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Preview of fully accepted papers, still not published in any volume

SHORT COMMUNICATION
Isolated Adrenocorticotropic Hormone Deficiency in Melanoma Patients Treated with Nivolumab
Seiya Kitano, Kazuki Tatsuno, Junichi Ishibe, Takatoshi Shimauchi, Toshiharu Fujiyama, Taisuke Ito, Noriyoshi Ogawa, Yoshiki Tokura
Abstract is missing (Short communication)
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CLINICAL REPORT
Unscheduled Visits of Patients with Familial Melanoma to a Pigmented Lesion Clinic: Evaluation of Patients' Characteristics and Suspicious Lesions
Rania Nabil, Elsemieke Plasmeijer, Remco van Doorn, Wilma Bergman, Nicole A. Kukutsch
Approximately 10% of all melanomas occur in subjects with a family history of melanoma. This retrospective follow-up study investigated the characteristics of patients with familial melanoma who made unscheduled visits to our pigmented lesions clinic, and the diagnosis of excised lesions. A total of 110 (9%) out of 1,267 patients made at least one unscheduled visit between May 2011 and February 20 ...
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CLINICAL REPORT
Treatment of Actinic Keratosis with Photodynamic Therapy Using Red or Green Light: A Comparative Study
Beata J. Osiecka, Piotr Nockowski, Jacek C. Szepietowski
Actinic keratosis (AK) is the most common in situ cancerous skin lesion. Compared with other approved treatment modalities photodynamic therapy is preferred by patients due to faster recovery and improved cosmetic outcome. However, pain during irradiation is an important drawback. The aim of this study was to compare the effectiveness and tolerability of topical aminolaevulinic acid-photodynamic t ...
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SHORT COMMUNICATION
Successful Multidisciplinary Treatment of Chronic Facial Wounds in Junctional Epidermolysis Bullosa
Antonia Reimer, Roland Laszig, Jens Pfeiffer, Philipp Eberwein, Hans Mittelviefhaus, Leena Bruckner-Tuderman, Cristina Has
Abstract is missing (Short communication)
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CLINICAL REPORT
Prognosis of Preschool Eczema and Factors of Importance for Remission
Emma Kristin Johansson, Anna Bergström, Inger Kull, Tomas Lind, Cilla Söderhäll, Erik Melén, Samina Asad, Maria Bradley, Agne Liedén, Natalia Ballardini, Carl-Fredrik Wahlgren
Information on factors of importance for remission of eczema is scarce. This study explored factors related to the remission and course of preschool eczema (PSE) (eczema at 1, 2 and/or 4 years of age) to 16 years of age (n = 889) in a Swedish cohort. Half of the children were in complete remission by school age (at age 8, 12, and 16 years). In multivariate prognostic models, persistent PSE (ec ...
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CLINICAL REPORT
Initial Results of Secukinumab Drug Survival in Patients with Psoriasis: A Multicentre Daily Practice Cohort Study
Juul M.P.A. van den Reek, Lieke J. van Vugt, Martijn B.A. van Doorn, Gayle E. van der Kraaij, Wim J.A. de Kort, Georges P.H. Lucker, Barbara Horvath, M. David Njoo, H. Jorn Bovenschen, Paul M. Ossenkoppele , Marjolein S. De Bruin-Weller , Marjan de Groot, Roland Mommers, Ruud L.M.A. Prevoo, Peter C.M. van de Kerkhof, Phyllis I. Spuls, Wietske Kievit, Elke M.G.J. de Jong
Interleukin 17-antagonist secukinumab demonstrated high efficacy for treatment of psoriasis in randomized controlled trials. However, performance in daily practice may differ from trials. Drug survival is a comprehensive outcome covering effectiveness and safety, suitable for analyses of daily practice. The aim of this study was to evaluate drug survival of secukinumab in a daily practice psoriasi ...
