Content

Content - Volume 94, Issue 5

Editors choice in this issue

INVESTIGATIVE REPORT
The Incidence of Melanoma is Increasing in the Susceptible Young Australian Population
Douglas Czarnecki
The number of melanomas removed from Australians is increasing. Despite this, it has been reported that the incidence of melanoma is decreasing in the young Australian population. However, the denominator for these estimates includes individuals at low risk of melanoma, and the proportion of such individuals has changed over recent decades due to immigration. In this study, the incidence was ca ...
Pages: 539-541
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CLINICAL REPORT
Efficacy of Fluorescence Diagnosis-guided Mohs Micrographic Surgery for Pigmented vs Non-pigmented Basal Cell Carcinoma
Su-Young Jeon, Ki-Ho Kim, Ki-Hoon Song
Pigmented basal cell carcinoma (PBCC) occurs more frequently in Asian population. The efficacy of fluore-scence diagnosis (FD) for PBCCs treated with Mohs micrographic surgery has not yet been determined. This study enrolled 255 patients with 258 biopsy-proven BCC lesions: 199 PBCCs (77.1%) and 59 non-PBCCs (22.9%). We compared the clinicopathological and surgical features of the PBCCs and non-PBC ...
Pages: 568-573
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CLINICAL REPORT
Implementing Best Practice in Psoriasis: A Nordic Expert Group Consensus
Knud Kragballe, Robert Gniadecki, Nils-Jørgen Mørk, Tapio Rantanen, Mona Ståhle
In the absence of Nordic-wide guidelines on the best practice management of psoriasis, this paper aims to provide Nordic recommendations for treatment goals, evaluation of quality of life impact and assessment/management of co-morbidities. This Delphi approach consisted of telephone interviews, local Nordic face-to-face meetings, and a Nordic-wide meeting, in which questions on treatment goals, qu ...
Pages: 547-552
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All articles

DEBATE ARTICLE
The Death of the Scientific Journal?
Hanna Norsted
Abstract is missing
Page: 500
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REVIEW
Microdialysis of Inflammatory Mediators in the Skin: A Review
Kamelia J. Hersini, Line Melgaard, Parisa Gazerani, Lars J. Petersen
Skin microdialysis is an established method for in vivo sample collection from the extracellular fluid space. This method has been extensively used in studies of inflammatory reactions in the skin of animals and humans. Skin microdialysis consists of the implantation of semi-permeable probes into the upper dermis, perfusion with a physiological buffer, and the recovery of the substances that diffu ...
Pages: 501-511
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INVESTIGATIVE REPORT
Calcipotriol Increases hCAP18 mRNA Expression but Inhibits Extracellular LL37 Peptide Production in IL-17/IL-22-stimulated Normal Human Epidermal Keratinocytes
Jun-ichi Sakabe, Takatsune Umayahara , Mizuho Hiroike, Takatoshi Shimauchi, Taisuke Ito, Yoshiki Tokura
Interleukins (IL)-17A and -22 are involved in the patho-genesis of psoriasis. Cathelicidin LL37 serves as not only antimicrobial peptide but also as autoinflammatory mediator. 1,25-Dihydroxyvitamin D3 analogues, such as calcipotriol, are used as topical treatment for psoriasis. However, the effect of calcipotriol on the mRNA expression/production of human cathelicidin antimicrobial protein (hCAP18 ...
Pages: 512-516
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INVESTIGATIVE REPORT
High Incidence of Naevi-associated BRAF Wild-type Melanoma and Dysplastic Naevi under Treatment with the Class I BRAF Inhibitor Vemurafenib
Daniela Göppner, Jan Müller, Sabine Krüger, Ingolf Franke, Harald Gollnick, Sven R. Quist
There is growing evidence that not only malign keratinocytic but also melanocytic tumours can arise during treatment with vemurafenib. During an on-going early access trial, 13 patients harbouring a BRAF-V600E mutation received vemurafenib (Zelboraf®) 960 mg twice daily to test the safety, tolerability, efficacy and response rate for advanced melanoma. Clinically or dermatoscopically suspicious c ...
