Content

Content - Volume 95, Issue 8

Editor's choice in this issue

REVIEW
Dermatitis Herpetiformis: Pathognomonic Transglutaminase IgA Deposits in the Skin and Excellent Prognosis on a Gluten-free Diet
Timo Reunala, Teea T. Salmi, Kaisa Hervonen
Dermatitis herpetiformis (DH) is an itchy, blistering skin disease with sites of predilection at the elbows, knees and buttocks. Although DH is mostly asymptomatic, all patients exhibit small bowel villous atrophy or at least coeliac-type inflammatory changes. Deposition of immunoglobulin A (IgA) in the papillary dermis is a key diagnostic feature of DH. Epidermal transglutaminase (TG3) is the ant ...
Pages: 917-922
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SPECIAL REPORT
Increased Risk of Melanoma in Organ Transplant Recipients: Systematic Review and Meta-analysis of Cohort Studies
Adèle C. Green, Catherine M. Olsen
Transplant recipients have a raised risk of melanoma but the relative magnitude is uncertain. We undertook a systematic review by searching major databases for relevant publications to June 2014. Cohort studies quantifying the association between transplantation and melanoma were included and data were pooled using the weighted average method. Among 20 eligible studies the pooled relative risk (pR ...
Pages: 923-927
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CLINICAL REPORT
The Role of Wet Wrap Therapy in Skin Disorders – A Literature Review
Rosa Marie Andersen, Jacob P. Thyssen, Howard I. Maibach
Wet wrap therapy, based on skin application of a double layer of tubular bandages or gauze with a moist first inner layer and a dry second outer layer, is utilized to treat various pruritic conditions, in particular severe and refractory atopic dermatitis. This review, by literature search, evaluates current knowledge about wet wrap therapy. Wet wrap therapy superimposed topical corticosteroids ap ...
Pages: 933-939
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All articles

IN THIS ISSUE
How to Learn Most About Your Patients
Gregor Jemec
Abstract is missing (In this Issue)
Page: 916
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IN THIS ISSUE
An Integrating Perspective
Gregor Jemec
Abstract is missing (In this Issue)
Page: 916
Abstract  HTML  PDF
REVIEW
Dermatitis Herpetiformis: Pathognomonic Transglutaminase IgA Deposits in the Skin and Excellent Prognosis on a Gluten-free Diet
Timo Reunala, Teea T. Salmi, Kaisa Hervonen
Dermatitis herpetiformis (DH) is an itchy, blistering skin disease with sites of predilection at the elbows, knees and buttocks. Although DH is mostly asymptomatic, all patients exhibit small bowel villous atrophy or at least coeliac-type inflammatory changes. Deposition of immunoglobulin A (IgA) in the papillary dermis is a key diagnostic feature of DH. Epidermal transglutaminase (TG3) is the ant ...
Pages: 917-922
Abstract  HTML  PDF
SPECIAL REPORT
Increased Risk of Melanoma in Organ Transplant Recipients: Systematic Review and Meta-analysis of Cohort Studies
Adèle C. Green, Catherine M. Olsen
Transplant recipients have a raised risk of melanoma but the relative magnitude is uncertain. We undertook a systematic review by searching major databases for relevant publications to June 2014. Cohort studies quantifying the association between transplantation and melanoma were included and data were pooled using the weighted average method. Among 20 eligible studies the pooled relative risk (pR ...
Pages: 923-927
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SPECIAL REPORT
Efficacy of Rituximab for Pemphigus: A Systematic Review and Meta-analysis of Different Regimens
Hsiao-Han Wang, Che-Wei Liu, Yu-Chuan Li, Yu-Chen Huang
This meta-analysis examined the efficacy of different dosing regimens containing rituximab (RTX) in treating pemphigus. The analysis included 578 patients with pemphigus from 30 studies. Seventy-six percent of patients achieved complete remission (CR) after 1 cycle of RTX. Mean time to remission was 5.8 months, with a remission duration of 14.5 months and a 40% relapse rate. Eighteen patients (3.3 ...
