List volumes - List articles in this issue

Clinical Report

Clinical Spectrum of Cutaneous Langerhans’ Cell Histiocytosis Mimicking Various Diseases

doi: 10.2340/00015555-0003


Langerhans’ cell histiocytosis summarizes a spectrum of diseases on the basis of histogenetic criteria. These are characterized by an accumulation of cells with Langerhans’ cell phenotype in one or multiple organs. Up to 50% of patients with either single or multi-organ manifestation of Langerhans’ cell histiocytosis initially present with cutaneous symptoms. Nevertheless, cutaneous Langerhans’ cell histiocytosis is rare and heterogeneous in its clinical features and therefore prone to misdiagnosis. We report on five patients, two infants and three adults, suffering from cutaneous Langerhans’ cell histiocytosis, either singly or as part of multi-organ disease. The different skin features morphologically mimicking other entities are shown and the differential diagnoses are discussed. The correct diagnosis in all presented cases is based on immunohistological examination, showing a histiocytic infiltrate positively staining with anti-S100 antibodies, CD1a and – apart from one case – with CD207 (langerin).


Kerstin QUERINGS, Hans STARZ and Bernd-Rüdiger BALDA
Department of Dermatology and Allergology, Klinikum Augsburg, Augsburg, Germany


Related articles

There are no related articles.

Share with your friends



Full text



There is no supplementary for this article.

Print information

Volume 86, Issue 1

DOI: 10.2340/00015555-0003

Pages: 39-43

View at PubMed