Content

Content - Volume 92, Issue 1

Editor's choice in this issue

REVIEW
Psychoneuroimmunology of Psychological Stress and Atopic Dermatitis: Pathophysiologic and Therapeutic Updates
Andrea L. Suárez, Jamison D. Feramisco, John Koo , Martin Steinhoff
Atopic dermatitis is a chronic inflammatory skin disease characterized by impaired epidermal barrier function, inflammatory infiltration, extensive pruritus and a clinical course defined by symptomatic flares and remissions. The mechanisms of disease exacerbation are still poorly understood. Clinical occurrence of atopic dermatitis is often associated with psychological stress. In response to stre ...
Pages: 7-15
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INVESTIGATIVE REPORT
IL-31 Expression by Inflammatory Cells is Preferentially Elevated in Atopic Dermatitis
Stephan Nobbe, Piotr Dziunycz , Beda Mühleisen , Janine Bilsborough, Stacey R. Dillon, Lars E. French, Günther F.L. Hofbauer
Interleukin-31 (IL-31) is a recently discovered cytokine expressed in many human tissues, and predominantly by activated CD4+ T cells. IL-31 signals through a heterodimeric receptor consisting of IL-31 receptor alpha (IL-31RA) and oncostatin M receptor beta (OSMR). Earlier studies have shown involvement of IL-31 and its receptor components IL-31RA and OSMR in atopic dermatitis, pruritus and Th2-we ...
Pages: 24-28
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All articles

IN THIS ISSUE
IL-31 Expression by Inflammatory Cells is Preferentially Elevated in Atopic Dermatitis
Jens Malte Baron and Bernhard Lüscher
Pages: 5-6
Abstract  HTML  PDF
REVIEW
Psychoneuroimmunology of Psychological Stress and Atopic Dermatitis: Pathophysiologic and Therapeutic Updates
Andrea L. Suárez, Jamison D. Feramisco, John Koo , Martin Steinhoff
Atopic dermatitis is a chronic inflammatory skin disease characterized by impaired epidermal barrier function, inflammatory infiltration, extensive pruritus and a clinical course defined by symptomatic flares and remissions. The mechanisms of disease exacerbation are still poorly understood. Clinical occurrence of atopic dermatitis is often associated with psychological stress. In response to stre ...
Pages: 7-15
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Co-culture of Melanocytes with Adipose-derived Stem Cells as a Potential Substitute for Co-culture with Keratinocytes
Ji-Young Kim, Chan Do Park, Joon Ho Lee, Chang-Hoon Lee, Ai-Young Lee
Cell-to-cell interactions between melanocytes and keratinocytes increase the proliferation and migration of melanocytes. In fact, mixed keratinocyte and melanocyte cultures have been used for autologous cell transplantation for treatment of vitiligo. However, this may require taking an amount of skin tissue large enough to leave scars. In this study, the in vitro effect of adipose-derived stem cel ...
Pages: 16-23
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INVESTIGATIVE REPORT
IL-31 Expression by Inflammatory Cells is Preferentially Elevated in Atopic Dermatitis
Stephan Nobbe, Piotr Dziunycz , Beda Mühleisen , Janine Bilsborough, Stacey R. Dillon, Lars E. French, Günther F.L. Hofbauer
Interleukin-31 (IL-31) is a recently discovered cytokine expressed in many human tissues, and predominantly by activated CD4+ T cells. IL-31 signals through a heterodimeric receptor consisting of IL-31 receptor alpha (IL-31RA) and oncostatin M receptor beta (OSMR). Earlier studies have shown involvement of IL-31 and its receptor components IL-31RA and OSMR in atopic dermatitis, pruritus and Th2-we ...
Pages: 24-28
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Antimicrobial Effects of Plasma-mediated Bipolar Radiofrequency Ablation on Bacteria and Fungi Relevant for Wound Infection
Henrik H. Sönnergren, Louise Strömbeck, Jan Faergemann
Infection constitutes an important part of wound pathology and impedes wound healing. Plasma-mediated bipolar radiofrequency ablation (Coblation®) is a tissue-removal technique suggested for use in wound treatment. The aims of this study were to determine the antimicrobial effect of ablation exposure on bacteria and fungi relevant to wound infection, and how exposure time, temperature and aerobic ...
