Content

Content - Volume 95, Issue 2

Editor's choice in this issue

INVESTIGATIVE REPORT
Casting Shadows on the Prevalence of Tanning Dependence: An Assessment of mCAGE Criteria
Sven Schneider, Frederike Schirmbeck, Christina Bock, Rüdiger Greinert, Eckhardt W. Breitbart, Katharina Diehl
Recently more and more studies have reported high prevalence rates for a ‘tanning dependence’ among tanning bed users. The authors of these studies base their argumentation on a modified (m) version of the CAGE (Cut-down, Annoyed, Guilty and Eye-opener) Criteria, initially used for alcohol addiction. By means of cognitive interviews and a large population survey, we tested the validity of the ...
Pages: 162-168
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CLINICAL REPORT
Smartphone Teledermoscopy Referrals: A Novel Process for Improved Triage of Skin Cancer Patients
Alexander Börve, Johan Dahlén Gyllencreutz, Karin Terstappen, Eva Johansson Backman, Anette Aldenbratt, Markus Danielsson, Martin Gillstedt, Carin Sandberg, John Paoli
In this open, controlled, multicentre and prospective observational study, smartphone teledermoscopy referrals were sent from 20 primary healthcare centres to 2 dermatology departments for triage of skin lesions of concern using a smartphone application and a compatible digital dermoscope. The outcome for 816 patients referred via smartphone teledermoscopy was compared with 746 patients referred v ...
Pages: 186-190
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REVIEW
New Drugs and Treatment Targets in Psoriasis
Kristian Kofoed, Lone Skov, Claus Zachariae
In recent years, the increased understanding of the pathophysiology of psoriasis has resulted in several new treatments. The success of ustekinumab proved the importance of the IL-23/T helper cell 17 axis in psoriatic diseases. Several new biologics targeting this axis will reach the clinic in the next years. Biologics are costly, require injections, and some patients experience tacaphylaxis, thus ...
Pages: 133-139
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All articles

EDITORIAL
A Successful 2014 Paves the Way for Acta Dermato-Venereologica’s Forthcoming Centenary
Anders Vahlquist
Abstract is missing (Editorial)
Page: 131
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DEBATE ARTICLE
Scholarly Vanity Press: Why You Should Judge the Book by its Cover
Hanna Norsted
Abstract is missing (Debate)
Page: 132
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REVIEW
New Drugs and Treatment Targets in Psoriasis
Kristian Kofoed, Lone Skov, Claus Zachariae
In recent years, the increased understanding of the pathophysiology of psoriasis has resulted in several new treatments. The success of ustekinumab proved the importance of the IL-23/T helper cell 17 axis in psoriatic diseases. Several new biologics targeting this axis will reach the clinic in the next years. Biologics are costly, require injections, and some patients experience tacaphylaxis, thus ...
Pages: 133-139
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Oxidation Reduction is a Key Process for Successful Treatment of Psoriasis by Narrow-band UVB Phototherapy
Xiaolian Gu, Elisabet Nylander, Philip J. Coates, Karin Nylander
Narrow-band UVB (NB-UVB) phototherapy is commonly used for treatment of psoriasis, though the mechanisms underlying its efficacy have not been completely elucidated. We used gene expression profiling to characterise gene expression in lesional epidermis from psoriasis patients in the middle and late stages of NB-UVB photo­therapy. Increased melanogenesis gene expression was the earliest response ...
Pages: 140-146
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INVESTIGATIVE REPORT
Nalfurafine Suppresses Pruritogen- and Touch-evoked Scratching Behavior in Models of Acute and Chronic Itch in Mice
Tasuku Akiyama, Mirela Iodi Carstens, Dorothea Piecha, Sonja Steppan, Earl Carstens
The kappa-opioid agonist, nalfurafine, has been approved in Japan for treatment of itch in patients with chronic kidney disease. We presently investigated if systemic administration of nalfurafine inhibited ongoing or touch-evoked scratching behavior (alloknesis) following acute intradermal injection of histamine or the non-histaminergic itch mediator, chloroquine, in mice. We also investigated if ...