Pages: 517-520
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INVESTIGATIVE REPORT
Effect of Dietary Supplementation with Omega-3 Fatty Acid and Gamma-linolenic Acid on Acne Vulgaris: A Randomised, Double-blind, Controlled Trial
Jae Yoon Jung, Hyuck Hoon Kwon, Jong Soo Hong, Ji Young Yoon, Mi Sun Park, Mi Young Jang, Dae Hun Suh
This study was undertaken to evaluate the clinical efficacy, safety, and histological changes induced by dietary omega-3 fatty acid and γ-linoleic acid in acne vulgaris. A 10-week, randomised, controlled parallel dietary intervention study was performed in 45 participants with mild to moderate acne, which were allocated to either an omega-3 fatty acid group (2,000 mg of eicosapentaenoic acid ...
Pages: 521-525
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INVESTIGATIVE REPORT
Genes Involved in Epithelial Differentiation and Development are Differentially Expressed in Oral and Genital Lichen Planus Epithelium Compared to Normal Epithelium
Karin Danielsson, Philip J. Coates, Majid Ebrahimi, Elisabet Nylander, Ylva Britt Wahlin, Karin Nylander
Lichen planus (LP) is a chronic mucocutaneous disease with unknown cause. Patients with LP often have both oral and genital lesions, but these conditions are often considered as separate diseases and treated accordingly. To find out which genes are differently expressed in mucosal LP compared to normal mucosa and establish whether oral and genital LP are in fact the same disease, whole genome expr ...
Pages: 526-530
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INVESTIGATIVE REPORT
A Retrospective Study of Clinical and Mutational Findings in 45 Danish Families with Ectodermal Dysplasia
Mathias Tiedemann Svendsen, Emil Henningsen, Jens Michael Hertz, Dorthe Vestergaard Grejsen, Anette Bygum
Ectodermal dysplasias form a complex, nosologic group of diseases with defects in at least 2 ectodermal structures. A retrospective study of patients with ectodermal dysplasia seen at our department over a period of 19 years (1994–2013) was performed. The study population consisted of 67 patients covering 17 different diagnoses. Forty-five families were identified of which 26 were sporadic cases ...
Pages: 531-533
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INVESTIGATIVE REPORT
Clonality and Anatomic Distribution on the Skin of Antibiotic Resistant and Sensitive Propionibacterium acnes
Hans B. Lomholt, Mogens Kilian
Increasing antibiotic resistance in the population of Propionibacterium acnes is a major concern. Our aims were to examine the clonal relationships and anatomical distribution of resistant and sensitive P. acnes. A collection of 350 P. acnes isolates was therefore used to determine the minimum inhibitory concentration of tetracycline, erythro-mycin and clindamycin, multilocus sequence type, and th ...
Pages: 534-538
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INVESTIGATIVE REPORT
The Incidence of Melanoma is Increasing in the Susceptible Young Australian Population
Douglas Czarnecki
The number of melanomas removed from Australians is increasing. Despite this, it has been reported that the incidence of melanoma is decreasing in the young Australian population. However, the denominator for these estimates includes individuals at low risk of melanoma, and the proportion of such individuals has changed over recent decades due to immigration. In this study, the incidence was ca ...
Pages: 539-541
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CLINICAL REPORT
The Clinical Spectrum of Lichen Sclerosus in Male Patients – A Retrospective Study
Despina Kantere, Gun-Britt Löwhagen, Gunilla Alvengren, Anna Månesköld, Martin Gillstedt, Petra Tunbäck
Lichen sclerosus (LS) is a chronic dermatosis mainly localised to the anogenital area. The aim of this study was to investigate the clinical features of LS in adult men. A retrospective analysis of records from 771 patients diagnosed with LS was made and a questionnaire was sent to all patients. The results showed that the clinical spectrum was wide. Itch, tenderness and pain were frequently repor ...
