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These articles have been accepted for publication in Acta Dermato-Venereologica and are currently being edited and typeset. Readers should note that articles published below have been fully refereed, but have not been through the copy-editing and proof correction process. Only Abstract is possible to read. When this process is finalized the complete paper will be able to find.
INVESTIGATIVE REPORT
Isatis tinctoria L.-derived Petroleum Ether Extract Mediates Anti-inflammatory Effects via Inhibition of Interleukin-6, Interleukin-33 and Mast Cell Degranulation
Tobias Lotts, Kathrin Kabrodt, Johanna Hummel, Dorit Binder, Ingo Schellenberg, Sonja Ständer, Konstantin Agelopoulos
Isatis tinctoria L. (woad) has been used in medicine for centuries and has demonstrated anti-inflammatory effects. However, to date, no well-defined extracts with precise analysis of active substances have been developed. The aim of this study was to develop novel extracts of Isatis tinctoria L., and to characterize their active ingredients and anti-inflammatory properties. Various extracts of Isa ...
Abstract
CLINICAL REPORT
Exploring the EQ-5D Dimension of Pain/Discomfort in Dermatology Outpatients from a Multicentre Study in 13 European Countries
Francesca Sampogna, Damiano Abeni, Uwe Gieler, Lucía Tomas Aragones, Lars Lien, Françoise Poot, Gregor B. E. Jemec, Csanád Szabó, Dennis Linder, Henriët van Middendorp, Jon Anders Halvorsen, Flora Balieva, Jacek C. Szepietowski, Dmitry V. Romanov, Servando E. Marron, Ilknur K. Altunay, Andrew Y. Finlay, Sam S. Salek, Jörg Kupfer, Laurent Misery, Florence J. Dalgard
Pain and discomfort are important symptoms in dermatology. The aim of this cross-sectional, multicentre study was to describe the prevalence of pain/discomfort and its associations in patients with several dermatological conditions across 13 European countries. The outcome was the prevalence of pain/discomfort according to a question of the EQ-5D questionnaire. Data collected from November 2011 to ...
Abstract
SHORT COMMUNICATION
Human Papilloma Virus-positive Squamous Cell Carcinoma of the Oropharynx Arising in Pemphigus Vulgaris
Sophia Lehr, Stefanie Heyne, Katja Berndt, Stefan Beissert, Susanne Abraham, Claudia Günther
Abstract is missing (Short communication)
Abstract
INVESTIGATIVE REPORT
Recurrent and Metastatic Cutaneous Squamous Cell Carcinomas in a Cohort of 774 Patients in Finland
Niina Korhonen, Leea Ylitalo, Tiina Luukkaala, Julius Itkonen, Henni Häihälä, Juha Jernman, Erna Snellman, Johanna Palve
Recognising patients with high risk cutaneous squamous cell carcinomas is essential in planning effective monitoring. The aim of this study was to determine the rate of local recurrences and metastases of cutaneous squamous cell carcinomas in a previously defined patient cohort in Finland. Pathology database search was performed to identify cutaneous squamous cell carcinomas patients and their med ...
Abstract
INVESTIGATIVE REPORT
Psoriatic Dermal-derived Mesenchymal Stem Cells Reduce Keratinocyte Junctions, and Increase Glycolysis
Junqin Li, Jianxiao Xing, Funa Lu, Wenjuan Chang, Nannan Liang, Juan Li, Ying Wang, Xiaofang Li, Xincheng Zhao, Ruixia Hou, Maoqiang Man, Guohua Yin, Xinhua Li, Kaiming Zhang
Although it is known that psoriatic dermal-derived mesenchymal stem cells (DMSCs) dysregulate keratinocyte proliferation, the biological activity profile of keratinocytes influenced by psoriatic DMSCs remain unknown. In the present study, we assessed the impact of psoriatic DMSCs on keratinocyte proliferation, differentiation, and glucose metabolism in normal human epidermal keratinocytes co-cultu ...
Abstract
SHORT COMMUNICATION
Unexpected Hair Regrowth in a Patient with Longstanding Alopecia Universalis During Treatment of Recalcitrant Dermatomyositis with the Janus Kinase Inhibitor Ruxolitinib
Tanja Fetter, German Cuevas Rios, Dennis Niebel, Thomas Bieber, Jörg Wenzel
Abstract is missing (Short communication)
Abstract
SHORT COMMUNICATION
Prevalence of Indoor Tanning Among Teenagers in Norway Before and After Enforcement of Ban for Ages Under 18 Years
Trude E. Robsahm, Jo S. Stenehjem, Leon A. McLaren Berge, Marit B. Veierød
Abstract is missing (Short communication)
Abstract
CLINICAL REPORT
Treatment and Burden of Disease in a Cohort of Patients with Prurigo Nodularis: A Survey-based Study
Tanja Todberg, Claus Zachariae, Lone Skov
Prurigo nodularis is a pruritic dermatosis with poor treatment options. To describe treatment patterns, comorbidities, pruritus, and quality of life a survey was administered to 92 patients with prurigo nodularis. A total of 52 patients completed the survey. The most frequently used treatments were topical corticosteroids, which were prescribed to 49/52 patients, with positive effect in 13/49. A t ...
Abstract
INVESTIGATIVE REPORT
Increasing Costs of Skin Cancer due to Increasing Incidence and Introduction of Pharmaceuticals, 2007–2017
Eline Noels, Loes Hollestein, Kees Luijkx, Marieke Louwman, Carin de Uyl-de Groot, Renate van den Bos, Astrid van der Veldt, Dirk Grünhagen, Marlies Wakkee
Skin cancer is the most common type of cancer and its incidence is increasing. The objective of this study was to describe the trends in reimbursed drug and hospital costs of benign and (pre)malignant skin tumours, and to present future projections. Therefore, nationwide hospital and drug reimbursement data (for the period 2007–17) were used. In 2017, malignant skin tumours were the 4th most cos ...
