Content

Content - Volume 96, Issue 6

Editor's choice in this issue

REVIEW
Glial Cells are Involved in Itch Processing
Hjalte H. Andersen, Lars Arendt-Nielsen, Parisa Gazerani
Recent discoveries in itch neurophysiology include itch-selective neuronal pathways, the clinically relevant non-histaminergic pathway, and elucidation of the notable similarities and differences between itch and pain. Potential involvement of glial cells in itch processing and the possibility of glial modulation of chronic itch have recently been identified, similarly to the established glial mod ...
Pages: 723-727
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INVESTIGATIVE REPORT
Granular C3 Dermatosis
Takashi Hashimoto, Daisuke Tsuruta, Atsushi Yasukochi, Hisayoshi Imanishi, Hideharu Sekine, Teizo Fujita, Hideki Wanibuchi, Min Gi, Sarolta Kárpáti, Cassian Sitaru, John J. Zone, Daisuke Endo, Shinichi Abe, Tomoya Nishino, Takehiko Koji, Norito Ishii
There has been no previous systematic study of bullous skin diseases with granular basement membrane zone deposition exclusively of C3. In this study we collected 20 such patients, none of whom showed cutaneous vasculitis histopathologically. Oral dapsone and topical steroids were effective. Various serological tests detected no autoantibodies or autoantigens. Direct immunofluorescence for various ...
Pages: 748-753
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All articles

REVIEW
Glial Cells are Involved in Itch Processing
Hjalte H. Andersen, Lars Arendt-Nielsen, Parisa Gazerani
Recent discoveries in itch neurophysiology include itch-selective neuronal pathways, the clinically relevant non-histaminergic pathway, and elucidation of the notable similarities and differences between itch and pain. Potential involvement of glial cells in itch processing and the possibility of glial modulation of chronic itch have recently been identified, similarly to the established glial mod ...
Pages: 723-727
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INVESTIGATIVE REPORT
The Role of Auditory Itch Contagion in Psoriasis
Samantha Swithenbank, Fiona Cowdell, Henning Holle
Itch and associated scratching is a common and distressing symptom of psoriasis. Here, we tested whether people with psoriasis, relative to healthy controls, show an increased vulnerability to auditory itch contagion (a deleterious influence) when presented with sounds of itch-associated actions of scratching and rubbing. We were also interested in whether manipulating the high frequency volume of ...
Pages: 728-731
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INVESTIGATIVE REPORT
Serotonergic Markers in Atopic Dermatitis
Aram Rasul, Husameldin El-Nour, Sol-Britt Lonne-Rahm, Oscar Fransson, Charlotta Johansson, Björn Johansson, Marwe Zubeidi, Emma Seeberg, Diana Radu Djurfeldt, Efrain C. Azmitia, Klas Nordlind
Stress and anxiety may worsen atopic dermatitis (AD) through the serotonin system. Serotonergic expression was measured in 28 patients with AD in relation to extent of the disease (SCORing of Atopic Dermatitis; SCORAD), pruritus intensity (visual analogue scale; VAS), anxiety traits (Swedish Universities Scales of Personality; SSP) and depression (Montgomery-Åsberg Depression Rating Scale-Self as ...
Pages: 732-736
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INVESTIGATIVE REPORT
KRAS, HRAS and EGFR Mutations in Sporadic Sebaceous Gland Hyperplasia
Leopold Groesser, Sebastian Singer, Eva Peterhof, Michael Landthaler, Ulrike Heigl, Wulf Schneider-Brachert, Mark Berneburg, Christian Hafner
Sporadic sebaceous gland hyperplasia (SGH) is a benign skin lesion, with a high prevalence in the general population. Although SGH has been attributed to both extrinsic and intrinsic factors, the underlying genetic changes have not yet been characterized. Recently, HRAS and KRAS mutations have been identified in sebaceous naevus, a hamartoma sharing histological characteristics with SGH. Therefore ...