Pages: 147-150
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INVESTIGATIVE REPORT
Regulatory T-cell Subsets with Acquired Functional Impairment: Important Indicators of Disease Severity in Atopic Dermatitis
Krisztián Gáspár, Sándor Baráth, Georgina Nagy, Gábor Mócsai, Edit Gyimesi, Péter Szodoray, Beatrix Irinyi, Margit Zeher, Éva Remenyik, Andrea Szegedi
Our aim was to assess whether the presence of highly active effector T cells in atopic dermatitis (AD) is associated with changes in the number and/or function of regulatory T cells (Tregs). Flow cytometry was utilised to determine the percentage of CD4+CD25brightCD127–/lowFOXP3+ and skin-homing CLA+CD4+CD25brightFOXP3+ Tregs in healthy controls and AD patients. The correlation between disease s ...
Pages: 151-155
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INVESTIGATIVE REPORT
Resource Use in Patients with Psoriasis After the Introduction of Biologics in Sweden
Jenny M. Norlin, Katarina Steen Carlsson, Ulf Persson, Marcus Schmitt-Egenolf
The introduction of biologics has changed treatment patterns as well as costs in patients with psoriasis. To estimate direct and indirect costs of the psoriasis population in Sweden, and to analyse changes in costs between 2006 and 2009. The study population was identified in national registers. Direct costs included health care visits with primary psoriasis diagnoses in specialist care and drugs ...
Pages: 156-161
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INVESTIGATIVE REPORT
Casting Shadows on the Prevalence of Tanning Dependence: An Assessment of mCAGE Criteria
Sven Schneider, Frederike Schirmbeck, Christina Bock, Rüdiger Greinert, Eckhardt W. Breitbart, Katharina Diehl
Recently more and more studies have reported high prevalence rates for a ‘tanning dependence’ among tanning bed users. The authors of these studies base their argumentation on a modified (m) version of the CAGE (Cut-down, Annoyed, Guilty and Eye-opener) Criteria, initially used for alcohol addiction. By means of cognitive interviews and a large population survey, we tested the validity of the ...
Pages: 162-168
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INVESTIGATIVE REPORT
Autonomic Nervous Tone in Vitiligo Patients – A Case-control Study
Eva-Maria Trapp, Michael Trapp, Francesca Sampogna, Peter Michael Rohrer, Josef Wilhelm Egger, Peter Wolf, Hans-Peter Kapfhammer, Michael Dennis Linder, Erika Richtig, Johannes Baulmann, Angelika Hofer
In this cross-sectional, exploratory case-control study the vegetative arousal in vitiligo patients compared to an age and gender matched healthy control group was assessed. Forty-eight participants (24 outpatients with generalised vitiligo and 24 healthy controls) completed a test procedure consisting of an initial period of rest (R1), a defined mental stress task (the d2 test of attention), a se ...
Pages: 169-172
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CLINICAL REPORT
Low Prevalence of Oral and Nasal Human Papillomavirus in Employees Performing CO2-laser Evaporation of Genital Warts or Loop Electrode Excision Procedure of Cervical Dysplasia
Kristian Kofoed, Christina Norrbom, Ola Forslund, Charlotte Møller, Ligita P. Frøding, Anders Elm Pedersen, Algirdas Markauskas, Maria Blomberg, Jane Baumgartner-Nielsen, Jakob Torp Madsen, Gitte Strauss, Klaus G. Madsen, Carsten Sand
Risk of human papillomavirus (HPV) transmission during laser vaporisation of genital warts or loop electrode excision procedure is controversial. An oral rinse, a nasal swabs, history of HPV related diseases and data on HPV exposure were collected from 287 employees at departments of dermato-venerology and gynaecology in Denmark. A mucosal HPV type was found among 5.8% of employees with experience ...
