Content

Content - Volume 96, Issue 2

Editor's choice in this issue

REVIEW
Rosacea: The Blessing of the Celts – An Approach to Pathogenesis Through Translational Research
Bodo C. Melnik
Increased expression of cathelicidin antimicrobial peptide (CAMP) is related to the pathogenesis of rosacea. CAMP plays a crucial role in antimicrobial defences, such as the killing of mycobacteria. CAMP gene expression is regulated by vitamin D-dependent (VDR) and vitamin D-independent (C/EBPα) transcription factors. VDR-dependent CAMP expression is sufficient during the summer months in Nor ...
Pages: 147-156
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REVIEW
Psychological Interventions in the Treatment of Chronic Itch
Christina Schut, Nicholas K. Mollanazar, Jörg Kupfer, Uwe Gieler, Gil Yosipovitch
Patients with chronic itch suffer from higher levels of depression and anxiety than their healthy counterparts. Furthermore, psychological factors, such as stress, are known to aggravate itch. The mere act of thinking about itching can induce the sensation. Interventions like habit reversal training and arousal reduction have been shown to have positive effects on itch relief. Yet, there is still ...
Pages: 157-161
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CLINICAL REPORT
Survival and Effectiveness of Tumour Necrosis Factor-alpha Inhibitors in the Treatment of Plaque Psoriasis under Daily Life Conditions: Report from the Psoriasis Registry Austria
Martin Inzinger, Katharina Wippel-Slupetzky, Wolfgang Weger, Leo Richter, Alexander Mlynek, Barbara Fleischander, Christine Scheurecker, Nikolaus Sandor, Daniela Mairhofer, Paul G. Sator, Sabine Moser-Oberthaler, Nina Häring, Petra Viznerova, Clemens Painsi, Adrian Tanew, Peter Ponholzer, Rafaella Tatarski, Wilhelm Brenner, Georg Stingl, Wolfgang Salmhofer, Klemens Rappersberger, Georg Klein, Werner Saxinger, Josef Auböck, Claudia Kölli, Franz Trautinger, Andreas Steiner, Gudrun Ratzinger, Robert Strohal, Elisabeth Riedl, Bernhard Lange-Asschenfeldt, Hubert Pehamberger, Beatrix Volc-Platzer, Sylvia Selhofer, Franz Josef Legat, Robert Müllegger, Norbert Reider, Matthias Schmuth, Helmut Hintner, Angelika Hofer, Alexandra Gruber-Wackernagel, Werner Aberer, Franz Quehenberger, Peter Wolf
This retrospective multicentre analysis from the Psoriasis Registry Austria (PsoRA) was conducted to determine drug effectiveness and survival of anti-tumour necrosis factor alpha (anti-TNF-α) agents in patients with moderate-to-severe chronic plaque psoriasis over a 9-year period. Data on 1,019 treatment cycles with adalimumab (n = 460), etanercept (n = 501), and/or i ...
Pages: 207-212
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All articles

REVIEW
Rosacea: The Blessing of the Celts – An Approach to Pathogenesis Through Translational Research
Bodo C. Melnik
Increased expression of cathelicidin antimicrobial peptide (CAMP) is related to the pathogenesis of rosacea. CAMP plays a crucial role in antimicrobial defences, such as the killing of mycobacteria. CAMP gene expression is regulated by vitamin D-dependent (VDR) and vitamin D-independent (C/EBPα) transcription factors. VDR-dependent CAMP expression is sufficient during the summer months in Nor ...
Pages: 147-156
Abstract  HTML  PDF
REVIEW
Psychological Interventions in the Treatment of Chronic Itch
Christina Schut, Nicholas K. Mollanazar, Jörg Kupfer, Uwe Gieler, Gil Yosipovitch
Patients with chronic itch suffer from higher levels of depression and anxiety than their healthy counterparts. Furthermore, psychological factors, such as stress, are known to aggravate itch. The mere act of thinking about itching can induce the sensation. Interventions like habit reversal training and arousal reduction have been shown to have positive effects on itch relief. Yet, there is still ...