Pages: 737-741
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INVESTIGATIVE REPORT
MicroRNA-155 is Dysregulated in the Skin of Patients with Vitiligo and Inhibits Melanogenesis-associated Genes in Melanocytes and Keratinocytes
Liisi Šahmatova, Stoyan Tankov, Ele Prans, Alar Aab, Helen Hermann, Paula Reemann, Maire Pihlap, Maire Karelson, Kristi Abram, Kai Kisand, Külli Kingo, Ana Rebane
Little is known about the functions of microRNAs (miRNAs) in skin pigmentation disorders. The aim of this study was to investigate the expression and potential role of miRNAs in vitiligo. Of 12 studied miRNAs with proven functions in cell proliferation, differentiation, immune responses and melanogenesis, miR-99b, miR-125b, miR-155 and miR-199a-3p were found to be increased and miR-145 was found t ...
Pages: 742-747
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INVESTIGATIVE REPORT
Granular C3 Dermatosis
Takashi Hashimoto, Daisuke Tsuruta, Atsushi Yasukochi, Hisayoshi Imanishi, Hideharu Sekine, Teizo Fujita, Hideki Wanibuchi, Min Gi, Sarolta Kárpáti, Cassian Sitaru, John J. Zone, Daisuke Endo, Shinichi Abe, Tomoya Nishino, Takehiko Koji, Norito Ishii
There has been no previous systematic study of bullous skin diseases with granular basement membrane zone deposition exclusively of C3. In this study we collected 20 such patients, none of whom showed cutaneous vasculitis histopathologically. Oral dapsone and topical steroids were effective. Various serological tests detected no autoantibodies or autoantigens. Direct immunofluorescence for various ...
Pages: 748-753
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INVESTIGATIVE REPORT
Decreased Number of Circulating Endothelial Progenitor Cells (CD133+/KDR+) in Patients with Psoriatic Arthritis
Aleksandra Batycka-Baran, Maria Paprocka, Wojciech Baran, Jacek C. Szepietowski
Cardiovascular diseases are a major cause of mortality in patients with psoriatic arthritis (PsA), but the precise mechanism of increased cardiovascular risk is unknown. Endothelial dysfunction plays a crucial role in the development of atherosclerosis. Circulating endothelial progenitor cells (CEPCs) contribute to endothelial regeneration and their level may be affected by chronic inflammation. T ...
Pages: 754-757
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INVESTIGATIVE REPORT
Risk of Death in Bullous Pemphigoid: A Retrospective Database Study in Finland
Anna-Kaisa Försti, Jari Jokelainen, Markku Timonen, Kaisa Tasanen
Bullous pemphigoid (BP) is an autoimmune skin disease of elderly people, which is associated with increased mortality. The aim of this study was to investigate the standardized mortality ratio (SMR) for BP in Finland, and concomitant comorbidities and medications. This was a retrospective database study of all cases of BP diagnosed at the Department of Dermatology, Oulu University Hospital, Finlan ...
Pages: 758-761
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INVESTIGATIVE REPORT
Clinical and Immunological Studies of 332 Japanese Patients Tentatively Diagnosed as Anti-BP180-type Mucous Membrane Pemphigoid: A Novel BP180 C-terminal Domain Enzyme-linked Immunosorbent Assay
Atsushi Yasukochi, Kwesi Teye, Norito Ishii, Takashi Hashimoto
Diagnosis of anti-BP180-type mucous membrane pemphigoid (BP180-MMP) is frustrated by the difficulty of detecting BP180 reactivity. A total of 721 patients with suspected MMP, selected from a cohort of 4,698 patients with autoimmune bullous disease (AIBD), were included in this study. Of these, 332 patients were tentatively diagnosed as BP180-MMP if they showed IgG/IgA reactivity with the epidermal ...
Pages: 762-767
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CLINICAL REPORT
Autoantibody Profile of a Cohort of 78 Italian Patients with Mucous Membrane Pemphigoid: Correlation Between Reactivity Profile and Clinical Involvement
Emanuele Cozzani, Giovanni Di Zenzo, Valentina Calabresi, Marco Carrozzo, Martina Burlando, Lora Longanesi, Amilcare Cerri, Marzia Caproni, Francesco Sera, Emiliano Antiga, Pietro Quaglino, Angelo V. Marzano, Aurora Parodi
Direct diagnosis of mucous membrane pemphigoid (MMP) is not easy. Circulating autoantibodies targeting bullous pemphigoid antigens of 180 kDa and 230 kDa (BP180 and BP230), α6β4 integrin, laminin 332 and type VII collagen (Col VII) are not always present. The aims of this study were to characterize the humoral immune response of a cohort of Italian patients with MMP, its association with ...
