Content

Content - Volume 89, Issue 3

Editor's choice in this issue

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IN THIS ISSUE
Does Iloprost Interfere with the Inflammatory Cascade in Systemic Sclerosis?
Elisabeth Aberer
In this issue (p. 245–249) Philipp Rehberger and co-workers report on the long-term impact of a 5–7-day course of iloprost infusion on endothelial-cell-associated soluble adhesion molecules and growth factors in 13 patients with systemic sclerosis. Serum levels of sE-selectin, sVCAM-1 and sICAM-1 were increased before therapy and were significantly reduced by the treatment. sE-selectin and sVC ...
Pages: 227-227
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IN THIS ISSUE
Not to be Forgotten: Cutaneous Langerhans' Cell Histio­cytosis in an Adult
Annamari Ranki
Campanati and coworkers (p. 299–301) describe an interesting differential diagnostic case: an elderly patient who developed large, diffuse erythematous inflammatory plaques resembling psoriasis inversa, impetiginized eczema or intertrigo. A skin biopsy revealed a lymphohistiocytic infiltration consisting of histiocytes with large kidney-shaped nuclei and abundant pink cytoplasm. A diagnosis of L ...
Pages: 227-227
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REVIEW
Progress in Heritable Skin Diseases: Translational Implications of Mutation Analysis and Prospects of Molecular Therapies
Jouni Uitto
Epidermolysis bullosa, a group of blistering disorders, serves as the paradigm of the tremendous progress made in understanding the molecular genetics of heritable skin diseases. Mutations in 10 distinct genes have been disclosed in the classic forms of epidermolysis bullosa, and the level of expression of the mutated genes within the cutaneous basement membrane zone, the types and combinations of ...
Pages: 228-235
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REVIEW
Drug-induced Pruritus: A Review
Adam Reich, Sonja Ständer and Jacek C. Szepietowski
Pruritus is an unpleasant sensation that leads to scratching. In addition to several diseases, the administration of drugs may induce pruritus. It is estimated that pruritus accounts for approximately 5% of all skin adverse reactions after drug intake. However, to date there has been no systematic review of the natural course and possible underlying mechanisms of drug-induced pruritus. For example ...
Pages: 236-244
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INVESTIGATIVE REPORT
Prostacyclin Analogue Iloprost Influences Endothelial Cell-associated Soluble Adhesion Molecules and Growth Factors in Patients with Systemic Sclerosis: A Time Course Study of Serum Concentrations
Philipp Rehberger, Petra Beckheinrich-Mrowka, Uwe-Frithjof Haustein and Michael Sticherling
Systemic sclerosis is a connective tissue disorder with unclear aetiology and pathogenesis. However, there is evidence that microvascular changes belong to the early symptoms of the disease. These are associated with increased serum levels of markers of endothelium activation, such as adhesion molecules and growth factors. The stable prostacyclin analogue iloprost is licensed for vascular symptoms ...
Pages: 245-249
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INVESTIGATIVE REPORT
Measuring the Prevalence of Chronic Itch in the General Population: Development and Validation of a Questionnaire for Use in Large-scale Studies
Uwe Matterne, Tamara Strassner, Christian J. Apfelbacher, Thomas L. Diepgen and Elke Weisshaar
Itching is the most frequent symptom in dermatology. Little is known about its occurrence and its characteristics in the general population. Instruments specifically designed to measure itch are scarce. The aim of this pilot study was to develop and validate an instrument measuring prevalence and characteristics of chronic itch in the general population. A questionnaire was developed and administe ...
Pages: 250-256
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CLINICAL REPORT
Total Serum IgE as a Parameter to Differentiate Between Intrinsic and Extrinsic Atopic Dermatitis in Children
Hagen Ott, Sven Stanzel, Christine Ocklenburg, Hans-Friedrich Merk, Jens Malte Baron and Sylvia Lehmann
Atopic dermatitis (AD) has been sub-classified into extrinsic and intrinsic types according to the presence or not of allergen-specific IgE antibodies. Although total serum IgE levels are frequently elevated in AD, their potential to predict allergen-specific IgE (asIgE) has rare ly been studied. We investigated 103 children with AD and suspected allergen-specific sensitization. A thorough clini ...
