Acta Dermato-Venereologica - Preview

Content - Preview

Preview of fully accepted papers, still not published in any volume

CLINICAL REPORT
Assessment of the Effect of 3% Diclofenac Sodium on Photodamaged Skin by Means of Reflectance Confocal Microscopy
Gonzalo Segurado-Miravalles, Natalia Jiménez-Gómez, Oscar Muñoz Moreno-Arrones, Ivette Alarcón-Salazar, Adrian Alegre-Sánchez, David Saceda-Corralo, Pedro Jaén-Olasolo, Salvador González-Rodríguez
Treatment of actinic keratosis with 3% diclofenac sodium w/w in hyaluronic acid is associated with a concomitant improvement in signs of photodamaged skin. However this effect has not yet been examined in depth. Twenty patients with actinic keratosis and signs of photodamaged skin were studied. They received treatment with diclofenac sodium w/w in hyaluronic acid for 2 months. Clinical and reflect ...
Abstract  PDF
REVIEW
Melanogenesis Inhibitors
Sulekha Kumari, Steven Tien Guan Thng, Navin Kumar Verma, Hemant K. Gautam
Abnormally high production of melanin or melanogenesis in skin melanocytes results in hyperpigmentation disorders, such as melasma, senile lentigines or freckles. These hyperpigmentary skin disorders can significantly impact an individual’s appearance, and may cause emotional and psychological distress and reduced quality of life. A large number of melanogenesis inhibitors have been developed, b ...
Abstract  PDF
SHORT COMMUNICATION
Tuberculosis Screening in Patients with Psoriasis Receiving Biologic Therapy: A Retrospective Cohort Study
Igor Snast, Einav Bercovici, Tomer Avni, Dorit Shitenberg, Emmilia Hodak, Lev Pavlovsky
Abstract is missing (Short communication)
Abstract  HTML  PDF
SHORT COMMUNICATION
Dipeptidyl Peptidase-4 Inhibitor-associated Bullous Pemphigoid: Recurrence with Epitope Spreading
Hiroyuki Takama, Makiko Yoshida, Kentaro Izumi, Takeshi Yanagishita, Jun Muto, Yuichiro Ohshima, Wataru Nishie, Hiroshi Shimizu, Masashi Akiyama, Daisuke Watanabe
Abstract is missing (Short communication)
Abstract  PDF
SHORT COMMUNICATION
Secondary Cutaneous Epstein–Barr Virus-associated Diffuse Large B-cell Lymphoma with Hodgkin/Reed-Sternberg-like Cells in a Patient with Angioimmunoblastic T-cell Lymphoma
Hao Chen, Yan-ning Xue, Chong-mei Xin, Jing-shu Xiong, Xiao Ni, Jian-Fang Sun
Abstract is missing (Short communication)
Abstract  HTML  PDF
SHORT COMMUNICATION
Eccrine Porocarcinoma of the Skin is Rising in Incidence in the East of England
Peter K.C. Goon, Puran Gurung, Nick J. Levell, Priya Subramanian, Adrian S.W. Yong, Kevin Y.C. Lee, Laszlo Igali, David Greenberg, Syed N. Shah, Eunice K.H. Tan
Abstract is missing (Short communication)
Abstract  PDF
SHORT COMMUNICATION
A Case of Pityriasis Rubra Pilaris Treated Successfully with the Phosphodiesterase-4 Inhibitor Apremilast
Maria Cho, Tetsuya Honda, Chiyuki Ueshima, Tatsuki Kataoka, Atsushi Otsuka, Kenji Kabashima
Abstract is missing (Short commuication)
Abstract  HTML  PDF
REVIEW
Antioxidative Phytochemicals Accelerate Epidermal Terminal Differentiation via the AHR-OVOL1 Pathway: Implications for Atopic Dermatitis
Masutaka Furue, Akiko Hashimoto-Hachiya, Gaku Tsuji
Aryl hydrocarbon receptor (AHR) is a chemical sensor that is expressed abundantly in epidermal keratinocytes. Oxidative AHR ligands induce the production of reactive oxygen species. However, antioxidant AHR ligands inhibit reactive oxygen species generation via activation of nuclear factor-erythroid 2-related factor-2, which is a master switch for antioxidative signalling. In addition, AHR signall ...
