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Investigative Report

Comparison of Foxp3+ Regulatory T cells and CD163+ Macrophages in Invasive and Non-invasive Extramammary Paget’s Disease

doi: 10.2340/00015555-1453

Abstract:

Regulatory T cells (Tregs), identified by the expression of CD4, CD25 and Foxp3, together with immunosuppressive macrophages, such as CD163+ M2 macrophages, are involved in maintaining peripheral tolerance. The aim of this study was to elucidate the involvement of Tregs and CD163+ macrophages in invasive and non-invasive extramammary Paget’s disease. The presence of CD4+CD25+Foxp3+ Tregs, CD163+ M2 macrophages and matrix metalloproteinase-9+ cells was examined immunohistologically in fixed sections of lesional skin from 10 patients with non-invasive extramammary Paget’s disease and 7 patients with invasive extramammary Paget’s disease. Fewer CD4+CD25+Foxp3+ Tregs were observed in non-invasive extramammary Paget’s disease than in invasive extramammary Paget’s disease. In contrast, higher numbers of CD163+ macrophages and metalloproteinase-9+ cells were detected only in invasive extramammary Paget’s disease. These findings suggest that the induction of immunosuppressive cells in extramammary Paget’s disease differs according to the tumour stage.

Authors:

Taku Fujimura, Yumi Kambayashi, Takanori Hidaka, Akira Hashimoto, Takahiro Haga, Setsuya Aiba
Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan. E-mail: tfujimura1@mac.com

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Volume 92, Issue 6

DOI: 10.2340/00015555-1453

Pages: 625-628

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