Pages: 928-932
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CLINICAL REPORT
The Role of Wet Wrap Therapy in Skin Disorders – A Literature Review
Rosa Marie Andersen, Jacob P. Thyssen, Howard I. Maibach
Wet wrap therapy, based on skin application of a double layer of tubular bandages or gauze with a moist first inner layer and a dry second outer layer, is utilized to treat various pruritic conditions, in particular severe and refractory atopic dermatitis. This review, by literature search, evaluates current knowledge about wet wrap therapy. Wet wrap therapy superimposed topical corticosteroids ap ...
Pages: 933-939
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INVESTIGATIVE REPORT
Role of Age and Sex in the Diagnosis of Early-stage Malignant Melanoma: A Cross-Sectional study
David Moreno-Ramírez, Teresa Ojeda-Vila, Juan J. Ríos-Martín, Adoración Nieto-García, Lara Ferrándiz
Age and sex have been identified as predictors of outcome in malignant melanoma (MM). This aim of this multicentre, cross-sectional study was to analyse the role of age and sex as explanatory variables for the diagnosis of thin MM. A total of 2430 patients with MM were recruited. Cases of in situ-T1 MM were more frequent than T2–T4 MM (56.26% vs. 43.74%). Breslow thickness increased throughout d ...
Pages: 940-942
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INVESTIGATIVE REPORT
High Serum Total IgE Predicts Poor Long-term Outcome in Atopic Dermatitis
Ville Kiiski, Oskar Karlsson, Anita Remitz, Sakari Reitamo
Most patients with severe atopic dermatitis have elevated serum IgE levels, but there has been little research into IgE as a predictive biomarker in long-term disease outcome. The aim of this study was to evaluate the predictive value of IgE and other factors in patients with atopic dermatitis in a university clinic setting. There were 169 eligible patients (14–78 years) with a mean follow-up of ...
Pages: 943-947
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INVESTIGATIVE REPORT
Regional Diffusion of Botulinum Toxin in Facial Muscles: A Rando­mised Double-blind Study and a Consideration for Clinical Studies with Split-face Design
Anna Rostedt Punga , Annika Eriksson, Mohammad Alimohammadi
Despite the extensive use of botulinum toxin A (BoNTA) in medical and cosmetic treatments, the potential spreading of BoNTA to surrounding tissues remains unknown. A patient with hemifacial paralysis upon blepharospasm treatment with low dose of BoNTA, prompted us to investigate the spreading effect. A randomised, double-blind study was conducted in which 5 healthy women (33–52 years) were treat ...
Pages: 948-951
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INVESTIGATIVE REPORT
Serum Reactivity Against Herpes Simplex Virus Type 1 UL48 Protein in Behçet’s Disease Patients and a Behçet’s Disease-like Mouse Model
Zhenlong Zheng, Seonghyang Sohn, Keun Jae Ahn, Dongsik Bang, Sung Bin Cho
Herpes simplex virus (HSV) infection is a possible pathogenic factor in Behçet’s disease (BD). Using proteomics analysis, this study detected a target HSV protein. Serum IgA and IgG reactivities against the identified protein were evaluated in patients with BD and in BD-like mice. A total of 4 protein bands generated by immunoprecipitation were analysed by proteomics, and HSV UL48 was commonly ...
Pages: 952-958
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INVESTIGATIVE REPORT
Self-reported Occupational Exposure to Chemical and Physical Factors and Risk of Skin Problems: A 3-year Follow-up Study of the General Working Population of Norway
Jose Hernan Alfonso, Jacob P. Thyssen, Tore Tynes, Ingrid Sivesind Mehlum, Håkon A. Johannessen
Prospective studies on occupational dermatoses in the general working population are sparse. This study investigated prospectively the impact of self-reported occupational exposure to chemicals and physical factors on the risk of skin problems. The cohort comprised respondents drawn randomly from the general population in Norway, who were registered employed in 2006 and 2009 (n = 6,745 ...
Pages: 959-962
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CLINICAL REPORT
Serum Creatinine Levels During and After Long-term Treatment with Cyclosporine A in Patients with Severe Atopic Dermatitis
Jorien van der Schaft, Arjan D. van Zuilen, Joukje Deinum, Carla A.F.M. Bruijnzeel-Koomen, Marjolein S. de Bruin-Weller
Safety data with respect to kidney function during long-term treatment with cyclosporine A (CsA) in patients with atopic dermatitis is limited. Data on serum creatinine levels before, during and after CsA treatment were collected in a retrospective cohort of adult patients with atopic dermatitis. The median duration of treatment of 150 patients was 280 days (interquartile range 203–528 days). Th ...