Abstract  HTML  PDF
CLINICAL REPORT
Nocebo Effects and Scratching Behaviour on Itch
Danielle J.P. Bartels, Antoinette I.M. van Laarhoven, Peter C.M. van de Kerkhof, Andrea W.M. Evers
Nocebo effects, i.e. reduced treatment effects due to patients’ negative expectations, play a role in itch. Recent studies have shown that nocebo effects can be induced experimentally on itch and also be minimized and even turned into the opposite direction, i.e. placebo effects. It is not known whether these effects generalize to itch-associated scratching behaviour. The aim of this study was t ...
Abstract  PDF
SHORT COMMUNICATION
Changes in Androgen Receptor Expression as a Molecular Marker of Progression from Normal Epithelium to Invasive Cancer in Elderly Patients with Penile Squamous Cell Carcinoma
Valerio Gaetano Vellone, Emanuele Cozzani, Leonardo Peñuela, Roberto Russo, Bruno Spina, Carlo Toncini, Carlo Terrone, Aurora Parodi
Abstract is missing (Short Communication)
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Modulation of Itch by Localized Skin Warming and Cooling
Kristen M. Sanders, Takashi Hashimoto, Kent Sakai, Tasuku Akiyama
Skin thermal changes modulate itch sensitivity. However, the mechanisms of this modulation are still unclear. Using mouse models of acute and chronic itch, we investigated whether local innocuous thermal stimulation of the skin alters itch sensitivity and if blockade of thermosensitive transient receptor potential (TRP) channels can reduce these changes. Localized thermal changes were achieved by ...
Abstract  HTML  PDF
SHORT COMMUNICATION
Efficacy of Oral Ruxolitinib in a Patient with Refractory Chronic Spontaneous Urticaria
Atsushi Fukunaga, Mitsuhiro Ito, Chikako Nishigori
Abstract is missing (Short communication)
Abstract  HTML  PDF
SHORT COMMUNICATION
Methotrexate for the Treatment of Recalcitrant Primary Localized Cutaneous Amyloidosis: A Case Series
Carolyn M. Stull, Hong Liang Tey, Gil Yosipovitch
Abstract is missing (Short communication)
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Sub-optimal Application of a High SPF Sunscreen Prevents Epidermal DNA Damage in Vivo
Antony R. Young, Jessica Greenaway, Graham I. Harrison, Karl P. Lawrence, Robert Sarkany, Thierry Douki, France Boyer, Gwendal Josse, Emmanuel Questel, Camille Monteil, Ana B. Rossi
The cyclobutane pyrimidine dimer (CPD) is a potentially mutagenic DNA photolesion that is the basis of most skin cancers. There are no data on DNA protection by sunscreens under typical conditions of use. The study aim was to determine such protection, in phototypes I/II, with representative sunscreen-user application. A very high SPF formulation was applied at 0.75, 1.3 and 2.0 mg/cm2. Unprotecte ...
Abstract  HTML  PDF
SHORT COMMUNICATION
Chlamydiales Bacterial Sequences in Lesional and Healthy Skin of Patients with Parapsoriasis
Kati Hokynar, Alexander Salava, Eero Vesterinen, Antti Lauerma, Annamari Ranki, Mirja Puolakkainen
Abstract is missing (Short communication)
Abstract  HTML  PDF
SHORT COMMUNICATION
Effects of Film Dressings on Itch Hypersensitivity Using Murine Dry Skin Models
Tomoyuki Iwanaga, Mitsutoshi Tominaga, Yui Hirata, Hironori Matsuda, Tomomasa Shimanuki, Hideoki Ogawa, Kenji Takamori
Abstract is missing (Short communication)
Abstract  PDF
SHORT COMMUNICATION
Nanostring Analysis of Skin Biopsies from Patients with Henoch-Schönlein Purpura Reveals Genes Associated with Pathology and Heterogeneity in the Disease Process
Yingrou Tan, Jackson Liang Yao Li, Bernett Teck Kwong Lee, Josephine Lum, Zacharias Aloysius Dwi Pramono, Maximilien Evrard, Michael Poidinger, Hong Liang Tey, Lai Guan Ng
Abstract is missing (Short communication)
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Genotype–Phenotype Correlations of Dystrophic Epidermolysis Bullosa in India: Experience from a Tertiary Care Centre
Vamsi K. Yenamandra, Shamsudheen K. Vellarikkal, Madhumita R. Chowdhury, Rijith Jayarajan, Ankit Verma, Vinod Scaria, Sridhar Sivasubbu, Subrata Basu Ray, Amit K. Dinda, Madhulika Kabra, Vinod K. Sharma, Gomathy Sethuraman
Recent advances in the field of genomics have seen the successful implementation of whole exome sequencing as a rapid and efficient diagnostic strategy in several genodermatoses. The aim of this study was to explore the potential of molecular studies in dystrophic epidermolysis bullosa (DEB) in India. Whole exome sequencing was performed using genomic DNA from each case of epidermolysis bullosa, f ...