Pages: 768-773
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CLINICAL REPORT
Verapamil is Less Effective than Triamcinolone for Prevention of Keloid Scar Recurrence After Excision in a Randomized Controlled Trial
Patricia L. Danielsen, Suzanne M. Rea, Fiona M. Wood, Mark W. Fear, Helena M. Viola, Livia C. Hool, Thilanee U. Gankande, Mansour Alghamdi, Andrew W. Stevenson, Mitali Manzur, Hilary J. Wallace
A double-blind randomized controlled trial with a paired split-scar design compared verapamil, an L-type Ca2+ channel antagonist, and triamcinolone for prevention of keloid recurrence after excision. Ca2+ channel blocking activity of verapamil in keloid cells was explored. One keloid was excised per subject and each wound half randomized to receive intralesional injections of triamcinolone (10 mg/ ...
Pages: 774-778
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CLINICAL REPORT
Teledermoscopy in High-risk Melanoma Patients: A Comparative Study of Face-to-face and Teledermatology Visits
Edith Arzberger, Clara Curiel-Lewandrowski, Andreas Blum , Dmitry Chubisov, Amanda Oakley, Marius Rademaker, Hans Soyer, Rainer Hofmann-Wellenhof
Teledermoscopy is considered a reliable tool for the evaluation of pigmented skin lesions. We compared the management decision in face-to-face visits vs. teledermatology in a high-risk melanoma cohort using total-body photography, macroscopic and dermoscopic images of single lesions. Patients were assessed both face-to face and by 4 remote teledermatologists. Lesions identified as suspicious for s ...
Pages: 779-783
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CLINICAL REPORT
Frequent Occurrence of Aplasia Cutis Congenita in Bullous Dermolysis of the Newborn
Andrea Diociaiuti, Daniele Castiglia, Simona Giancristoforo, Liliana Guerra, Vittoria Proto, Andrea Dotta, Renata Boldrini, Giovanna Zambruno, Maya El Hachem
Bullous dermolysis of the newborn (BDN) is a subtype of dystrophic epidermolysis bullosa characterized by rapid improvement in skin fragility within the first months of life, associated with typical immunofluorescence and ultrastructural features. Inheritance can be autosomal dominant or recessive. We report here 4 cases of BDN, 2 of which presented with aplasia cutis congenita of the lower extrem ...
Pages: 784-787
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CLINICAL REPORT
Throat Infections are Associated with Exacerbation in a Substantial Proportion of Patients with Chronic Plaque Psoriasis
Ragna H. Thorleifsdottir, Jenna H. Eysteinsdóttir, Jón H. Olafsson, Martin I. Sigurdsson, Andrew Johnston, Helgi Valdimarsson, Bardur Sigurgeirsson
Streptococcal throat infections are known to trigger or exacerbate psoriasis, and several studies support the benefit of tonsillectomy. To evaluate the potential of tonsillectomy as a treatment, we used a retrospective study-specific questionnaire to assess the proportion of psoriasis patients with sore throat-associated psoriasis exacerbations. Our survey sampled 275 psoriasis patients. Of patien ...
Pages: 788-791
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CLINICAL REPORT
Anti-pruritic Effect of Sertaconazole 2% Cream in Atopic Dermatitis Subjects: A Prospective, Randomized, Double-blind, Vehicle-controlled, Multi-centre Clinical Trial of Efficacy, Safety and Local Tolerability
Sonja Ständer, Martin Metz, Mac H. Ramos F., Marcus Maurer, Nicole Schoepke, Athanasios Tsianakas, Claudia Zeidler, Thomas A. Luger
This study was a prospective, parallel-group, randomized, double-blind, vehicle-controlled, multi-centre clinical trial to compare the efficacy of topical sertaconazole 2% cream with vehicle in reducing chronic pruritus in subjects with atopic dermatitis, and to assess its safety and local tolerability. A total of 70 subjects applied either of the 2 treatments twice daily for a period of 4 weeks o ...