Pages: 29-33
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INVESTIGATIVE REPORT
Effects of Silver-based Wound Dressings on the Bacterial Flora in Chronic Leg Ulcers and Its Susceptibility In Vitro to Silver
Susanne Sütterlin, Eva Tano, Agneta Bergsten, Anna-Britta Tallberg, Åsa Melhus
Silver-based dressings have been used extensively in wound management in recent years, but data on their antimicrobial activity in the clinical setting are limited. In order to explore their effects on chronic leg ulcer flora, 14 ulcers were cultured after at least 3 weeks treatment with Aquacel Ag® or Acticoat®. Phenotypic and genetic silver resistance were investigated in a total of 56 isolate ...
Pages: 34-39
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INVESTIGATIVE REPORT
Prevalence of Acne Vulgaris in Chinese Adolescents and Adults: A Community-based Study of 17,345 Subjects in Six Cities
Yiwei Shen, Tinglin Wang, Cheng Zhou, Xiaoyan Wang, Xiaolan Ding, Shan Tian, Ying Liu, Guanghui Peng, Shuqi Xue, June Zhou, Renli Wang, Xuemei Meng, Guangde Pei, Yunhua Bai, Qing Liu, Hang Li, Jianzhong Zhang
Acne vulgaris is a common skin condition in adolescents. The prevalence of acne is thought to vary between ethnic groups and countries. A large-scale community-based study was performed in six cities in China to determine the prevalence and possible risk factors for acne in the Chinese population. A total of 17,345 inhabitants were included in this study. Of these, 1,399 were found to have acne. N ...
Pages: 40-44
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INVESTIGATIVE REPORT
Genital and Extra-genital Screening for Gonorrhoea using the BD Probetec ET System with an In-house PCR Method Targeting the porA Pseudogene as Confirmatory Test
Sissel Skovgaard , Helle Kiellberg Larsen, Carsten Sand, Alice Friis-Møller , Kristian Schønning , Jørgen Skov Jensen, Henrik Westh
Diagnosing gonorrhoea from extra-genital as well as genital sites is important in managing this sexually transmitted disease. In this study we evaluated a screening procedure for Neisseria gonorrhoeae (GC) from all sample sites in a low-prevalence setting. A total of 69,252 specimens submitted for Chlamydia trachomatis testing were also examined for GC on the BD Viper™ platform using the BD Prob ...
Pages: 45-49
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CLINICAL REPORT
Genotype–Phenotype Correlation in Chinese Patients with Dystrophic Epidermolysis Bullosa Pruriginosa
Wei Jiang, Ting-ting Sun, Peng-cheng Lei, Xue-jun Zhu
Dystrophic epidermolysis bullosa pruriginosa (DEB-Pr) is a rare variant of dystrophic epidermolysis bullosa (DEB) due to dominant or recessive mutations in the COL7A1 gene. More than 40 mutations in COL7A1 have been described in DEB-Pr. The aim of this study was to understand the genotype–phenotype correlation in Chinese patients with DEB-Pr. Three Chinese families with typical clinical features ...
Pages: 50-53
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CLINICAL REPORT
Metachronous Merkel Cell Carcinoma on Both Cheeks
Taisuke Kamiyama, Noboru Ohshima, Hiroyuki Satoh, Hitomi Fukumoto, Harutaka Katano, Sumihisa Imakado
Merkel cell carcinoma (MCC), an aggressive skin cancer with neuroendocrine features, has been found to be associated with a new type of human polyomavirus called Merkel cell polyomavirus (MCV). Patients diagnosed with MCC have a significantly increased risk of a second primary cancer. We report here the first case of two primary MCCs arising on the face at different times, associated with MCV inf ...
