Content

Content - Volume 93, Issue 6

Editor's choice in this issue

CLINICAL REPORT
The Many Faces of Solitary and Multiple Erythema Migrans
Pernilla Eriksson, Marika T. Schröder, Kirsi Niiranen, Antti Nevanlinna, Jaana Panelius, Annamari Ranki
Case definitions for European Lyme disease have been published. However, multiple erythema migrans may pose a diagnostic challenge. Therefore, we retrospectively reviewed the clinical and serological findings and response to therapy in a cohort of consecutive 54 patients with PCR-confirmed erythema migrans, referred to a university dermatology clinic. The proportion of patients with multiple eryth ...
Pages: 693-700
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CLINICAL REPORT
The Importance of a Full Clinical Examination: Assessment of Index Lesions Referred to a Skin Cancer Clinic Without a Total Body Skin Examination Would Miss One in Three Melanomas
R. Benjamin Aldridge, Lisa Naysmith, Ee Ting Ooi, Caroline S. Murray, Jonathan L. Rees
Traditional clinical teaching emphasises the importance of a full clinical examination. In the clinical assessment of lesions that may be skin cancer, full examination allows detection of incidental lesions, as well as helping in the characterisation of the index lesion. Despite this, a total body skin examination is not always performed. Based on two prospective studies of over 1,800 sequential p ...
Pages: 689-692
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INVESTIGATIVE REPORT
Negative Pigment Network Identifies a Peculiar Melanoma Subtype and Represents a Clue to Melanoma Diagnosis: A Dermoscopic Study of 401 Melanomas
Sara Bassoli, Chiara Ferrari, Stefania Borsari, Francesca Giusti, Cristina Magnoni, Giovanni Pellacani, Stefania Seidenari
The dermoscopic descriptor ”negative pigment network” (NPN) has been reported in several types of melanocytic and non-melanocytic lesions, although it has a higher frequency of association with melanoma and Spitz naevus. In a study of 401 consecutive melanomas, excluding facial, acral and mucosal locations, the frequency and variability of NPN were investigated, and the results of NPN correlat ...
Pages: 650-655
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REVIEW
Acne: Risk Indicator for Increased Body Mass Index and Insulin Resistance
Bodo C. Melnik, Swen Malte John, Gerd Plewig
Acne appears to represent a visible indicator disease of over-activated mTORC1 signalling, an unfavour-able metabolic deviation on the road to serious common Western diseases of civilisation associated with increased body mass index and insulin resistance. Exaggerated mTORC1 signalling by Western diet explains the association of acne with increased body mass index, insulin resistance, and early on ...
Pages: 644-649
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All articles

EDITORIAL
Acne Vulgaris – Not Just Pimples!
Hanna Norsted
Page: 643
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EDITORIAL
Searching for Melanomas
Hanna Norsted
Page: 643
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REVIEW
Acne: Risk Indicator for Increased Body Mass Index and Insulin Resistance
Bodo C. Melnik, Swen Malte John, Gerd Plewig
Acne appears to represent a visible indicator disease of over-activated mTORC1 signalling, an unfavour-able metabolic deviation on the road to serious common Western diseases of civilisation associated with increased body mass index and insulin resistance. Exaggerated mTORC1 signalling by Western diet explains the association of acne with increased body mass index, insulin resistance, and early on ...
Pages: 644-649
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Negative Pigment Network Identifies a Peculiar Melanoma Subtype and Represents a Clue to Melanoma Diagnosis: A Dermoscopic Study of 401 Melanomas
Sara Bassoli, Chiara Ferrari, Stefania Borsari, Francesca Giusti, Cristina Magnoni, Giovanni Pellacani, Stefania Seidenari
The dermoscopic descriptor ”negative pigment network” (NPN) has been reported in several types of melanocytic and non-melanocytic lesions, although it has a higher frequency of association with melanoma and Spitz naevus. In a study of 401 consecutive melanomas, excluding facial, acral and mucosal locations, the frequency and variability of NPN were investigated, and the results of NPN correlat ...