Pages: 542-546
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CLINICAL REPORT
Implementing Best Practice in Psoriasis: A Nordic Expert Group Consensus
Knud Kragballe, Robert Gniadecki, Nils-Jørgen Mørk, Tapio Rantanen, Mona Ståhle
In the absence of Nordic-wide guidelines on the best practice management of psoriasis, this paper aims to provide Nordic recommendations for treatment goals, evaluation of quality of life impact and assessment/management of co-morbidities. This Delphi approach consisted of telephone interviews, local Nordic face-to-face meetings, and a Nordic-wide meeting, in which questions on treatment goals, qu ...
Pages: 547-552
Abstract  HTML  PDF
CLINICAL REPORT
The Influence of Body Weight on the Prevalence and Severity of Hidradenitis Suppurativa
Charles Kromann, Kristina S. Ibler, Viggo Kristiansen, Gregor B.E. Jemec
The prevalence of hidradenitis suppurativa (HS) has been estimated to be 1% of the population. Obesity is considered a co-morbidity, but the prevalence of HS in obese population is not known. A retrospective questionnaire was distributed to 383 patients over 2 years after bariatric surgery. Data on pre- and post-surgery HS symptoms and disease severity were studied. Disease severity was assessed b ...
Pages: 553-557
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CLINICAL REPORT
Hair Zinc Levels and the Efficacy of Oral Zinc Supplementation in Patients with Atopic Dermatitis
Jeong Eun Kim, Seo Rye Yoo, Myeong Gil Jeong, Joo Yeon Ko, Young Suck Ro
Zinc deficiency in patients with atopic dermatitis (AD) and the use of zinc supplementation is still controversial. We measured hair zinc levels in 58 children with AD and 43 controls (age range 2–14 years). We also investigated the efficacy of oral zinc supplementation in AD patients with low hair zinc levels by comparing eczema assessment severity index (EASI), transepidermal water loss (TEWL) ...
Pages: 558-562
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CLINICAL REPORT
The Proportion of Lymphocytic Inflammation with CD123-positive Cells in Lupus Erythematous Profundus Predict a Clinical Response to Treatment
Azusa Miyashita, Satoshi Fukushima, Takamitsu Makino, Yuichiro Yoshino, Junji Yamashita, Noritoshi Honda, Jun Aoi, Asako Ichihara, Masatoshi Jinnin, Yuji Inoue, Hironobu Ihn
Lupus erythematosus profundus is a rare inflammatory disorder of subcutaneous fat in patients with lupus ery-thematosus. Previous reports suggested that plasmacytoid dendritic cells, which expressed CD123 and CD303 antigens, play a central proinflammatory role in the patho-genesis of lupus erythematosus. To find the factors that determine the response to treatment, we analysed 23 skin specimens fr ...
Pages: 563-567
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CLINICAL REPORT
Efficacy of Fluorescence Diagnosis-guided Mohs Micrographic Surgery for Pigmented vs Non-pigmented Basal Cell Carcinoma
Su-Young Jeon, Ki-Ho Kim, Ki-Hoon Song
Pigmented basal cell carcinoma (PBCC) occurs more frequently in Asian population. The efficacy of fluore-scence diagnosis (FD) for PBCCs treated with Mohs micrographic surgery has not yet been determined. This study enrolled 255 patients with 258 biopsy-proven BCC lesions: 199 PBCCs (77.1%) and 59 non-PBCCs (22.9%). We compared the clinicopathological and surgical features of the PBCCs and non-PBC ...
Pages: 568-573
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CLINICAL REPORT
Livedoid Vasculopathy: Clinical Features and Treatment in 24 Chinese Patients
Suiying Feng, Wei Su, Peiying Jin , Changgeng Shao
Livedo vasculopathy (LV) is a chronic cutaneous disorder characterised by recurrent, painful ulceration ending in stellate scars. We have conducted a retrospective study of clinical features and treatment response of LV in 24 Chinese patients. LV occurred more frequently in women (male:female ratio  1:3). The peak age at onset of disease ranged from 14 to 20 years, younger than previously publ ...