Pages: 157-161
Abstract  HTML  PDF
CLINICAL REPORT
Insulin Resistance May Contribute to Upregulation of Adhesion Molecules on Endothelial Cells in Psoriatic Plaques
Kathrin Schlüter, Sandra Diehl, Victoria Lang, Roland Kaufmann, Wolf-Henning Boehncke, Claudia Bürger
Psoriasis primarily affects the skin, but also has a systemic dimension and is associated with severe comorbidities. Since endothelial cells play an important role in psoriasis as well as in the development of cardiovascular comorbidities, we investigated whether a common mechanism, namely cytokine-induced insulin resistance, underlies both pathologies. Activation of the insulin pathway was studie ...
Pages: 162-168
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INVESTIGATIVE REPORT
A Promoter Polymorphism of the Vitamin D Metabolism Gene Cyp24a1 is Associated with Severe Atopic Dermatitis in Adults
Jana Hallau, Lutz Hamann, Ralf R. Schumann, Margitta Worm, Guido Heine
Atopic dermatitis (AD) is a chronic inflammatory skin disease in which genetic and environmental factors result in impaired epidermal barrier functioning and an altered immune response. Vitamin D influences these 2 pathomechanisms, and beneficial results have been suggested in AD. The aim of this study was to investigate the potential roles of the 2 essential vitamin D metabolizing enzymes. The fr ...
Pages: 169-172
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INVESTIGATIVE REPORT
Cost-effectiveness of Maintenance Treatment with a Barrier-strengthe­ning Moisturizing Cream in Patients with Atopic Dermatitis in Finland, Norway and Sweden
Hanna Norrlid, Frida Hjalte, Adam Lundqvist, Åke Svensson, Gunnel Ragnarson Tennvall
Atopic dermatitis is a chronic skin disorder with high prevalence, especially in the Nordic countries. Effective maintenance therapy during symptom-free episodes may prolong the time to eczema relapse according to a previously published clinical trial. The present study evaluates the cost-effectiveness of a barrier-strengthening moisturizer containing 5% urea, compared with a moisturizer with no a ...
Pages: 173-176
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INVESTIGATIVE REPORT
Corticosteroid Phobia Among Pharmacists Regarding Atopic Derma­titis in Children: A National French Survey
Delphine Raffin, Bruno Giraudeau, Mahtab Samimi, Laurent Machet, Xavier Pourrat, Annabel Maruani
Fear of corticosteroid use among patients and parents of children with atopic dermatitis (AD) may be increased by professional caregiver’s mistrust to corticosteroids and a lack of consistency in information provision. This study used a French national survey to assess mistrust among pharmacists of the use of topical steroids for treatment of AD in children. From all pharmacies in France, a rand ...
Pages: 177-180
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INVESTIGATIVE REPORT
Modelling the Future: System Dynamics in the Cutaneous Malignant Melanoma Care Pathway
Magdalena Claeson, Stefan Hallberg, Paul Holmström, Ann-Marie Wennberg, Helena Gonzalez, John Paoli
Incidence rates for cutaneous malignant melanoma are increasing worldwide. Estimates of the future number of melanoma cases are important for strategic planning of the care pathway. The aim of this study was to use system dynamics modelling to evaluate the long-term effects of changes in incidence, population growth and preventive interventions. Historical data on invasive melanoma cases in Wester ...
Pages: 181-185
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INVESTIGATIVE REPORT
Total Body Photography as an Aid to Skin Self-examination: A Patient’s Perspective
Lisanne J. Secker, Wilma Bergman, Nicole A. Kukutsch
Skin self-examination can help patients who are at high risk for developing melanoma to become more involved in their own surveillance and treatment. This study examined the use of total body photography as an aid to skin self-examination from the patients’ perspective. A total of 179 individuals at high risk for developing melanoma who had undergone total body photography (60.5% response rate) ...