Pages: 173-176
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INVESTIGATIVE REPORT
Lichen Planopilaris is Associated with HLA DRB1*11 and DQB1*03 Alleles
Lev Pavlovsky, Moshe Israeli, Eti Sagy, Amy L. Berg, Michael David, Avner Shemer, Tirza Klein, Emmilia Hodak
There are no studies of the possible association of the human leukocyte antigen (HLA) system with lichen planopilaris (LPP). To determine whether the HLA system is associated with LPP, 40 consecutive Jewish Israeli patients with LPP (study group) and 252 volunteers (controls) were typed for DRB1*and DQB1* loci by molecular methods. Compared with controls, the study group had a significantly higher ...
Pages: 177-180
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CLINICAL REPORT
Correlation Between Histological Findings on Punch Biopsy Specimens and Subsequent Excision Specimens in Cutaneous Squamous Cell Carcinoma
Annet Westers-Attema, Valerie M.H.J. Joosten, Marieke H. Roozeboom, Patty J. Nelemans, Bjorn G.P.M. Lohman, Anita A. Botterweck, Peter M. Steijlen, Arienne M.W. van Marion, Nicole W.J. Kelleners-Smeets
Diagnosis and subsequent treatment of cutaneous squamous cell carcinoma are frequently based on punch biopsies. Regarding the current TNM classification and stage grouping for cutaneous squamous cell carcinoma, it is important to identify the high-risk features (infiltration depth > 4 mm, perineural and/or lymphovascular invasion and poor differentiation). This study investigates the agreeme ...
Pages: 181-185
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CLINICAL REPORT
Smartphone Teledermoscopy Referrals: A Novel Process for Improved Triage of Skin Cancer Patients
Alexander Börve, Johan Dahlén Gyllencreutz, Karin Terstappen, Eva Johansson Backman, Anette Aldenbratt, Markus Danielsson, Martin Gillstedt, Carin Sandberg, John Paoli
In this open, controlled, multicentre and prospective observational study, smartphone teledermoscopy referrals were sent from 20 primary healthcare centres to 2 dermatology departments for triage of skin lesions of concern using a smartphone application and a compatible digital dermoscope. The outcome for 816 patients referred via smartphone teledermoscopy was compared with 746 patients referred v ...
Pages: 186-190
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CLINICAL REPORT
Malassezia spp.-specific Immunoglobulin E Level is a Marker for Severity of Atopic Dermatitis in Adults
Martin Glatz, Matthias Buchner, Wibke von Bartenwerffer, Peter Schmid-Grendelmeier, Margitta Worm, Jürgen Hedderich, Regina Fölster-Holst
The significance of allergen-specific IgE as marker for severity of atopic dermatitis is controversial. The aim of this study was to determine the frequency of IgE-mediated sensitisation to food and environmental allergens in 132 children and 67 adults with atopic dermatitis, and its correlation to severity of atopic dermatitis (SCORAD). Total IgE was elevated (> 100 kU/l) in 79.7% of adults ...
Pages: 191-196
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CLINICAL REPORT
Immunotherapy-induced Leukoderma from Treatment of Melanoma with IL-2: A Case Report and a Review of the Literature
Robert Gathings, Robin Lewallen, Gil Yosipovitch
Melanoma-associated leukoderma (MAL) is a relatively uncommon phenomenon in the literature that can present (1) before melanoma detection, (2) after detection and before treatment, and (3) after treatment with immunotherapeutic agents. We report a case of MAL in an 83-year-old man after treatment with high dose IL-2 for metastatic melanoma and further describe the literature of the underlying mech ...
Pages: 197-200
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CLINICAL REPORT
Topical Corticosteroids Minimise the Risk of Postinflammatory Hyper­pigmentation After Ablative Fractional CO2 Laser Resurfacing in Asians
Nutjira Cheyasak, Woraphong Manuskiatti, Pitchaya Maneeprasopchoke, Rungsima Wanitphakdeedecha
Postinflammatory hyperpigmentation (PIH) is the most common adverse effect of laser treatment in dark-skinned individuals. Little is known whether PIH can be prevented or minimised. The objective of this study was to investigate the effect of short-term application of topical corticosteroids on the incidence of PIH after ablative fractional resurfacing in Asians. Forty subjects with skin phototype ...
