Content » Vol 89, Issue 3

Clinical Report

Neopterin and C-Reactive Protein in the Course of Stevens-Johnson Syndrome: Report of a Case

Linda Bertram, Yvonne Liss and Michael Grözinger
DOI: 10.2340/00015555-0631


We describe a patient originally suffering from a depressive syndrome who developed Stevens-Johnson syndrome after 12 days of treatment with lamotrigine. The clinical symptoms and the inflammation parameters neopterin and C-reactive protein were documented. Neopterin values showed a good correlation with the course of the disease, which, to the best of our knowledge, has not been reported previously. C-reactive protein followed the neopterin curve with a delay of 4 days. Since neopterin is a widely available parameter it should be considered as a routine measurement in this type of hyperergic reaction. It might help to identify the beginning, the maximum and the regression of the disease in order to support therapeutic decisions.


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