Pages: 186-190
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INVESTIGATIVE REPORT
Enzyme-linked Immunoassay Index for Anti-NC16a IgG and IgE Auto­antibodies Correlates with Severity and Activity of Bullous Pemphigoid
Monika Kalowska, Olga Ciepiela, Cezary Kowalewski, Urszula Demkow, Robert A. Schwartz, Katarzyna Wozniak
Bullous pemphigoid (BP) is characterized by IgG and IgE autoantibodies to the NC16a domain of BP180. This study evaluated the correlation between body surface area (BSA), total serum IgE and enzyme-linked immunoassay (ELISA) for IgG and IgE anti-NC16a in 77 patients with BP in the active stage, and the degree of conversion to negative of the studied parameters in clinical remission. Statistically ...
Pages: 191-196
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INVESTIGATIVE REPORT
Complement Fixation Test: An Update of an Old Method for Diagnosis of Bullous Pemphigoid
Jana Jankásková, Orsolya N. Horváth, Rita Varga, Thomas Ruzicka, Miklós Sárdy
The complement fixation test (CFT) is a method traditionally used for diagnosis of gestational pemphigoid. Its performance in diagnosis of bullous pemphigoid (BP) has not been investigated in a large patient cohort. The aim of this single-centre, retrospective, serological case-control study of 300 patients with BP and 136 control patients was to analyse its operating characteristics. CFT was foun ...
Pages: 197-201
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INVESTIGATIVE REPORT
Molecular Typing of Treponema pallidum in Denmark: A Nationwide Study of Syphilis
Kirsten Salado-Rasmussen, Susan Cowan, Jan Gerstoft, Helle Kiellberg Larsen, Steen Hoffmann, Troels Bygum Knudsen, Terese Lea Katzenstein, Jørgen Skov Jensen
The aim of this nationwide study is to determine the strain type diversity among patients diagnosed with syphilis by PCR during a 4-year period in Denmark. Epidemiological data, including HIV status, for all patients were obtained from the Danish national syphilis registration system. Molecular strain typing was based on characterization of 3 variable treponemal genes, arp, tpr and tp0548. A total ...
Pages: 202-206
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CLINICAL REPORT
Survival and Effectiveness of Tumour Necrosis Factor-alpha Inhibitors in the Treatment of Plaque Psoriasis under Daily Life Conditions: Report from the Psoriasis Registry Austria
Martin Inzinger, Katharina Wippel-Slupetzky, Wolfgang Weger, Leo Richter, Alexander Mlynek, Barbara Fleischander, Christine Scheurecker, Nikolaus Sandor, Daniela Mairhofer, Paul G. Sator, Sabine Moser-Oberthaler, Nina Häring, Petra Viznerova, Clemens Painsi, Adrian Tanew, Peter Ponholzer, Rafaella Tatarski, Wilhelm Brenner, Georg Stingl, Wolfgang Salmhofer, Klemens Rappersberger, Georg Klein, Werner Saxinger, Josef Auböck, Claudia Kölli, Franz Trautinger, Andreas Steiner, Gudrun Ratzinger, Robert Strohal, Elisabeth Riedl, Bernhard Lange-Asschenfeldt, Hubert Pehamberger, Beatrix Volc-Platzer, Sylvia Selhofer, Franz Josef Legat, Robert Müllegger, Norbert Reider, Matthias Schmuth, Helmut Hintner, Angelika Hofer, Alexandra Gruber-Wackernagel, Werner Aberer, Franz Quehenberger, Peter Wolf
This retrospective multicentre analysis from the Psoriasis Registry Austria (PsoRA) was conducted to determine drug effectiveness and survival of anti-tumour necrosis factor alpha (anti-TNF-α) agents in patients with moderate-to-severe chronic plaque psoriasis over a 9-year period. Data on 1,019 treatment cycles with adalimumab (n = 460), etanercept (n = 501), and/or i ...
