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INVESTIGATIVE REPORT
Internal Migration and Leprosy in Shanghai from 2000 to 2019: an Epidemiological Study of New Cases
Jianyu Zhu, Chao Shi, Degang Yang, Yeqiang Liu, Jia Chen, Meiping Ye, Chunjie Liao, Zhichun Jing, Pingyu Zhou
Leprosy is a chronic infectious disease caused by Mycobacterium leprae. Massive internal migration from rural to urban areas poses new challenges for leprosy control in Shanghai, China. This retrospective epidemiological study examined new cases of leprosy diagnosed in Shanghai from 2000 to 2019, with emphasis on internal migration cases. There were 145 cases of leprosy in the study period; the ma ...
Abstract
INVESTIGATIVE REPORT
The Burden of Autosomal Recessive Congenital Ichthyoses on Patients and their Families: An Italian Multicentre Study
Damiano Abeni, Roberta Rotunno, Andrea Diociaiuti, Simona Giancristoforo, Domenico Bonamonte, Angela Filoni, Carmelo Schepis, Maddalena Siragusa, Iria Neri, Annalucia Virdi, Daniele Castiglia, Giovanna Zambruno, Christine Bodemer, May El Hachem
Autosomal recessive congenital ichthyoses (ARCI) are characterized by generalized skin scaling, hyperkeratosis, erythroderma, and disabling features affecting the skin (palmoplantar keratoderma, fissures, pain, itch), eyes, ears, and joints. Disease severity and chronicity, patient disfigurement, and time and costs required for care impose a major burden on quality of life. This multicentre cross- ...
Abstract
CLINICAL REPORT
Patients’ Perception of Vitiligo Severity
Nanja van Geel, Charlotte Moock, Marloes Zuidgeest, Sanne Elisabeth Uitentuis, Albert Wolkerstorfer, Reinhart Speeckaert
Identifying which factors contribute to vitiligo severity and determining their individual weight are important in the management of vitiligo. The aim of this study is to investigate the predictive variables concerning vitiligo severity as perceived by the patients. Based on a questionnaire, several factors that may contribute to the Patient Global Assessment (PtGA) of severity were investigated w ...
Abstract
CLINICAL REPORT
Patient and Tumour Characteristics of Keratoacanthoma in a Large, Community-based Cohort Study from Queensland, Australia
Agnes Kolmodin, Nirmala P. Pandeya, Catherine M. Olsen, Jean Claude Dusingize, David C. Whiteman, Magdalena Claeson
Keratoacanthomas are common keratinocyte skin tumours. However, there is little community-based data on the patient and tumour characteristics of keratoacanthoma. The aim of this study was to investigate this subject using data from the QSkin study, a prospective cohort of 40,438 randomly sampled and consented participants aged 40–69 years in Queensland, Australia. In 2010, a baseline survey col ...
Abstract
CLINICAL REPORT
Impact of Bariatric Surgery on Moderate to Severe Psoriasis: A Retrospective Nationwide Registry Study
Marta Laskowski, Linus Schiöler, Johan Ottosson, Marcus Schmitt-Egenolf, Ann-Marie Wennberg, Torsten Olbers, Kjell Torén, Helena Gustafsson
Studies of the effects of bariatric surgery on psoriasis are few, with conflicting results. By linking the Swedish National Register for Systemic Treatment of Psoriasis (PsoReg) with the Scandinavian Obesity Surgery Registry (SOReg), individuals with psoriasis who had undergone bariatric surgery in Sweden during 2008 to 2018 were identified, and matched with data for patients with psoriasis in Pso ...
Abstract
CLINICAL REPORT
Visual Impact of Large and Giant Congenital Naevi: Comparison of Surgical Scars with Naevi Before Surgery
Francesca Sampogna, Melinda González, Mirella Pascini-Garrigós, Neus Calbet-Llopart, Jennifer L. Hay, Bruce S. Bauer, Susana Puig, Josep Malvehy, Ashfaq A. Marghoob, Cristina Carrera
Surgical attempts to remove large/giant congenital melanocytic naevi (LGCMN) are supported mainly by the theoretical improvement in patients’ self-image; however such surgery can result in unaesthetic scarring. We hypothesize that difference in appearance itself has an impact, and hence surgery cannot negate this impact. The aim of this cross-sectional study was to explore how LGCMN and scarring ...
