Content

Content - Volume 96, Issue 4

Editor's choice in this issue

EDITORIAL
Farewell and Welcome!
Anders Vahlquist
Page: 435
Abstract  PDF
CLINICAL REPORT
Basal Cell Carcinoma is as Common as the Sum of all Other Cancers: Implications for Treatment Capacity
Ann-Sofie Holm, Christoffer V. Nissen, Hans Christian Wulf
Reliable estimates of disease incidence are fundamental to planning future healthcare services. However, in many countries registration of basal cell carcinoma (BCC) is often non-existent. This study examines how many BCC treatments were carried out in Denmark in 2013. The Danish Cancer Registry and the Danish Pathology Registry were used to examine how many BCC treatments were registered, and a t ...
Pages: 505-509
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SHORT COMMUNICATION
The Behavioral Addiction Indoor Tanning Screener (BAITS): An Evaluation of a Brief Measure of Behavioral Addictive Symptoms
Jerod L. Stapleton, Joel J. Hillhouse, Rob Turrisi, Katie Baker, Sharon L. Manne, Elliot J. Coups
Abstract is missing (Short communication)
Pages: 552-553
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CLINICAL REPORT
Long-term Sequelae of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis
Che-Wen Yang , Yung-Tsu Cho, Kai-Lung Chen , Yi-Chun Chen, Hsiang-Lin Song , Chia-Yu Chu
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse drug reactions characterized by different extents of epidermal necrosis and mucosal breakdown. A limited number of studies have reported the long-term patterns of SJS and TEN complications in patient populations over long follow-up periods. The aim of this retrospective study was to collect data on lon ...
Pages: 525-529
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All articles

EDITORIAL
Farewell and Welcome!
Anders Vahlquist
Page: 435
Abstract  PDF
REVIEW
Psoriasis and Psoriatic Arthritis: Flip Sides of the Coin?
Wolf-Henning Boehncke
Presence (current or past) of psoriasis of the skin is a major criterion to establish the diagnosis of psoriatic arthritis. However, in individual patients, the course of psoriasis and psoriatic arthritis do not seem to correlate. This raises the issue of whether psoriasis and psoriatic arthritis are distinct entities, or parts of the spectrum of a “psoriatic disease”. Arguments in favour of b ...
Pages: 436-441
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REVIEW
Post-transplant Merkel Cell Carcinoma
Virve Koljonen, Helka Sahi, Tom Böhling, Heikki Mäkisalo
Malignant tumours are the foremost complications of immunosuppressive treatment. They are a major challenge for organ transplant recipients and their treating physicians. This paper reviews the aetiology and current treatment of an unusual neuroendocrine skin cancer, Merkel cell carcinoma (MCC), caused by a Merkel cell polyomavirus infection. MCC occurs more frequently than expected in immunosuppr ...
Pages: 442-447
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SPECIAL REPORT
Efficacy and Safety of Mammalian Target of Rapamycin Inhibitors in Vascular Anomalies: A Systematic Review
Marion Nadal, Bruno Giraudeau, Elsa Tavernier, Annie-Pierre Jonville-Bera, Gerárd Lorette, Annabel Maruani
Mammalian target of rapamycin (mTOR) inhibitors are a promising new treatment in vascular anomalies, but no published randomized controlled trials are available. The aim of this systematic review of all reported cases was to assess the efficacy and safety of mTOR inhibitors in all vascular anomalies, except cancers, in children and adults. In November 2014 MEDLINE, CENTRAL, LILACS and EMBASE were ...
Pages: 448-452
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SPECIAL REPORT
Effectiveness of Biologic and Conventional Systemic Therapies in Adults with Chronic Plaque Psoriasis in Daily Practice: A Systematic Review
Jeffrey Zweegers, Marisol E. Otero, Juul M.P.A. van den Reek, Paula P. van Lümig, Rieke J. Driessen, Wietske Kievit, Marieke M.B. Seyger, Peter C.M. van de Kerkhof, Elke M.G.J. de Jong
The efficacy of biologic or conventional systemic therapies for psoriasis has been shown in randomized controlled trials. Effectiveness, however, has been studied in daily practice cohorts, and no aggregation of effectiveness data is available. This systematic review searched PubMed and EMBASE and summarized the real-world evidence on effectiveness of biologics (adalimumab, etanercept, infliximab ...