Pages: 207-212
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CLINICAL REPORT
Increased Prevalence of Advanced Liver Fibrosis in Patients with Psoriasis: A Cross-sectional Analysis from the Rotterdam Study
Ella A.M. van der Voort, Edith M. Koehler, Tamar Nijsten, Bruno H. Stricker, Albert Hofman, Harry L.A. Janssen, Jeoffrey N.L. Schouten, Marlies Wakkee
Prevalence of non-alcoholic fatty liver disease is increased in patients with psoriasis. However, it is not known how liver fibrosis correlates with psoriasis. This study investigated the association between psoriasis and liver fibrosis compared with participants without psoriasis within the population-based Rotterdam Study. All participants were screened for liver fibrosis using transient elastog ...
Pages: 213-217
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CLINICAL REPORT
Impact of Depression on Risk of Myocardial Infarction, Stroke and Cardiovascular Death in Patients with Psoriasis: A Danish Nationwide Study
Alexander Egeberg, Usman Khalid, Gunnar Hilmar Gislason, Lotus Mallbris , Lone Skov, Peter Riis Hansen
Psoriasis is associated with depression, myocardial infarction (MI) and stroke. Patients with depression have increased cardiovascular risk. However, the link between psoriasis, depression and cardiovascular disease is unclear. This link was investigated in a nationwide Danish cohort of patients with psoriasis (n = 29,406). Incidence rates were calculated, and incidence rate ratios (IR ...
Pages: 218-221
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CLINICAL REPORT
Disutility in Patients with Hidradenitis Suppurativa: A Cross-sectional Study Using EuroQoL-5D
Peter Theut Riis, Gabrielle R. Vinding, Hans Christian Ring, Gregor B.E. Jemec
Disutility reflects the disability caused by a disease. The EuroQoL-5D (EQ-5D) questionnaire is a measure of health-related overall utility. The questionnaire has only been applied previously to a small number of patients with hidradenitis. In this study a survey of 421 patients with hidradenitis suppurativa was conducted using the EQ-5D questionnaire. Questions regarding pain, malodour and prurit ...
Pages: 222-226
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CLINICAL REPORT
Are Common Skin Diseases among Norwegian Dermatological Outpatients Associated with Psychological Problems Compared with Controls? An Observational Study
Flora Balieva, Lars Lien, Jörg Kupfer, Jon Anders Halvorsen, Florence Dalgard
Dermatological disease has been shown to be associated with psychological comorbidity. The aim of this observational study is to describe the distribution of skin disease and the prevalence of depression, anxiety and stress among Norwegian dermatological outpatients. Thirteen percent of outpatients had clinical anxiety compared with 3.7% of healthy controls, and 5.8% had clinical depression compar ...
Pages: 227-231
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CLINICAL REPORT
Disability Pensions due to Skin Diseases: A Cohort Study in Swedish Construction Workers
Birgitta Meding, Karin Wrangsjö, Alex Burdorf, Bengt Järvholm
Disability pensions due to skin diseases in Swedish male construction workers were studied by linking data from pension registers and an occupational health service. Incidence rates of disability pensions for cement workers, painters and plumbers were compared with 2 control groups. A total of 623 disability pensions were granted during 4 decades of follow-up. The main diagnoses were eczema (36%) ...
Pages: 232-236
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CLINICAL REPORT
Contact Allergy in Danish Healthcare Workers: A Retrospective Matched Case-control Study
Jakob F. Schwensen, Torkil Menné, Mette Sommerlund, Klaus E. Andersen, Charlotte G. Mortz, Claus Zachariae, Jeanne D. Johansen
Contact dermatitis in healthcare workers is a world wide problem. We conducted a retrospective observational study of the patch-test results of 1402 healthcare workers and 1402 matched controls with contact dermatitis who were treated at 3 hospitals departments in Denmark between 2007 and 2014. The primary objective was to determine whether healthcare work was associated with contact allergy to th ...
