot Air Sauna Burn in an Elderly Patient Initially Misdiagnosed as Bullous Pemphigoid
Nicolas Kluger, Johanna Laipio, Susanna Virolainen, Annamari Ranki, Virve Koljonen
Abstract is missing (Letter)
Pages: 732-733
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All articles

REVIEW
Mast Cells as Regulators of Skin Inflammation and Immunity
Ilkka T. Harvima, Gunnar Nilsson
Mast cells are known to be the effector cells of immediate-type allergy, but experimental evidence obtained during the last decade has revealed their role in innate and acquired immunity. Upon activation mast cells can undergo an anaphylactic or piecemeal degranulation or degranulation-independent mediator secretion, resulting in rapid or slow release of soluble mediators, such as serine proteinas ...
Pages: 644-650
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Pre-treatment Evaluation of Basal Cell Carcinoma for Photodynamic Therapy: Comparative Measurement of Tumour Thickness in Punch Biopsy and Excision Specimens
Eidi Christensen, Patricia Mjønes, Olav A. Foss, Ole M. Rørdam, Eirik Skogvoll
Tumour thickness affects the outcome of photodynamic therapy in basal cell carcinoma (BCC). The aim of this study was to evaluate whether punch biopsy provides reliable information on BCC tumour thickness, by comparing corresponding measurements in biopsy and excision specimens for 48 lesions in 43 patients. BCC tumours were between 0.2 and 6.1 mm thick. The mean depth of the excisions were 0.14 ...
Pages: 651-654
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INVESTIGATIVE REPORT
Innovative Neurophysiological Methods in Itch Research: Long-latency Evoked Potentials after Electrical and Thermal Stimulation in Patients with Atopic Dermatitis
Marina M. Yudina, Galina G. Toropina, Andrey N. Lvov, Uwe Gieler
The aim of this study was to examine the findings of innovative neurophysiological methods of itch research. Short-latency and pain-related somatosensory-evoked potentials after electrical stimulation, as well as long-latency evoked potentials after thermal stimulation were studied in 38 patients with atopic dermatitis (AD) and 26 healthy volunteers. Quantitative Sensory Testing of thermal percept ...
Pages: 656-659
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INVESTIGATIVE REPORT
Validation of a Specific Health-related Quality of Life Instrument in a Large Cohort of Patients with Psoriasis: The QualiPso Questionnaire
Bruno Quintard, Aymery Constant, Marie-Laure Bouyssou-Gauthier, Carle Paul, François Truchetet, Pierre Thomas, Yves Guiguen, Alain Taieb
The aim of this study was to develop and validate a standardized tool designed to assess health-related quality of life (HRQoL) in a large cohort of French patients with psoriasis, the QualiPso Questionnaire. A draft question­naire was developed based on a literature review, followed by one-to-one interviews of 50 patients with psoriasis conducted by trained psychologists. The interview transcrip ...
Pages: 660-665
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INVESTIGATIVE REPORT
Patient–Doctor Interaction, Psychobehavioural Characteristics and Mental Disorders in Patients with Suspected Allergies: Do They Predict “Medically Unexplained Symptoms”?
Constanze Hausteiner-Wiehle, Martine Grosber, Esther Bubel , Sylvie Groben, Susanne Bornschein , Claas Lahmann , Florian Eyer, Bernadette Eberlein, Heidrun Behrendt , Bernd Löwe, Peter Henningsen, Dorothea Huber, Johannes Ring, Ulf Darsow
In approximately 20% of patients with suspected allergies, no organic symptom explanation can be found. Limited knowledge about patients with “medically unexplained symptoms (MUS)” contributes to them being perceived as “difficult” and being treated inadequately. This study examined the psychobehavioural characteristics of patients presenting for a diagnostic allergy work-up. Patients were ...
Pages: 666-673
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INVESTIGATIVE REPORT
Prevalence, correlates and characteristics of chronic pruritus: a population-based cross-sectional study
Uwe Matterne, Christian J. Apfelbacher, Adrian Loerbroks, Tamara Schwarzer, Marion Büttner, Robert Ofenloch, Thomas L. Diepgen, Elke Weisshaar
Pruritus is the most frequent symptom in dermatology. Its impact on quality of life is substantial. Epidemiological data on chronic pruritus (> 6 weeks) at the population level is sparse, but is important in order to understand the burden and risk factors of this distressing symptom. The aim of this population-based cross-sectional study was to estimate the point, 12-month and lifetime prevalenc ...
Pages: 674-679
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CLINICAL REPORT
Teledermatological Monitoring of Psoriasis Patients on Biologic Therapy
Silvia Koller, Rainer Hofmann-Wellenhof, Dieter Hayn, Wolfgang Weger, Peter Kastner, Günter Schreier, Wolfgang Salmhofer
Patients with psoriasis who are being treated with biologics require intensive monitoring. However, the monitoring tool teledermatology is not commonly used. We investigated the applicability of a mobile phone based teledermatological system for monitoring psoriasis patients on biologic therapy. Nineteen patients were given mobile phones with built-in cameras, in order to transmit health status da ...