Pages: 54-56
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CLINICAL REPORT
Progressive Muscle Relaxation Therapy for Atopic Dermatitis: Objective Assessment of Efficacy
Byung Gi Bae, Sang Ho Oh, Chang Ook Park, Seongmin Noh, Ji Yeon Noh, Kyung Ran Kim, Kwang Hoon Lee
The aims of this study were to validate the efficacy of progressive muscle relaxation (PMR) in patients with atopic dermatitis and to evaluate the serological parameters that may serve as objective measures of the efficacy of PMR. A total of 25 patients with atopic dermatitis were randomly assigned to either a PMR group (n = 15) or a control group (n = 10). Serum levels of nerve growth, ne ...
Pages: 57-61
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CLINICAL REPORT
Profile and Pattern of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in a General Hospital in Singapore: Treatment Outcomes
Siew-Kiang Tan, Yong-Kwang Tay
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, but potentially life-threatening, reactions to medications. Both conditions have significant morbidity and mortality. The aim of this study was to document the epidemiological features, aetiologies, treatment and clinical outcomes of retrospectively reviewed data of all patients with SJS or TEN treated from January 2004 ...
Pages: 62-66
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CLINICAL REPORT
Patients with Psoriasis Feel Stigmatized
Ewa Hrehorów, Joanna Salomon, Łukasz Matusiak, Adam Reich, Jacek C. Szepietowski
Stigmatization is defined as having a discrediting mark that leads to social discrimination and alienation. The aim of this study was to estimate the level of stigmatization experienced by patients with psoriasis. A total of 102 individuals with psoriasis were recruited and was assessed using the 6-item Stigmatization Scale and the 33-item Feelings of Stigmatization Questionnaire. In addition, qua ...
Pages: 67-72
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CLINICAL REPORT
Rosacea Treatment with Intermediate-dose Isotretinoin: Follow-up with Erythema and Sebum Measurements
Meltem Uslu, Ekin Şavk, Göksun Karaman, Neslihan Şendur
Isotretinoin is one of the therapeutic options for rosacea. However, the response of erythema to treatment with isotretinoin is usually slow and incomplete with common (0.5–1 mg/kg/day) or low (10 mg/day) doses. This study investigated the efficacy of, and relapse on, 20 mg/day isotretinoin treatment in rosacea, with the aid of instrumental measurement of facial erythema and sebum levels. A 20 m ...
Pages: 73-77
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CLINICAL REPORT
Efficacy of Fluconazole and Nystatin in the Treatment of Vaginal Candida Species
Helen Priscila Rodrigues Martins , Mariana Clivati da Silva, Luciene Cássia Farias Paiva , Terezinha Inez Estivalet Svidzinski, Marcia Edilaine Lopes Consolaro
The aim of this study was to determine and compare the efficacy of treatment with fluconazole and nystatin in Brazilian women with vaginal Candida. In a population of 932 women, vaginal cultures were performed for yeasts, whether or not the women showed signs and symptoms of vulvovaginal candidiasis. Yeasts were isolated from 12.2% of the women (114/932): 53.2% of the yeasts were Candida albicans, ...
Pages: 78-82
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LETTER TO THE EDITOR
Characterization of Peripheral Natural Killer Cells and their Reduction in Drug-induced Hyper­sensitivity Syndrome
Kazunari Sugita, Kenji Kabashima, Yoshiki Tokura
Abstract is missing (letter)
Pages: 83-84
Abstract  PDF
LETTER TO THE EDITOR
Polymorphisms in the ATG16L1 Gene are Associated with Psoriasis Vulgaris
Konstantinos Douroudis, Külli Kingo, Tanel Traks, Ene Reimann, Kristi Raud, Ranno Rätsep, Rotraut Mössner, Helgi Silm, Eero Vasar, Sulev Kõks
Abstract is missing (letter)
Pages: 85-87
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LETTER TO THE EDITOR