Pages: 574-578
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CLINICAL REPORT
Early Immunopathological Diagnosis of Ichthyosis with Confetti in Two Sporadic Cases with New Mutations in Keratin 10
Andrea Diociaiuti, Paola Fortugno, May El Hachem, Corrado Angelo, Vittoria Proto, Naomi De Luca, Diego Martinelli, Renata Boldrini, Daniele Castiglia, Giovanna Zambruno
Ichthyosis with confetti (IC) is a severe non-syndromic ichthyosis due to heterozygous mutations in the KRT10 gene. The disease manifests at birth with erythroderma and scaling and is characterised by the gradual development of numerous confetti-like spots of normal skin. Diag-nosis of IC is frequently delayed until adolescence or even adulthood. We report 2 young children who were first diagnosed ...
Pages: 579-582
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SHORT COMMUNICATION
Increased Risk of Malignant Melanoma in Patients with Systemic Mastocytosis?
Hans Hägglund, Birgitta Sander, Theo Gülen, Bernt Lindelöf, Gunnar Nilsson
Abstract is missing (Short)
Pages: 583-584
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SHORT COMMUNICATION
Treatment of Generalised Vitiligo with Tacrolimus 0.1% Ointment vs. UVB Intense Pulsed Light Phototherapy: A Pilot Study
Anke Hartmann, Lisa Löhberg, Petra Keikavoussi, Saskia Eichner, Gerold Schuler
Abstract is missing (Short)
Pages: 585-587
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SHORT COMMUNICATION
Genetic Analysis of CARD14 in Non-familial Pityriasis Rubra Pilaris: A Case Series
Jin-Bon Hong, Pei-Lung Chen, You-Tzung Chen, Tsen-Fang Tsai
Abstract is missing (Short Communication)
Pages: 587-588
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SHORT COMMUNICATION
Novel TGM1 Missense Mutation p.Arg727Gln in a Case of Self-healing Collodion Baby
Kana Tanahashi, Kazumitsu Sugiura, Kenji Asagoe, Yumi Aoyama, Keiji Iwatsuki, Masashi Akiyama
Abstract is missing (Short)
Pages: 589-590
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SHORT COMMUNICATION
Lethal Form of Keratitis–Ichthyosis–Deafness Syndrome Caused by the GJB2 Mutation p.Ser17Phe
Juliette Mazereeuw-Hautier, Christine Chiaverini, Nathalie Jonca, Eric Bieth, Isabelle Dreyfus, Aude Maza, Nathalie Cardot-Leccia, Christophe Perrin, Jean-Philippe Lacour
Abstract is missing (Short Communication)
Pages: 591-592
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SHORT COMMUNICATION
Dermoscopic Features of Plasma Cell Cheilitis and Actinic Cheilitis
Takamasa Ito, Ken Natsuga, Shintaro Tanimura, Satoru Aoyagi, Hiroshi Shimizu
Abstract is missing (Short)
Pages: 593-594
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SHORT COMMUNICATION
Increased Expression of S100A6 in Malignant Granular Cell Tumours
Yasutaka Mitamura, Takamichi Ito, Misa Nakano-Nakamura, Hiroshi Uchi, Yoichi Moroi, Masutaka Furue
Abstract is missing (Short)
Pages: 595-596
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SHORT COMMUNICATION
Human Papillomaviruses in Anogenital Epithelial Lesions
Madoka Kato, Akira Shimizu, Yuko Takeuchi, Tomoyasu Hattori, Masatoshi Abe, Hiroo Amano, Sei-ichiro Motegi, Atsushi Tamura, Osamu Ishikawa
Abstract is missing (Short)
Pages: 597-599
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SHORT COMMUNICATION
Coexistence of Eccrine Squamous Syringometaplasia and Graft-Versus-Host Disease in a Patient with Secondary Myelodysplastic Syndrome
Raquel Carrascosa, Maria Concha, Javier Sánchez-Pérez, Maximiliano Aragües, Javier Fraga
Abstract is missing (Short)
Pages: 599-600
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SHORT COMMUNICATION
Detection of Autoantibodies to Precursor Proteins of Desmogleins in Sera of a Patient with Bowen Carcinoma
Toshio Demitsu, Tomoko Yamada, Satoshi Nakamura, Maki Kakurai, Takashi Dohmoto, Koji Kamiya, Yumi Aoyama, Keiji Iwatsuki, Jun Yamagami, Bungo Ohyama, Chika Ohata, Hiroshi Koga, Takashi Hashimoto
Abstract is missing (Short)
Pages: 601-603
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SHORT COMMUNICATION
Febrile Ulceronecrotic Mucha-Habermann Disease in a Young Boy: A Case Report and Review of the Literature
Kazuya Yamada, Sei-ichiro Motegi, Yoichiro Matsushima
Abstract is missing (Letter)
Pages: 603-604
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SHORT COMMUNICATION
Duloxetine-induced Pseudolymphoma with Features of Lymphocytic Infiltration of Jessner-Kanof
Monica Corazza, Alessandro Borghi, Sara Minghetti, Lucia Mantovani, Roberta Gafà, Annarosa Virgili
Abstract is missing (Short)
Pages: 605-606
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SHORT COMMUNICATION
Epidermal Insulin Resistance as a Therapeutic Target in Acanthosis nigricans?
