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Evaluation of Three Serological Tests Manufactured in Belarus for the Diagnosis of Syphilis
The performance of three serological tests manufactured in Belarus for the diagnosis of syphilis, i.e. a microprecipitation reaction (MPR) and two enzyme-linked immunosorbent assays (ELISAs) were compared with internationally recognized assays, namely the rapid plasma reagin test and the Treponema pallidum passive particle agglutination assay (TPPA). Sera from 392 consecutive patients attending Brest (Belarus) regional dermatovenereological dispensaries were tested. The sensitivity of the MPR test was low (77.3%) compared with the rapid plasma reagin test, while the specificity was high (100%). In contrast, both Belarusian ELISAs performed well when compared with the TPPA (sensitivities of 99.2% and 100%, specificities of 98.7% and 99.0%, respectively). There is a clear need to improve the sensitivity of the existing Belarusian MPR test or to use a more sensitive screening test in order to improve diagnosis of the disease in Belarus.
Iryna Shimanskaya, Larisa Zhurauskaya, Oleg Pankratov, Magnus Unemo, Ronald C. Ballard, Marius Domeika
Wikipedia. The free encyclopedia: Belarus. Available from: http://en.wikipedia.org/wiki/Belarus#Demographics. Cited in 2010.
Belarus Ministry of Health. Health care system of Belarus: official statistical catalogue of Health Ministry. Minsk, 2007, 390 pp (in Russian). Available from: http://www.minzdrav.by. Cited in 2010.
Cesnojt R, Khulup G, Brovko I, Shimanskaya I, Domeika M. [Belarusian-Swedish project Optimization of STI/HIV management in Belarus]. Ars Medica 2008; VI: 4–6 (in Russian).
Domeika M, Litvinenko I, Smirnova T, Gaivaronskaya O, Savicheva A, Sokolovskiy E, et al. Laboratory diagnostics for non-viral sexually transmitted infections in St. Petersburg, Russia: current situation and hallmarks for improvements. J Eur Acad Dermatol Venereol 2008; 22: 1094–1100.
Sokolovskiy E, Frigo N, Rotanov S, Savicheva A, Dolia O, Kitajeva N, et al. Guidelines for the laboratory diagnosis of syphilis in East European countries. J Eur Acad Dermatol Venereol 2009; 23: 623–632.
Brilene T. Laboratory diagnosis of STI in Eastern European countries. Proceedings of the 4th Meeting of the Eastern European Network for Sexual and Reproductive Health (EE SRH), M Domeika (editor). Uppsala: Uppsala Printing House, 30 May, 2009, p. 106-125.
Kourbatova EV, Akovbyan VA, Chesson HW, Lytkina IN, Dmitriev GA, Tikhonova LI, et al. Assessment of the routine, occupation-based gonorrhoea and syphilis screening program in Moscow, Russia: an analysis of sexually transmitted infection prevalence and cost-effectiveness. Sex Transm Dis 2008; 35: 453–460.
Aktas G, Young H, Moyes A, Badur S. Evaluation of the Serodia Treponema pallidum particle agglutination, the Murex Syphilis ICE and the Enzywell TP tests for serodiagnosis of syphilis. Int J STD AIDS 2005; 16: 294–298.
Peterman T, Schillinger J, Blank S, Berman S, Ballard R, Cox D, et al. Syphilis testing algorithms using treponemal tests for initial screening. Four laboratories, New York City, 2005–2006. MMWR 2008; 57: 872–875.
Borisenko KK, Tichonova LI, Renton AM. Syphilis and other sexually transmitted infections in the Russian Federation. Int J STD AIDS 1999; 10: 665–668.
Smacchia C, Parolin A, Di Perri G, Vento S, Concia E. Syphilis in prostitutes from Eastern Europe. Lancet 1998; 351: 572.
Abdala N, Carney JM, Durante AJ, Klimov N, Ostrovski D, Somlai AM, et al. Estimating the prevalence of syringe-borne and sexually transmitted diseases among injection drug users in St Petersburg, Russia. Int J STD AIDS 2003; 14: 697–703.
Shakarishvili A, Dubovskaya LK, Zohrabyan LS, St Lawrence JS, Aral SO, Dugasheva LG, et al. LIBRA Project Investigation Team. Sex work, drug use, HIV infection, and spread of sexually transmitted infections in Moscow, Russian Federation. Lancet 2005; 366: 57–60.
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Volume 91, Issue 3
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