Pages: 453-458
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INVESTIGATIVE REPORT
Association of a Single Nucleotide Polymorphism in a Late Cornified Envelope-like Proline-rich 1 Gene (LELP1) with Atopic Dermatitis
Magdalena Trzeciak , Martyna Wesserling, Tomasz Bandurski, Jolanta Glen, Roman Nowicki, Tadeusz Pawelczyk
There is some evidence that genes involved in the pathogenesis of atopic dermatitis, in addition to the filaggrin (FLG) gene, may be located at chromosome region 1q21. The aim of this study was to examine the association of single nucleotide polymorphisms in the region of the late cornified envelope-like proline-rich 1 (LELP1), hornerin (HRNR) and FLG genes with the course and risk of atopic derma ...
Pages: 459-463
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INVESTIGATIVE REPORT
Expression of CD164 on Malignant T cells in Sézary Syndrome
Emmanuella Guenova, Desislava Ignatova, Yun-Tsan Chang, Emmanuel Contassot, Tarun Mehra, Ieva Saulite, Alexander A. Navarini, Vanyo Mitev, Reinhard Dummer, Dmitry V. Kazakov, Lars E. French, Wolfram Hoetzenecker, Antonio Cozzio
Sézary syndrome is a primary cutaneous T-cell lymphoma characterized by pruritic erythroderma, peripheral lymphadenopathy and the presence of malignant T cells in the blood. Unequivocal detection of malignant cells in patients with Sézary syndrome is of important diagnostic, prognostic and therapeutic value. However, no single Sézary syndrome specific cell surface marker has been identified. In ...
Pages: 464-467
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INVESTIGATIVE REPORT
Eight Novel Mutations Confirm the Role of AAGAB in Punctate Palmoplantar Keratoderma Type 1 (Buschke-Fischer-Brauer) and Show Broad Phenotypic Variability
Kathrin A. Giehl , Thomas Herzinger, Hans Wolff, Miklós Sárdy, Tanja von Braunmühl, Valérie Dekeuleneer, Yves Sznajer, Dominique Tennstedt, Pascaline Boes, Stefan Rapprich, Nicola Wagner, Regina C. Betz, Markus Braun-Falco, Tim Strom, Thomas Ruzicka, Gertrud N. Eckstein
Punctate palmoplantar keratoderma (PPKP1; Buschke-Fischer-Brauer) is a rare autosomal dominant inherited skin disease characterized by multiple hyperkeratotic papules involving the palms and soles. Mutations have been found at 2 loci, on chromosomes 15q22–15q24 and 8q24.13–8q24.21. We recently identified mutations in 3 families, in the AAGAB gene on 15q, which encodes the alpha- and gamma-adap ...
Pages: 468-472
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INVESTIGATIVE REPORT
Expanding the Clinical and Genetic Spectrum of KRT1, KRT2 and KRT10 Mutations in Keratinopathic Ichthyosis
Alrun Hotz, Vinzenz Oji, Emmanuelle Bourrat, Nathalie Jonca, Juliette Mazereeuw-Hautier, Regina C. Betz, Ulrike Blume-Peytavi, Karola Stieler, Fanny Morice-Picard, Ines Schönbuchner, Susanne Markus, Nina Schlipf, Judith Fischer
Twenty-six families with keratinopathic ichthyoses (epidermolytic ichthyosis, superficial epidermolytic ichthyosis or congenital reticular ichthyosiform erythroderma) were studied. Epidermolytic ichthyosis is caused by mutations in the genes KRT1 or KRT10, mutations in the gene KRT2 lead to superficial epidermolytic ichthyosis, and congenital reticular ichthyosiform erythroderma is caused by frame ...
Pages: 473-478
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INVESTIGATIVE REPORT
Epidemiology of Melanocytic Naevi in Children from Lleida, Catalonia, Spain: Protective Role of Sunscreen in the Development of Acquired Moles
Sara Moreno, Xavier Soria, Montserrat Martínez, Rosa M. Martí, Josep M. Casanova
The worldwide incidence of malignant melanoma is increasing. The number of pigmented naevi and amount of solar exposure are important risk factors. The aim of this study was to characterize a paediatric population (from Lleida, Catalonia, Spain) in terms of phenotype, sun behaviour and naevi prevalence. Data on the numbers and distributions of acquired naevi in 369 children, aged 4, 8 and 14 years ...
Pages: 479-484
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INVESTIGATIVE REPORT
Up-regulation of Proinflammatory Genes and Cytokines Induced by S100A8 in CD8+ T Cells in Lichen Planus
Gabriel Costa de Carvalho, Rosana Domingues, Marcelle Almeida de Sousa Nogueira, Anna C. Calvielli Castelo Branco, Kelly C. Gomes Manfrere, Naiura Vieira Pereira, Valéria Aoki, Mirian Nacagami Sotto, Alberto J. Da Silva Duarte, Maria Notomi Sato
Lichen planus (LP) is a chronic inflammatory mucocutaneous disease. The inflammatory status of LP may be related to S100A8 (myeloid-related protein 8; MRP8) activation of cytotoxic cells. The aims of this study were to evaluate S100A8 expression in skin lesions and the in vitro effects of S100A8 on CD8+ T cells and natural killer (NK) cells in LP. Increased levels of S100A8/S100A9 were detected in ...
