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Role of Small Intestinal Bacterial Overgrowth and Helicobacter pylori Infection in Chronic Spontaneous Urticaria: A Prospective Analysis
The aim of this study is to assess the associations between chronic spontaneous urticaria (CSU), Helicobacter pylori infection and small intestinal bacterial overgrowth. Forty-
eight patients with CSU were studied by scoring the urticaria activity and assesing the quality of life. Patients with H. pylori infection (n = 11) or small intestinal bacterial overgrowth (n = 13) were specifically treated for one week and clinically evaluated both before and 4 weeks after the eradication therapy. Eradication of H. pylori infection led to a significant improvement in CSU (p < 0.002). In contrast, eradication of small intestinal bacterial overgrowth was not associated with any clinical improvement in CSU, despite the fact that these patients had statistically significant more urticaria activity at baseline. Thus there is no evidence to support the eradication of small intestinal bacterial overgrowth in CSU, but eradication of H. pylori infection may result in an improvement of the disease.
Anna Campanati, Rosaria Gesuita, Melania Giannoni, Francesca Piraccini, Lucia Sandroni, Emanuela Martina, Luca Conocchiari, Emanuele Bendia, Antonio Di Sario, Annamaria Offidani
Dermatological Clinic, Department of Clinical and Molecular Medicine, Polytechnic Marche University, IT-60200 Ancona, Italy. E-mail: email@example.com; firstname.lastname@example.org
Zuberbier T, Asero R, Bindslev-Jensen C, Walter Canonica G, Church MK, Giménez-Arnau A, et al. EAACI/GA(2)LEN/EDF/WAO guideline: definition, classification and diagnosis of urticaria. Allergy 2009; 64: 1417–1426.
Zuberbier T, Asero R, Bindslev-Jensen C, Walter Canonica G, Church MK, Giménez-Arnau AM, et al. EAACI/GA(2)LEN/EDF/WAO guideline: management of urticaria. Allergy 2009; 64: 1427–1443.
Wedi B, Raap U, Wieczorek D, Kapp A. Urticaria and infections. Allergy Asthma Clin Immunol 2009; 5: 10.
Wedi B, Wagner S, Werfel T, Manns MP, Kapp A. Prevalence of helicobacter pylori-associated gastritis in chronic urticaria. Int Arch Allergy Immunol 1998; 116: 288–294.
Reddymasu SC, Sostarich S, McCallum RW. Small intestinal bacterial overgrowth in irritable bowel syndrome: are there any predictors? BMC Gastroenterology 2010; 10: 23.
Parodi A, Paolino S, Greco A, Drago F, Mansi C, Parodi A, et al. Small intestinal bacterial overgrowth in rosacea: clinical effectiveness of its eradication. Clin Gastroenterol Hepatol 2008; 6: 759–764.
Moss R, Hsu YP, Esrig S. Performance characteristics of immunoenzymatic allergosorbent testing for total and specific immunoglobulin E. Ann Allergy 1987; 59: 185–191.
Sabroe RA, Grattan CE, Francis DM, Barr RM, Kobza Black A, Greaves MV. The autologous serum skin test: a screening test for autoantibodies in chronic idiopathic urticaria. Br J Dermatol 1999; 140: 446–452.
Ruëff F, Bergmann KC, Brockow K, Fuchs T, Grübl A, Jung K, et al. Skin tests for diagnostics of allergic immediate-type reactions. Pneumologie 2011; 65: 484–495.
Savarino V, Vigneri S, Celle G. The 13C urea breath test in the diagnosis of Helicobacter pylori infection. GUT 1999; 45: 118–122.
Redéen S, Petersson E, Törnkrantz, Levander H, Mårdh E, Borch K. Reliability of diagnostic tests for helicobacter pylori infection. Gastroenterol Res Pract 2011;2011:940650.
Gasbarrini A, Corazza GR, Gasbarrini G, Montalto M, Di Stefano M, Basilisco G, et al. Methodology and indications of H2-breath testing in gastrointestinal disease: the Rome Consensus Conference. Alim Pharmacol Ther 2009; 29: 1–49.
Bures J, Cyrany J, Kahoutova D, Forstl M, Rejchrt S, Kvetina J, et al. Small intestinal bacterial overgrowth syndrome. World J Gastroenterol 2010; 16: 2978–2990.
Mlynek A, Zalewska-Januwska A, Martus P, Staubach P, Zuberbier T, Maurer M. How to assess disease activity in patients with chronic urticaria? Allergy 2008; 63: 777–780.
Mathias SD, Dreskin SC, Kaplan A, Saini SS, Spector S, Rosén KE. Development of a daily diary for patients with chronic idiopathic urticaria. Ann Allergy Asthma Immunol 2010; 105: 142–148.
Finlay AY, Khan GK. Dermatology life quality index (DLQI) – a simple practical measure for routine clinical use. Clin Exp Dermatol 1994; 19: 210–216.
Grob JJ, Auquier P, Dreyfus I, Ortonne JP. Quality of life in adults with chronic idiopathic urticaria receiving desloratadine: a randomized, double-blind, multicentre, placebo-controlled study. J Eur Acad Dermatol Venereol 2008; 22: 87–93.
Shikiar R, Harding G, Leahy M, Lennox RD. Minimal important difference (MID) of the Dermatology Life Quality Index (DLQI): results from patients with chronic idiopathic urticaria. Health Qual Life Outcomes 2005; 20: 33–36.
Chey WD, Wong BC. American College of Gastroenterology guideline on the management of Helicobacter pylori infection. Am J Gastroenterol 2007; 102: 1808–1825.
Bures J, Cyrany J, Kohoutova D, Förstl M, Rejchrt S, Kvetina J, Vorisek V, Kopacova M. Small intestinal bacterial overgrowth syndrome. World J Gastroenterol 2010; 16: 2978–2990.
Jais M, Baruna S. Seroprevalence of anti Helicobacter pylori IgG/IgA in asymptomatic population from Delhi. J Commun Dis 2004; 36: 132–135.
Bruce MG, Maaroos HI. Epidemiology of Helicobacter pylori infection. Helicobacter 2008; 13 Suppl 1: 1–6.
Quingley EM, Abu-Shanab A. Small intestinal bacterial overgrowth. Infect Dis Clin North Am 2010; 24: 943–959.
Shakouri A, Compalati E, Lang DM, Khan DA. Effectiveness of Helicobacter pylori eradication in chronic urticaria: evidence-based analysis using the Grading of Recommendations Assessment, Development, and Evaluation system. Curr Opin Allergy Clin Immunol 2010; 10: 362–369.
Dauden E, Alionso IJ, Diez AG. H. pylori and chronic idiopathic urticaria. Int J Dermatol 2000; 39: 446–452.
Wedi B, Raap U, Wieczorek D, Kapp A. Infections and chronic spontaneous urticaria. A review. Hautarzt 2010; 61: 758–764.
Fokuda S, Shimoyama T, Umegaki N, Mikami T, Nakano H, Munakata A. Effect of Helicobacter pylori eradication in the treatment of Japanese patients with chronic idiopathic urticaria. J Gastroenterol 2004; 39: 827–830.
Yadav MK, Rishi JP, Nijawan S. Chronic urticaria and Helicobacter pylori. Indian J Med Sci 2008; 62: 157–162.
Magen E, Mishal J, Schlesinger M, Scharf S. Eradication of HP infection equally improves chronic urticaria with positive and negative autologous serum skin test. Helicobacter 2007; 12: 567–571.
Zuberbier T. Urticaria. Allergy 2003; 58: 1224–1234.
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Volume 93, Issue 2
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