Content

Content - Volume 92, Issue 5

Editors choice in this issue

INVESTIGATIVE REPORT
Epidemiology of Non-hereditary Angioedema
Flemming Madsen, Jørn Attermann, Allan Linneberg
The prevalence of non-hereditary angioedema was investigated in a general population sample (n = 7,931) and in a sample of Danish patients (n = 7,433) tested for deficiency of functional complement C1 esterase inhibitor protein (functional C1 INH). The general population sample (44% response rate) reported a lifetime prevalence of 7.4% for angioedema. In both groups symptom ...
Pages: 475-479
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INVESTIGATIVE REPORT
Itch Severity and Quality of Life in Patients with Pruritus: Preliminary Validity of a Danish Adaptation of the Itch Severity Scale
Robert Zachariae, Ulrikke Lei, Merete Hædersdal, Claus Zachariae
The aim of this study was to examine the validity of a Danish adaptation of the Itch Severity Scale (ISS) by exploring the associations between pruritus severity, psychological symptoms, and quality of life in a consecutively recruited sample of 20 patients with atopic dermatitis, 20 with psoriasis, 20 with urticaria, 12 with genital pruritus, 11 with nephrogenic pruritus, and 20 controls with vas ...
Pages: 508-514
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INVESTIGATIVE REPORT
Decreased Expression of Semaphorin-3A, a Neurite-Collapsing Factor, is Associated With Itch in Psoriatic Skin
Kenzen Kou, Fumio Nakamura, Michiko Aihara, Huichin Chen, Katsuya Seto, Junko Komori-Yamaguchi, Takeshi Kambara, Yoji Nagashima, Yoshio Goshima, Zenro Ikezawa
Pruritus is a common symptom of psoriasis, which affects quality of life. This symptom accompanies the hyper­innervation of sensory C-fibres in psoriatic lesions. Two extracellular molecules, nerve growth factor (NGF) and semaphorin-3A, regulate C-fibre extension. In this study, the expression levels of these 2 molecules in biopsy specimens from psoriatic and healthy skin were quantified by immu ...
Pages: 521-528
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SPECIAL REPORT
European Guideline on Chronic Pruritus
Elke Weisshaar, Jacek C. Szepietowski, Ulf Darsow, Laurent Misery, Joanna Wallengren, Thomas Mettang, Uwe Gieler, Torello Lotti, Julien Lambert, P. Maisel, Markus Streit, Malcolm W. Greaves, Andrew J. Carmichael, Erwin Tschachler, Johannes Ring, Sonja Ständer
Pages: 563-581
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All articles

IN THIS ISSUE
Augmentation to Anaphylaxis: The Role of Aspirin and Physical Exercise as Co-factors
Florian Wölbing, Tilo Biedermann
Abstract is missing (In This Issue)
Pages: 451-453
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IN THIS ISSUE
The Evolution of Atopic Dermatitis
Kristian Thestrup-Pedersen
Abstract is missing (In This Issue)
Pages: 451-451
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IN THIS ISSUE
Assessment of Pruritus
Elke Weisshaar
Abstract is missing (In This Issue)
Pages: 453-454
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REVIEW
Relieving the Pruritus of Atopic Dermatitis: A Meta-analysis
Lindsay G. Sher, Jongwha Chang, Isha B. Patel, Rajesh Balkrishnan, Alan B. Fleischer Jr
The goal of this study was to perform a meta-analysis on randomized controlled trials of topical therapies compared against their vehicles, and systemic therapies compared against their placebos, and to record how these therapies changed the magnitude of pruritus associated with atopic dermatitis. A systematic search of the literature was performed using Medline, Embase, and the Cochrane Controlle ...
Pages: 455-461
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INVESTIGATIVE REPORT
Atopic Dermatitis, Attachment and Partnership: A Psychodermatological Case-control Study of Adult Patients
Jan Dieris-Hirche, Wolfgang E. Milch, Jörg Kupfer, Frank Leweke, Uwe Gieler
Adult patients with atopic dermatitis were examined from a psychodermatological perspective with respect to attachment attitudes and satisfaction with partnerships. In addition, the correlation between these variables and skin symptoms, as well as the skin-specific quality of life, was also studied. A total of 62 adult patients with atopic dermatitis were compared with a parallel control group wit ...