Abstract  PDF
CLINICAL REPORT
Livedoid Vasculopathy: A French Observational Study Including Therapeutic Options
Emma Gardette, Philippe Moguelet, Jean-David Bouaziz, Dan Lipsker, Olivier Dereure, Francois Le Pelletier, Catherine Lok, Thierry Maisonobe, Didier Bessis, Jacqueline Conard, Camille Francès, Stéphane Barete
Livedoid vasculopathy is a rare thrombotic cutaneous disease. This observational study aimed to assess the clinical and biological features of livedoid vasculopathy and the efficacy of treatments. Patients enrolled had typical livedoid vasculopathy both clinically and histologically. Investigation of thrombophilia was performed. Electromyography was undertaken in the presence of symptoms suggestin ...
Abstract  HTML  PDF
SHORT COMMUNICATION
Alopecia Areata-like Hair Loss Accompanying Toxic Epidermal Necrolysis
Emi Mashima, Yu Sawada, Akiha Inoue, Natsuko Saito-Sasaki, Takashi Yamaguchi, Haruna Yoshioka, Shun Ohmori, Sanehito Haruyama, Manabu Yoshioka, Etsuko Okada, Motonobu Nakamura
Abstract is missing (Short Communication)
Abstract  HTML  PDF
SHORT COMMUNICATION
A Nodular Hidradenoma of Atypical Location in Pregnancy
Chen Yao, Michael G. Swaby, Michael R. Migden, Sirunya Silapunt
Abstract is missing (Short Communication)
Abstract  HTML  PDF
SHORT COMMUNICATION
Premature Aging Syndrome, Penttinen Type: Report of a Chinese Case with a PDGFRB Mutation
Zhiyong Zhang, Shuguang Zheng, Song Zheng, Yanyan Wang, Xue-Gang Xu, Xing-Hua Gao, Hong-Duo Chen
Abstract is missing (Short communication)
Abstract  HTML  PDF
SHORT COMMUNICATION
Disfiguring Leukoderma Caused by Banned Cosmetics: A Quiz
Laura Atzori, Ramona Zanniello, Giorgia Sarais, Viviana Piras, Luca Pilloni, Myriam Zucca, Maria Angela Brundu, Franco Rongioletti
Abstract is missing (Quiz)
Abstract  HTML  PDF
CLINICAL REPORT
Aggressive Rare T-cell Lymphomas with Manifestation in the Skin: A Monocentric Cross-sectional Case Study
Marie-Charlotte Brüggen, Katrin Kerl, Eugenia Haralambieva, Urs Schanz, Yun-Tsan Chang, Desislava Ignatova, Reinhard Dummer, Antonio Cozzio, Wolfram Hoetzenecker, Lars E. French, Emmanuella Guenova
Rare T- or NK-cell lymphomas with cutaneous manifestation may display a highly aggressive clinical course and major diagnostic/therapeutic challenges. This report describes our experiences with different lymphomas of this rare category and the therapeutic options used. This retrospective, descriptive, monocentric, cross-sectional case study, identified 4 rare aggressive T-/NK-cell lymphomas with m ...
Abstract  HTML  PDF
CLINICAL REPORT
Safety Profile of Secukinumab in Treatment of Patients with Psoriasis and Concurrent Hepatitis B or C: A Multicentric Prospective Cohort Study
Hsien-Yi Chiu, Rosaline Chung-yee Hui, Yu-Huei Huang, Ruey-Yun Huang, Kai-Lung Chen, Ya-Chu Tsai, Po-Ju Lai, Ting-Shun Wang, Tsen-Fang Tsai
Safety data for secukinumab in patients with psoriasis and viral hepatitis are lacking. The aim of this study is to investigate the risk of reactivation of hepatitis B virus (HBV)/hepatitis C virus (HCV) in patients with psoriasis who are receiving secukinumab therapy. This multicentre study screened 284 patients with psoriasis with available HBV and HCV serological data and 63 patients with concu ...