Pages: 792-796
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CLINICAL REPORT
Is There an Additional Value of Inpatient Treatment for Patients with Atopic Dermatitis?
Jorien van der Schaft, Welmoed W. Keijzer, Koos J.G. Sanders, Jette J.C. de Groot, Donna L.C.M. van den Bersselaar, Harmieke van Os-Medendorp, Margreet M. van Doorn-op den Akker, Carla A.F.M. Bruijnzeel-Koomen, Marjolein S. de Bruin-Weller
An inpatient treatment and education programme has been developed for patients with difficult to control atopic dermatitis (AD), with the aim of achieving adequate self-management and long-term disease control. This observational study included adult patients diagnosed with difficult to control AD, admitted for a structured inpatient treatment and education programme. The primary outcome was the S ...
Pages: 797-801
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CLINICAL REPORT
Long-term Use of Systemic Treatments for Moderate-to-Severe Atopic Dermatitis in Adults: A Monocentric Retrospective Study
Anne-Laure Védie, Khaled Ezzedine, Emmanuelle Amazan, Franck Boralevi, Brigitte Milpied, Alain Taïeb, Julien Seneschal
Data regarding systemic therapies in the management of atopic dermatitis are limited. The aim of this study was to provide evidence for the efficacy and tolerance of systemic immunosuppressive treatments for moderate-to-severe adult atopic dermatitis. A single-centre retrospective study was conducted. A total of 54 patients were prescribed systemic treatments between 2000 and 2014. Of these, 28 re ...
Pages: 802-806
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CLINICAL REPORT
Serological Response to Treatment of Syphilis with Doxycycline Compared with Penicillin in HIV-infected Individuals
Kirsten Salado-Rasmussen, Steen Hoffmann, Susan Cowan, Jørgen Skov Jensen, Thomas Benfield, Jan Gerstoft, Terese Lea Katzenstein
Serological response to treatment of syphilis with orally administered doxycycline or intramuscularly administered penicillin was assessed in patients with concurrent HIV. All HIV-infected individuals diagnosed with syphilis attending 3 hospitals in Copenhagen, Denmark were included. Odds ratios (ORs) with 95% confidence intervals (CI) associated with serological outcome were modelled using propen ...
Pages: 807-811
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SHORT COMMUNICATION
Implementation of Web-based Education for Patients with Chronic Skin Disease
Oda D. van Cranenburgh, Jacqueline A. ter Stege, Menno A. de Rie , Ellen M.A. Smets, Mirjam A.G. Sprangers, John de Korte
Abstract is missing (Short communication)
Pages: 812-813
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SHORT COMMUNICATION
A Case of Syndromic X-linked Ichthyosis with Léri-Weill Dyschondrosteosis
Claire Abasq-Thomas , Sébastien Schmitt, Emilie Brenaut, Chantal Metz, Jean Chiesa, Laurent Misery
Abstract is missing (Short communication)
Pages: 814-815
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SHORT COMMUNICATION
Allogeneic Haematopoietic Stem Cell Transplantation for Patients with Cutaneous T-cell Lymphoma
Liisa Väkevä, Riitta Niittyvuopio, Sirpa Leppä, Jouni Heiskanen, Vesa Lindström, Annamari Ranki, Liisa Volin
Abstract is missing (Short communication)
Pages: 816-817
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SHORT COMMUNICATION
Cutaneous Manifestations of Thymoma-associated Multi-organ Autoimmunity: A Fatal Sign
Ken Muramatsu, Yasuyuki Fujita, Daisuke Inokuma, Ichiro Tsukinaga, Kenichiro Ito, Youichi Nishiura, Hiroshi Shimizu
Abstract is missing (Short communication)
Pages: 818-819
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SHORT COMMUNICATION
Squamous Cell Carcinoma of the Skin has More Than Doubled Over the Last Decade in the UK
Peter K.C. Goon, David C. Greenberg, Laszlo Igali, Nick J. Levell
Abstract is missing (Short communication)
Pages: 820-821
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SHORT COMMUNICATION
A Case of Pyoderma Gangrenosum in a Patient with Rheumatoid Arthritis Treated with Abatacept
Maki Akahoshi-Ikeda, Seiji Yoshizawa, Junichi Motoshita, Masutaka Furue, Satoshi Takeuchi
Abstract is missing (Short communication)
Pages: 822-823
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SHORT COMMUNICATION
Cutaneous B-cell Pseudolymphoma in a Psoriatic Patient Treated with Cyclosporine
Tomoko Takahashi, Maiko Hata, Hitoshi Iwata, Mariko Seishima
Abstract is missing (Short communication)
Pages: 824-825
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SHORT COMMUNICATION
Increasing Incidence within PubMed of the Use of the Misspelling “Pruritis” (sic) Instead of “Pruritus” for Itch
Alan B. Fleischer, Jr.