Pages: 462-466
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INVESTIGATIVE REPORT
Prevalence and Risk Factors for Atopic Dermatitis: A Cross-sectional Study of 6,453 Korean Preschool Children
Won Jun Choi , Joo Yeon Ko, Jin Wou Kim, Kwang Hoon Lee, Chun Wook Park, Kyu Han Kim, Myeung Nam Kim, Ai Young Lee, Sang Hyun Cho, Young Lip Park, Jee Ho Choi, Seong Jun Seo, Yang Won Lee, Joo Young Roh, Young Min Park, Dong Jae Kim, Young Suck Ro
The aims of this study were to evaluate the prevalence, severity and risk factors for atopic dermatitis in Korean pre­school children as determined by dermatological examination vs questionnaire survey. A total of 6,453 pre­school children from 59 kindergartens and 14 day-care centres were evaluated. Parents responded to an International Study of Asthma and Allergies in Childhood (ISAAC)-based q ...
Pages: 467-471
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INVESTIGATIVE REPORT
Prevalence and Severity of Atopic Dermatitis in Jeju Island: A Cross-sectional Study of 4,028 Korean Elementary Schoolchildren by Physical Examination Utilizing the Three-item Severity Score
Dae Suk Kim, Ju Hee Lee, Kwang Hoon Lee, Min-Geol Lee
The objective of this study was to evaluate the precise prevalence of atopic dermatitis (AD) in schoolchildren in Jeju Island in South Korea examined in 2009. Nine elementary schools were randomly selected from Jeju Island and a total of 4,028 schoolchildren were examined by a dermatologist. AD was diagnosed based on the Korean Atopic Dermatitis Research Group criteria for the disease. The severit ...
Pages: 472-474
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INVESTIGATIVE REPORT
Epidemiology of Non-hereditary Angioedema
Flemming Madsen, Jørn Attermann, Allan Linneberg
The prevalence of non-hereditary angioedema was investigated in a general population sample (n = 7,931) and in a sample of Danish patients (n = 7,433) tested for deficiency of functional complement C1 esterase inhibitor protein (functional C1 INH). The general population sample (44% response rate) reported a lifetime prevalence of 7.4% for angioedema. In both groups symptom ...
Pages: 475-479
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INVESTIGATIVE REPORT
Limited Influence of Aspirin Intake on Mast Cell Activation in Patients with Food-dependent Exercise-induced Anaphylaxis: Comparison Using Skin Prick and Histamine Release Tests
Atsushi Fukunaga, Hideki Shimizu, Mami Tanaka, Ayuko Kikuzawa, Mariko Tsujimoto, Akiko Sekimukai, Junji Yamashita, Tatsuya Horikawa, Chikako Nishigori
Food-dependent exercise-induced anaphylaxis (FDEIA) is a severe systemic syndrome induced by physical exercise after ingesting causative food. Aspirin is a well-known trigger for anaphylaxis in patients with FDEIA. Possible mechanisms by which symptoms are aggravated by aspirin include enhanced antigen absorption and mast cell activation. The aim of this study was to determine whether aspirin inta ...
Pages: 480-483
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INVESTIGATIVE REPORT
Impact of Age and Heterophilic Interference on the Basal Serum Tryptase, a Risk Indication for Anaphylaxis, in 1,092 Dermatology Patients
Sibylle Schliemann, Florian Seyfarth, Uta-Christina Hipler , Peter Elsner
A raised baseline serum tryptase is a risk indicator for anaphylactic reactions, especially in patients with hymenoptera venom allergy. Borderline elevations (> 11.4 μg/l) occur frequently and may necessitate invasive diagnostic procedures to rule out systemic mastocytosis. We retrospectively analysed 1,092 non-mastocytotic patients from our general dermatology clinic with respect to ag ...
Pages: 484-489
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LETTER TO THE EDITOR
Remission of Wheat-dependent Exercise-induced Anaphylaxis after the Cessation of Hydrolysed Wheat-containing Soap Usage
Kaori Ishii, Makiko Hiragun, Hiroaki Matsuo, Takaaki Hiragun, Michihiro Hide
Abstract is missing (Letter)
Pages: 490-491
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SPECIAL REPORT
Questionnaires to Assess Chronic Itch: A Consensus Paper of the Special Interest Group of the International Forum on the Study of Itch
Elke Weisshaar, Uwe Gieler, Jörg Kupfer, Masutaka Furue, Hidehisa Saeki, Gil Yosipovitch
Chronic itch affects millions of patients worldwide and has a significant impact on quality of life. The assessment of itch and its associated effects is a significant component of clinical practice in itch management. Despite itch being a common complaint, there are few studies describing the use of structured questionnaires for evaluation and measurement of itch and its sensory and affective dim ...