Pages: 485-489
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INVESTIGATIVE REPORT
Narrowband Ultraviolet B Exposures Maintain Vitamin D Levels During Winter: A Randomized Controlled Trial
Toni Karppinen, Meri Ala-Houhala, Lasse Ylianttila, Hannu Kautiainen, Heli Viljakainen, Timo Reunala, Erna Snellman
Exposure to solar ultraviolet B radiation during the summer months is the main source of vitamin D (VD) for people living in northern latitudes. The aim of this study was to determine whether artificial narrowband ultraviolet B (NB-UVB) whole-body exposures could maintain VD levels in winter. The intervention group received 2 standard erythema doses (SEDs) of NB-UVB exposures every second week fro ...
Pages: 490-493
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INVESTIGATIVE REPORT
Anogenital Human Papillomavirus Prevalence is Unaffected by Therapeutic Tumour Necrosis Factor-alpha Inhibition
Alessandra Handisurya, Stefanie Lázár, Pavol Papay, Christian Primas, Andrea Haitel, Reinhard Horvat, Adrian Tanew, Harald Vogelsang, Reinhard Kirnbauer
Patients receiving tumour necrosis factor alpha (TNF-α) inhibitors are at increased risk of exacerbation of (myco-)bacterial and some viral infections. However, information on anogenital human papillomavirus (HPV) infection in these patients is sparse or conflicting. In this study 222 patients with psoriasis or inflammatory bowel disease (IBD), who received either anti-TNF-α inhibitors o ...
Pages: 494-498
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INVESTIGATIVE REPORT
Economic Evaluation of a Multifaceted Implementation Strategy for the Prevention of Hand Eczema Among Healthcare Workers in Comparison with a Control Group: The Hands4U Study
Esther W.C. van der Meer, Johanna M. van Dongen, Cécile R.L. Boot, Joost W.J. van der Gulden, Judith E. Bosmans, Johannes R. Anema
The aim of this study was to evaluate the cost-effectiveness of a multifaceted implementation strategy for the prevention of hand eczema in comparison with a control group among healthcare workers. A total of 48 departments (n=1,649) were randomly allocated to the implementation strategy or the control group. Data on hand eczema and costs were collected at baseline and every 3 months. Cost-effecti ...
Pages: 499-504
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CLINICAL REPORT
Basal Cell Carcinoma is as Common as the Sum of all Other Cancers: Implications for Treatment Capacity
Ann-Sofie Holm, Christoffer V. Nissen, Hans Christian Wulf
Reliable estimates of disease incidence are fundamental to planning future healthcare services. However, in many countries registration of basal cell carcinoma (BCC) is often non-existent. This study examines how many BCC treatments were carried out in Denmark in 2013. The Danish Cancer Registry and the Danish Pathology Registry were used to examine how many BCC treatments were registered, and a t ...
Pages: 505-509
Abstract  HTML  PDF
CLINICAL REPORT
Use of Mycophenolate Mofetil in Patients with Severe Localized Scleroderma Resistant or Intolerant to Methotrexate
Jorre S. Mertens, Diane Marsman, Peter C.M. van de Kerkhof, Esther P.A.H. Hoppenreijs, Hanneke K.A. Knaapen, Timothy R.D. Radstake, Elke M.G.J. de Jong, Marieke M.B. Seyger
To assess the efficacy and safety of mycophenolate mofetil (MMF) in patients with localized scleroderma (LoS) resistant or intolerant to previous treatment with methotrexate (MTX). A case series of patients with LoS treated with MMF. Outcome was assessed through clinical examination. Adverse events were documented. Seven patients with LoS were treated with MMF. Median age at MMF initiation was 15 ...
Pages: 510-513
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CLINICAL REPORT
Effects of Apremilast on Pruritus and Skin Discomfort/Pain Correlate With Improvements in Quality of Life in Patients With Moderate to Severe Plaque Psoriasis
Jeffrey M. Sobell, Peter Foley, Darryl Toth, Ulrich Mrowietz, Giampiero Girolomoni, Joana Goncalves, Robert M. Day, Rongdean Chen, Gil Yosipovitch
Pruritus and skin discomfort/pain negatively impact health-related quality of life (HRQoL). The effects of apremilast, an oral phosphodiesterase inhibitor, on pruritus, skin discomfort/pain, and patient global assessment of psoriasis disease activity (PgAPDA) were assessed in moderate/severe chronic plaque psoriasis patients in the phase 3 ESTEEM trials. Significant improvements in pruritus and sk ...