Pages: 257-261
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INVESTIGATIVE REPORT
Epidemiological Study of Psoriasis in the National Health Insurance Database in Taiwan
Yun-Ting Chang, Tzeng-Ji Chen, Pei-Chi Liu, Yu-Chun Chen, Yi-Ju Chen, Yu-Lin Huang, Jaw-Shyang Jih, Chih-Chiang Chen, Ding-Dar Lee, Wen-Jen Wang, Ming-Wei Lin and Han-Nan Liu1
The aim of this study was to determine the prevalence, treatment modalities and comorbidity of psoriasis in Taiwan. A nationally representative cohort of 1,000,000 individuals from the National Health Insurance database was followed up for the years 2000 to 2006. Their claims data was used for an epidemiological study. The mean one-year prevalence of psoriasis was 0.23% for men and 0.16% for women ...
Pages: 262-266
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INVESTIGATIVE REPORT
Frequency and Treatment of Trichotillomania in Poland
Jacek C. Szepietowski, Joanna Salomon, Przemysław Pacan, Ewa Hrehorów and Anna Zalewska
Although trichotillomania is a relatively common disorder no large epidemiological studies are available. The aims of this study were to determine the frequency of trichotillomania as identified by Polish dermatologists, and to evaluate the treatment modalities used. A questionnaire was sent to 172 dermatologists; 118 (68.6%) responded. The questions covered demographic data, frequency of trichoti ...
Pages: 267-270
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INVESTIGATIVE REPORT
Impact of Scratching on Itch and Sympathetic Reflexes Induced by Cowhage (Mucuna pruriens) and Histamine
Frauke Kosteletzky, Barbara Namer, Clemens Forster and Hermann O. Handwerker
Cowhage and histamine, both applied via spicules, were used to induce itch. The quality and intensity of the sensations, axon reflex flare, sympathetic skin vasoconstrictions and the interference of scratching with itch processing were studied. Axon reflex flare reactions were measured by laser Doppler imaging and reflex vasoconstrictions in the finger were recorded by laser Doppler flowmetry. Mag ...
Pages: 271-277
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CLINICAL REPORT
Onychophagia as a Spectrum of Obsessive-compulsive Disorder
Przemysław Pacan, Magdalena Grzesiak, Adam Reich and Jacek C. Szepietowski
Onychophagia can be explained as a kind of a compulsion that may cause destruction of the nails. Habitual nail biting is a common behaviour among children and young adults. By the age of 18 years the frequency of this behaviour decreases, but it may persist in some adults. Nail biting is an under-recognized problem, which may occur on a continuum ranging from mild to severe. Nail biting has receiv ...
Pages: 278-280
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INVESTIGATIVE REPORT
Body Dysmorphic Disorder in University Students with Skin Diseases Compared with Healthy Controls
Yeşim Kaymak, Ender Taner and Işıl Şimşek
Body dysmorphic disorder appears relatively frequently in dermatological and cosmetic surgery settings; in fact, dermatologists may be the type of practitioner most often consulted by patients with body dysmorphic disorder. The aim of this study was to evaluate body dysmorphic disorder symptoms in Turkish university students with skin diseases. A total of 107 outpatients diagnosed with any skin di ...
Pages: 281-284
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CLINICAL REPORT
Neopterin and C-Reactive Protein in the Course of Stevens-Johnson Syndrome: Report of a Case
Linda Bertram, Yvonne Liss and Michael Grözinger
We describe a patient originally suffering from a depressive syndrome who developed Stevens-Johnson syndrome after 12 days of treatment with lamotrigine. The clinical symptoms and the inflammation parameters neopterin and C-reactive protein were documented. Neopterin values showed a good correlation with the course of the disease, which, to the best of our knowledge, has not been reported previous ...