Abstract is missing (Short communication)
Pages: 826-827
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SHORT COMMUNICATION
Exacerbation of a Primary Follicular Centre Cutaneous B-cell Lymphoma during Pregnancy and Resolution to Anetoderma After Delivery
Serena Pezzetta, Irene Russo, Marta Brumana, Filippo Marino, Mauro Alaibac
Abstract is missing (Short communication)
Pages: 828-829
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SHORT COMMUNICATION
A 45-year-old Woman with Ehlers-Danlos Syndrome Caused by Dermatan 4-O-sulfotransferase-1 Deficiency: Implications for Early Ageing
Michihiro Kono, Yoshie Hasegawa-Murakami, Kazumitsu Sugiura, Masashi Ono, Kazuhiro Toriyama, Noriko Miyake, Atsushi Hatamochi, Yuzuru Kamei, Tomoki Kosho, Masashi Akiyama
Abstract is missing (Short communication)
Pages: 830-831
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SHORT COMMUNICATION
Bullous Pemphigoid with Immunoglobulin G anti-LAD-1 Antibodies without Evident Erythema and Eosinophil Infiltration
Tetsuya Ikawa, Yayoi Tada, Takamitsu Ohnishi, Tomomitsu Miyagaki, Rei Watanabe, Norito Ishii, Takashi Hashimoto, Shinichi Watanabe
Abstract is missing (Short communication)
Pages: 832-833
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SHORT COMMUNICATION
Topical Calcineurin Inhibitors, Topical Glucocorticoids and Cancer in Children: A Nationwide Study
Mette Deleuran, Christian Vestergaard, Aage Vølund, Kristian Thestrup-Pedersen
Abstract is missing (Short communication)
Pages: 834-835
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SHORT COMMUNICATION
Dermoscopic and Reflectance Confocal Microscopy Findings in Extra-genital HPV16-associated Pigmented Squamous Cell Carcinoma in situ
Tatiana P. Blumetti, Alon Scope, Mariana P. de Macedo, Juliana B. Ferreira, Elimar E. Gomes , Mauro Y. Enokihara, Clovis A. Lopes Pinto, Mauricio M. Nascimento, Gisele G. Rezze, Juliana C. Braga
Abstract is missing (Short communication)
Pages: 836-837
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SHORT COMMUNICATION
Management of Chronic Spontaneous Urticaria Exacerbated by Antihistamines: When Treatment Can Act as a Causal Agent Itself
Gustavo Deza, Lidia García-Colmenero, Laia Curto-Barredo, Ramon M. Pujol, Ana M. Giménez-Arnau
Abstract is missing (Short communication)
Pages: 838-839
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SHORT COMMUNICATION
A Case of Giant Primary Dermal Melanoma with BRAF V600E Mutation
Taichi Imamura, Yasuhiro Nakamura, Yukiko Teramoto, Sayuri Sato, Yuri Asami, Eiichi Arai, Akifumi Yamamoto
Abstract is missing (Short communication)
Pages: 840-841
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SHORT COMMUNICATION
Severe Agranulocytosis in Two Patients with Drug-induced Hypersensitivity Syndrome/Drug Reaction with Eosinophilia and Systemic Symptoms
Miyuki Kato, Yoko Kano, Yohei Sato, Tetsuo Shiohara
Abstract is missing (Short communication)
Pages: 842-843
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SHORT COMMUNICATION
Livedoid Vasculopathy Associated with HIV Infection in Two Patients: A Causal Relationship?
