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These articles have been accepted for publication in Acta Dermato-Venereologica and are currently being edited and typeset. Readers should note that articles published below have been fully refereed, but have not been through the copy-editing and proof correction process. Only Abstract is possible to read. When this process is finalized the complete paper will be able to find.
CLINICAL REPORT
Efficacy of Biologics Targeting Tumour Necrosis Factor-alpha, Interleukin-17 -12/23, -23 and Small Molecules Targeting JAK and PDE4 in the Treatment of Nail Psoriasis: A Network Meta-analysis
Júlia Szebényi, Noémi Gede, Péter Hegyi, Zsolt Szakács, Margit Solymár, Bálint Erőss, András Garami, Kornélia Farkas, Dezső Csupor, Rolland Gyulai
The comparative efficacy of registered anti-psoriatic biologics and small molecules in treating nail symptoms has not been systematically evaluated. The aim of this study was to perform a network meta-analysis to determine the efficacy of biologics and small mole­cules in nail psoriasis. A Bayesian network meta- analysis of 17 randomized clinical trials (a total of 6,053 nail psoriatic patients) ...
Abstract
SHORT COMMUNICATION
An Isolated Peculiar Gianotti-Crosti Rash in the Course of a COVID-19 Episode
Cécile Brin, Pierre Sohier, Anne-Sophie L'honneur, Stéphane Marot, Stephanie Matar, Sélim Aractingi, Nicolas Dupin
Abstract is missing (Short communication)
Abstract
CLINICAL REPORT
The Course of Mycosis Fungoides under Cytokine Pathway Blockers: A Multicentre Analysis of Real-Life Clinical Data
Iris Amitay-Laish, Emmanuella Guenova, Pablo L. Ortiz-Romero, Cristina Vico-Alonso, Sima Rozati, Larisa J. Geskin, Vasiliki Nikolaou, Evangelia Papadavid, Aviv Barzilai, Lev Pavlovsky, Elena Didkovsky, Hadas Prag Naveh, Oleg E. Akilov, Emmilia Hodak
Literature regarding the effect of biologics on the course of mycosis fungoides (MF) is scarce. This multicentre study analysed retrospective data on 19 patients with MF, who were treated with biologics; 12 for inflammatory conditions coexisting with MF, and 7 for MF misdiagnosed as an inflammatory skin disease. Eight patients were treated with anti-tumour necrosis factor-α-monotherapy; 6 had ear ...
Abstract
SHORT COMMUNICATION
Novel TGM1 Gene Mutation in a Japanese Patient with Bathing Suit Ichthyosis
Naomi Tani, Nanako Yamada, Tetsuya Okazaki, Takashi Horie, Hajime Nakano, Daisuke Sawamura, Osamu Yamamoto
Abstract is missing (Short communication)
Abstract
CLINICAL REPORT
Locoregional Lymph Node Recurrence of Trunk Melanoma in Non-sentinel Lymph Node Basins: An Observational Retrospective Study
Ruggero Moro, Jessica González-Ramos, Silvestre Martínez-García, Celia Requena, Victor Traves, Esperanza Manrique-Silva, Eduardo Nagore
Locoregional lymph node recurrences of primary trunk melanoma can occur in basins not identified during sentinel lymph node biopsy. However, the factors associated with recurrences in non-sentinel lymph node basins are unknown. To evaluate these factors, this observational retrospective study examined the patterns of first lymph node recurrence and the factors associated with recurrence in non-sen ...
Abstract
CLINICAL REPORT
Quality of Life of Cohabitants of People Living with Acne
Eliseo Martínez-García, Salvador Arias-Santiago, Enrique Herrera-Acosta, Andrew Affleck, Enrique Herrera-Ceballos, Agustin Buendía-Eisman
The aim of this study was to analyse the levels of anxiety, depression, and quality of life of individuals living with acne patients (cohabitants). The study included patients, cohabitants, and controls; a total of 204 participants. Patients’ health-related quality of life was measured with the Dermatology Life Quality Index (DLQI), while cohabitants’ quality of life was measured with the Fami ...
Abstract
SHORT COMMUNICATION
Acquired Reactive Perforating Collagenosis Associated with Linear Immunoglobulin A Bullous Disease
Qi Tan, Li Liu, Jian Zhang, Si-li Ni
Abstract is missing (Short communication)
Abstract
INVESTIGATIVE REPORT
Longitudinal Changes in Skin Microbiome and Microbes Associated with Change in Skin Status in Patients with Psoriasis
Hailun Wang, Mandy W.M. Chan, Henry H. Chan, Herbert Pang
The aim of this study was to identify key microbes associated with change in skin status in patients with psoriasis over time. Longitudinal changes in the skin microbiome between patients with psoriasis and healthy family controls living in the same household were studied using whole genome metagenomic shotgun sequencing at 4 time-points. There were significant changes in abundance of the pathogen ...