Pages: 963-967
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CLINICAL REPORT
Recall Bias in Childhood Atopic Diseases Among Adults in The Odense Adolescence Cohort Study
Charlotte G. Mortz, Klaus E. Andersen, Carsten Bindslev-Jensen
Atopic dermatitis (AD) is a common disease in childhood and an important risk factor for the later development of other atopic diseases. Many publications on childhood AD use questionnaires based on information obtained in adulthood, which introduce the possibility of recall bias. In a prospective cohort study, recall bias was evaluated in 1,501 unselected schoolchildren (mean age 14 years) evalua ...
Pages: 968-972
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CLINICAL REPORT
Factors Associated with Drug Survival of Methotrexate and Acitretin in Patients with Psoriasis
Guy Shalom, Devy Zisman, Ilana Harman-Boehm, Haim Biterman, Sari Greenberg-Dotan, Ilya Polishchuk, Hadas Moser, Tamar Freud, Ilan Feldhamer, Arnon D. Cohen
Drug survival has recently become an important clinical issue in psoriasis. However, there has been little research into factors associated with drug survival of methotrexate and acitretin. The aim of this study was to investigate factors associated with drug survival of methotrexate and acitretin treatment for psoriasis. Survival analysis was performed in patients who received methotrexate or aci ...
Pages: 973-977
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CLINICAL REPORT
Pathogenesis of Multiple Lentigines in LEOPARD Syndrome with PTPN11 Gene Mutation
Sei-ichiro Motegi, Yoko Yokoyama, Sachiko Ogino, Kazuya Yamada, Akihiko Uchiyama, Buddhini Perera, Yuko Takeuchi, Hiroshi Ohnishi, Osamu Ishikawa
LEOPARD syndrome (LS) is an autosomal dominant condition with multiple anomalies, including multiple lentigines. LS is caused by mutations in PTPN11, encoding the protein tyrosine phosphatase, SHP-2. We report here 2 unrelated Japanese cases of LS with different PTPN11 mutations (p.Y279C and p.T468P). To elucidate the pathogenesis of multiple lentigines in LS, ultrastructural and immunohistochemic ...
Pages: 978-984
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CLINICAL REPORT
Cutaneous Infections Caused by Rapidly Growing Mycobacteria: Case Reports and Review of Clinical and Laboratory Aspects
Xiaodong Zhang, Weijun Liu, Weida Liu, Haiqin Jiang, Wenkai Zong, Guoyi Zhang, Peiying Jin, Hongsheng Wang
Skin and soft tissue infections caused by rapidly growing non-tuberculous mycobacteria (RG-NTM) have become a growing clinical concern over the past decades. These RG-NTM are ubiquitous environmental organisms and most are resistant to traditional antituberculous agents. In this report, we describe 3 cutaneous infections caused by RG-NTM, namely, Mycobacterium abscessus, M. chelonae, and M. concep ...