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SHORT COMMUNICATION
Localized Scleroderma of the Head and Face Area: A Retrospective Cross-Sectional Study of 96 Patients from 5 German Tertiary Referral Centres
Alexander Kreuter, Georg Mitrakos, Silke C. Hofmann, Percy Lehmann, Michael Sticherling, Thomas Krieg, Nina Lahner, Christian Tigges, Nicolas Hunzelmann, Pia Moinzadeh
Abstract is missing (Short communication)
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QUIZ
Scalp Hair Hypopigmentation in a Five-month-old Infant: A Quiz
Sophie Leducq, Emmanuelle Blanchard, Thierry Perez, Annabel Maruani
Abstract is missing (Quiz)
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SHORT COMMUNICATION
Successful Treatment with Dupilumab in a Patient with Severe, Difficult to Treat Atopic Dermatitis: Beware of Symptomatic Adrenal Insufficiency due to Abrupt Discontinuation of Potent Topical Corticosteroids
Lieneke F.M. Ariëns, Jorien van der Schaft, Aline M.E. Stades, Anthonie A. van de Woestijne , Marjolein S. De Bruin-Weller
Abstract is missing (Short Communication)
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SHORT COMMUNICATION
A Case of Refractory Subcutaneous Panniculitis-like T-cell Lymphoma with Bone Marrow and Lung Involvement Treated Successfully with Oral Etoposide
Akimasa Saito, Naoko Okiyama, Ryota Tanaka, Hiroshi Maruyama, Manabu Fujimoto
Abstract is missing (Short communication)
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SHORT COMMUNICATION
Calcinosis Cutis Caused by Subcutaneous Injection of Calcium-containing Heparin in a Patient with Systemic Lupus Erythematosus
Mai Hattori , Akira Shimizu, Osamu Ishikawa
Abstract is missing (Short communication)
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INVESTIGATIVE REPORT
Ten-eleven Translocation-2 Regulates DNA Hydroxymethylation Status and Psoriasiform Dermatitis Progression in Mice
Xin Wang, Xinxin Liu, Xiaoru Duan, Ke Zhu, Song Zhang, Lu Gan, Nian Liu, Himanshu Jaypaul, Johanna T. Makamure, Zhangyin Ming, Hongxiang Chen
Epigenetics plays an important role in the development and progression of many diseases. There is increasing evidence for the importance of epigenetic modifications in the progression of psoriasis. The aim of this study was to examine the role and potential mechanism of action of 5-hydroxymethylcytosine (5-hmC) and ten-eleven translocation-2 (TET2) in psoriasiform dermatitis in mice. Immunohistoch ...
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QUIZ
Yellow-brown Papules on the Cheeks and Limbs of a Male Infant: A Quiz
Julia K. Winkler, Susanne Hanner, Arno Rütten, Alexander H. Enk, Holger Haenssle, Ferdinand Toberer
Abstract is missing (Quiz)
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SHORT COMMUNICATION
Spontaneous Regression of Primary Cutaneous Diffuse Large B-cell Lymphoma, Leg Type
Ferdinand Toberer, Gunhild Mechtersheimer, Hannah Jaschinski, Alexander Enk, Lara Hakim-Meibodi, Holger A. Haenssle
Abstract is missing (Short communication)
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SHORT COMMUNICATION
Up-regulation of Human Herpesvirus 6B-derived microRNAs in the Serum of Patients with Drug-induced Hypersensitivity Syndrome/Drug Reaction with Eosinophilia and Systemic Symptoms
Kazuya Miyashita, Fumi Miyagawa, Yuki Nakamura, Rie Ommori, Hiroaki Azukizawa, Hideo Asada
Abstract is missing (Short communication)
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INVESTIGATIVE REPORT
Inflammasome Activation Characterizes Lesional Skin of Folliculitis Decalvans
Alexia Eyraud, Brigitte Milpied, Denis Thiolat, Anne-Sophie Darrigade, Katia Boniface, Alain Taïeb, Julien Seneschal
Folliculitis decalvans (FD) is a chronic inflammatory disease leading to scarring alopecia with poorly defined pathogenesis. The aim of this study was to investigate the expression of markers associated with the activation of innate immune signals, such as inflammasome (NALP1 and NALP3), interleukin (IL)-1β and IL-8 and type I interferon (MxA). A retrospective monocentric study was conducted and ...
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CLINICAL REPORT
Metastasis Risk of Cutaneous Squamous Cell Carcinoma in Organ Transplant Recipients and Immunocompetent Patients
Roel E. Genders, Joris A.J. Osinga, Elise E. Tromp, Peter O'Rourke, Jan N. Bouwes Bavinck, Elsemieke I. Plasmeijer
Organ transplant recipients (OTRs) have a high incidence of cutaneous squamous cell carcinoma (cSCC), and immunosuppression has been reported to be an important risk factor for metastasis. The aim of this study was to identify the metastasis risk over a 10-year period for 593 patients with cSCC, of whom 134 were OTR and 459 were immunocompetent. Metastasis incidence rate was 1,046 (95% confidence ...