Pages: 285-287
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CLINICAL REPORT
Effect of Calcipotriol on Etanercept Partial Responder Psoriasis Vulgaris and Psoriatic Arthritis Patients
Elena Campione, Annamaria Mazzotta, Evelin Jasmine Paternò, Laura Diluvio, Joerg Christoph Prinz and Sergio Chimenti
Patients who respond only partially to etanercept may require additional treatments that act synergistically to improve their therapeutic response while at the same time reducing the dose required and the risk of side-effects. The aim of this study was to evaluate the effecti veness of topical calcipotriol in etanercept partial responder patients. We enrolled 120 patients affected by psoriasis vul ...
Pages: 288-291
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CLINICAL REPORT
Assessment of Cryotherapy for the Treatment of Verrucous Epidermal Naevi
Antonios Panagiotopoulos, Vasiliki Chasapi, Vasiliki Nikolaou, Panagiotis G. Stavropoulos, Kyriockos Kafouros, Athanasios Petridis and Andreas Katsambas
Epidermal naevi are hamartomas that are characterized by hyperplasia of the epidermis and adnexal structures and may be associated with serious disfiguration. Management of epidermal naevi is challenging. We present here our experience with cryosurgery in the treatment of verrucous epidermal naevi. The aim of this study was to determine the efficacy and safety of cryosurgery for the treatment of e ...
Pages: 292-294
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CLINICAL REPORT
Treatment of Disseminated Granuloma Annulare with Low-dose Fumaric Acid
H. Oliver Weber, Claudia Borelli, Martin Röcken and Martin Schaller
While localized variants of granuloma annulare are typically self-limited, disseminated granuloma annulare tends to be chronic and often therapy-resistant. Treatment with fumaric acid esters is effective for severe forms of psoriasis. Disseminated granuloma annulare has also been reported to respond to fumaric acid esters. We treated 8 patients (mean age 64.2 years; 4 men, 4 women) with low-dose f ...
Pages: 295-298
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CLINICAL REPORT
Purely Cutaneous Langerhans' Cell Histiocytosis in an Adult Woman
Anna Campanati, Oriana Simonetti, Barbara Marconi, Katia Giuliodori, Giulia Ganzetti, Giuliano Brandozzi, Maria Luisa Bernardini, Renzo Ranaldi, Annamaria Offidani
Langerhans’ cell histiocytosis (LCH) is a clonal, histiocytic, proliferative disorder of unknown aetiology originating from Langerhans’ cells. Although the clinical presentation and therapeutic approach to the disease in children have been well established, few data are available concerning the disease in adults. Moreover, unique cutaneous involvement by LCH in a woman older than 70 years ...
Pages: 299-301
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LETTER TO THE EDITOR
Ex Vivo Analyses of Ano-genital Wart Lymphocytes to Study the Human Papillomavirus Immune Response
Adrian Heaps, Nashat Hanna, Margaret Stanley and Peter Goon
This article does not have an abstract.
Pages: 303-304
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LETTER TO THE EDITOR
A Randomized, Single-blind Comparison of the Efficacy, Tolerability and Cosmetic Acceptance of Propyless® or Fenuril® Treatment of Patients with Dry Skin
Jan Faergemann, Petter Olsson and Åke Svensson
This article does not have an abstract.
Pages: 305-307
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LETTER TO THE EDITOR
Is There a Connection Between Mannan-binding Lectin Deficiency and Chronic Leg Ulcers?
Mikael Bitsch, Michael Christiansen, Inga Laursen, Anne-Marie Engel, Per Evald Holstein and Tonny Karlsmark
This article does not have an abstract.
Pages: 307-308
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LETTER TO THE EDITOR
Phacomatosis Cesioflammea Associated with Pectus Excavatum
Ching-Ying Wu, Po-Hung Chen and Gwo-Shing Chen
This article does not have an abstract.
Pages: 309-310
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LETTER TO THE EDITOR
Lichen Spinulosus in an Alcoholic Patient
Rieko Kabashima, Kazunari Sugita, Kenji Kabashima, Motonobu Nakamura and Yoshiki Tokura
This article does not have an abstract.