Pages: 985-989
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SHORT COMMUNICATION
Hidradenitis Suppurativa Disproportionately Affects African Americans: A Single-center Retrospective Analysis
Natalia Vlassova, Diane Kuhn, Ginette A. Okoye
Abstract is missing (Short communication)
Pages: 990-991
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SHORT COMMUNICATION
Naevus Comedonicus Syndrome Complicated by Hidradenitis Suppurativa-like Lesions Responding to Acitretin Treatment
Ge Qian, Tao Liu, Chongchen Zhou, Yinghui Zhang
bstract is missing (Short communication)
Pages: 992-993
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SHORT COMMUNICATION
Increased Expression of Integrin α6β4 in the Basement Membrane Zone Lining the Sebaceous Glands in Hidradenitis Suppurativa
Janine L. Blok, Ineke C. Janse , Barbara Horváth , Marcel F. Jonkman
Abstract is missing (Short communication)
Pages: 994-996
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SHORT COMMUNICATION
Subtyping Basal Cell Carcinoma by Clinical Diagnosis Versus Punch Biopsy
Marieke H. Roozeboom, Hilke Kreukels, Patty J. Nelemans, Klara Mosterd, Veronique J.L. Winnepenninckx, Myrurgia A. Abdul Hamid, Ellen R.M. de Haas, Nicole W.J. Kelleners-Smeets
Abstract is missing (Short communication)
Pages: 996-998
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SHORT COMMUNICATION
Eccrine Squamous Syringometaplasia of Underlying Syringoma Associated with Tegafur/Gimeracil/Oteracil (TS-1)
Jihee Kim, Su Hee Kim, Min-Geol Lee, Kee Yang Chung, Dae Suk Kim
Abstract is missing (Short communication)
Pages: 999-1000
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SHORT COMMUNICATION
Subungual Angiokeratoma Presenting as a Longitudinal Pigmented Band in the Nail
Michiko Hasegawa, Atsushi Tamura
Abstract is missing (Short communication)
Pages: 1001-1002
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SHORT COMMUNICATION
Localized Scleroderma Presenting as Port-wine Stains: Report of Two Cases and a Literature Review
Hiroyuki Kanoh, En Shu, Yoshiro Ichiki, Mariko Seishima
Abstract is missing (Short communication)
Pages: 1003-1004
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SHORT COMMUNICATION
Familial Primary Localized Cutaneous Amyloidosis Results from Either Dominant or Recessive Mutations in OSMR
Abdul Wali, Lu Liu, Takuya Takeichi, Musharraf Jelani, Obaid Ur Rahman, Yee Kiat Heng, Steven Thng, Joyce Lee, Masashi Akiyama, John A. McGrath, Regina C. Betz
Abstract is missing (Short communication)
Pages: 1005-1007
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SHORT COMMUNICATION
Large Deletions in the NSDHL Gene in Two Patients with CHILD Syndrome
Zhou Yang, Britta Hartmann, Zhe Xu, Lin Ma, Rudolf Happle, Nina Schlipf, Li-xin Zhang, Zi-gang Xu, Zhao-yang Wang, Judith Fischer
Abstract is missing (Short communication)
Pages: 1007-1008
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SHORT COMMUNICATION
Effective Palliation of Intractable Bleeding from Noonan Syndrome-associated Lymphatic Malformations by Radiotherapy
Brian C. Baumann, Kelly M. MacArthur, Misha Rosenbach, Jean C. Miller, Edgar Ben-Josef
Abstract is missing (Short communication)
Pages: 1009-1010
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SHORT COMMUNICATION
Successful Treatment of Lipedematous Alopecia using Mycophenolate Mofetil
Raúl Cabrera, Jorge Larrondo, Carolina Whittle, Alex Castro, Marianne Gosch
Abstract is missing (Short communication)
Pages: 1011-1012
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SHORT COMMUNICATION
Childhood Epidermolysis Bullosa Acquisita with Underlying Coeliac Disease
Michael Kasperkiewicz, Irén Orosz, Dietrich Abeck, Sibylle Koletzko, Thomas Ruzicka, Miklós Sárdy
Abstract is missing (Short communication)
Pages: 1013-1014
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SHORT COMMUNICATION
A Case of Neonatal Linear IgA Bullous Dermatosis with Severe Eye Involvement
Lorenza Romani, Andrea Diociaiuti, Patrizia D'Argenio, May El Hachem, Livia Gargiullo, Renata Boldrini, Ornella De Pità, Sergio Petroni, Giovanna Zambruno
Abstract is missing (Short communication)
Pages: 1015-1017
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SHORT COMMUNICATION
Quadrivalent Human Papillomavirus Vaccination: A Promising Treatment for Recalcitrant Cutaneous Warts in Children
Dietrich Abeck, Regina Fölster-Holst
Abstract is missing (Short communication)
Pages: 1017-1019
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SHORT COMMUNICATION
Increased Expression of Caspase-1 and Interleukin-18 in Peeling Skin Disease, and a Novel Mutation of Corneodesmosin
Frederic Valentin, Vinzenz Oji, Ingrid Hausser, Eva Liebau, Tatjana Tarinski, Dieter Metze, Dirk Breitkreutz, Heiko Traupe, Nathalie Jonca, Patrick Terheyden
Abstract is missing (Short communication)
Pages: 1019-1021
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SHORT COMMUNICATION
H Syndrome: A Multifaceted Histiocytic Disorder with Hyperpigmentation and Hypertrichosis
Burak Tekin, Zeynep Atay, Tulin Ergun, Meryem Can, Davut Tuney, Sofia Babay, Serap Turan, Abdullah Bereket, Abraham Zlotogorski, Vered Molho-Pessach
Abstract is missing (Short communication)
Pages: 1021-1023
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SHORT COMMUNICATION
CD4/CD8 Double-negative T-cell Lymphoma: A Variant of Primary Cutaneous CD8+ Aggressive Epidermotropic Cytotoxic T-cell Lymphoma?