Abstract
CLINICAL REPORT
Non-contrast-enhanced 3-Tesla Magnetic Resonance Imaging Using Surface-coil and Sonography for Assessment of Hidradenitis Suppurativa Lesions, and a Literature Review
S. Morteza Seyed Jafari, Fatemeh Jabbary Lak, Mona Mazinani, Johannes T. Heverhagen, Robert E. Hunger, Keivan Daneshvar
Hidradenitis suppurativa has a substantial negative effect on quality of life of affected persons. Diagnosis is based mainly on clinical examination. However, physi­cal examination alone might underestimate disease severity compared with imaging modalities. We report here the application of non-contrast-enhanced 3-Tesla magnetic resonance imaging using surface-coil and sonography for assessment o ...
Abstract
CLINICAL REPORT
Risk Factors and Prognosis for Metastatic Cutaneous Squamous Cell Carcinoma: A Cohort Study
Jaakko S. Knuutila, Pilvi Riihilä, Samu Kurki, Liisa Nissinen, Veli-Matti Kähäri
Cutaneous squamous cell carcinoma (cSCC) has metastatic potential. The aims of this study were to identify the risk factors for metastasis of primary cSCC and for poor prognosis in metastatic cSCC. Retrospective primary tumour cohorts of metastatic cSCCs (n = 85) and non-metastatic cSCCs (n = 218) were analysed. The mean annual rate of metastasis for primary cSCCs was 2.28%. In 49.4% of pa ...
Abstract
INVESTIGATIVE REPORT
Ten-year Follow-up Study of Grenz Ray Treatment for Lentigo Maligna and Early Lentigo Maligna Melanoma
Iara R.T. Drakensjö, Einar Rosen, Margareta Frohm Nilsson, Ada Girnita
Radiotherapy is often used to treat lentigo maligna. However, the long-term efficacy and safety of radiotherapy approaches have not been thoroughly evaluated. We aimed to evaluate the long-term efficacy and safety of ultrasoft X-ray/Grenz ray treatment in those patients. A total of 161 lesions from 159 patients received treatment with Grenz ray between 2005 and 2007. Follow-up of recurrence was pe ...
Abstract
SHORT COMMUNICATION
A Novel NCSTN Gene Mutation in a Japanese Family with Hidradenitis Suppurativa
Nobuyuki Nishimori, Koremasa Hayama, Kumiko Kimura, Hideki Fujita, Kyoko Fujiwara, Tadashi Terui
Abstract is missing (Short communication)
Abstract
INVESTIGATIVE REPORT
Apparent Missense Variant in COL7A1 Causes a Severe Form of Recessive Dystrophic Epidermolysis Bullosa via Effects on Splicing
Syed Ashraf Uddin, Nicole Cesarato, Aytaj Humbatova, Axel Schmidt, Fazal ur Rehman, Muhammad Naeem, Sabrina Wolf, Muhammad Anwar Panezai, Holger Thiele, Abdul Wali, Regina Fölster-Holst, Sulman Basit, Muhammad Ayub, Regina C. Betz
Dystrophic epidermolysis bullosa is an inherited skin disorder characterized by fragile skin that is prone to blistering. We report here a consanguineous Pakistani family with two siblings, in whom a severe recessive dystrophic epidermolysis bullosa was suspected. Using whole-exome sequencing for one sibling, the homozygous base substitution c.7249C>G in COL7A1 was identified, and could be confirm ...
Abstract
SHORT COMMUNICATION
Clinical Remission of Loricrin Keratoderma with Tamoxifen: A Case Report
Elena Fontana, Francesca Caroppo, Anna Belloni Fortina
Abstract is missing (Short communication)
Abstract
SHORT COMMUNICATION
Remission of Anti-laminin 332 Mucous Membrane Pemphigoid Associated with Non-small Cell Lung Cancer after Therapy with Rituximab and Intravenous Immunoglobulin
Evelyne Tarnowietzki, Thorsten Peters, Lea Kraus, Enno Schmidt, Karin Scharffetter-Kochanek
Abstract is missing (Short communication)
Abstract
INVESTIGATIVE REPORT
Increased Risk of Squamous Cell Carcinoma of the Skin and Lymphoma Among 5,739 Patients with Bullous Pemphigoid: A Swedish Nationwide Cohort Study
Zeyad Albadri, Kristofer Thorslund, Henrike Häbel, Oliver Seifert, Carina Grönhagen
Evidence about the association of bullous pemphigoid and the risk of cancer is conflicting. Patients diagnosed with bullous pemphigoid (n = 5,739) between 2005 and 2016 were matched with a control cohort from the general population (n = 17,168) to estimate their overall and specific risk of cancer. The risk of squamous cell cancer of the skin (cSCC) was increased in patients with bullous p ...