Late-onset, Eruptive Syringoma in an Elderly Man: Correlation with Carbamazepine
Ayumi Korekawa, Koji Nakajima, Yohei Nishikawa, Yasushi Matsuzaki, Hajime Nakano, Daisuke Sawamura
Abstract is missing (letter)
Pages: 87-88
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LETTER TO THE EDITOR
Sequential Occurrence of Pemphigus Vulgaris and Palmoplantar Pustulosis: Possible Role of Cytokine Profile
Akihiko Asahina, Kazuko Uno, Hideki Fujita
Abstract is missing (Letter)
Pages: 89-90
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LETTER TO THE EDITOR
Disseminated Erosive Pustular Dermatosis also Involving the Mucosa: Successful Treatment with Oral Dapsone
Jamison D. Feramisco, Tobias George, Sarah E. Schulz, Huong Lan Ma, Dieter Metze, Martin Steinhoff
Abstract is missing (Letter)
Pages: 91-92
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LETTER TO THE EDITOR
A Case of Epidermolysis Bullosa Acquisita Associated with Laryngeal Stenosis
Yukiko Kiniwa, Atsuko Ashida, Atsuko Ohashi , Ryosuke Kitoh, Shunpei Fukuda, Takashi Hashimoto, Ryuhei Okuyama
Abstract is missing (Letter)
Pages: 93-94
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LETTER TO THE EDITOR
Allergic Nickel Dermatitis Caused by Shaving: Case Report and Assessment of Nickel Release from an Electric Shaver
Jacob P. Thyssen, Torkil Menné, Claus Zachariae
Abstract is missing (Letter)
Pages: 95-96
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LETTER TO THE EDITOR
Proliferative Nodule in Small Congenital Melanocytic Naevus After Childhood
Takahiro Kiyohara, Takahiro Sawai, Masanobu Kumakiri
Abstract is missing (Letter)
Pages: 96-97
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LETTER TO THE EDITOR
Primary Cutaneous Melanoma Arising in Agminated Melanocytic Nevi: CDKN2A and CDK4 Mutation Screening
Gisele G. Rezze, Alexandre Leon, Débora C. Silva, Rogério I. Neves, Gustavo C. Molina, Dirce M. Carraro, Gilles Landman, João P. Duprat
Abstract is missing (Letter)
Pages: 98-99
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LETTER TO THE EDITOR
High-dose Intravenous Immunoglobulin Monotherapy for Drug-induced Hypersensitivity Syndrome
Yukiko Kito, Taisuke Ito, Yoshiki Tokura, Hideo Hashizume
Abstract is missing (Letter)
Pages: 100-101
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LETTER TO THE EDITOR
Narrow-band Ultraviolet B Treatment for Diphenylcyclopropenone-induced Vitiliginous Lesions
Yu-Jin Oh, Min-Kyung Shin , Mu-Hyoung Lee
Abstract is missing (Letter)
Pages: 102-103
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LETTER TO THE EDITOR
Pustular Penile Pyoderma Gangrenosum Successfully Treated with Topical Tacrolimus Ointment
Christian Grønhøj Larsen, Jacob P. Thyssen
Abstract is missing (Letter)
Pages: 104-105
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LETTER TO THE EDITOR
Rapid Progression of Hidradenitis Suppurativa in the Lower Leg of a Patient with Psoriasis Vulgaris
Asuka Tanaka, Yasufumi Goto, Maiko Iwade, Hisashi Uhara, Ryuhei Okuyama
Abstract is missing (Letter)
Pages: 105-106
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LETTER TO THE EDITOR
Achromic Superficial Spreading Melanoma Accidentally Treated with Imiquimod
Edoardo Zattra, Roberto Salmaso, Elena Tonin, Mauro Alaibac
Abstract is missing (Letter)
Pages: 107-108
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QUIZ
A Brownish-grey Plaque with Ulceration on the Nasolabial Area: A Quiz
Yuichi Yoshida, Tatsushi Shiomi, Masahisa Shindo, Yoshiko Suyama, Bin Nakayama, Osamu Yamamoto
Abstract is missing (Quiz)
Pages: 109-112
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QUIZ
Bluish Pigmentation of the Gingiva in a Homeless Patient: A Quiz
Nicolas Kluger, Pierre Francès
Abstract is missing (Quiz)
Pages: 109-112
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QUIZ
Recurrent Boils of the Axilla and Groin: A Quiz
Kristina Ibler, Lars Erik Bryld, Preben Løvgreen Nielsen, Gregor B.E. Jemec
Abstract is missing (Quiz)
Pages: 109-112
Abstract  HTML  PDF