Pages: 201-205
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CLINICAL REPORT
Course of Skin Symptoms and Quality of Life in Children Referred for Patch Testing – A Long-term Follow-up Study
Anne B. Simonsen, Mette Sommerlund, Mette Deleuran, Charlotte G. Mortz, Jeanne D. Johansen
Children are patch tested in the same manner as adults, but little has been done to establish whether positive or negative findings influence the course of skin symptoms. To uncover the course of skin symptoms and the impact of persistent eczema on life quality in paediatric patients referred for patch testing, a retrospective questionnaire was sent to children and adolescents referred for patch t ...
Pages: 206-210
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CLINICAL REPORT
Genital Psoriasis Awareness Program: Physical and Psychological Care for Patients with Genital Psoriasis
Kim A.P. Meeuwis, Joanne A. de Hullu, Joanna IntHout, Iris M.P. Hendriks, Emilie E. Sparreboom, Leon F.A.G. Massuger, Peter C.M. van de Kerkhof, Michelle M. van Rossum
Genital psoriasis is a neglected manifestation of psoriasis, although it affects numerous patients and has major effects on sexual quality of life (SQoL). We aimed to assess the value of specialised care for patients with genital psoriasis. Patients were treated for at least one year at a specialised research outpatient clinic with extensive attention for genital lesions and SQoL. The genital lesi ...
Pages: 211-216
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CLINICAL REPORT
Use of Aspirin, Non-steroidal Anti-inflammatory Drugs, and Aceta­minophen (Paracetamol), and Risk of Psoriasis and Psoriatic Arthritis: A Cohort Study
Shaowei Wu, Jiali Han, Abrar A. Qureshi
Non-steroidal anti-inflammatory drugs (NSAIDs) have been reported to induce or exacerbate psoriasis. We aimed to evaluate the association between several widely used analgesics, including aspirin, non-aspirin NSAIDs, and acetaminophen (paracetamol), and risk of psoriasis and psoriatic arthritis (PsA) in a large cohort of US women, the Nurses’ Health Study II (1991–2005). Information on regula ...
Pages: 217-222
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SHORT COMMUNICATION
A Th2 Cytokine Interleukin-31 Signature in a Case of Sporadic Lichen Amyloidosis
Léa Dousset, Julien Seneschal, Katia Boniface, Sandrine Charreau, Khaled Ezzedine, Brigitte Milpied, Mohammad D. Mossalayi, John A. McGrath, Jean Claude Lecron, Alain Taieb
Abstract is missing (Short Communication)
Pages: 223-224
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SHORT COMMUNICATION
Health-related Quality of Life in Danish Patients with Hereditary Angioedema
Anne Aabom, Klaus Ejner Andersen , Elia Perez-Fernández , Teresa Caballero , Anette Bygum
Abstract is missing (Short Comunication)
Pages: 225-226
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SHORT COMMUNICATION
Idiopathic Angioedema and Urticarial Vasculitis in a Patient with a History of Acquired Haemophilia
Julie Christiansen, Robin Kahn, Artur Schmidtchen, Karin Berggård
Abstract is missing (Short Communication)
Pages: 227-228
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SHORT COMMUNICATION
DIHS/DRESS with Remarkable Eosinophilic Pneumonia Caused by Zonisamide
Rintaro Shibuya, Hideaki Tanizaki, Saeko Nakajima, Itsuko Koyanagi, Tatsuki R. Kataoka, Yoshiki Miyachi, Kenji Kabashima
Abstract is missing (Short Communication)
Pages: 229-230
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SHORT COMMUNICATION
Blastic Plasmacytoid Dendritic Cell Neoplasm in a 7-year-old Girl with a Solitary Skin Lesion Mimicking Traumatic Purpura