Pages: 493-496
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CLINICAL REPORT
Visual Analogue Scale: Evaluation of the Instrument for the Assess­ment of Pruritus
Adam Reich, Monika Heisig, Ngoc Quan Phan, Kenichi Taneda, Kenji Takamori, Satoshi Takeuchi, Masutaka Furue, Christine Blome, Matthias Augustin, Sonja Ständer, Jacek C. Szepietowski
The aim of this study was to evaluate the visual analogue scale (VAS) as a method of pruritus assessment. A total of 310 subjects with pruritic dermatoses (148 Caucasian subjects and 162 Asian subjects) were recruited. The patients assessed pruritus intensity using the horizontal and vertical VAS, numeric rating scale (NRS) and verbal rating scale (VRS). All scales showed very good reproducibility ...
Pages: 497-501
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CLINICAL REPORT
Assessment of Pruritus Intensity: Prospective Study on Validity and Reliability of the Visual Analogue Scale, Numerical Rating Scale and Verbal Rating Scale in 471 Patients with Chronic Pruritus
Ngoc Quan Phan, Christine Blome, Fleur Fritz, Joachim Gerss, Adam Reich, Toshiya Ebata, Matthias Augustin, Jacek C. Szepietowski, Sonja Ständer
The most commonly used tool for self-report of pruritus intensity is the visual analogue scale (VAS). Similar tools are the numerical rating scale (NRS) and verbal rating scale (VRS). In the present study, initiated by the International Forum for the Study of Itch assessing reliability of these tools, 471 randomly selected patients with chronic itch (200 males, 271 females, mean age 58.44 years) r ...
Pages: 502-507
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INVESTIGATIVE REPORT
Itch Severity and Quality of Life in Patients with Pruritus: Preliminary Validity of a Danish Adaptation of the Itch Severity Scale
Robert Zachariae, Ulrikke Lei, Merete Hædersdal, Claus Zachariae
The aim of this study was to examine the validity of a Danish adaptation of the Itch Severity Scale (ISS) by exploring the associations between pruritus severity, psychological symptoms, and quality of life in a consecutively recruited sample of 20 patients with atopic dermatitis, 20 with psoriasis, 20 with urticaria, 12 with genital pruritus, 11 with nephrogenic pruritus, and 20 controls with vas ...
Pages: 508-514
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INVESTIGATIVE REPORT
Opioid Modulation of Facial Itch- and Pain-related Responses and Grooming Behavior in Rats
Jessica M. Spradley, Auva Davoodi, Mirela Iodi Carstens, Earl Carstens
Intradermal facial injections of pruritogens or algogens elicit distinct behavioral hindlimb scratch or forelimb wiping responses in rodents. We systematically investigated the parameters and opioid modulation of these evoked behaviors and spontaneous facial grooming in rats. Serotonin (5-HT) elicited hindlimb scratch bouts with few wipes. Scratching was attenuated by the µ-opiate antagonist nalt ...
Pages: 515-520
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INVESTIGATIVE REPORT
Decreased Expression of Semaphorin-3A, a Neurite-Collapsing Factor, is Associated With Itch in Psoriatic Skin
Kenzen Kou, Fumio Nakamura, Michiko Aihara, Huichin Chen, Katsuya Seto, Junko Komori-Yamaguchi, Takeshi Kambara, Yoji Nagashima, Yoshio Goshima, Zenro Ikezawa
Pruritus is a common symptom of psoriasis, which affects quality of life. This symptom accompanies the hyper­innervation of sensory C-fibres in psoriatic lesions. Two extracellular molecules, nerve growth factor (NGF) and semaphorin-3A, regulate C-fibre extension. In this study, the expression levels of these 2 molecules in biopsy specimens from psoriatic and healthy skin were quantified by immu ...