Pages: 514-520
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CLINICAL REPORT
Usefulness of Rajka & Langeland Eczema Severity Score in Clinical Practice
Agneta Gånemo, Åke Svensson, Cecilia Svedman, Britt-Marie Grönberg, Ann-Charlotte Öhman Johansson, Carl-Fredrik Wahlgren
Simple, validated eczema severity scores are required for the evaluation of interventions. The Rajka & Langeland (R&L) scale is based on 3 domains (extent, course, and intensity); however, its validity is not yet confirmed. The aim of this study was to investigate the quality aspects of the R&L scale in clinical practice. In the first part of the study, experts and consumers judged the content val ...
Pages: 521-524
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CLINICAL REPORT
Long-term Sequelae of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis
Che-Wen Yang , Yung-Tsu Cho, Kai-Lung Chen , Yi-Chun Chen, Hsiang-Lin Song , Chia-Yu Chu
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse drug reactions characterized by different extents of epidermal necrosis and mucosal breakdown. A limited number of studies have reported the long-term patterns of SJS and TEN complications in patient populations over long follow-up periods. The aim of this retrospective study was to collect data on lon ...
Pages: 525-529
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CLINICAL REPORT
Risk of Acute Myocardial Infarction or Stroke in Patients with Mycosis Fungoides and Parapsoriasis
Lise M. Lindahl, Uffe Heide-Jørgensen, Lars Pedersen, Henrik Toft Sørensen, Lars Iversen
Mycosis fungoides (MF) and parapsoriasis display increased inflammation, which may be associated with increased risk of arterial cardiovascular events. The aim of this Danish nationwide population-based cohort study was to assess the relative risk (RR) of acute myocardial infarction (AMI) or stroke in patients with MF and parapsoriasis. In patients with MF, the RR of AMI or stroke was 1.0 (95% con ...
Pages: 530-534
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CLINICAL REPORT
Cutaneous Lymphoma in Korea: A Nationwide Retrospective Study
Hyun Soo Lee, Kee Suck Suh, Dong-Youn Lee, Kwang Hyun Cho, Sang Ho Oh, Soo-Chan Kim, Seok-Jong Lee, Dong Hoon Shin, Tae Young Yoon, Young Ho Won, You Chan Kim
The epidemiological and clinicopathological features of cutaneous lymphoma may vary by geographical area. However, only a few large-scale epidemiological studies of cutaneous lymphoma have been performed, mainly in the USA and Europe. This aim of this study was to determine the recent characteristics of cutaneous lymphoma in Korea according to the WHO/EORTC classification. A total of 422 patients ...
Pages: 535-539
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CLINICAL REPORT
Hereditary Angioedema in Swedish Adults: Report From the National Cohort
Patrik Nordenfelt, Mats Nilsson , Janne Björkander, Lotus Mallbris , Anders Lindfors, Carl-Fredrik Wahlgren
Hereditary angioedema (HAE) is rare, disabling and sometimes life-threatening. The aim of this study is to describe its prevalence, symptomatology and treatment in Sweden. A total of 146 patients were identified; 110 adults and 36 children with HAE type I (n = 136) or II (n = 10), giving a minimal HAE prevalence of 1.54/100,000. All patients received a written questionnaire ...
Pages: 540-545
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CLINICAL REPORT
Coxsackievirus A6 Polymorphic Exanthem in Israeli Children
Yael Renert-Yuval, Eytan Marva, Merav Weil, Lester M. Shulman, Nilsu Gencylmaz, Sivan Sheffer, Dana G. Wolf, Vered Molho-Pessach
Hand foot and mouth disease (HFMD) is an acute childhood viral exanthem usually associated with coxsackievirus A16 or enterovirus 71. Atypical HFMD associated with coxsackievirus A6 was reported recently. The aim of the current study was to describe coxsackievirus A6-associated atypical HFMD in a series of 8 toddlers who were referred with idiopathic extensive eruptions. Demographic and clinical c ...