Pages: 311-312
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LETTER TO THE EDITOR
Acne Keloidalis of the Scalp in a Renal Transplant Patient Treated with Cyclosporine
Stefano Piaserico, Anna Belloni Fortina, Federica Cavallini and Mauro Alaibac
This article does not have an abstract.
Pages: 312-313
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LETTER TO THE EDITOR
Prolonged Course of Acute Generalized Exanthematous Pustulosis with Liver Involvement due to Sensitization to Amoxicillin and Paracetamol
Regina Treudler, Sonja Grunewald, Carl Gebhardt and Jan-Christoph Simon
This article does not have an abstract.
Pages: 314-315
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LETTER TO THE EDITOR
Multiple Accessory Tragi without Cartilage: Relationship with Hair Follicle Naevi?
Akihiko Asahina, Hiroyuki Mitomi, Naoki Sakurai, Hideki Fujita
This article does not have an abstract.
Pages: 316-317
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LETTER TO THE EDITOR
Fatal Lymphangiosarcoma Revealed by Lymphoedema of the Neck
Nathalie Lalanne, Khaled Ezzedine, Béatrice Vergier, François Liferman, Alain Taieb and Thomas Jouary
This article does not have an abstract.
Pages: 318-319
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LETTER TO THE EDITOR
Erythema Annulare Centrifugum Associated with Mantle B-cell Non-Hodgkin's Lymphoma
Marta Carlesimo, Laura Fidanza, Elena Mari, Guglielmo Pranteda, Claudio Cacchi, Barbara Veggia, Maria Cristina Cox and Germana Camplone
This article does not have an abstract.
Pages: 319-320
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LETTER TO THE EDITOR
Erythematous Macules on the Feet in a Case of Cardiac Myxoma
Anne-Claire Bursztejn, Anne Bellut, Frédérique Weber-Muller, Jacqueline Champigneulle, Philippe Beurey, Jean-Francois Cuny, Annick Barbaud and Jean-Luc Schmutz
This article does not have an abstract.
Pages: 321-322
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LETTER TO THE EDITOR
Cutaneous Ciliated Cyst on the Leg in a Woman of Menopausal Age
Hitoe Torisu-Itakura, Eijun Itakura, Rie Horiuchi, Miyuki Matsumura, Hiromaro Kiryu, Taizo Takeshita, Yuko Ohjimi and Masutaka Furue
This article does not have an abstract.
Pages: 323-324
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LETTER TO THE EDITOR
Cutaneous Lichenoid Eruption Caused by Imatinib Mesylate in a Japanese Patient with Chronic Myeloid Leukaemia
Tamihiro Kawakami, Takeshi Kawanabe and Yoshinao Soma
This article does not have an abstract.
Pages: 325-326
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LETTER TO THE EDITOR
Tattoo-associated Pseudolymphomatous Reaction and its Successful Treatment with Hydroxychloroquine
Annalisa Patrizi, Beatrice Raone, Francesco Savoia, Francesco Bacci, Alessandro Pileri, Carlotta Gurioli and Iria Neri
This article does not have an abstract.
Pages: 327-328
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LETTER TO THE EDITOR
Coexistence of Recurrent Generalized Morphea and Systemic Sclerosis
Miho Hayashi, Yoshiro Ichiki and Yasuo Kitajima
Abstract is missing (Letter)
Pages: 329-330
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LETTER TO THE EDITOR
Subcutaneous Metastasis due to Primary Central Nervous System Malignant Lymphoma
Monji Koga, Yuichi Yoshida, Kaori Koga and Juichiro Nakayama
This article does not have an abstract.
Pages: 331-332
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LETTER TO THE EDITOR
Efficiency and Safety of Etanercept after Acute Hepatitis Induced by Infliximab for Psoriasis
Nicolas Kluger, Céline Girard, Bernard Guillot and Didier Bessis
This article does not have an abstract.
Pages: 332-334
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LETTER TO THE EDITOR
Keloid Occurring in a Tattoo after Laser Hair Removal
Nicolas Kluger, Sophie Hakimi and Pascal Del Giudice
This article does not have an abstract.
Pages: 334-335
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