Abstract
SHORT COMMUNICATION
Direct Costs of Epidermolysis Bullosa by Disease Severity
Darragh Flannery, Claire Doyle, Sineád Hickey, Fiona Aherne, Avril Kenan
Abstract is missing (Short communication)
Abstract
REVIEW
A Systematic Review of Drug-Induced Pemphigoid
Matthew J. Verheyden, Asli Bilgic, Dédée F. Murrell
Bullous pemphigoid is an autoimmune subepithelial disease characterised by pruritus followed by urticarial plaques and finally bullae on the skin and mucosa. Drug-associated bullous pemphigoid (DABP) is a term used to describe instances of bullous pemphigoid demonstrating clinical, histological, or immunopathological features identical or similar to those of the idiopathic form of bullous pemphigo ...
Abstract
SHORT COMMUNICATION
Factors Influencing Family Burden of Paediatric Patients with Atopic Dermatitis: A Cross-sectional Study
Xiaomeng Xu, Louise Sandra van Galen, Ram Bajpai, Mark Jean-Aan Koh, Steven Thng, Yik Weng Yew, Krister Järbrink, Josip Car
Abstract is missing (Short communication)
Abstract
INVESTIGATIVE REPORT
Patient Satisfaction and Expectations Regarding Mobile Teledermoscopy in General Practice for Diagnosis of Non-melanoma Skin Cancer and Malignant Melanoma
Sofie Gilling, Charlotte G. Mortz, Tine Vestergaard
The incidence of non-melanoma skin cancer and malignant melanoma is increasing. Diagnosing these skin lesions is primarily done visually, making it suitable to use new technology, such as teledermoscopy. Before the implementation of teledermoscopy, patient satisfaction, clinician satisfaction and diagnostic accuracy, need to be evaluated. A cross-sectional quantitative survey was conducted to eval ...
Abstract
CLINICAL REPORT
Subjective and Objective Characteristics of Patients Seen at a Psychodermatology Unit: One-year Experience in Malmö, Sweden
Florence J. Dalgard, Karin Sjöström, Johan Fhager, Åke Svensson, Ewa Wallin, Inese Hauksson
Clinical epidemiological knowledge concerning psychodermatology patients is scarce. The objective of this study was to assess morbidity in a new psychodermatology service. Information was gathered from patient records at the psychodermatology unit in Skåne University Hospital, Malmö, Sweden, from 1 February 2017 to 31 January 2018. All patients were screened with the Hospital Anxiety and Depress ...
Abstract
SHORT COMMUNICATION
Inflammatory Vegetative Lesions of the Perineum: A Rare and Severe Clinical Presentation of Netherton Syndrome
Shatha Albluwi, Aude Maza, Maella Severino-Freire, Emilie Tournier, Juliette Mazereeuw-Hautier
Abstract is missing (Short communication)
Abstract
CLINICAL REPORT
Short-term Effect and Acceptability of Manual Lymphatic Drainage for Paediatric Limb Lymphoedema: A Prospective Study
Chakib El Habnouni, Valérie Tauveron, Sophie Leducq, Stéfania Gérémia, Pierre Allain, Hortense Touchard, Sophie-Anne Benejean, Laurent Machet, Annabel Maruani
Paediatric lymphoedema (LE) is a rare condition, for which there is little data available regarding treatments. The aim of this study was to assess the short-term effect and acceptability of a 30-min session of manual lymphatic drainage (MLD) in children with well-documented LE of the lower limbs. Fifteen children were included (8 males; median age 11 years). Comparison of the sum of circumference ...
Abstract
QUIZ
Itchy Erythematous Plaques after Scuba Diving: A Quiz
Emilie Schwob, Nicolas Marmion, Olivier Dereure, Aurélie Du-Thanh
Abstract is missing (Quiz)
Abstract
SHORT COMMUNICATION
A Negative Association of Hypothalamic Volume and Perceived Stress in Patients with Atopic Dermatitis
Hideki Mochizuki, Christina Schut, Alina Shevchenko, Rodrigo Valdes-Rodriguez, Leigh A. Nattkemper, Gil Yosipovitch
Abstract is missing (Short communication)
Abstract
CLINICAL REPORT
Pilot Study of a Novel Therapeutic Approach for Refractory Advanced Stage Folliculotropic Mycosis Fungoides
Christina A. Del Guzzo, Neha N. Jariwala, Paul L. Haun, Kelly M. MacArthur, Christen M. Mowad, Elisabeth G. Richard, Joseph P. Holton, Alain H. Rook
Folliculotropic mycosis fungoides is a variant of cutaneous T-cell lymphoma characterized as having a folliculocentric infiltrate of malignant T cells along with a worse prognosis in comparison to the epidermotropic variants. Patients with advanced forms of folliculotropic mycosis fungoides are often poorly responsive to both skin-directed as well as to systemic therapies. We report here a high re ...
Abstract
INVESTIGATIVE REPORT
Neutrophil Extracellular Traps are Present in Immune-complex-mediated Cutaneous Small Vessel Vasculitis and Correlate with the Production of Reactive Oxygen Species and the Severity of Vessel Damage
Christina Bergqvist, Rémi Safi, George El Hasbani, Ossama Abbas, Abdulghani Kibbi, Dany Nassar
Formation of neutrophil extracellular traps has been implicated in autoimmunity. However, the presence and clinical relevance of neutrophil extracellular traps in immune-complex-mediated cutaneous small and medium vessel vasculitides has not been investigated. This study retrospectively analysed 72 patients with histology-proven hypersensitivity vasculitis (n = 21), IgA vasculitis (n = 22) ...