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INVESTIGATIVE REPORT
8-Methoxypsoralen Plus Ultraviolet A Reduces the Psoriatic Response to Imiquimod in a Murine Model
Nitesh Shirsath, Karin Wagner, Simone Tangermann, Michaela Schlederer, Christian Ringel, Lukas Kenner, Bernhard Brüne, Peter Wolf
The effects of 8-Methoxypsoralen plus ultraviolet A (PUVA) or ultraviolet B (UVB) alone on imiquimod-induced psoriasis were examined in a mouse model. Mouse skin was treated with repetitive sub-phototoxic doses of PUVA or UVB before or during the induction of toll-like receptor 7/8 activation and psoriasis through the application of imiquimod. PUVA, to a greater degree than UVB, suppressed the est ...
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CLINICAL REPORT
The Role of Therapy in Impairing Quality of Life in Dermatological Patients: A Multinational Study
Flora N. Balieva, Andrew Y. Finlay, Jörg Kupfer, Lucía Tomas Aragones, Lars Lien, Uwe Gieler, Françoise Poot, Gregor B. E. Jemec, Laurent Misery, Lajos Kemeny, Francesca Sampogna, Henriët van Middendorp, Jon Anders Halvorsen, Thomas Ternowitz, Jacek C. Szepietowski, Nikolay Potekaev, Servando E. Marron, Ilknur K. Altunay, Sam S. Salek, Florence J. Dalgard
Skin disease and its therapy affect health-related quality of life (HRQoL). The aim of this study was to measure the burden caused by dermatological therapy in 3,846 patients from 13 European countries. Adult outpatients completed questionnaires, including the Dermatology Life Quality Index (DLQI), which has a therapy impact question. Therapy issues were reported by a majority of patients with ato ...
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SHORT COMMUNICATION
Extensive Nasal Plaque: An Unusual Presentation of IgG4-related Disease
Camila Cortés, Silvia Bielsa, Josep Manel Fernandez, Felip Vilardell, Blanca Gonzalez-Farré, Josep Manel Casanova
Abstract is missing (Short communication)
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CLINICAL REPORT
Dysplastic vs. Common Naevus-associated vs. De novo Melanomas: An Observational Retrospective Study of 1,021 Patients
Alejandro Martin-Gorgojo, Celia Requena, Zaida Garcia-Casado, Victor Traves, Rajiv Kumar, Eduardo Nagore
The aim of this case-case study was to determine the differences between dysplastic and common naevus-associated melanomas (NAM) and de novo melanomas. A total of 1,021 prospectively collected patients with invasive cutaneous melanoma from an oncology referral centre were included in the study. Of these, 75.51% had de novo melanomas, 12.93% dysplastic NAM, and 11.56% common NAM. Dysplastic NAM, co ...
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CLINICAL REPORT
Duration of Psoriatic Skin Disease as Risk Factor for Subsequent Onset of Psoriatic Arthritis
Alexander Egeberg, Lone Skov, Claus Zachariae, Gunnar H. Gislason, Jacob P. Thyssen, Lotus Mallbris
It is unclear whether psoriasis is a progressive disease that requires early aggressive intervention. This population-based study identified patients with psoriasis and psoriatic arthritis (PsA). Survival analysis and Kaplan–Meier life table techniques were used. The study comprised 10,011 psoriasis patients (severe n = 4,618), and 1,269 patients also had PsA. Incidence of PsA increased with ...
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SHORT COMMUNICATION
Simultaneous Induction of Benign Condyloma and High-grade Anal Dysplasia Induced by Low-risk Human Papillomavirus Type 42
Alexander Kreuter, Martin Hufbauer, Steffi Silling, Frank Oellig, Baki Akgül, Ulrike Wieland
Abstract is missing (Short communication)
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INVESTIGATIVE REPORT
Overexpression of Amyloid Precursor Protein Promotes the Onset of Seborrhoeic Keratosis and is Related to Skin Ageing
Yuanying Li, Yu Wang, Wei Zhang, Leiwei Jiang, Wenming Zhou, Zhi Liu, Shijun Li, Hongguang Lu
Seborrhoeic keratosis (SK) is an age-related skin disease. Amyloid precursor protein (APP) plays an important role in the pathogenesis of age-related Alzheimer’s disease. The aim of this study was to elucidate the expression characteristics of APP in SK tissues (n = 50), and explore whether the production of APP is related to the onset of SK and skin ageing, including ultraviolet (UV)-induce ...