Toshinari Miyauchi, Riichiro Abe, Yusuke Morita, Maki Adachi, Keiko Shiba, Yohei Hamade, Nao Saito, Machiko Nishimura, Makoto Ibata, Kohei Okada, Akio Shigematsu, Tomoyuki Endo, Kazuhiro Kawai, Takanori Teshima, Hiroshi Shimizu
Abstract is missing (Short communication)
Pages: 1024-1025
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SHORT COMMUNICATION
Nail Dystrophy as a Presenting Sign of a Chondrosarcoma of the Distal Phalanx – Case Report and Review of the Literature
Sonoa Au, Mark E. Juhl, Rajyasree Emmadi, Aleksander L. Krunic
Abstract is missing (Short communication)
Pages: 1026-1027
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SHORT COMMUNICATION
Disseminated Mycobacterium mantenii Infection with Multiple Purulent Cutaneous Lesions
Yuki Honda, Hideaki Tanizaki, Atsushi Otsuka, Mirei Shirakashi, Yoshitaka Imura, Tsuneyo Mimori, Yoshiki Miyachi, Kenji Kabashima
Abstract is missing (Short communication)
Pages: 1028-1029
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SHORT COMMUNICATION
No Major Effect of Cyclosporin A in Patients with Severe Solar Urticaria: A French Retrospective Case Series
Charlotte Hurabielle, Christophe Bedane, Martine Avenel-Audran, Henri Adamski, François Aubin, Michel Jeanmougin, Marie-Claude Marguery, Jean-Louis Peyron, Claire Poreaux, Jean-Luc Schmutz, Manuelle Viguier
Abstract is missing (Short communication)
Pages: 1030-1031
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SHORT COMMUNICATION
Erythema Annulare Centrifugum Associated with Ovarian Cancer
Aleksandra Batycka-Baran, Magdalena Zychowska, Wojciech Baran, Jacek C. Szepietowski, Joanna Maj
Abstract is missing (Short communication)
Pages: 1032-1033
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LETTER TO THE EDITOR
Comment on Zhao et al. “Palmoplantar Keratoderma of the Gamborg-Nielsen Type is Caused by Mutations in the SLURP1 Gene and Represents a Variant of Mal de Meleda”
Ruud G.L. Nellen, Peter M. Steijlen, Michel van Geel, Maurice A.M. van Steensel
Abstract is missing (Letter to the Editor)
Pages: 1034-1035
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LETTER TO THE EDITOR
Measuring Family Impact of Skin Diseases: FDLQI and FROM-16
Andrew Y. Finlay, Sam S. Salek, Vincent Piguet
Abstract is missing (Letter)
Pages: 1036-1036
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QUIZ
Brown Nodule on the Lower Eyelid: A Quiz
Shiho Shirota, Akane Minagawa, Hiroshi Koga, Masanobu Momose, Hisashi Uhara, Ryuhei Okuyama
Abstract is missing (Quiz)
Pages: 1037-1039
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QUIZ
Vesicles on the Breast Post-mastectomy: A Quiz
Jade Nicolette Chee, Mark Jean-Aan Koh
Abstract is missing (Qujiz)
Pages: 1037-1039
Abstract  HTML  PDF
ERRATUM
ERRATUM
Abstract is missing (Erratum)
Page: 1040
Abstract  PDF
INDEX
INDEX 95
Page: 1041
Abstract  PDF