Pages: 650-655
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INVESTIGATIVE REPORT
Microvessel Density and Expression of Vascular Endothelial Growth Factor and its Receptors in Different Subtypes of Primary Cutaneous B-cell Lymphoma
Marion Wobser, Claudia Siedel, Hermann Kneitz, Eva-Bettina Bröcker, Matthias Goebeler, Roland Houben, Eva Geissinger
A proangiogenic micromilieu is associated with a worse prognosis in systemic lymphoma. Hence, targeting the tumour microenvironment and its vasculature has evolved as a promising novel treatment strategy. The role of tumour neoangiogenesis in cutaneous B-cell lymphoma, however, has not yet been elucidated. Therefore, we examined the expression of vascular endothelial growth factor (VEGF) and its r ...
Pages: 656-662
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INVESTIGATIVE REPORT
Comparison of Immunosuppressive and Immunomodulatory Cells in Keratoacanthoma and Cutaneous Squamous Cell Carcinoma
Yumi Kambayashi, Taku Fujimura, Setsuya Aiba
An imbalance of immunosuppressive and immunomodulatory cells plays an important role in inhibiting the anti-tumour immune response in a tumour-bearing host. Among such cells, regulatory T cells (Tregs), together with immunosuppressive macrophages, such as CD163+ M2 macrophages, play roles in maintaining the tumour microenvironment. In contrast, interleukin-27 (IL-27) induces STAT1 and STAT3 activa ...
Pages: 663-668
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CLINICAL REPORT
Decreased Tissue and Serum Expression of Galectin-7 in Patients with Hypertrophic Scars
Sung Bin Cho, Jun-Sub Kim, Zhenlong Zheng, Min Ju Choi, Ihn Geun Choi, Hong Shik Oh, Keun Jae Ahn
Hypertrophic scars (HS) result from an imbalance between collagen biosynthesis and matrix degradation during wound healing. In this study a proteomics approach was used to compare the protein profiles of skin tissue obtained from patients with HS and healthy controls. One of the epidermal proteins, galectin-7 was markedly down-regulated in HS. Serum levels of galectin-7 in 27 patients with HS were ...
Pages: 669-673
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INVESTIGATIVE REPORT
Effect of Botulinum Toxin Concentration on Reduction in Sweating: A Randomized, Double-blind Study
Alma Rystedt, Mattias Karlqvist, Maria Bertilsson, Hans Naver, Carl Swartling
Dose–response studies of botulinum toxin for reduction of sweating are sparse in the literature. The aim of this study was to determine the most appropriate concentrations of Botox®, Dysport®, Xeomin® and NeuroBloc®, respectively, in order to achieve the greatest reduction in sweating, thus reducing the costs and increasing the safety of treatment. Four concentrations of each product were in ...
Pages: 674-678
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INVESTIGATIVE REPORT
Predictive Value of Obsessive Compulsive Symptoms Involving the Skin on Quality of Life in Patients with Acne Vulgaris
Yasin Bez, Yavuz Yesilova, Mustafa Arı, Mehmet Cemal Kaya, Gokay Alpak, Mahmut Bulut
Acne is one of the most common dermatological diseases, and obsessive compulsive disorder is among the most frequent psychiatric conditions seen in dermatology clinics. Comorbidity of these conditions may therefore be expected. The aim of this study was to measure obsessive compulsive symptoms and quality of life in patients with acne vulgaris, compare them with those of healthy control subjects, ...
Pages: 679-683
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INVESTIGATIVE REPORT
A Higher Score on the Dermatology Life Quality Index, Being on Systemic Treatment and Having a Diagnosis of Psoriatic Arthritis is Associated with Increased Costs in Patients with Plaque Psoriasis
Mats Ekelund, Lotus Mallbris, Susanne Qvitzau, Berndt Stenberg
The aim of this study was to examine the relationship between measures of disease severity and costs from a socie-tal perspective in patients with plaque psoriasis. Dermatologists in Sweden recruited 443 consecutive patients who had had no biological treatment during the past 12 months. Following a Psoriasis Area and Severity Index (PASI) assessment, subjects completed self-assessments on health s ...
