Content

Content - Volume 93, Issue 5

Editor's choice in this issue

CLINICAL REPORT
Increased Antidepressant Drug Exposure in Psoriasis Patients: A Longitudinal Population-based Cohort Study
Emmilia A. Dowlatshahi, Marlies Wakkee, Ronald M.C. Herings, Loes M. Hollestein, Tamar Nijsten
Psoriasis has a major impact on health-related quality of life. The present cohort study investigated the use of antidepressant drugs in psoriasis patients and a reference cohort, using pharmacy and hospitalization data from 1998 to 2008 for more than 2.5 million Dutch residents. Multivariate Cox regression was used to compare the risk of first antidepressant use, and Poisson regression to compare ...
Pages: 544-550
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Incidence and Determinants of Chronic Pruritus: A Population-based Cohort Study
Uwe Matterne, Christian J. Apfelbacher, Lena Vogelgsang, Adrian Loerbroks, Elke Weisshaar
Epidemiological data on chronic pruritus (> 6 weeks) in the general population are sparse. We aimed to provide data on the incidence and prevalence of chronic pruritus, and identify its determinants based on cross-sectional and longitudinal analyses. A cohort of 1,190 participants from a cross-sectional baseline-study (response rate: 57.8%) was followed up after one year. The questionnaire a ...
Pages: 532-537
Abstract  HTML  PDF
REVIEW
Management of Childhood Urticaria: Current Knowledge and Practical Recommendations
Helene Pite, Bettina Wedi, Luís Miguel Borrego, Alexander Kapp, Ulrike Raap
Urticaria, defined by the presence of wheals and/or angio-edema, is a common condition in children, prompting parents to consult physicians. For its successful management, paediatric-specific features must be taken into account, regarding the identification of eliciting triggers and pharmacological therapy. This review systematically discusses the current best-available evidence on spontaneous acu ...
Pages: 500-508
Abstract  HTML  PDF