Pages: 237-240
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CLINICAL REPORT
Photodynamic Therapy for Actinic Keratoses: A Randomized Prospective Non-sponsored Cost-effectiveness Study of Daylight-mediated Treatment Compared with Light-emitting Diode Treatment
Noora Neittaanmäki-Perttu, Mari Grönroos, Toni Karppinen, Erna Snellman, Pekka Rissanen
Daylight-mediated photodynamic therapy (DL-PDT) is considered as effective as conventional PDT using artificial light (light-emitting diode (LED)-PDT) for treatment of actinic keratoses (AK). This randomized prospective non-sponsored study assessed the cost-effectiveness of DL-PDT compared with LED-PDT. Seventy patients with 210 AKs were randomized to DL-PDT or LED-PDT groups. Effectiveness was as ...
Pages: 241-244
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CLINICAL REPORT
Secondary Cutaneous Diffuse Large B-cell Lymphoma has a Higher International Prognostic Index Score and Worse Prognosis Than Diffuse Large B-cell Lymphoma, Leg Type
Woo Jin Lee, Kwang Hee Won, Chong Hyun Won, Sung Eun Chang, Jee Ho Choi, Kee Chan Moon, Chan-Sik Park, Jooryung Huh, Cheolwon Suh, Mi Woo Lee
Diffuse large B-cell lymphoma (DLBCL) can be separated into 2 groups: nodal and extranodal disease. The aim of this study was to analyse the clinical features of skin lesions and survival outcomes of cutaneous DLBCL according to the primary tumour site. A total of 44 patients with cutaneous DLBCL were classified as primary cutaneous DLBCL, leg type or cutaneous DLBCL secondary to primary disease. ...
Pages: 245-250
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SHORT COMMUNICATION
Down-titration of Adalimumab and Etanercept in Psoriatic Patients: A Multicentre Observational Study
Stefano Piaserico, Paolo Gisondi, Clara De Simone, Elena Marinello, Andrea Conti, Paolo Amerio, Andrea Peserico
Abstract is missing (Short communication)
Pages: 251-252
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SHORT COMMUNICATION
Improving Dermatological Care for Elderly People Living in Permanent Healthcare Institutions: Suggestions from Dutch Dermatologists
Satish F.K. Lubeek, Eric R. van der Geer , Marleen M.H.J. van Gelder , Peter C.M. van de Kerkhof, Marie-Jeanne P. Gerritsen
Abstract is missing (Short communication)
Pages: 253-254
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SHORT COMMUNICATION
Zileuton for Pruritus in Sjögren-Larsson Syndrome: A Randomized Double-blind Placebo-controlled Crossover Trial
Joris Fuijkschot, Marieke M.B. Seyger, Diane E.T. Bastiaans, Ron A. Wevers, Nel Roeleveld, Michèl A.A.P. Willemsen
Abstract is missing (Short communication)
Pages: 255-256
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SHORT COMMUNICATION
Treatment of Skin Calcifications with Intra-lesional Injection of Sodium Thiosulphate: A Case Series
Jane Baumgartner-Nielsen, Anne Braae Olesen
Abstract is missing (Short communication)
Pages: 257-258
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SHORT COMMUNICATION
Exacerbation of Psoriasis During Nivolumab Therapy for Metastatic Melanoma
Natsuko Matsumura, Mikio Ohtsuka, Nobuyuki Kikuchi, Toshiyuki Yamamoto
Abstract is missing (Short communication)
Pages: 259-260
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SHORT COMMUNICATION
Paraneoplastic Autoimmune Multi-organ Syndrome: Association with Retroperitoneal Kaposi’s Sarcoma
Giovanni Ghigliotti, Giovanni Di Zenzo, Emanuele Cozzani, Franco Rongioletti, Elena De Col, Carlotta Pastorino, Giovanni Murialdo, Aurora Parodi
Abstract is missing (Short communication)
Pages: 261-262
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SHORT COMMUNICATION
Exceptional Association of Syringotropic Mycosis Fungoides with Chronic Lymphocytic Leukaemia
Gaëlle Quéreux, Nicolas Josselin, Mélanie Saint-Jean, Lucie Peuvrel, Anabelle Brocard, Brigitte Dréno