Pages: 546-549
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SHORT COMMUNICATION
Psychological Stress and Skin Symptoms in College Students: Results of a Cross-sectional Web-based Questionnaire Study
Christina Schut, Nicholas K. Mollanazar, Mansha Sethi, Leigh A. Nattkemper, Rodrigo Valdes-Rodriguez, MacKenzie M. Lovell, Gina L. Calzaferri, Gil Yosipovitch
Abstract is missing (Short communication)
Pages: 550-551
Abstract  HTML  PDF
SHORT COMMUNICATION
The Behavioral Addiction Indoor Tanning Screener (BAITS): An Evaluation of a Brief Measure of Behavioral Addictive Symptoms
Jerod L. Stapleton, Joel J. Hillhouse, Rob Turrisi, Katie Baker, Sharon L. Manne, Elliot J. Coups
Abstract is missing (Short communication)
Pages: 552-553
Abstract  HTML  PDF
SHORT COMMUNICATION
Pain in Hidradenitis Suppurativa: A Pilot Study
Hans C. Ring, Henrik Sørensen, Iben M. Miller, Emil K. List, Ditte M. Saunte, Gregor B. Jemec
Abstract is missing (Short communication)
Pages: 554-556
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SHORT COMMUNICATION
Acute Edema Blisters on a Skin Swelling: An Unusual Manifestation of Hereditary Angioedema
José Fabiani, Konrad Bork
Abstract is missing (Short communcation)
Pages: 556-557
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SHORT COMMUNICATION
Erythrokeratoderma Variabilis Caused by p.Gly45Glu in Connexin 31: Importance of the First Extracellular Loop Glycine Residue for Gap Junction Function
Takuya Takeichi, Kazumitsu Sugiura, Chao-Kai Hsu, Toshifumi Nomura, Hiroyuki Takama, Michael A. Simpson, Hiroshi Shimizu, John A. McGrath, Masashi Akiyama
Abstract is missing (Short communication)
Pages: 557-559
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SHORT COMMUNICATION
A Case of Miliary Tuberculosis Presenting with Whitlow of the Thumb
Romaric Larcher, Albert Sotto, Jean-Marc Mauboussin, Jean-Philippe Lavigne, François-Xavier Blanc, Didier Laureillard
Abstract is missing (Short communication)
Pages: 560-561
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SHORT COMMUNICATION
Gonococcal Osteomyelitis Resulting in Permanent Sequelae
Magnus Rehnström, Magnus Unemo, Petra Tunbäck
Abstract is missing (Short communication)
Pages: 562-563
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SHORT COMMUNICATION
Dual CD4/CD8-positive Ichthyosiform Mycosis Fungoides with Lymph Node, Peripheral Blood and Cardiac Involvement: A Case Report
Yo Kaku, Atsushi Otsuka, Hideaki Tanizaki, Rintaro Shibuya, Yuichiro Endo, Yumi Nonomura, Masahiro Hirata, Masakazu Fujimoto, Katsuyuki Ohmori, Takaki Sakurai, Kenji Kabashima
Abstract is missing (Short communication)
Pages: 564-566
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SHORT COMMUNICATION
Non-infectious Panniculitis during Hydroxyurea Therapy in a Patient with Myeloproliferative Disease
Yasushi Ogawa, Masashi Akiyama
Abstract is missing (Short communication)
Pages: 566-567
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SHORT COMMUNICATION
Cryoglobulinaemia (IgG-κ-type and IgM-γ-type) with Occluding Leukocytoclastic Vasculitis in a Patient with Vitiligo and Demyelinating Polyneuropathy
Masako Sato, Naoki Oiso, Toshihiko Shiga, Ryoko Morita, Masatomo Kimura, Masanori Funauchi, Itaru Matsumura, Akira Kawada
Abstract is missing (short communcation)
Pages: 568-569
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SHORT COMMUNICATION
CD30-positive Cutaneous Pseudolymphoma Caused by Tocilizumab in a Patient with Rheumatoid Arthritis: Case Report and Literature Review
Akiha Inoue, Yu Sawada , Shun Ohmori, Daisuke Omoto, Sanehito Haruyama, Manabu Yoshioka, Daisuke Nishio, Motonobu Nakamura
Abstract is missing (Short communication)
Pages: 570-571
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CORRESPONDENCE
Comment: Clinical Pathology Correlation: Clinical First, then Pathology, and Lastly Immunochemistry
Kan Wu
Abstract is missing (Correspondence)
Pages: 573-573
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CORRESPONDENCE
Urticaria as a Presenting Prodromal Manifestation of Attacks of Hereditary Angioedema
Ludovic Martin, Thomas Renné, Christian Drouet
Abstract is missing (Correspondence)
Pages: 574-575
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QUIZ
Symmetrical, Hypopigmented Papules and Plaques on the Palms Induced by Contact with Water: A Quiz
Elena Marinello, Giovanna Dan, Dennis Michael Linder, Anna Belloni Fortina, Andrea Peserico, Stefano Piaserico
Abstract is missing (Quiz)
Pages: 575-576
Abstract  HTML  PDF