Abstract
QUIZ
Round Granulomatous Lesions in a Young Girl: A Quiz
Fuh-Miin Liang, Xiaobo Feng, Li Li, Qiangqiang Zhang, Junhao Zhu, Mei Zeng, Ferry Hagen, Jiping Zhu, Min Zhu
Abstract is missing (Quiz)
Abstract
INVESTIGATIVE REPORT
Diagnostic Value of Genotypic Analysis in Primary Cutaneous Lymphomas using Standardized BIOMED-2 Polymerase Chain Reaction Protocols: Experience in Daily Clinical Practice
Daniel López Aventín, Fernando Gallardo, Luis Colomo, Ester Moragón, María Carmen Vela, Xavier Duran Jordà, Beatriz Bellosillo, Ramon M. Pujol
BIOMED-2 Concerted Action BMH4-CT98-3936 (BIOMED-2) PCR protocols are an important diagnostic tool in the evaluation of cutaneous lymphomas. The aim of this study was to assess the diagnostic value of the genotyping results obtained by these techniques in daily clinical practice. A total of 360 paraffin-embedded skin samples were retrospectively reviewed from 114 cutaneous T-cell lymphomas and 35 ...
Abstract
CLINICAL REPORT
Psoriasis on the Leg: Site-specific Histopathological and Immuno­histochemical Features and Diagnostic Difficulties
Mihaela Fülle, Dieter Metze, Almut Böer-Auer, Nani Osada, Stephan A. Braun
The histopathology of psoriasis can lack classical features on certain anatomical sites. The aim of this study was to detail the histopathology and immunophenotype of psoriasis on the legs, in order to differentiate it from other inflammatory dermatoses, such as stasis dermatitis. The histopathology of psoriasis on the legs was retrospectively compared with psoriasis on the trunk and stasis dermat ...
Abstract
INVESTIGATIVE REPORT
Patients with Darier Disease Exhibit Cognitive Impairment while Patients with Hailey-Hailey Disease Do Not: An Experimental, Matched Case-control Study
Philip Curman, Johanna Bern, Linnea Sand, Martin Cederlöf, Etty Bachar-Wikström, Jakob D. Wikström
Darier disease and Hailey-Hailey disease are severe, monogenetic dermatological disorders with mutations affecting all cells, making them liable to exhibit extra-dermal symptoms. The aim of this study is to assess broad cognitive function in individuals with these diseases, using an experimental, case-control set-up comparing cognition in patients with that in healthy controls matched for age, sex ...
Abstract
INVESTIGATIVE REPORT
Investigation of Genetic Mutations in High-risk and Low-risk Basal Cell Carcinoma in a Non-Caucasian Population by Whole Exome Sequencing
Hyun Jee Kim, Minho Lee, Young Bok Lee, Dong Su Yu
This study analysed genomic mutations in basal cell carcinoma using whole exome sequencing of DNA specimens obtained from 20 Korean patients. Histological evaluation determined that 15 (75%) were low-risk basal cell carcinomas, and 5 (25%) were high-risk basal cell carcinomas. Seventy-five percent of the basal cell carcinomas harboured somatic mutations in hedge­hog pathway genes (PTCH1, 40% and ...
Abstract
CLINICAL REPORT
Topical Application of Glycerol Increases Penetration Depth of Optical Coherence Tomography in Diagnosis of Basal Cell Carcinoma
Fieke Adan, Ellen M.M. Oyen, Robert J. Holtackers, Eva van Loo, Gert-Jan Dermont, Nicole W.J. Kelleners-Smeets, Patty J. Nelemans, Klara Mosterd
Optical coherence tomography is a non-invasive imaging technique that enables high-resolution in vivo imaging of skin. Although optical coherence tomography is promising for diagnosing basal cell carcinoma, its limited penetration depth may impede basal cell carcinoma subtyping. This study evaluated whether topical application of glycerol can increase penetration depth and improve the image qualit ...