Pages: 680-685
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CLINICAL REPORT
Abatacept is a Promising Treatment for Patients with Disseminated Morphea Profunda: Presentation of Two Cases
Birgitte Stausbøl-Grøn, Anne B. Olesen, Bent Deleuran, Mette S. Deleuran
Morphea profunda is a rare disease that mainly affects young women and often has a progressive course with physical and psychological sequelae. The skin becomes sclerotic after an initial inflammatory reaction and joint contractures can develop. The aetiology is unknown. Until now, no successful therapy has been proven for this morphea variant. On the basis of new insights into the key role of eff ...
Pages: 686-688
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CLINICAL REPORT
5-year Recurrence Rates of Mohs Micrographic Surgery for Aggressive and Recurrent Facial Basal Cell Carcinoma
John Paoli, Samuel Daryoni, Ann-Marie Wennberg, Lena Mölne, Martin Gillstedt, Marinko Miocic, Bo Stenquist
Mohs micrographic surgery allows for complete micro­scopic examination of the surgical margin when treating aggressive and recurrent facial basal cell carcinomas. This leads to the highest cure rates and maximal preservation of healthy tissue. The 5-year recurrence rates of 587 aggressive and/or recurrent facial basal cell carcinomas treated during 1993 to 2003 at our centre were studied retrospe ...
Pages: 689-693
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CLINICAL REPORT
Evaluation of an IFN-gamma Assay in the Diagnosis of Latent Tuberculosis in Patients with Psoriasis in a Highly Endemic Setting
Emerson de Andrade Lima, Mariana de Andrade Lima, Virgínia M. Barros de Lorena, Yara de Miranda Gomes, Omar Lupi, Gil Benard
Screening for latent tuberculosis infection is mandatory before starting anti-tumour necrosis factor treatments, but its diagnosis still poses a challenge. While studies performed in developed countries have demonstrated superior performance of T-cell based interferon-γ release assay (IGRA) compared with the tuberculin skin test, there is a debate about whether this holds true in tuberculosis end ...
Pages: 694-697
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CLINICAL REPORT
Lactase Deficiency: A Potential Novel Aetiological Factor in Chronic Pruritus of Unknown Origin
Sonja A. Grundmann, Ewelina Stratmann, Randolf Brehler, Thomas A. Luger, Sonja Ständer
Chronic pruritus, which is associated with a wide variety of underlying diseases, represents a challenge in diagnostics and treatment in dermatology and general medicine. The cause of pruritus remains unknown in up to 45% of patients. In this study, 718 patients with chronic pruritus were analysed concerning lactase deficiency, demographic data, aetiology, duration and intensity of pruritus. A tot ...
Pages: 698-703
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CLINICAL REPORT
Oral Lesion in Leprosy: Borderline Tuberculoid Diagnosis Based on Detection of Mycobacterium leprae DNA by qPCR
Talita da Silva Martinez, André A. Nahas, Márcia M.N.R. Figueira, Adeilson V. Costa, Maria A. Gonçalves, Luiz R. Goulart, Isabela M. B. Goulart
Oral lesions are rarely reported in paucibacillary forms of leprosy. We report here a case with an erythematous hyposensitive lesion in the palate and no skin lesions. In addition to routine tests, biopsies of the lesion in the palate and of clinically normal surrounding areas were performed and subjected to real-time PCR for detection of Mycobacterium leprae DNA. The biopsy of the oral lesion was ...
Pages: 704-707
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CLINICAL REPORT
Tinea Capitis and Tinea Corporis with a Severe Inflammatory Response due to Trichophyton tonsurans
Anita Hryncewicz-Gwóźdź, Vera Beck-Jendroschek, Jochen Brasch, Katarzyna Kalinowska, Tomasz Jagielski
Trichophyton tonsurans is an anthropophilic dermato­phyte, with a worldwide distribution, although its prevalence varies considerably between different geographical regions. Whereas in North America infections due to this fungus are exceptionally common, on the European continent they appear relatively seldom. Although T. tonsurans is primarily associated with tinea capitis, it can also be the ca ...