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QUIZ
Painful Papules on the Hand: A Quiz
Elizabeth Lee, Tejesh Patel, Gillian Hale, Sherif Zaki, Kristopher Fisher
Abstract is missing (Quiz)
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SHORT COMMUNICATION
Toe Gangrene Associated with Macroangiopathy in Systemic Sclerosis: A Case Series on the Unreliability of the Ankle-brachial Pressure Index
Takashi Hashimoto, Takahiro Satoh, Hiroo Yokozeki
Abstract is missing (Short communication)
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SHORT COMMUNICATION
Generalized Chronic Itch as a First Sign of Malignancy Resembling Paraneoplastic Sensomotoric Neuropathy
Minaya Beigi, Michael Häberle, Andreas Gschwendtner, Ulrich Baum, Elke Weisshaar
Abstract is missing (Short communication)
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CLINICAL REPORT
Stand-alone Emollient Treatment Reduces Flares After Discontinuation of Topical Steroid Treatment in Atopic Dermatitis: A Double-blind, Randomized, Vehicle-controlled, Left-right Comparison Study
Irena Angelova-Fischer, Frank Rippke, Daniel Richter, Alexander Filbry, Craig Arrowitz, Teresa Weber, Tobias W. Fischer, Detlef Zillikens
Prevention of the flares is a main goal in the long-term treatment of atopic dermatitis (AD). Therefore we investigated the efficacy of a water-in-oil emollient, containing licochalcone A, omega-6-fatty acids, ceramide 3 and glycerol, for prevention of the flares in adults with mild to moderately severe AD, treated with topical steroids, that led to clearing of the inflammatory lesions and had bee ...
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CLINICAL REPORT
Aquagenic Pruritus in Polycythemia Vera: Clinical Characteristics
Edyta Lelonek, Łukasz Matusiak, Tomasz Wróbel, Jacek C. Szepietowski
Aquagenic pruritus is one of the main clinical features of polycythemia vera. The aim of this study was to analyse the clinical characteristics of aquagenic pruritus. The study group comprised 102 patients with molecularly confirmed polycythemia vera. Demographic data, data on disease history, polycythemia vera status and treatment modalities were collected. Moreover, various clinical features of ...
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CLINICAL REPORT
Characteristics of Familial Melanoma in Valencia, Spain, Based on the Presence of CDKN2A Mutations and MC1R Variants
Claudia Huerta, Zaida Garcia-Casado, José Bañuls, Manuel Moragon, Vicente Oliver, Blanca Unamuno, Celia Requena, Rajiv Kumar, Eduardo Nagore
Melanoma results from a complex interplay between environmental factors and individual genetic susceptibility. Familial melanoma is attributable to predisposition genes with variable penetrance. The aim of this study was to identify differences between familial melanoma and sporadic cases in our population, based on the presence of CDKN2A mutations and MC1R variants. Comparing 107 patients with fa ...
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REVIEW
Light and Laser Modalities in the Treatment of Cutaneous Sarcoidosis: A Systematic Review
Ana Luiza Lima, Steven Goetze, Tanja Illing, Peter Elsner
Sarcoidosis is a systemic non-caseating granulomatous disease of unknown aetiology. Cutaneous manifestations are present in approximately 10–30% of the patients with the systemic form. Therapy is indicated in case of disabling symptoms, organ dysfunction or cosmetically distressing manifestation. Despite different therapeutic possibilities, cutaneous sarcoidosis remains exceptionally difficult t ...
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SHORT COMMUNICATION
Folate Supplementation During Methotrexate Therapy: A Population-based Retrospective Cohort Study
Canelle Mazaud, Laurence Fardet
Abstract is missing (Short communication)
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CLINICAL REPORT
Evaluation of IgG4+ Plasma Cell Infiltration in Patients with Systemic Plasmacytosis and Other Plasma Cell-infiltrating Skin Diseases
Shintaro Takeoka, Masahiro Kamata, Carren Sy Hau, Mihoko Tateishi, Saki Fukaya, Kotaro Hayashi, Atsuko Fukuyasu, Takamitsu Tanaka, Takeko Ishikawa, Takamitsu Ohnishi, Yuko Sasajima, Shinichi Watanabe, Yayoi Tada
Systemic plasmacytosis is a rare skin disorder characterized by marked infiltration of plasma cells in the dermis. IgG4-related disease is pathologically characterized by lymphoplasmacytic infiltration rich in IgG4+ plasma cells, storiform fibrosis, and obliterative phlebitis, accompanied by elevated levels of serum IgG4. Reports of cases of systemic plasmacytosis with abundant infiltration of IgG ...