Abstract
SHORT COMMUNICATION
Diagnostic Challenge of Bilateral Martorell Hypertensive Ischaemic Leg Ulcers
Lea F. Kraus, Katrin Elsharkawi-Welt, Thorsten Peters, Sabine Kastler, Diana Crisan, Anna Lipke, Codruta Tncau, Elisabeth Lormes, Michael Mühlberger, Karin Scharffetter-Kochanek
Abstract is missing (Short communication)
Abstract
SHORT COMMUNICATION
Therapeutic Inertia in the Management of Moderate-to-Severe Plaque Psoriasis in Adolescents
Audrey Melin, Jean-François Sei, Florence Corgibet, Cristèle Nicolas, Rémi Maghia, Bruno Halioua, Alain Beauchet, Emmanuel Mahé; and the Fédération Française de Formation Continue et d’Evaluation en Dermatologie-Vénéréologie
Abstract is missing (Short communication)
Abstract
CLINICAL REPORT
Evaluation of Psoriasis Area and Severity Index as a Proxy for Bio­markers of Systemic Disease under Treatment with Tumour Necrosis Factor-alpha and Interleukin 12/23 Antagonists in Patients with Psoriasis: a Retrospective Cohort Study of 186 Treatment Cycles
Jochen H.O. Hoffmann, Christian Knoop, Knut Schäkel, Alexander H. Enk, Eva N. Hadaschik
The efficacy of psoriasis treatments is usually evaluated using the Psoriasis Area and Severity Index (PASI). However, there is a lack of systematic statistical assessments of PASI as a proxy for systemic disease in individual patients. Therefore, a retrospective study of 186 treat­ments with adalimumab, etanercept, and ustekinumab for psoriasis (341 patient-years) was performed. While PASI signi ...
Abstract
CLINICAL REPORT
Evaluation of a One-step Dose Reduction Strategy of Adalimumab, Etanercept and Ustekinumab in Patients with Psoriasis in Daily Practice
Selma Atalay, Lara S. van der Schoot, Laura Vandermaesen, Lieke J. van Vugt, Mascha Eilander, Juul M.P.A. van den Reek, Elke M.G.J. de Jong
Dose reduction of biologics for psoriasis could contribute to lower drug exposure. This study evaluated a one-step, tightly controlled, biologic dose reduction strategy in a prospective daily practice cohort. In patients with psoriasis with low disease activity using adalimumab, etanercept or ustekinumab for at least 6 months, the dosing interval was prolonged with 33%. Patients could return to th ...
Abstract
CLINICAL REPORT
Secukinumab Exhibits Sustained and Stable Response in Patients with Moderate-to-Severe Psoriasis: Results from the SUPREME Study
Antonio Costanzo, Filomena Russo, Marco Galluzzo, Luca Stingeni, Roberta Scuderi, Leonardo Zichichi, Manuela Papini, Luisa Di Costanzo, Andrea Conti, Martina Burlando, Andrea Chiricozzi, Francesca Maria Gaiani, Cristina Mugheddu, Maria Letizia Musumeci, Paolo Gisondi, Stefano Piaserico, Paolo Dapavo, Marina Venturini, Gianluca Pagnanelli, Paolo Amerio, Concetta Potenza, Ketty Peris, Franca Cantoresi, Sara Trevisini, Francesco Loconsole, Annamaria Offidani, Santo Raffaele Mercuri, Viviana Lora, Francesca Prignano, Marta Bartezaghi, Giovanni Oliva, Elisabetta Aloisi, Roberto Orsenigo for the SUPREME study group
Secukinumab, a fully human monoclonal antibody, neutralizes interleukin-17A, a cornerstone cytokine driving the multiple manifestations of psoriasis. This post-hoc analysis of the SUPREME study was performed to determine the sustainability of response to secukinumab in terms of Psoriasis Area and Severity Index (PASI) 90 in patients with moderate-to-severe plaque psoriasis. Based on PASI 90 respon ...