Pages: 708-710
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LETTER TO THE EDITOR
Lymphomatoid Papulosis Showing γδ T-cell Phenotype
Sohshi Morimura, Makoto Sugaya, Zenshiro Tamaki, Tomonori Takekoshi, Shinichi Sato
Abstract is missing (Letter)
Pages: 712-713
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LETTER TO THE EDITOR
An Unusual Missense Mutation in the GJB3 Gene Resulting in Severe Erythrokeratodermia Variabilis
Martin Glatz, Maurice A.M. van Steensel, Michel van Geel, Peter M. Steijlen, Peter Wolf
Abstract is missing (Letter)
Pages: 714-715
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LETTER TO THE EDITOR
Bosentan is Effective Against Digital Ulcerations and Hyperkeratosis in Systemic Sclerosis
Zsuzsanna Kurgyis, Rita Varga, Isabell Sick , Martin Ulrich Lang , Thomas Ruzicka, Miklós Sárdy
Abstract is missing (Letter)
Pages: 716-717
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LETTER TO THE EDITOR
A Case of Systemic Sclerosis with Sarcoidosis
Hiraku Suga, Yoshihide Asano, Zenshiro Tamaki, Mizuho Yamamoto, Makoto Sugaya, Jun Shimizu, Shinichi Sato
Abstract is missing (Letter)
Pages: 718-720
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LETTER TO THE EDITOR
Experimentally Confirmed Induction of Sweet’s Syndrome by Phototesting
Volker Meyer, Stefan W. Schneider, Gisela Bonsmann, Stefan Beissert
Abstract is missing (Letter)
Pages: 720-721
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LETTER TO THE EDITOR
Immunohistochemical Features of Merkel Cell Carcinoma in Correlation with Presence of Merkel Cell Polyomavirus DNA
Christian Andres, Benedetta Belloni , Teresa Jaeger, Ursula Puchta, Alexander Konstantinow, Johannes Ring, Michael J. Flaig
Abstract is missing (Letter)
Pages: 722-723
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LETTER TO THE EDITOR
Serum CXCL13 Chemokine is Not a Marker for Active Lyme Borreliosis
Nora Wutte, Andrea Berghold, Ingrid Krainberger , Elisabeth Aberer
Abstract is missing (Letter)
Pages: 724-725
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LETTER TO THE EDITOR
New Approach in Combined Therapy of Perifolliculitis Capitis Abscedens et Suffodiens
Felix Jacobs, Gisela Metzler, Jakub Kubiak, Martin Röcken, Martin Schaller
Abstract is missing (letter)
Pages: 726-727
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LETTER TO THE EDITOR
Multiple Follicular Pustules as an Atypical Cutaneous Manifestation of Drug-induced Hypersensitivity Syndrome
Yuri Ueharaguchi, Kenji Kabashima, Chihiro Shimizuhira, Wataru Nakajo, Takeshi Kondo, Toru Kamiya, Kunihiko Matsubara, Setsuko Kondo
Abstract is missing (letter)
Pages: 728-729
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LETTER TO THE EDITOR
Bullous Dermolysis of the Newborn and Dystrophic Epidermolysis Bullosa Pruriginosa within the Same Family: Two Phenotypes Associated with a COL7A1 Mutation
Kana Murase , Hiroyuki Kanoh, Norito Ishii, Takashi Hashimoto, Hajime Nakano, Daisuke Sawamura, Mariko Seishima
Abstract is missing (Letter)
Pages: 730-731
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LETTER TO THE EDITOR
A Fatal Case of Hot Air Sauna Burn in an Elderly Patient Initially Misdiagnosed as Bullous Pemphigoid
Nicolas Kluger, Johanna Laipio, Susanna Virolainen, Annamari Ranki, Virve Koljonen
Abstract is missing (Letter)
Pages: 732-733
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LETTER TO THE EDITOR
Acquired Angioedema Responding to Rituximab
Amr Hassan, Stéphanie Amarger, Arlette Tridon, Denise Ponard, Pierre Souteyrand , Michel D'Incan
Abstract is missing (Letter)
Pages: 733-734
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LETTER TO THE EDITOR
Photoallergic Erythroderma due to Doxycycline Therapy of Erythema Chronicum Migrans
Alexander V. Kuznetsov, Peter Weisenseel, Michael J. Flaig, Thomas Ruzicka, Joerg C. Prinz
Abstract is missing (Letter)
Pages: 734-736
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QUIZ
A Dermoscopic Figure of Polymorphous Atypical Vessels with Colour Gradation: A Quiz
Naoki Oiso, Masatomo Kimura, Akira Kawada
Abstract is missing (Quiz)
Pages: 737-740
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QUIZ
”Bathing Trunk” Eruption of Papules and Nodules in a Young Woman: A Quiz
Andrea Saggini, Alessandro Di Stefani, Rosita Saraceno, Sergio Chimenti
Abstract is missing (Quiz)
Pages: 737-740
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QUIZ
Palmoplantar Hyperkeratoses and Hypopigmentation: A Quiz
Astrid Schmieder, Ingrid Hausser, Stefan W. Schneider, Sergij Goerdt, Wiebke K. Peitsch
Abstract is missing (Quiz)
Pages: 737-740
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