Pages: 684-688
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CLINICAL REPORT
The Importance of a Full Clinical Examination: Assessment of Index Lesions Referred to a Skin Cancer Clinic Without a Total Body Skin Examination Would Miss One in Three Melanomas
R. Benjamin Aldridge, Lisa Naysmith, Ee Ting Ooi, Caroline S. Murray, Jonathan L. Rees
Traditional clinical teaching emphasises the importance of a full clinical examination. In the clinical assessment of lesions that may be skin cancer, full examination allows detection of incidental lesions, as well as helping in the characterisation of the index lesion. Despite this, a total body skin examination is not always performed. Based on two prospective studies of over 1,800 sequential p ...
Pages: 689-692
Abstract  HTML  PDF
CLINICAL REPORT
The Many Faces of Solitary and Multiple Erythema Migrans
Pernilla Eriksson, Marika T. Schröder, Kirsi Niiranen, Antti Nevanlinna, Jaana Panelius, Annamari Ranki
Case definitions for European Lyme disease have been published. However, multiple erythema migrans may pose a diagnostic challenge. Therefore, we retrospectively reviewed the clinical and serological findings and response to therapy in a cohort of consecutive 54 patients with PCR-confirmed erythema migrans, referred to a university dermatology clinic. The proportion of patients with multiple eryth ...
Pages: 693-700
Abstract  HTML  PDF
CLINICAL REPORT
Anxiety, Depression, Quality of Life and Patient Satisfaction in Acne Patients Treated with Oral Isotretinoin
Servando E. Marron, Lucia Tomas-Aragones, Santiago Boira
Oral isotretinoin is effective in the clinical control of acne, but the relationship between this treatment and its psychosocial impact on the patient has not been completely clarified. The aim of this study was to determine if the use of oral isotretinoin in total accumulated doses of 120 mg/kg in a sample of 346 patients with moderate acne was useful in controlling symptoms of anxiety and/or dep ...
Pages: 701-706
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CLINICAL REPORT
A Case of Rapidly Progressive, Fatal Mycosis Fungoides Presenting as a Haematoma-like Lesion
Tomoyasu Hattori, Akihiko Uchiyama, Osamu Tago, Yayoi Nagai, Osamu Ishikawa
Mycosis fungoides usually follows an indolent clinical course. We report here a rapidly progressive case of mycosis fungoides with peculiar clinical and histological features, presenting as a haematoma-like mass on the thigh accompanied by multiple reddish brown erythematous lesions on the trunk and extremities. Histopathologically, the erythematous lesions showed epidermotropism of atypical T lym ...
Pages: 707-710
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CLINICAL REPORT
Cutaneous Mycobacterium intracellulare Infection in an Immuno­competent Person
Lu Zhou , Hong-Sheng Wang, Su-Ying Feng, Qiu-Ling Wang
Mycobacterium intracellulare-caused pulmonary infections have mostly been reported in immunocompromised hosts, while cutaneous M. intracellulare infections are rare. We describe here an immunocompetent patient with cutaneous lesions due to M. intracellulare, which was diagnosed by acid-fast staining, in vitro culture, histopathology, and PCR-restriction fragment length polymorphism analysis and ge ...
