Masami Uehara
DOI: 10.2340/0001555592109110

A total of 41 biopsy specimens of the first visible prurigo papule were obtained from 32 adult patients with atopic dermatitis. In 38 of the 41 biopsy specimens, histological changes were seen in connection with hair follicle. The follicular wall showed spongiosis and vesicle formation with mononuclear cell migration. The remaining 3 biopsy specimens revealed an eczematous change which involved the surface epidermis. Multinucleated epidermal cells were observed in 34 of the 41 biopsy specimens. The giant cells occurred at skin sites of eczematous inflammation.