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Methotrexate Exposure and Risk of Cutaneous Malignant Melanoma: Investigation of a Possible Dose-response Relationship
Sam Polesie, Martin Gillstedt, John Paoli, Amra Osmancevic
Methotrexate treatment has been linked with an increased risk of melanoma. However, a possible dose-response relationship with respect to methotrexate exposure and melanoma has not been addressed. The aim of the present study was to investigate whether higher accumulated doses of methotrexate correlate with an increased risk of melanoma, which would further support a possible association. A nation ...
Abstract  HTML  PDF
SHORT COMMUNICATION
Squamous Cell Carcinoma and Multiple Familial Trichoepitheliomas: A Recurrent Association
Anna Dubois, Tiago Mestre, Thomas Oliphant, Akhtar Husain, Neil Rajan
Abstract is missing (Short communication)
Abstract  HTML  PDF
INVESTIGATIVE REPORT
CDKN2A/CDK4 Status in Greek Patients with Familial Melanoma and Association with Clinico-epidemiological Parameters
Fani Karagianni, Ching-Ni Njauw, Katerina P. Kypreou, Aravela Stergiopoulou, Michaela Plaka, Dorothea Polydorou, Vasiliki Chasapi, Leontios Pappas, Ioannis A. Stratigos, Gregory Champsas, Peter Panagiotou, Helen Gogas, Evangelos Evangelou, Hensin Tsao, Alexander J. Stratigos, Irene Stefanaki
Approximately 5–10% of melanoma cases occur in a familial context. CDKN2A/CDK4 were the first high-penetrance melanoma genes identified. The aims of this study were to evaluate CDKN2A/CDK4 variants in Greek familial melanoma patients and to correlate the mutational status with specific clinico-epidemiological characteristics. A cross-sectional study was conducted by genotyping CDKN2A/CDK4 varian ...
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Overexpression of Androgen, Oestrogen and Progesterone Receptors in Skin Lesions of Becker’s Naevus
Ping Sheng, Yun-Long Cheng, Chuan-Chuan Cai, Ya-Yun Wu, Ge Shi, Ying Zhou, Yi-Ming Fan
Becker’s naevus is androgen-dependent. The aim of this study was to investigate whether oestrogen and progesterone receptors are involved in this disorder. Immunohistochemistry showed that epidermal expression of androgen receptors, oestrogen receptors (α, β) and progesterone receptors was higher in skin lesions of Becker’s naevus than in perilesional and control skin. Androgen receptor over ...
Abstract  HTML  PDF
QUIZ
An Erythematous-squamous Lesion of the Foot: A Quiz
Stefano Veraldi, Paolo Pontini, Gianluca Nazzaro
Abstract is missing (Quiz)
Abstract  HTML  PDF
SHORT COMMUNICATION
Soluble Receptor for Advanced Glycation End Products: A Novel Biomarker for Psoriasis Severity with Therapeutic Implications?
Aleksandra Batycka-Baran, Wojciech Baran, Danuta Nowicka-Suszko, Jacek C. Szepietowski
Abstract is missing (Short communication)
Abstract  HTML  PDF
SHORT COMMUNICATION
Atopic Dermatitis Linked Cytokine Interleukin-31 Induced Itch Mediated via a Neuropeptide Natriuretic Polypeptide B
Saumitra Pitake, Patrick C. Ralph, Jennifer DeBrecht, Santosh K. Mishra
Abstract is missing (Short Communication)
Abstract  HTML  PDF
CLINICAL REPORT
Clinical Characteristics of Pruritus in Systemic Sclerosis Vary According to the Autoimmune Subtype
Greta Gourier, Chloé Théréné, Margaux Mazeas, Claire Abasq-Thomas, Emilie Brenaut, Flavien Huet, Haitham Sonbol, Elize Campillo, Julie Lemerle, Elisabeth Pasquier, Emmanuelle Le Moigne, Alain Saraux, Valérie Devauchelle-Pensec, Laurent Misery, Yves Renaudineau
Pruritus is a frequent symptom in systemic sclerosis (SSc), with a prevalence of 40–65%, but its pathophysiology is poorly understood. This study investigated the immunological component of pruritus. Fifty-six patients with SSc responded to a standardized questionnaire regarding both SSc disease and pruritus characteristics. Among patients with SSc, those with pruritus did not display a particul ...