Abstract is missing (Short communication)
Pages: 263-264
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SHORT COMMUNICATION
Acute Generalized Exanthematous Pustulosis Caused by Faropenem: A Possible Pathogenetic Role for Interleukin-23
Yumiko Sakuragi, Yu Sawada , Yoko Hara, Shun Ohmori, Daisuke Omoto, Sanehito Haruyama, Manabu Yoshioka, Daisuke Nishio, Motonobu Nakamura
Abstract is missing (Short communication)
Pages: 265-266
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SHORT COMMUNICATION
Lichen Planus Possibly Induced by Acyclovir in a Child
Angela Alani, Muriel Sadlier, Kashif Ahmad
Abstract is missing (Short communication)
Pages: 266-267
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SHORT COMMUNICATION
Sclerosing Lipogranuloma with Multiple Skin Lesions and Pulmonary Involvement, Secondary to a Factitious Disorder
Maria Claudia Tirico, Cyro Festa Neto, Neusa Y.S. Valente, Marcello Menta S. Nico
Abstract is missing (Short communication)
Pages: 268-269
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SHORT COMMUNICATION
Disseminated Favus Caused by Microsporum gypseum in a Patient with Systemic Lupus Erythematosus
Tutyana Sanusi, Jin Gong, Xia Wang, Mengjie Zhao, Yun Zhao, Xiangjie An, Chunsen Wang, Changzheng Huang, Siyuan Chen
Abstract is missing (Short communication)
Pages: 270-271
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SHORT COMMUNICATION
Pigmented Dermatofibrosarcoma Protuberans and Blue Naevi with Similar Dermoscopy: A Case Report
Yuko Ehara, Yuichi Yoshida, Tatsushi Shiomi, Osamu Yamamoto
Abstract is missing (Short communication)
Pages: 272-273
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SHORT COMMUNICATION
Acquired Port-wine Stain with Local Heat
Shiang-Yu Yang, Cheng-Che E. Lan
Abstract is missing (Short communication)
Pages: 274-275
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SHORT COMMUNICATION
Evaluation of Mononuclear Cells in Lichen Planus Pemphigoides
Miho Kabuto, Noriki Fujimoto, Akihiko Yamaguchi, Toshihiro Tanaka
Abstract is missing (Short communication)
Pages: 276-278
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SHORT COMMUNICATION
The Adult Phenotype of Tuberous Sclerosis Complex
Neera Nathan, Kristina Burke, Cory Trickett, Joel Moss, Thomas N. Darling
Abstract is missing (Short communication)
Pages: 278-280
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SHORT COMMUNICATION
Phacomatosis Melanorosea: A Further Case of an Unusual Skin Disorder
Burak Tekin, Deniz Yucelten, Rudolf Happle
Abstract is missing (Short communication)
Pages: 280-282
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SHORT COMMUNICATION
Dietary Regimes for Treatment of Acne Vulgaris: A Critical Review of Published Clinical Trials
Sofia Norstedt, Magnus Lindberg
Abstract is missing (Short communication)
Pages: 283-284
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QUIZ
Dyskeratosis of the Face: A Quiz
Valérie Vuong, Gentiane Monsel, Bénedicte Cavelier-Balloy, Maxime Battistella, Evelyne Collet, Martine Bagot, Nicole Basset-Seguin, Manuelle Viguier
Abstract is missing (Quiz)
Pages: 285-287
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QUIZ
Alopecic Lesions on the Scalp in a Young Woman: A Quiz
Elena del Alcázar Viladomiu, Arantxa López Pestaña, Sara Ibarbia Oruezabal, María Paula Gutiérrez Tamara, Anna Tuneu Valls
Abstract is missing (Quiz)
Pages: 285-287
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BOOK REVIEW
Current Problems in Dermatology, Vol. 48. Tattooed Skin and Health
Kristian Thestrup-Pedersen
Abstract is missing (Book review)
Page: 288
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BOOK REVIEW
Food Allergy: Molecular Basis and Clinical Practice
Carl-Fredrik Wahlgren
Abstract is missing (Book review)
Page: 288
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