Bartosz Malisiewicz, Sandra Boehncke, Victoria Lang, Wolf-Henning Boehncke, Claudia Bürger
Abstract is missing (Short)
Pages: 607-608
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SHORT COMMUNICATION
Segmented Heterochromia in a Single Scalp Hair
Sung Bin Cho, Zhenlong Zheng, Ji Young Kim, Sang Ho Oh
Abstract is missing (Short)
Pages: 609-610
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SHORT COMMUNICATION
Successful Treatment of Adult Onset Langerhans Cell Histiocytosis with Bi-weekly Administration of Pegylated Interferon-α
Sadanori Furudate, Taku Fujimura, Yumi Kambayashi, Mitsuko Kawano, Kouetsu Ogasawara, Akira Tsukada, Erika Tamabuchi, Takahiro Haga, Akira Hashimoto, Setsuya Aiba
Abstract is missing (Short)
Pages: 611-612
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SHORT COMMUNICATION
Recurrent Course and CD30 Expression of Atypical T Lymphocytes Distinguish Lymphomatoid Papulosis From Primary Cutaneous Aggressive Epidermotropic CD8+ Cytotoxic T-cell Lymphoma
Masumi Tsujiwaki, Riichiro Abe, Yuka Ohguchi, Daichi Hoshina, Junko Murata, Yasuyuki Fujita, Toshifumi Nomura, Midori Ambo, Hiroshi Shimizu
Abstract is missing (Short Communication)
Pages: 613-614
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SHORT COMMUNICATION
Inflammatory Epidermolysis Bullosa Acquisita Effectively Treated with Minocycline
Kana Kawase, Yoko Oshitani, Yoko Mizutani, En Shu, Etsuko Fujine, Mariko Seishima
Abstract is missing (Short)
Pages: 615-616
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SHORT COMMUNICATION
Primary Syphilis Presenting as Bilateral Nipple-areola Eczematoid Lesions
Song Zheng, Jia Liu, Xue-Gang Xu, Xing-Hua Gao, Hong-Duo Chen
Abstract is missing (Short)
Pages: 617-618
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QUIZ
Unilateral Eruption of Painful Papules: A Quiz
Annabel D. Scott, Nicholas Francis, Sarita Singh
Abstract is missing (Quiz)
Pages: 619-622
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QUIZ
Solitary Tumour on the Neck: A Quiz
Keita Horie, Riichiro Abe, Erina Homma, Junko Murata, Toshifumi Nomura, Hiroshi Shimizu
Abstract is missing (Quiz)
Pages: 619-622
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QUIZ
Hypertrophic Left Calf and Multiple Flesh-coloured Subcutaneous Tumours in a 5-year-old Girl: A Quiz
Maartje J. van Geel, Marc Wijnen, Esther P.A.H. Hoppenreijs, Nicole Gierenz, Liesbeth Spruijt, Martine P.A. van Koolwijk, Uta Flucke, Willeke A.M. Blokx, Marieke M.B. Seyger
Abstract is missing (Quiz)
Pages: 619-622
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