Cardiovascular disease risk in adults with spastic bilateral cerebral palsy
Wilma M.A. van der Slot, Marij E. Roebroeck, Channah Nieuwenhuijsen, Michael P. Bergen, Henk J. Stam, Alex Burdorf, Rita J. G. van den Berg-Emons
Rijndam Rehabilitation Centre Westersingel 300, 3015 LJ Rotterdam, The Netherlands
Objective: To explore: (i) cardiovascular disease risk factors and the 10-year clustered risk of a fatal cardiovascular event in adults with spastic bilateral cerebral palsy; and (ii) relationships between the 10-year risk and body fat, aerobic fitness and physical activity.
Design: Cross-sectional study.
Subjects: Forty-three adults with spastic bilateral cerebral palsy without severe cognitive impairment (mean age 36. 6 years (standard deviation 6); 27 men).
Methods: Biological and lifestyle-related risk factors and the 10-year risk according to the Systematic Coronary Risk Evaluation (SCORE) were assessed. Relationships were studied using multivariable linear regression analysis.
Results: The following single risk factors were present: hypertension (n = 12), elevated total cholesterol (n = 3), low high-density lipoprotein cholesterol (n = 5; all men), high-risk waist circumference (n = 11), obesity (body mass index; n = 5; all men), reduced aerobic fitness (on average 80% of reference values), reduced level of everyday physical activity (on average 78% of reference values) and smoking (n=9). All participants had a 10-year risk <1%. Corrected for gender, participants with higher waist circumference (β = 0. 28; p = 0. 06) or body mass index (β=0. 25; p = 0. 08) tended to have a higher 10-year risk.
Conclusion: In this relatively young adult sample of people with spastic bilateral cerebral palsy several single cardiovascular disease risk factors were present. The 10-year fatal cardiovascular disease risk was low, and higher body fat tended to be related to higher 10-year risk.
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