Content » Vol 86, Issue 1

Clinical Report

Topical Photodynamic Therapy for Prevention of New Skin Lesions in Renal Transplant Recipients

Hans Christian WULF, Stan PAVEL, Ida STENDER, Christianne AHB BAKKER-WENSVEEN
DOI: 10.1080/00015550510042868


Preclinical data suggest that topical methyl aminolevulinate photodynamic therapy may have potential in preventing new skin lesions in transplant recipients. An open intra-patient randomized study investigated the prevention potential of this treatment in 27 renal transplant patients with actinic keratoses and other skin lesions in two circular contralateral areas (5 cm diameter). The treatment area surface was debrided and methyl aminolevulinate cream (160 mg/g) was applied for 3 h prior to illumination by non-coherent red light (570–670 nm, light dose 75 J/cm 2 ). The control area was not treated. The mean time to occurrence of the first new lesion was significantly longer in treated than control areas (9.6 vs 6.8 months, treatment difference 2.9 [95% confidence interval 0.2 to 5.5] months, p< =0.034). Over 12 months, 62% (16/26) of treated areas were free from new lesions compared with 35% (9/26) in control areas. These findings indicate that topical methyl aminolevulinate photodynamic therapy is a promising preventive treatment against new skin lesions in immunosuppressed patients.


Supplementary content


Not logged in! You need to login/create an account to comment on articles. Click here to login/create an account.