Abstract
QUIZ
Multiple Firm Livid Nodules on the Proximal Lower Leg: A Quiz
Kai-Philipp Linse, Christine Fink, Ferdinand Toberer
Abstract is missing (Quiz)
Abstract
REVIEW
Patient-reported Outcome Measures for Angioedema: A Literature Review
Anna Trier Heiberg Brix, Henrik Balle Boysen, Karsten Weller, Teresa Caballero, Anette Bygum
Angioedema and hereditary angioedema are characterized by swelling of the subcutaneous and/or submucosal tissue, resulting in localized oedema. The rarity, but also the diverse clinical presentation, of these conditions can be challenging regarding diagnosis, treatment, and management. Patient-reported outcome measures (PROMs) are data received directly from the patient, providing the patient’s ...
Abstract
SHORT COMMUNICATION
Establishment of a Nationwide Patient Database for Clinical Trial Recruitment in Dermatology: Concept and Patient Characteristics
Dorra Bouazzi, Anette Bygum, Lone Skov, Mikkel Lindskov Sachs, Lars Iversen, Merete Hædersdal, Gregor B.E. Jemec, Simon F. Thomsen
Abstract is missing (Short communication)
Abstract
CLINICAL REPORT
Long-term Mortality among Patients with Chronic Ulcers
Jenni E. Salenius, Minna Suntila, Tiina Ahti, Heini Huhtala, Annikki Vaalasti, Teea T. Salmi, Teija Kimpimäki
Chronic ulcers cause a significant burden to patients and society. This study evaluated long-term mortality among patients with chronic ulcers diagnosed at a dermatology clinic between 1980 and 2010. The mortality risk and causes of death of 3,489 patients with ulcers were compared with a matched reference group of 10,399 individuals, and factors associated with increased mortality risk were exami ...
Abstract
INVESTIGATIVE REPORT
Contact Allergy to Oxidized Linalool and Oxidized Limonene is Over-represented in Individuals with Photocontact Allergy to Ketoprofen
Magnus Bruze, Victoria Marmgren, Annarita Antelmi, Monica Hindsén Stenström, Cecilia Svedman, Erik Zimersson, Martin Mowitz
Simultaneous contact allergies are common in individuals with photocontact allergy to ketoprofen. The rate of contact allergy to the fragrance substances oxidized linalool and oxidized limonene in ketoprofen-photo­allergic individuals were investigated in comparison with the corresponding rates in individuals without photo­contact allergy to ketoprofen, using Fisher’s exact test. A total of 4, ...
Abstract
INVESTIGATIVE REPORT
An Ecological Study Indicates the Importance of Ultraviolet A Protection in Sunscreens
Samar Merhi, Pascale Salameh, Peter Kaplan, Shayak Banerjee, Mohamed Lajnef, Emmanuel L.P. Dumont, Khaled Ezzedine
The use of sunscreens is recommended to limit the impact of sun exposure on the skin. The objective of this study was to examine the relationship between sunscreen sales and melanoma in 4 different countries with diverse sunscreen regulations. Data from publicly avail­able databases were examined for Sweden, England, Australia, and the USA from 1999 to 2018. The association between incidence of m ...
Abstract
INVESTIGATIVE REPORT
Choice of Systemic Drugs for the Management of Moderate-to-severe Psoriasis: A Cross-country Comparison Based on National Health Insurance Data
Emilie Sbidian, Myriam Mezzarobba, Jason Shourick, Cécile Billionnet, Joël Coste, Alain Weill, Jérémie Rudant, Olivier Chosidow, Loes Hollestein, Tamar Nijsten
Current management of moderate-to-severe psoriasis may be heterogeneous between European countries, probably due to differences in the organization of care. The aim of this study was to compare the utilization of systemic treatments for psoriasis between 2 coun­tries. All adults with psoriasis who were registered in the French (SNDS) and the Dutch (VEKTIS) national health insurance databases betw ...