Pages: 711-714
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SHORT COMMUNICATION
TIF1γ-overexpressing, Highly Progressive Endometrial Carcinoma in a Patient with Dermato-myositis Positive for Malignancy-associated Anti-p155/140 Autoantibody
Akira Kasuya, Yasuhito Hamaguchi, Manabu Fujimoto, Yoshiki Tokura
Abstract is missing (Short)
Pages: 715-716
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SHORT COMMUNICATION
Lymphocytic Infiltration of the Eyelid: Two Cases Responding to Tacrolimus and Topical Glucocorticoid
Dan Hao, QingSi Liu, Xiang Wen, Xian Jiang
Abstract is missing (Short)
Pages: 717-718
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SHORT COMMUNICATION
A Novel ATP2C1 Early Truncation Mutation Suggests Haploinsufficiency as a Pathogenic Mechanism in a Patient with Hailey-Hailey Disease
Akitaka Shibata, Kazumitsu Sugiura, Utako Kimura, Kenji Takamori, Masashi Akiyama
Abstract is missing (Short)
Pages: 719-720
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SHORT COMMUNICATION
Dental Infection as a Triggering Factor in Palmoplantar Pustulosis
Nobuyuki Kikuchi, Toshiyuki Yamamoto
Abstract is missing (Short)
Pages: 721-722
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SHORT COMMUNICATION
Detection of Human Papillomavirus Type 58 in Periungual Bowen’s Disease
Madoka Kato, Akira Shimizu, Tomoyasu Hattori, Masatoshi Abe, Hiroo Amano, Sei-ichiro Motegi, Osamu Ishikawa
Abstract is missing (Short)
Pages: 723-724
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SHORT COMMUNICATION
Recurrent Keratoacanthomas Developing after Spontaneous Resolution
Noriyuki Misago, Shinichi Koba, Yutaka Narisawa
Abstract is missing (Short)
Pages: 725-726
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SHORT COMMUNICATION
Netherton Syndrome with Multiple Non-melanoma Skin Cancers
Ella A.M. van der Voort, Errol P. Prens
Abstract is missing (Short)
Pages: 727-728
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SHORT COMMUNICATION
Metastatic Melanoma with Leukaemia-like Evolution
Antoine Bertolotti, Héléne Conte, Emmanuelle Amazan, Caroline Dutriaux, Khaled Ezzedine, Marie Parrens, Béatrice Vergier, Alain Taieb, Thomas Jouary
Abstract is missing (Short)
Pages: 729-730
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SHORT COMMUNICATION
A Case of Toxic Epidermal Necrolysis Induced by Allopurinol with Human Herpesvirus-6 Reactivation
Yuko Watanabe, Setsuko Matsukura, Yuji Isoda, Akiko Morita, Michiko Aihara, Takeshi Kambara
Abstract is missing (Short)
Pages: 731-732
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SHORT COMMUNICATION
Acute Generalized Exanthematous Pustulosis Induced by Paroxetine in an Adolescent Girl
Chiara Mameli, Gianluca Tadini, Dario Cattaneo, Chiara Cerini, Gian Vincenzo Zuccotti
Abstract is missing (Short)
Pages: 733-734
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SHORT COMMUNICATION
Acquired Reactive Perforating Collagenosis: A Rare Association with Dermatomyositis
Nobuyuki Kikuchi, Mikio Ohtsuka, Toshiyuki Yamamoto
Abstract is missing (Short)
Pages: 735-736
Abstract  HTML  PDF
SHORT COMMUNICATION
A Case of Atypical Fibrous Histiocytoma with Positivity for CD163 and CD44
Kanako Tsunoda, Kazuhiro Takahashi, Fumihiko Maeda, Hiroki Oikawa, Toshihide Akasaka
Abstract is missing (Short)
Pages: 737-738
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SHORT COMMUNICATION
Clinical Phenotypes and ABCC6 Gene Mutations in Brazilian Families with Pseudoxanthoma Elasticum
Caroline Silvério Faria, Qiaoli Li, Haitao Guo, Jouni Uitto, Sylvia Satomi Takeno, Marilia de Arruda Cardoso Smith, Dertia Villalba Freire-Maia
Abstract is missing (Short)
Pages: 739-740
Abstract  HTML  PDF
SHORT COMMUNICATION
Diagnostic and Molecular Genetic Challenges in Male Incontinentia Pigmenti: A Case Report