Hisashi Nomura, Shohei Egami, Hiroko Kasai, Tomoaki Yokoyama, Atsushi Fujimoto, Makoto Sugiura, Hiroaki Yagi, Hideto Iwafuchi, Kazuko Kudo
Abstract is missing (Short Communication)
Pages: 231-232
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SHORT COMMUNICATION
Complete Remission of Refractory, Ulcerated, Primary Cutaneous CD30+ Anaplastic Large Cell Lymphoma Following Brentuximab Vedotin Therapy
Nikolaos Patsinakidis, Alexander Kreuter, Rose K.C. Moritz, Markus Stücker, Peter Altmeyer, Katrin Möllenhoff
Abstract is missing (Short Communication)
Pages: 233-234
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SHORT COMMUNICATION
A Case of Tinea Imbricata in an Italian Woman
Stefano Veraldi, Paolo Pontini, Gianluca Nazzaro
Abstract is missing (Short Communication)
Pages: 235-237
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SHORT COMMUNICATION
Pemphigoid Nodularis Mimicking Nodular Prurigo in an Immune-suppressed Patient with Rheumatoid Arthritis
Hui Li Kwong, Su-Ping Regina Lim
Abstract is missing (Short Communication)
Pages: 237-238
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SHORT COMMUNICATION
Pemphigoid Nodularis with Diverse IgG, IgA and IgE Antibodies Showing Neutrophilic Papillary Microabscesses
Akihiko Asahina, Atsuko Niizuma, Ayaka Ohzono, Norito Ishii, Hiroshi Koga, Takashi Hashimoto
Abstract is missing (Short Communication)
Pages: 239-240
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SHORT COMMUNICATION
Disseminated Giant Hyperkeratotic Porokeratosis and Treatment with Acitretin: A Case Report
Anneli Uusküla, Triin Erm
Abstract is missing (Short Communication)
Pages: 241-242
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SHORT COMMUNICATION
Naevoid Basal Cell Carcinoma Syndrome in a 22-month-old Child Presenting with Multiple Basal Cell Carcinomas and a Fetal Rhabdomyoma
Andrea Diociaiuti, Alessandro Inserra, Irene Fuertes De Vega, Cristina Rota, Tiziana Surrenti, Loredana Giraldi, Maria Rosaria Piemontese, Isabella Giovannoni, Francesco Callea, May El Hachem
Abstract is missing (Short Communication)
Pages: 243-244
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SHORT COMMUNICATION
Zosteriform Metastases of Eccrine Porocarcinoma Mimicking Eruptive Seborrhoeic Keratoses
Nina S. Müller, Carolin Zschoche, Wolfgang Hartschuh, Anke S. Lonsdorf
Abstract is missing (Short Communication)
Pages: 245-246
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SHORT COMMUNICATION
Nickel Exposure When Working Out in the Gym
Martin Gumulka, Mihály Matura, Carola Lidén, Jolinde A.B. Kettelarij, Anneli Julander
Abstract is missing (Short Communication)
Pages: 247-249
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SHORT COMMUNICATION
A Syndrome of Leukonychia, Koilonychia and Multiple Pilar Cysts
Mayuko Mutoh, Shiro Niiyama, Saori Nishikawa, Toshiaki Oharaseki, Hideki Mukai
Abstract is missing (Short Communication)
Pages: 249-250
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SHORT COMMUNICATION
Efficacy of Fluconazole at a 400 mg Weekly Dose for the Treatment of Onychomycosis
Anita Hryncewicz-Gwóźdź, Ewa Plomer-Niezgoda, Katarzyna Kalinowska, Anna Czarnecka, Joanna Maj, Tomasz Jagielski
Abstract is missing (Short Communication)
Pages: 251-252
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BOOK REVIEW
Photodermatology, An Issue of Dermatologic Clinics
Berit Berne
Abstract is missing (Book review)
Page: 253
Abstract  PDF
BOOK REVIEW
Laser Treatment of Vascular Lesions
Agneta Troilius
Abstract is missing (Book review)
Page: 253
Abstract  PDF