Abstract  HTML  PDF
SHORT COMMUNICATION
Remission of Cutaneous Involvement in Splenic Marginal Zone Lymphoma after Splenectomy
Shoko Mai, Ken Natsuga, Souichi Shiratori, Yoshimasa Takahashi, Hiroshi Shimizu
Abstract is missing (Short Communication)
Abstract  HTML  PDF
SHORT COMMUNICATION
Wells' Syndrome Associated with Coxsackievirus A6 Infection
Yuta Yoshii, Takahiro Ishikawa, Takichi Munetsugu, Aya Nishizawa, Norihiro Fujimoto, Takahiro Satoh
Abstract is missing (Short communication)
Abstract  HTML  PDF
QUIZ
Blisters, Sores and Scars on the Dorsal Hands in a 17-year-old Girl: A Quiz
Anna Trier Heiberg Brix, Anne Lindegaard Christensen, Anette Bygum
Abstract is missing (Quiz)
Abstract  PDF
CLINICAL REPORT
Association Between Premature Hair Greying and Metabolic Risk Factors: A Cross-sectional Study
Seung Hwan Paik , Sihyeok Jang, Hee-Kyung Joh, Chun Soo Lim, BeLong Cho, Ohsang Kwon, Seong Jin Jo
The association of hair greying with metabolic syndrome is not well known, while association with obesity and coronary artery disease has been suggested. A cross-sectional study was conducted to identify an association between premature hair greying and metabolic risk factors. Of the 1,929 young healthy subjects (1,067 men and 862 women), 704 (36.4%) were categorized in the premature hair greying ...
Abstract  HTML  PDF
CLINICAL REPORT
Epidemiological Analysis of Major Complications Requiring Medical Intervention in Patients with Neurofibromatosis 1
Yuichi Yoshida, Yuko Ehara, Monji Koga, Shinichi Imafuku, Osamu Yamamoto
Neurofibromatosis 1 has various complications. To elucidate the frequency of neurofibromatosis 1-related major complications requiring medical intervention, a nationwide retrospective study was conducted of 3,530 patients with neurofibromatosis 1 registered from 2001 to 2014 in Japan. The ratio of certified patients requiring medical intervention (>stage 3) was 82%. Patients classified in the most ...
Abstract  HTML  PDF
SHORT COMMUNICATION
Desmoglein 4 Mutation Underlies Autosomal Recessive Keratosis Pilaris Atrophicans
Eran Cohen-Barak, Nada Danial-Farran, Helwa Hammad, Ola Aleme , Judith Krauz, Ester Gavish, Morad Khayat, Michael Ziv, Stavit Shalev
Abstract is missing (Short Communication)
Abstract  HTML  PDF
CLINICAL REPORT
Effect of Maternal Psoriasis on Pregnancy and Birth Outcomes: A Population-based Cohort Study from Denmark and Sweden
Gabriella Bröms, Ann Haerskjold, Fredrik Granath, Helle Kieler, Lars Pedersen, Ingegärd A. Berglind
Studies on pregnancy and birth outcomes in women with psoriasis are scarce and the findings inconsistent. The effect of maternal psoriasis and its severity on the risk of adverse pregnancy and birth outcomes was examined. A cross-national population-based cohort study was performed using prospectively collected data from Denmark and Sweden. Singleton births in women with psoriasis were identified ...
Abstract  HTML  PDF
SHORT COMMUNICATION
Ichthyosis Prematurity Syndrome due to a Novel SLC27A4 Homozygous Mutation in an Italian Patient
Andrea Diociaiuti, Enrico Rosati, Maria Giovanna Paglietti, Paola Vacca, Renata Boldrini, Elisa Pisaneschi, Daniele Castiglia, Antonio Novelli, Maya El Hachem
Abstract is missing (Short communication)
Abstract  HTML  PDF
CLINICAL REPORT
Influence of Itch and Pain on Sleep Quality in Patients with Hidradenitis Suppurativa
Karolina Kaaz, Jacek C. Szepietowski, Łukasz Matusiak
There is a lack of data evaluating the influence of hidradenitis suppurativa-related subjective symptoms on sleep quality. The aim of this study was to assess the influence of itch and pain on sleep quality in 108 patients with hidradenitis suppurativa compared with 50 controls. The Athens Insomnia Scale (AIS) and Pittsburgh Sleep Quality Index (PSQI) were used to evaluate a spectrum of sleep dist ...
