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Clinical Report

Efficacy of Fluconazole and Nystatin in the Treatment of Vaginal Candida Species

doi: 10.2340/00015555-1194


The aim of this study was to determine and compare the efficacy of treatment with fluconazole and nystatin in Brazilian women with vaginal Candida. In a population of 932 women, vaginal cultures were performed for yeasts, whether or not the women showed signs and symptoms of vulvovaginal candidiasis. Yeasts were isolated from 12.2% of the women (114/932): 53.2% of the yeasts were Candida albicans, 27.0% C. glabrata, 13.5% C. tropicalis and 6.3% C. parapsilosis. Treatment was carried out with both drugs. The overall mean cure rates with fluconazole (87.0%) and nystatin (74.0%) were similar; among women with non-albicans, the cure rate with fluconazole was 100%, whereas that with nystatin was 44.4%. The cure rate for women with C. albicans was high with both fluconazole and nystatin; however, for those with non-albicans species the cure rate was excellent with fluconazole and very low with nystatin, differing from the majority of in vitro studies.


Helen Priscila Rodrigues Martins , Mariana Clivati da Silva, Luciene Cássia Farias Paiva , Terezinha Inez Estivalet Svidzinski, Marcia Edilaine Lopes Consolaro


  • Sobel JD. Vulvovaginal candidosis. Lancet 2007; 369: 1961–1971.
  • Fan SR, Liu XP, Li JW. Clinical characteristics of vulvovaginal candidiasis and antifungal susceptibilities of Candida species isolates among patients in southern China from 2003 to 2006. J Obst Gynecol Research 2008; 34: 561–566.
  • Ferraza MHSH, Maluf MLF, Consolaro MEL, Shinobu CS, Svidzinski TIE, Batista MR. [Characterization of yeasts isolated from the vagina and its association vulvovaginal candidiasis in two cities in southern Brazil]. Rev Bra Ginecol Obstet 2005; 27: 58–63 (in Portuguese).
  • Wei Y, Feng J, Luo C. Isolation and genotyping of vaginal non-albicans in women from two different ethnic groups in Lanzhou, China. Int J Gynecol Obstet 2010; 110: 227–230.
  • Consolaro MEL, Albertoni TA, Yoshida CS, Mazucheli J, Peralta RM, Svidzinski, TIE. Correlation of Candida species and symptoms among patients with vulvovaginal candidiasis in Maringá, Paraná, Brazil. Rev Iberoam Micol 2004; 21: 202–205.
  • Mårdh PA, Rodrigues AG, Genç M, Novikova N, Martinez-de-Oliveira J, Guaschino S. Facts and myths on recurrent vulvovaginal candidosis: a review on epidemiology, clinical manifestations, diagnosis, pathogenesis and therapy. Int J STD AIDS 2002; 13: 522–539.
  • Ghannoum MA, Rice LB. Antifungal agents: mode of actions, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance. Clin Microbiol Rev 1999; 12: 501–517.
  • Dota KFD, Shinobu CS, Patussi EV, Consolaro MEL, Svidzinski TIE. [Susceptibility to vaginal yeast in most used antifungal in Maringá, Paraná, Brazil]. Acta Bioquim Cliin Latinoam 2008; 42: 561–566 (in Portuguese).
  • Sobel JD, Faro S, Force RW, Foxman B, Ledger WJ, Nyirjesy PR, et al. Vulvovaginal candidiasis: epidemiologic, diagnostic, and therapeutic considerations. Am J Obstet Gynecol 1998; 178: 211.
  • Kurtzman CP, Fell JW. The yeast. A taxonomic study. 4th edn. Amsterdam: Elsevier, 1998.
  • Paulitsch A, Weger W, Ginter-Hanselmayer G, Marth E, Buzina W. A 5-year (2000–2004) epidemiological survey of candida and non-candida species causing vulvovaginal candidiasis in Graz, Austria. Mycoses 2006; 49: 471–475.
  • Holland J, Young OL, Chen SCA. Vulvovaginal carriage of yeasts other than Candida albicans. Sex Transmit Infect 2003; 79: 249–250.
  • Spinillo A, Carrata L, Pizzoli G. Reccurent vaginal candidiasis. Result of a cohort study of sexual transmission and intestinal reservoir. J Repr Med 1992; 37: 343–347.
  • Hetticarachchi N, Ashbee HR, Wilson JD. Prevalence and management of non-albicans vaginal candidiasis. Sex Transm Infect 2010; 86: 99–100.
  • Vermitsky JP, Self MJ, Chadwick SG, Trama JP, Adelson ME, Mordechai E, et al. Survey of vaginal-flora Candida species isolates from women of different age groups by use of species-specifc PCR detection. J Clin Microbiol 2008; 46: 1501–1503.
  • Dalben-Dota KF, Faria MG, Bruschi ML, Pelloso SM, Lopes-Consolaro ME, Svidzinski TI. Antifungal activity of propolis extract against yeasts isolated from vaginal exudates. J Altern Complem Med 2010; 16: 1–6.
  • Nyirjesy P, Alexander AB, Weitz MV. Vaginal Candida parapsilosis: pathogen or bystander. Inf Dis Obstet Gynecol 2005; 13: 3741.
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    Volume 92, Issue 1

    DOI: 10.2340/00015555-1194

    Pages: 78-82

    View at PubMed