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These articles have been accepted for publication in Acta Dermato-Venereologica and are currently being edited and typeset. Readers should note that articles published below have been fully refereed, but have not been through the copy-editing and proof correction process. Only Abstract is possible to read. When this process is finalized the complete paper will be able to find.
INVESTIGATIVE REPORT
Validation of Pruritus Measures Gathered with the Electronic Patient-reported Outcome System MoPat
Michael Storck, Claudia Zeidler, Mirjam Rehr, Claudia Riepe, Martin Dugas, Sonja Ständer, Iñaki Soto-Rey
In order to improve diagnosis and treatment, physicians require information about the social context and quality of life of their patients. The Center for Chronic Pruritus at the University Hospital Münster achieves this goal using the electronic patient-reported outcome system "Mobile Patient Survey", which assesses pruritus and quality of life measures. The aim of this study is to evaluate th ...
Abstract
SHORT COMMUNICATION
Dermatofibrosarcoma Protuberans Presenting as a Large Atrophic Plaque on the Chest
Ryosuke Saigusa, Takuya Miyagawa, Satoshi Toyama, Jun Omatsu, Tomomitsu Miyagaki, Yuri Masui, Daisuke Yamada, Shinichi Sato
Abstract is missing (Short communication)
Abstract
INVESTIGATIVE REPORT
Long-term Impact of Ixekizumab on Psoriasis Itch Severity: Results From a Phase III Clinical Trial and Long-term Extension
Alexandra B. Kimball, Thomas Luger, Alice Gottlieb, Luis Puig, Roland Kaufmann, Russel Burge, Chen-Yen Lin, Gil Yosipovitch
Itching is a prevalent plaque psoriasis symptom. Ixekizumab, an IL-17A antagonist, has demonstrated rapid, significant improvements in itch severity over 12 weeks in Phase III psoriasis trials (UNCOVER-1, UNCOVER-2). We assessed the long-term (through 60 weeks) effect of ixekizumab maintenance therapy (80-mg ixekizumab every 4 weeks [IXEQ4W]) on itch severity, using the Itch Numeric Rating Scale, ...
CLINICAL REPORT
Brachioradial Pruritus and Notalgia Paraesthetica: A Comparative Observational Study of Clinical Presentation and Morphological Pathologies
Manuel P. Pereira, Hannah Lüling, Anette Dieckhöfer, Sabine Steinke, Claudia Zeidler, Sonja Ständer
Brachioradial pruritus (BRP) and notalgia paraesthetica (NP) represent 2 of the most common neuropathic itch syndromes. A total of 58 consecutive patients presenting at the Center for Chronic Pruritus, University Hospital Münster, were analysed with regard to clinical presentation, anatomical and morphological pathologies, impairment in quality of life, and response to treatment with topical ca ...
SHORT COMMUNICATION
Predominant Contribution of CD4 T Cells to Human Herpesvirus 6 (HHV-6) Load in the Peripheral Blood of Patients with Drug-induced Hypersensitivity Syndrome and Persistent HHV-6 Infection
Fumi Miyagawa, Yuki Nakamura, Rie Ommori, Kazuya Miyashita, Hiroshi Iioka, Natsuki Miyashita, Mitsuko Nishikawa, Yukiko Himuro, Kohei Ogawa, Hideo Asada
Abstract is missing (Short communication)
SHORT COMMUNICATION
Successful Treatment of Severe Recalcitrant Hidradenitis Suppurativa with the Interleukin-17A Antibody Secukinumab
Anna Schuch, Tatjana Fischer, Alexander Boehner, Tilo Biedermann, Thomas Volz
Abstract is missing (Short communication)
INVESTIGATIVE REPORT
The Association Between Low Grade Systemic Inflammation and Skin Diseases: A Cross-sectional Survey in the Northern Finland Birth Cohort 1966
Suvi-Päivikki Sinikumpu, Laura Huilaja, Juha Auvinen, Jari Jokelainen, Katri Puukka, Aimo Ruokonen, Markku Timonen, Kaisa Tasanen
Low grade inflammation is associated with many noncommunicable diseases. The association between skin diseases in general and systemic inflammation has not previously been studied at the population level. A whole-body investigation on 1,930 adults belonging to Northern Finland Birth Cohort 1966 was performed and high sensitive C-reactive protein (CRP) level was measured as a marker of low grade in ...
CLINICAL REPORT
Psychological Health Status and Health-related Quality of Life in Adults with Atopic Dermatitis: A Nationwide Cross-sectional Study in South Korea
Sul Hee Lee, Si Hyung Lee, Sung Yul Lee, Bora Lee, Sang-Hoon Lee, Young Lip Park
Atopic dermatitis (AD) is a chronic inflammatory skin disorder. Patients with AD often experience psychological distress and poor health-related quality of life (HRQoL). The aim of this study was to investigate the association of several psychological health statuses and poor HRQoL in an adult population with AD in South Korea. A total of 38,741 adults who participated in the Korean National Healt ...
CLINICAL REPORT
Distinct Patterns and Aetiology of Chromonychia
Soo Hyeon Bae , Min Young Lee , Jee-Bum Lee
Abnormal colouring of the nails may be a sign of underlying systemic or local disorders. This study investigated the prevalence and causes of chromonychia as a whole, as well as of each subtype. Among 163 patients with chromonychia, trauma was the pathogenesis in up to 20.9% (34/163) of cases. The most common subtype was melanonychia (54.0%; 88/163), followed by leukonychia (23.9%), red (8.6%), gr ...