Abstract  HTML  PDF
QUIZ
Erythematous Papular Lesions on the Neck: A Quiz
Alice Mouchard, Matthias Tallegas, Marie-Christine Machet, Laurent Machet, Hélène Cornillier
Abstract is missing (Quiz)
Abstract  HTML  PDF
SHORT COMMUNICATION
Restrictive Dermopathy: Four Case Reports and Structural Skin Changes
Mona Bidier, Mareen Salz, Jochen Meyburg, Adelheid Elbe-Bürger, Felix Lasitzschka, Ingrid Hausser, Knut Schäkel
Abstract is missing (Short communication)
Abstract  HTML  PDF
QUIZ
A Subcutaneous Tumour on the Posterior Neck: A Quiz
Jun Omatsu, Ryosuke Saigusa, Takuya Miyagawa, Hiroko Numajiri, Kaname Akamata, Yuri Masui, Daisuke Yamada, Shinichi Sato
Abstract is missing (Quiz)
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Toll-like Receptor 3 Agonist, Polyinosinic-polycytidylic Acid, Upregulates Carbonic Anhydrase II in Human Keratinocytes
Bani Kaur Suri, Navin Kumar Verma, Artur Schmidtchen
Carbonic anhydrases are ubiquitously expressed enzymes that reversibly hydrate carbon dioxide to bicarbonate and protons. While the main function of carbonic anhydrases is to regulate pH and osmotic balance, their involvement in other physiological processes remains to be explored. This study analysed changes in mRNA and protein levels of carbonic anhydrase II in human primary keratinocytes treate ...
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Alopecia Areata is Associated with Increased Expression of Heart Disease Biomarker Cardiac Troponin I
Eddy Hsi Chun Wang, Leopoldo Santos, Xi Yuan Li, Annie Tran, Sandra S.Y. Kim, Katrina Woo, Jerry Shapiro, Kevin J. McElwee
The development of androgenetic alopecia is associated with a risk of developing cardiovascular diseases, but the association of alopecia areata with cardiovascular diseases in humans is largely unexplored. We measured the plasma level of two common cardiovascular disease markers, cardiac troponin I and C-reactive protein, in alopecia areata and androgenetic alopecia affected subjects. Also, we in ...
Abstract  HTML  PDF
SHORT COMMUNICATION
Characteristics of Chronic Itch in Systemic Sclerosis: A Cross-sectional Survey
Carolyn M. Stull, Leslie A. Weaver, Rodrigo Valdes-Rodriguez, Srikanth Naramala, Michael J. Lavery, Yiong-Huak Chan, Fabian A. Mendoza, Gil Yosipovitch
Abstract is missing (Short communication)
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Patients with Acne Vulgaris Have a Distinct Gut Microbiota in Comparison with Healthy Controls
Yongqiong Deng, Hong Wang, Jiyuan Zhou, Yunzhou Mou, Guiqiang Wang, Xia Xiong
Acne vulgaris has been postulated to have a gastrointestinal mechanism; however, little is known about gut microbiota dysfunction in this condition. The aim of this cross-sectional study was to investigate whether the gut microbiota is altered in acne. Faecal bacterial diversity was analysed in 43 patients with acne and 43 controls, using hypervariable tag sequencing of the V3–V4 region of the 1 ...
Abstract  HTML  PDF
CLINICAL REPORT
Skin Manifestations in Patients with Adult-onset Immunodeficiency due to Anti-interferon-gamma Autoantibody: A Relationship with Systemic Infections
Kamonwan Jutivorakool, Prattana Sittiwattanawong, Kornphaka Kantikosum, Cameron P. Hurst, Chanat Kumtornrut, Pravit Asawanonda, Jettanong Klaewsongkram, Pawinee Rerknimitr
Adult-onset immunodeficiency due to anti-interferon-γ autoantibody is an emerging acquired immunodeficiency with frequent skin manifestations. A retrospective chart review was conducted and identified 41 patients with the syndrome. Skin involvement was detected in 33 (80%) patients, 15 (45%) with infective skin diseases and 27 (82%) with reactive skin disorders. Reactive lesions were mostly neutr ...