Pernille A. Gregersen, Mette Sommerlund, Mette Ramsing, Hans Gjørup, Anders A. Rasmussen, Anni Aggerholm
Abstract is missing (letter)
Pages: 741-742
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SHORT COMMUNICATION
A Mutational Hotspot in CYLD Causing Cylindromas: A Comparison of Phenotypes Arising in Different Genetic Backgrounds
Nikoletta Nagy, Neil Rajan, Katalin Farkas, Ágnes Kinyó, Lajos Kemény, Márta Széll
Abstract is missing (Short)
Pages: 743-745
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SHORT COMMUNICATION
Benign Symmetric Lipomatosis of the Medial Knees: A Case Report
Hiroo Amano, Chikako Kishi, Akira Shimizu, Osamu Ishikawa
Abstract is missing (Short)
Pages: 745-746
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SHORT COMMUNICATION
Onychomycosis as a Warning Sign for Peripheral Arterial Disease
Atsushi Fukunaga, Ken Washio, Kanako Ogura, Kumiko Taguchi, Kohji Chiyomaru, Yoshiharu Ohno, Taro Masaki, Hiroshi Nagai, Tohru Nagano, Masahiro Oka, Chikako Nishigori
Abstract is missing (Short)
Pages: 747-748
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SHORT COMMUNICATION
Atopic Dermatitis and Non-atopic Hand Eczema Have Similar Negative Impacts on Quality of Life: Implications for Clinical Significance
Yin-Chun Chen, Ching-Shuang Wu, Yi-Wei Lu, Wan-Chen Li, Ying-Chin Ko, Hsin-Su Yu, Gwo-Shing Chen, Cheng-Che E. Lan
Abstract is missing (Short)
Pages: 749-750
Abstract  HTML  PDF
SHORT COMMUNICATION
Dermoscopic Characteristics of Acquired Melanocytic Naevus in Childhood Affecting the Acral Region
Akane Minagawa, Hiroshi Koga, Hisashi Uhara, Ryuhei Okuyama
Abstract is missing (Short)
Pages: 751-752
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SHORT COMMUNICATION
A Case of Drug Reaction with Eosinophilia and Systemic Symptoms Induced by Ethambutol with Early Features Resembling Stevens-Johnson Syndrome
Ju-Young Kim, Kyoung-Hee Sohn, Woo-Jung Song, Hye-Ryun Kang
Abstract is missing (Short)
Pages: 753-754
Abstract  HTML  PDF
SHORT COMMUNICATION
Eosinophilic Cellulitis Induced by Subcutaneous Administration of Interferon-β
Yumi Kambayashi, Taku Fujimura, Masaya Ishibashi, Takahiro Haga, Setsuya Aiba
Abstract is missing (Short)
Pages: 755-756
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SHORT COMMUNICATION
Erosive Pustular Dermatosis of the Arm Following Burn Injury
Hiromi Mizutani, Mitsuhiro Suehiro, Yasutaro Okuzawa, Koji Masuda, Norito Katoh
Abstract is missing (Short)
Pages: 757-758
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SHORT COMMUNICATION
Recurrent High-risk Human Papillomavirus-induced Anogenital Dysplasia in Chronic Idiopathic CD4+ T Lymphocytopaenia
Alexander Kreuter, Ulrike Wieland, Monika Hampl
Abstract is missing (Short)
Pages: 759-760
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SHORT COMMUNICATION
Reactivation of Herpes Simplex Virus and Cytomegalovirus in a Case of Thymoma-associated Graft-versus-host Disease-like Erythroderma
Teruasa Murata, Mizue Yamamoto , Satoshi Kore-eda, Teruhisa Azuma , Kenji Kabashima, Kazumasa Morita
Abstract is missing (Short)
Pages: 761-762
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QUIZ
An Erythematous Plaque on the Breast: A Quiz
Hanako Koguchi, Ken Arita, Shinichi Nakazato, Reine Moriuchi, Naoko Yamane, Satoru Shinkuma, Kazuko Matsumura, Hiroshi Shimizu
Abstract is missing (Quiz)
Pages: 763-765
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QUIZ
Gigantic Erythematous Plaques with Violaceous Oedematous Borders: A Quiz
Norma Mechow , Ioana Cosgarea , Edward Ogwang , Ingolf Franke, Harald P. Gollnick, Sven R. Quist
Abstract is missing (Quiz)
Pages: 763-765
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LETTER TO THE EDITOR
Skin Cancer After Solid Organ Transplantation
Behzad Einollahi, Zohreh Rostami
Abstract is missing (Letter)
Pages: 766-766
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