Abstract
CLINICAL REPORT
Alteration in the Skin Microbiome in Cutaneous Graft Versus Host Disease
Ying Gu, Jing Sun, Kun Li, Xia Wu, Jianzhong Zhang
Graft versus host disease (GVHD) is a common complication of haematopoietic stem cell transplantation. This study examined the cutaneous microbiome in relation to the pathogenesis of cutaneous GVHD. Bacterial swabs were taken from several sites on 12 patients with cutaneous GVHD. Microbiotas were characterized by sequencing 16S rRNA bacterial genes on the MiSeq platform. Microbiome diversity in pa ...
Abstract
CLINICAL REPORT
Towards More Shared Decision Making in Dermatology: Develop­ment of Evidence-based Decision Cards for Psoriasis and Atopic Eczema Treatments
Francisca M. Vermeulen, Gayle E. van der Kraaij, Ronald A. Tupker, Anne Bijlsma, Hans Blaauwbroek, Francine Das, Tessa Geltink, Josine S. van der Kraan, Renske Kranenburg, Dirk J. van der Veen, Kristie Venhorst, Phyllis I. Spuls
In shared decision making (SDM) patients and physi­cians make treatment decisions together based on the best available evidence and the values and preferences of patients. SDM is very suitable for use in dermatological practice, but is infrequently applied by dermatologists. To support the application of SDM in dermatology we developed Decision Cards: 1-page overviews of possible treatment option ...
Abstract
INVESTIGATIVE REPORT
Increased Risk of Pemphigus among Patients with Psoriasis: A Large-scale Cohort Study
Khalaf Kridin, Ralf J. Ludwig, Giovanni Damiani, Arnon D. Cohen
Although pemphigus has recently been linked to psoriasis, the risk of emergence of pemphigus during the course of psoriasis is yet to be delineated. The aim of this study was to evaluate the risk of developing pemphigus during the course of psoriasis. A large-scale population-based longitudinal retrospective cohort study was performed to assess the hazard ratio (HR) of pemphigus among 68,836 patie ...
Abstract
SHORT COMMUNICATION
Dupilumab Treatment in Two Patients with Cutaneous T-cell Lymphomas
Ingrid Lazaridou, Caroline Ram-Wolff, Jean-David Bouaziz, Edouard Bégon, Maxime Battistella, Jacqueline Rivet, Marie Jachiet, Martine Bagot, Adèle de Masson
Abstract is missing (Short communication)
Abstract
CLINICAL REPORT
Concordance Between Physician-rated and Caregiver-perceived Disease Severity in Children with Atopic Dermatitis: A Cross-sectional Study
Xiaomeng Xu, Maja Olsson, Ram Bajpai, Mark Koh Jean Aan, Yik Weng Yew, Sharon Wong, Alice Foong, Steven Thng, Krister Järbrink, Josip Car
This study examined concordance between caregiver-reported and physician-rated estimates of severity of atopic dermatitis (AD) in paediatric patients and explored potential explanatory factors. Physician-reported severity of AD was retrieved from medical records, while caregiver-reported disease severity and sociodemographic data were obtained through a survey that also collected information on ou ...
Abstract
INVESTIGATIVE REPORT
Neutrophil Extracellular Traps are Present in Immune-complex-mediated Cutaneous Small Vessel Vasculitis and Correlate with the Production of Reactive Oxygen Species and the Severity of Vessel Damage
Christina Bergqvist, Rémi Safi, George El Hasbani, Ossama Abbas, Abdulghani Kibbi, Dany Nassar
Formation of neutrophil extracellular traps has been implicated in autoimmunity. However, the presence and clinical relevance of neutrophil extracellular traps in immune-complex-mediated cutaneous small and medium vessel vasculitides has not been investigated. This study retrospectively analysed 72 patients with histology-proven hypersensitivity vasculitis (n = 21), IgA vasculitis (n = 22) ...