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CLINICAL REPORT
Methotrexate Treatment for Pityriasis Rubra Pilaris: A Case Series and Literature Review
Lukas Koch, Clemens Schöffl, Werner Aberer, Cesare Massone
Treatment recommendations for pityriasis rubra pilaris (PRP) are based solely on case reports and small case series, as to-date no randomized controlled trials are available. We present here a case series of 3 patients and a literature review of 28 studies treating a total of 116 patients, with the aim of providing data regarding efficacy and safety of methotrexate in the treatment of PRP. Methotr ...
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SHORT COMMUNICATION
Pyoderma Gangrenosum Under Dabrafenib and Trametinib for Metastatic Melanoma
Mélanie Saint-Jean, Marie Le Moigne, Justine Daguze, Céline Bossard, Lucie Peuvrel, Gaëlle Quéreux, Brigitte Dréno
Abstract is missing (Short communication)
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CLINICAL REPORT
Propionibacterium acnes Abundance Correlates Inversely with Staphylococcus aureus: Data from Atopic Dermatitis Skin Microbiome
Wojciech Francuzik, Kristin Franke, Ralf R. Schumann, Guido Heine, Margitta Worm
The microbiome may influence disease severity in atopic dermatitis. The skin of atopic dermatitis patients and healthy individuals was sampled in a standardized manner and the microbial composition analysed using next-generation sequencing. Optical density measurements were used to investigate bacterial growth under defined conditions in vitro. Lesional skin from patients with atopic dermatitis ha ...
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CORRESPONDENCE
RASA1 Variants in Capillary Malformations of Children: A Comment to Maruani A et al.
Rudolf Happle
Abstract is missing (Correspondence)
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SHORT COMMUNICATION
A Postzygotic SMO Mutation Caused the Original Case of Happle–Tinschert Syndrome
Martin Zenker, Sigrid Tinschert, Ilse Wieland, Denny Schanze, Rudolf Happle
Abstract is missing (Short communication)
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QUIZ
Brownish Plaque with Progressive Growth on the Breast: A Quiz
Javier Arellano, Maria Jose Mesa, Yamile Corredoira
Abstract is missing (Quiz)
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SHORT COMMUNICATION
Testicular Cancer in Monozygotic Twin Brothers with Urticaria Pigmentosa
Tatiana Péčová, Karolína Vorčáková, Markéta Žaliová, Tatiana Burjanivová, Bibiana Malicherová, Lukáš Plank, Jan Trka, Klaudia Péčová, Katarína Adamicová, Martin Péč, Juraj Pec
Abstract is missing (Short communication)
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SHORT COMMUNICATION
Two Severe Cases of Adult-onset Still's Disease with Persistent Pruritic Eruptions
Yang Liu, Tetsuya Ikawa, Yayoi Tada, Takamitsu Tanaka, Takamitsu Ohnishi, Shinichi Watanabe, Daisuke Tsukui, Kurumi Asako, Hajime Kono
Abstract is missing (Short communication)
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CLINICAL REPORT
Early Relief of Pruritus in Atopic Dermatitis with Crisaborole Ointment, A Non-steroidal, Phosphodiesterase 4 Inhibitor
Gil Yosipovitch, Linda F. Stein Gold, Mark G. Lebwohl, Jonathan I. Silverberg, Anna M. Tallman, Lee T. Zane
Pruritus occurs in all patients with atopic dermatitis and requires quick relief to reduce disease exacerbation and improve quality of life. Crisaborole ointment is a non-steroidal phosphodiesterase 4 inhibitor for the treatment of mild-to-moderate atopic dermatitis. This post hoc analysis explores crisaborole ointment for early relief of pruritus in patients with mild to moderate atopic dermatiti ...
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BOOK REVIEW
Therapy for Severe Psoriasis, 1st Edition
Lone Skov
Abstract is missing (Book review)
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IN THIS ISSUE
Comment on: Quimp: A word meaning “quality of life impairment”
Pavel V. Chernyshov
Abstract is missing (In this Issue...)
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IN THIS ISSUE
Have you measured the patient’s quimp?
Magnus Lindberg
Abstract is missing (In this Issue...)
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BOOK REVIEW
Neonatal and Infant Dermatology, 3rd edition
Regina Fölster-Holst
Abstract is missing (Book review)
Abstract  PDF