Content » Vol 43, Issue 7

Original report

Outcomes of high- and low-intensity rehabilitation programme for persons in chronic phase after Guillain-Barré syndrome: A randomized controlled trial

Fary Khan, Julie F. Pallant, Bhasker Amatya, Louisa Ng, Alexandra Gorelik , Caroline Brand
DOI: 10.2340/16501977-0826


Objective: To assess the effectiveness of a high- vs low-­intensity multidisciplinary ambulatory rehabilitation programme over 12 months for persons in the chronic phase after Guillain-Barré syndrome (pwGBS) in an Australian community cohort.
Method: A total of 79 pwGBS, recruited from a tertiary hospital, were randomized to a treatment group (n = 40) for an individualized high-intensity programme, or a control group (n = 39) for a lower intensity programme. The primary outcome the Functional Independence Measure (FIM) motor subscale assessed “activity limitation”; while secondary measures for “participation” included: World Health Organization Quality of Life; Depression, Anxiety Stress Scale; and Perceived Impact Problem Profile (PIPP) scales. All outcome measures were assessed at baseline and at 12 months.
Results: Intention to treat analysis of data from 69 participants (treatment n = 35, control n = 34) showed reduced disability in the treatment group in post-treatment FIM domains (mobility, transfers, sphincter control and locomotion; all p < 0. 005) and PIPP scores (relationships; p = 0. 011), with moderate-to-small effect sizes (r = 0. 36–0. 23). The treatment group compared with control group showed significant improvement in function (FIM scores): 68% vs 32%.
Conclusion: Higher intensity rehabilitation compared with less intense intervention reduces disability in pwGBS in later stages of recovery. Further information on rehabilitation modalities and impact on quality of life is needed.

Lay Abstract


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