All articles

EDITORIAL
Itch – Basic Science, Quality of Life and New Treatments
Hanna Norsted and Anders Vahlquist
Page: 499
Abstract  PDF
REVIEW
Management of Childhood Urticaria: Current Knowledge and Practical Recommendations
Helene Pite, Bettina Wedi, Luís Miguel Borrego, Alexander Kapp, Ulrike Raap
Urticaria, defined by the presence of wheals and/or angio-edema, is a common condition in children, prompting parents to consult physicians. For its successful management, paediatric-specific features must be taken into account, regarding the identification of eliciting triggers and pharmacological therapy. This review systematically discusses the current best-available evidence on spontaneous acu ...
Pages: 500-508
Abstract  HTML  PDF
SPECIAL REPORT
Pruritus Assessment in Clinical Trials: Consensus Recommendations from the International Forum for the Study of Itch (IFSI) Special Interest Group Scoring Itch in Clinical Trials
Sonja Ständer, Matthias Augustin, Adam Reich, Christine Blome, Toshiya Ebata, Ngoc Quan Phan, Jacek C. Szepietowski
Chronic pruritus is a common symptom and there is an urgent need to test new anti-pruritic substances in high-quality clinical trials. However, no widely accepted standardized and validated method for objectively measuring pruritus is yet available. A special interest group of the International Forum for the Study of Itch has been established to assess scoring methods and questionnaires for use in ...
Pages: 509-514
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Effects of Pimecrolimus Compared with Triamcinolone Acetonide Cream on Skin Barrier Structure in Atopic Dermatitis: a Randomized, Double-blind, Right–Left Arm Trial
Jens-Michael Jensen, Merle Weppner, Stephan Dähnhardt-Pfeiffer, Claudia Neumann, Matthias Bräutigam, Thomas Schwarz, Regina Fölster-Holst, Ehrhardt Proksch
Patients with atopic dermatitis (AD) have an epidermal barrier dysfunction, which allows invasion of allergens to occur. Stratum corneum skin barrier is formed by corneocytes and extracellular lipids extruded from the epidermal lamellar bodies. In a controlled, randomized, double-blinded, right–left comparison study we investigated the effect of pimecrolimus (PIM) cream compared with triamcinolo ...
Pages: 515-519
Abstract  HTML  PDF
INVESTIGATIVE REPORT
A Novel Topical Formulation Containing Strontium Chloride Significantly Reduces the Intensity and Duration of Cowhage-Induced Itch
Alexandru D.P. Papoiu, Rodrigo Valdes-Rodriguez, Leigh A. Nattkemper, Yiong-Huak Chan, Gary S. Hahn, Gil Yosipovitch
The aim of this double-blinded, vehicle-controlled study was to test the antipruritic efficacy of topical strontium to relieve a nonhistaminergic form of itch that would be clinically relevant for chronic pruritic diseases. Itch induced with cowhage is mediated by PAR2 receptors which are considered to play a major role in itch of atopic dermatitis and possibly other acute and chronic pruritic con ...
Pages: 520-526
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Systemically Elevated Th1-, Th2- and Th17-associated Chemokines in Psoriasis Vulgaris Before and After Ultraviolet B Treatment
Anna-Karin Ekman, Gunnthorunn Sigurdardottir, Maria Carlström, Natalja Kartul, Maria C. Jenmalm, Charlotta Enerbäck
Chemokines may contribute to the systemic inflammation that is linked to the increased risk of co-morbidities in patients with psoriasis. The aim of this study was to investigate circulating chemokines in patients with psoriasis and their relationship to disease severity. Analysis of plasma levels of chemokines in patients with psoriasis before narrowband ultraviolet B (UVB) therapy revealed incre ...
Pages: 527-531
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Incidence and Determinants of Chronic Pruritus: A Population-based Cohort Study
Uwe Matterne, Christian J. Apfelbacher, Lena Vogelgsang, Adrian Loerbroks, Elke Weisshaar
Epidemiological data on chronic pruritus (> 6 weeks) in the general population are sparse. We aimed to provide data on the incidence and prevalence of chronic pruritus, and identify its determinants based on cross-sectional and longitudinal analyses. A cohort of 1,190 participants from a cross-sectional baseline-study (response rate: 57.8%) was followed up after one year. The questionnaire a ...
Pages: 532-537
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Cost-of-illness Analysis of Patients with Chronic Hand Eczema in Routine Care in Germany: Focus on the Impact of Occupational Disease
Thomas L. Diepgen, Sandra Purwins, Jan Posthumus, Daniel Kuessner, Swen M. John, Matthias Augustin
Chronic hand eczema places a heavy burden on patients, often affecting their ability to work. This paper compares the cost-of-illness and treatment approaches for patients with refractory chronic hand eczema, in relation to whether the disease was occupational or unrelated to work factors. Data from 2 surveys, comprising 310 patients with chronic hand eczema insured by German statutory health insu ...
Pages: 538-543
Abstract  HTML  PDF
CLINICAL REPORT
Increased Antidepressant Drug Exposure in Psoriasis Patients: A Longitudinal Population-based Cohort Study
Emmilia A. Dowlatshahi, Marlies Wakkee, Ronald M.C. Herings, Loes M. Hollestein, Tamar Nijsten
Psoriasis has a major impact on health-related quality of life. The present cohort study investigated the use of antidepressant drugs in psoriasis patients and a reference cohort, using pharmacy and hospitalization data from 1998 to 2008 for more than 2.5 million Dutch residents. Multivariate Cox regression was used to compare the risk of first antidepressant use, and Poisson regression to compare ...
Pages: 544-550
Abstract  HTML  PDF
CLINICAL REPORT
Health-related Quality of Life in Psoriasis: Important Role of Personal Resources
Joanna Miniszewska, Zygfryd Juczyński, Alicja Ograczyk, Anna Zalewska