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Eosinophils are a Major Source of Interleukin-31 in Bullous Pemphigoid
Urda Rüdrich, Manuela Gehring, Eleni Papakonstantinou, Anja Illerhaus, Judith Engmann, Alexander Kapp, Karin Hartmann, N. Helge Meyer, Bernhard F. Gibbs, Ulrike Raap
Bullous pemphigoid (BP) is characterized by substantial skin and blood eosinophilia as well as intensive pruritus. Since the pruritogenic cytokine interleukin (IL)-31 is increased in inflammatory skin diseases the aim of this study was to determine whether IL-31 plays a role in BP. Using immunofluorescence, IL-31 expression was analysed in eosinophils derived from blister fluids and skin from pati ...
Abstract  HTML  PDF
SHORT COMMUNICATION
Failure of a Print Media Sun Safety Campaign to Reach High-risk Occupational Groups
Alexander G.S. Zink, Melvin Rüth, Reinhold Watzele, Claudio R. Nigg, Eva A. Rehfuess
Abstract is missing (Short communication)
Abstract  HTML  PDF
QUIZ
Coccygeal Nodule in an Infant: A Quiz
Kazumasa Oya, Yosuke Ishitsuka, Manabu Fujimoto
Abstract is missing (Quiz)
Abstract  HTML  PDF
SHORT COMMUNICATION
Slowly Progressing Asymptomatic Disseminated Telangiectasias: A Quiz
Justyna Szczęch, Marcelina Pojawa-Gołąb, Dominik Samotij, Adam Reich
Abstract is missing (Quiz)
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Tofacitinib Represses the Janus Kinase-Signal Transducer and Activators of Transcription Signalling Pathway in Keratinocytes
Ankit Srivastava, Mona Ståhle, Andor Pivarcsi, Enikö Sonkoly
Tofacitinib is a Janus kinase (JAK) inhibitor, which has shown efficacy in treating psoriasis. The mode of action of tofacitinib is not completely understood but it has been thought to be mediated by the inhibition of CD4+ T-cell activation. Here, we investigated whether the molecular targets of tofacitinib are expressed in keratinocytes, and whether tofacitinib can modulate the activity of the JA ...
Abstract  HTML  PDF
BOOK REVIEW
Cutaneous Malignancies. A surgical perspective
Lisa Naysmith
Abstract is missing (Book review)
Abstract  HTML  PDF
SHORT COMMUNICATION
Psoriasis-like Dermatitis in Adulthood: A Skin Manifestation of Holocarboxylase Synthetase Deficiency
Daisuke Watabe, Ayano Watanabe, Toshihide Akasaka, Osamu Sakamoto, Hiroo Amano
Abstract is missing (Short Communication)
Abstract  HTML  PDF
CLINICAL REPORT
Usability of Validated Sleep-assessment Questionnaires in Patients with Chronic Pruritus: An Interview-based Study
Theresa Suilmann, Claudia Zeidler, Nani Osada, Claudia Riepe, Sonja Ständer
Impaired sleep due to nocturnal pruritus is a common symptom in patients with chronic pruritus. However, there is no standardized, simplified instrument for assessing sleep-related problems in patients with chronic pruritus. After a literature search, we conducted 50 interviews with patients with chronic pruritus and tested 12 items most frequently used in routine sleep questionnaires. Afterwards, ...
Abstract  HTML  PDF
BOOK REVIEW
Therapy for Severe Psoriasis, 1st Edition
Lone Skov
Abstract is missing (Book review)
Abstract  PDF
IN THIS ISSUE
Comment on: Quimp: A word meaning “quality of life impairment”
Pavel V. Chernyshov
Abstract is missing (In this Issue...)
Abstract  PDF
IN THIS ISSUE
Have you measured the patient’s quimp?
Magnus Lindberg
Abstract is missing (In this Issue...)
Abstract  PDF
BOOK REVIEW
Neonatal and Infant Dermatology, 3rd edition
Regina Fölster-Holst
Abstract is missing (Book review)
Abstract  PDF