Charlotte Hurabielle, Gwendoline Sebille, Benoît Barrou, Philippe Moguelet, Camille Francès, Stéphane Barete
Abstract is missing (Short communication)
Pages: 844-845
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SHORT COMMUNICATION
Dermatophyte Prevalence in Tools of 43 Hairdressing Salons in Copenhagen
Charles B. Kromann, Christine Graversgaard, Peter T. Riis, Gregor B.E. Jemec, Jørgen Serup, Ditte M. Lindhardt Saunte
Abstract is missing (Short communication)
Pages: 846-847
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SHORT COMMUNICATION
Aquagenic Palmoplantar Keratoderma as a CFTR-related Disorder
Christelle Cabrol, Thierry Bienvenu, Lyse Ruaud, Emmanuelle Girodon, Gérald Noacco, Marine Delobeau, Ferial Fanian, Bénédicte Richaud-Thiriez, Lionel Van Maldergem, François Aubin
Abstract is missing (Short communication)
Pages: 848-849
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SHORT COMMUNICATION
Neoplastic Cells of Primary Cutaneous CD4+ Small/Medium-sized Pleomorphic T-cell Lymphoma Lack the Expression of Follicular T-helper Cell Defining Chemokine Receptor CXCR5
Dóra Krenács, Annamária Bakos, László Török, Lajos Kocsis, Enikő Bagdi, László Krenács
Abstract is missing (Short communication)
Pages: 850-852
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SHORT COMMUNICATION
Cold Contact Urticaria Following Vaccination: Four Cases
Nadia Raison-Peyron, Christelle Philibert, Nathalie Bernard, Aurélie Du-Thanh, Annick Barbaud, Didier Bessis
Abstract is missing (Short communication)
Pages: 852-853
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SHORT COMMUNICATION
Upregulation of PI3K/AKT/mTOR, FABP5 and PPARβ/δ in Human Psoriasis and Imiquimod-induced Murine Psoriasiform Dermatitis Model
Jean Christopher Chamcheu, Maria-Ines Chaves-Rodriquez, Vaqar M. Adhami, Imtiaz A. Siddiqui, Gary S. Wood, B. Jack Longley, Hasan Mukhtar
Abstract is missing (Short communication)
Pages: 854-856
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SHORT COMMUNICATION
Extensive Erythema and Hyperkeratosis on the Extremities and Lumbar Area as an Unusual Mani-festation of Nagashima-type Palmoplantar Keratosis
Toshinari Miyauchi, Toshifumi Nomura, Shotaro Suzuki, Yuka Ohguchi, Yasuyuki Yamaguchi, Satoru Shinkuma, Ken Natsuga, Yasuyuki Fujita, Hiroshi Shimizu
Abstract is missing (Short communication)
Pages: 856-858
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SHORT COMMUNICATION
Different Responses to Ustekinumab of Two HLA-Cw6-positive Homozygous Twins with Psoriasis
Martina Burlando, Emanuele Cozzani, Caterina Campisi, Antonio Di Costanzo, Aurora Parodi
Abstract is missing (Short communication)
Pages: 858-859
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SHORT COMMUNICATION
Acute Generalized Exanthematous Pustulosis Secondary to Acyclovir Confirmed by Positive Patch Testing
Minna E. Kubin, Päivi Jackson, Riitta Riekki
Abstract is missing (Short communication)
Pages: 860-861
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CORRESPONDENCE
Diagnostic Accuracy in Subtyping Basal Cell Carcinoma by Clinical Diagnosis Compared with Punch Biopsy
Eidi Christensen, Patricia Mjønes, Øystein Grimstad, Ole Martin Rørdam, Olav A. Foss
Abstract is missing (Correspondence)
Pages: 862-863
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