Pages: 521-528
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LETTER TO THE EDITOR
Cutaneous Innervation and Itch in Keloids
Hong Liang Tey, Ben Maddison, Hui Wang, Yozo Ishiju, Amy McMichael, Malcolm Marks, Philip Willford, Daren Maruzivab, Dudley Ferdinando, Jo Dick, Gil Yosipovitch
Abstract is missing (Letter)
Pages: 529-531
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LETTER TO THE EDITOR
Prurigo Nodularis in Hepatitis C Infection: Result of an Occupational Disease?
Elke Weisshaar, Sonja Ständer
Abstract is missing (Letter)
Pages: 532-533
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CLINICAL REPORT
Notalgia Paraesthetica: A Descriptive Two-cohort Study of 65 Patients from Brazil and Germany
Timo Huesmann, Paulo R. Cunha, Nani Osada, Mario Huesmann, Tiago P. Zanelato, Ngoc Quan Phan, Gabriela M. Abreu Gontijo, Martin Marziniak, Sonja Ständer
Notalgia paraesthetica is a neuropathic pruritus on the back. The aim of this retrospective study was to examine patient characteristics in a consecutive cohort from Brazil and Germany. A total of 65 patients (49 women, 16 men; age range 25–80 years, mean 56.2 ± 12.7 years; median 57.0 years) were investigated in order to determine the spinal or peripheral origin of notalgia paraest ...
Pages: 535-540
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LETTER TO THE EDITOR
Epidemiology of Pruritus in France
Laurent Misery, Nora Rahhali, Antoine Duhamel, Charles Taieb
Abstract is missing (Letter)
Pages: 541-542
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INVESTIGATIVE REPORT
Itch and Pain in Adolescents are Associated with Suicidal Ideation: A Population-based Cross-sectional Study
Jon Anders Halvorsen, Florence Dalgard, Magne Thoresen, Espen Bjertness, Lars Lien
The association between itch and suicidal ideation has not been explored previously in the general population. The aim of the present study is to analyse the association between itch and suicidal ideation in adolescents, and to compare the findings with an expected association between pain and suicidal ideation in the same sample. A total of 4,744 adolescents were invited to join the questionnaire ...
Pages: 543-546
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INVESTIGATIVE REPORT
Itch, Stress and Self-efficacy Among 18-year-old Boys and Girls: A Norwegian Population-based Cross-sectional Study
Florence Dalgard, Robert Stern, Lars Lien, Stuart Hauser
Itch is the most common dermatological symptom and worsens with stress. The general belief of a person in their own ability to cope in stressful situations, known as self-efficacy, is relevant in the management of chronic diseases other than skin diseases. The aim of this study was to explore the association between perceived self-efficacy, itch and stress among late-stage adolescents. The study w ...
Pages: 547-552
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LETTER TO THE EDITOR
Do Patients With Chronic Pruritus Benefit From a Specialized Itch Clinic? A Patient Survey
Elke Weisshaar, Marion Büttner, Robert Ofenloch, Uwe Matterne
Abstract is missing (letter)
Pages: 553-554
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REVIEW
Systemic Kappa Opioid Receptor Agonists in the Treatment of Chronic Pruritus: A Literature Review
Ngoc Quan Phan, Tobias Lotts, Attila Antal, Jeffrey D. Bernhard, Sonja Ständer
Chronic pruritus is frequently refractory to currently available treatments. Studies suggest that pruritus may arise from an imbalance of the mu- and kappa-opioid receptor system activity in either the skin or the central nervous system. Stimulation of kappa-opioid receptors by their agonists inhibits pruritus in both animals and humans. The antipruritic effect of kappa-opioid receptors agonists c ...
Pages: 555-560
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LETTER TO THE EDITOR
Topical TRPM8 Agonist (Icilin) Relieved Vulva Pruritus Originating From Lichen Sclerosus et Atrophicus
Jung Hyun Han, Hoo-Kyun Choi, Seong J. Kim
Abstract is missing (Letter)
Pages: 561-562
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SPECIAL REPORT
European Guideline on Chronic Pruritus
Elke Weisshaar, Jacek C. Szepietowski, Ulf Darsow, Laurent Misery, Joanna Wallengren, Thomas Mettang, Uwe Gieler, Torello Lotti, Julien Lambert, P. Maisel, Markus Streit, Malcolm W. Greaves, Andrew J. Carmichael, Erwin Tschachler, Johannes Ring, Sonja Ständer
Pages: 563-581
Abstract  HTML  PDF