SPECIAL REPORT
Granuloma Faciale Treatment: A Systematic Review
Claudia Lindhaus, Peter Elsner
Granuloma faciale is an uncommon benign chronic dermatosis characterized by reddish-brown to violaceous asymptomatic plaques appearing predominantly on the face. The pathogenesis of granuloma faciale remains unclear, and it is frequently unresponsive to therapy. This systematic review aims to summarize all recent publications on the management of granuloma faciale. The publications are mainly indi ...
SHORT COMMUNICATION
Staphylococcal Scalded Skin Syndrome Caused by a Rare Variant of Exfoliative-toxin-A + S. aureus in an Adult Immunocompromised Woman
Simona Saluzzo, Franziska Layer, Georg Stingl, Georg Stary
Abstract is missing (Short communication)
INVESTIGATIVE REPORT
Differential Diagnosis of Palmoplantar Eczema in Psoriatico: Chronic Allergic Contact Dermatitis and/or Psoriasis?
Malgorzata Kolesnik, Ingolf Franke, Anke Lux, Sven R. Quist, Harald P. Gollnick
Differential diagnosis of palmoplantar non-pustular psoriasis and chronic allergic contact dermatitis (ACD) and the combination of these conditions, termed “eczema in psoriatico” (EIP), is difficult, especially in cases of isolated involvement. A blind re-evaluation of 63 archived formalin-fixed palmoplantar samples, previously diagnosed clinically as either psoriasis or chronic ACD, was ...
CLINICAL REPORT
Role of Substance P and Its Receptor Neurokinin 1 in Chronic Prurigo: a Randomized, Proof-of-Concept, Controlled Trial with Topical Aprepitant
Tatevik Ohanyan, Nicole Schoepke, Stefan Eirefelt, Gert Hoey, Witte Koopmann, Tomasz Hawro, Marcus Maurer, Martin Metz
Substance P (SP) and its receptor neurokinin 1 (NK1R) are thought to be involved in the pathogenesis of chronic prurigo. Here, we assessed SP serum levels, cutaneous NK1R expression, and the effects of topical aprepitant, an NK1R antagonist, in patients with chronic prurigo. SP and NK1R were increased, compared with controls, in the serum and in lesional vs. non-lesional skin of the patients, resp ...
SHORT COMMUNICATION
Assessment of Quality of Life in Chronic Pruritus: Relationship Between ItchyQoL and Dermatological Life Quality Index in 1,150 Patients
Astrid Stumpf, Bettina Pfleiderer, Fleur Fritz, Nadi Osada, Suephy C. Chen, Sonja Ständer
Abstract is missing (Short communication)
REVIEW
Chronic Prurigo of Nodular Type: A Review
Claudia Zeidler, Athanasios Tsianakas, Manuel Pereira, Hartmut Ständer, Gil Yosipovitch, Sonja Ständer
Prurigo nodularis (PN) is a subtype of chronic prurigo presenting single to multiple symmetrically distributed, hyperkeratotic and intensively itching papules and nodules. PN evolves along with chronic pruritus in the context of diverse dermatological, systemic, neurological or psychiatric conditions. Permanent scratching is possibly a major trigger of PN, although its exact pathophysiology remain ...
INVESTIGATIVE REPORT
Temporal Stability of the Healthy Human Skin Microbiome Following Dead Sea Climatotherapy
Michael Brandwein, Garold Fuks, Avigail Israel, Ashraf Al-Ashhab, Deborah Nejman, Ravid Straussman, Emmilia Hodak, Marco Harari, Doron Steinberg, Zvi Bentwich, Noam Shental, Shiri Meshner
Dead Sea climatotherapy (DSC) is a therapeutic modality for a variety of chronic skin conditions, yet there has been scarce research on the relationship between the cutaneous microbiota and disease states in response to DSC. We characterized the skin bacterial and fungal microbiome of healthy volunteers who underwent DSC. Bacterial community diversity remained similar before and after treatment, w ...
QUIZ
Disseminated Vesicular Rash in an Immunocompetent Adult Woman: A Quiz
Trine Høgsberg, Anette Bygum
Abstract is missing (Quiz)
SHORT COMMUNICATION
Photodynamic Therapy: Influence of Clinical and Procedure Variables on Treatment Response in Basal Cell Carcinoma and Bowen Disease
Tamara Gracia-Cazaña, Marta Mascaraque, Nerea Salazar, Jesús Vera-Álvarez, María Pilar Frías, Salvador González, Ángeles Juarranz, Yolanda Gilaberte
Abstract is missing (Short communication)
SHORT COMMUNICATION
Locally Aggressive Trichoblastic Tumours (Low-grade Trichoblastic Carcinomas): Clinicopathological Analysis and Follow-up
Camille Hua, Charles Velter, Amelie Osio, Céleste Lebbe, Nicole Basset-Seguin, Bernard Cribier, Maxime Battistella
Abstract is missing (Short communication)
BOOK REVIEW
Hurwitz Clinical Pediatric Dermatology: A Textbook of Skin Disorders of Childhood and Adolescence, 5th Edition
Regina Fölster-Holst
Abstract is missing (Book review)
BOOK REVIEW
Skin Barrier Function
Magnus Lindberg
Abstract is missing (Book review)
BOOK REVIEW
Current Problems in Dermatology, Vol. 48. Tattooed Skin and Health
Kristian Thestrup-Pedersen
Abstract is missing (Book review)
BOOK REVIEW
Chemical Immunology and Allergy, Vol. 100. History of Allergy
Carl-Fredrik Wahlgren
Abstract is missing (Book review)