Many patients with psoriasis demonstrate psychological disturbances, including decreased health-related quality of life (HRQoL). The aim of this study was to evaluate selected personal resources and HRQoL in 168 in-patients with psoriasis vulgaris. The following questionnaires were used: Skindex-29, General Health Questionnaire, Coping with Skin Disease Scale, Acceptance of Illness Scale, Life Ori ...
Pages: 551-556
Abstract  HTML  PDF
CLINICAL REPORT
Proactive Treatment of Adult Facial Seborrhoeic Dermatitis with 0.1% Tacrolimus Ointment: Randomized, Double-blind, Vehicle-controlled, Multi-centre Trial
Tae-Wook Kim, Je-Ho Mun, Seung-Wook Jwa, Margaret Song, Hoon-Soo Kim, Hyun-Chang Ko, Moon-Bum Kim, Ki-Hoon Song, Sook-Kyung Lee, Jong-Keun Seo, Deborah Lee, Byung-Soo Kim
The effectiveness of intermittent topical tacrolimus to prevent relapse in patients with stabilized facial seborrhoeic dermatitis has not been evaluated. The aim of this study was to determine whether proactive use of 0.1% tacrolimus ointment can keep adult facial seborrhoeic dermatitis in remission. A total of 75 patients who had stabilized facial seborrhoeic dermatitis after 2 weeks’ (open-lab ...
Pages: 557-561
Abstract  HTML  PDF
CLINICAL REPORT
German Version of ItchyQoL: Validation and Initial Clinical Findings
Karoline Krause, Birgit Kessler, Karsten Weller, Jennifer Veidt, Suephy C. Chen, Peter Martus, Martin K. Church, Martin Metz, Marcus Maurer
Pruritus is a major symptom of numerous skin and systemic diseases and causes a substantial burden on patients’ quality of life (QoL). We report here the validation of the German version (GerItchyQoL) of the first pruritus-specific QoL instrument ItchyQoL. GerItchyQoL was created from the original version following standard protocols. It was completed by 308 patients with chronic pruritus of dif ...
Pages: 562-568
Abstract  HTML  PDF
CLINICAL REPORT
Nasal Tip Cutaneous Metastases Secondary to Lung Carcinoma: Three Case Reports and a Review of the Literature
Seung Min Chun, Young Chul Kim, Jee-Bum Lee, Seong-Jin Kim, Seung-Chul Lee, Young Ho Won, Sook Jung Yun
Cutaneous metastatic carcinoma of the nose is a rare presentation associated with lung cancer. We report here 3 cases of cutaneous metastatic carcinoma of the nose that originated from lung cancer. Two men, age 61 and 76 years, with lung cancers were referred for evaluation of a tumour on the tip of the nose. The third patient, a 57-year-old man, had developed a rosacea-like tumour on the tip of t ...
Pages: 569-572
Abstract  HTML  PDF
SHORT COMMUNICATION
Itch Characteristics in Five Dermatoses: Non-atopic Eczema, Atopic Dermatitis, Urticaria, Psoriasis and Scabies
Emilie Brenaut, Ronan Garlantezec, Karen Talour, Laurent Misery
Abstract is missing (Short)
Pages: 573-574
Abstract  HTML  PDF
SHORT COMMUNICATION
Clinical and Histopathological Features of Itch in Patients with Alopecia Areata
Takako Yamakoshi, Tsugunobu Andoh, Teruhiko Makino, Yasushi Kuraishi, Tadamichi Shimizu
Abstract is missing (Short)
Pages: 575-576
Abstract  HTML  PDF
SHORT COMMUNICATION
Evaluation of a Method for Detecting Metal Release from Gold; Cysteine Enhances Release
Cecilia Svedman, Birgitta Gruvberger, Jakob Dahlin, Lena Persson, Halvor Möller, Magnus Bruze
Abstract is missing (Short)
Pages: 577-578
Abstract  HTML  PDF
SHORT COMMUNICATION
Sporadic VACTERL Association in a Japanese Family with Sjögren-Larsson Syndrome
Takuya Takeichi, Kazumitsu Sugiura, Hidee Arai, Ken Ishii, Michihiro Kono, Masashi Akiyama
Abstract is missing (Short)
Pages: 579-580
Abstract  HTML  PDF
SHORT COMMUNICATION
An Unusual Form of Lupus Erythematosus Profundus Associated with Antiphospholipid Syndrome: Report of Two Cases
Satoru Arai, Kensei Katsuoka, Hikaru Eto
Abstract is missing (Short)
Pages: 581-582
Abstract  HTML  PDF
SHORT COMMUNICATION
Squamous Cell Carcinoma Arising from Keratitis–Ichthyosis–Deafness Syndrome
Hiroshi Mayama, Taku Fujimura, Masayuki Asano, Yumi Kambayashi, Yukikazu Numata, Setsuya Aiba
Abstract is missing (Short)
Pages: 583-584
Abstract  HTML  PDF
SHORT COMMUNICATION
A Novel Keratin 5 Mutation in an African Family with Epidermolysis Bullosa Simplex Indicates the Importance of the Amino Acid Located at the Boundary Site Between the H1 and Coil 1A Domains
Satoru Shinkuma, Wataru Nishie, Witold K. Jacyk, Ken Natsuga, Hideyuki Ujiie, Hideki Nakamura, Masashi Akiyama, Hiroshi Shimizu
Abstract is missing (Short)
Pages: 585-587
Abstract  HTML  PDF
SHORT COMMUNICATION
Efficacy of Adalimumab for the Treatment of Refractory Paediatric Acrodermatitis Continua of Hallopeau
Valentina Dini, Sabrina Barbanera, Marco Romanelli
Abstract is missing (Short)
Pages: 588-589
Abstract  HTML  PDF
SHORT COMMUNICATION
Pigmented Contact Dermatitis Secondary to Benzyl Salicylate
Uma Alagappan, Yong-Kwang Tay, Su-Ping Regina Lim
Abstract is missing (Short)
Pages: 590-590
Abstract  HTML  PDF
SHORT COMMUNICATION
Itchy Hair – Trichoknesis: A Variant of Trichodynia or a New Entity?
Adam Reich, Karolina Mędrek, Zygmunt Adamski, Jacek C. Szepietowski
Abstract is missing (Short)
Pages: 591-591
Abstract  HTML  PDF
SHORT COMMUNICATION
Atypical Shock and Skin Lesions Revealing Lymphoma
Marion Fenot, Vincent Lassalle, Hervé Maillard, Louis-Rémi De Ybarlucea, Philippe Celerier
Abstract is missing (Short)
Pages: 592-593
Abstract  HTML  PDF
SHORT COMMUNICATION
Transient Telangiectatic Purpura after Axillary Dissection: A Postoperative Phenomenon
Mette Eline Brunbjerg, Birgitte Kiil, Christian Vestergaard, Torben Steiniche, Birgitte Stausbøl-Grøn
Abstract is missing (Short)
Pages: 594-595
Abstract  HTML  PDF
SHORT COMMUNICATION
A Case of Tuberculous Cellulitis Lacking Epithelioid Granuloma
Shinichi Koba, Takeshi Okawa, Noriyuki Misago, Asuka Yokoyama, Yosuke Aoki, Shigehisa Aoki, Yutaka Narisawa
Abstract is missing (Short)
Pages: 596-597
Abstract  HTML  PDF